• Journal of Korean Society of Industrial and Systems Engineering
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• v.16 no.27
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• pp.83-89
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• 1993

In order to model the Group Technology Problem three formulations are used, that is, generally the following formulations are used: (1) Matrix formulation, (2) Mathematical programming formulation, (3) Graph formulation. In the case of Matrix formulation, it is difficult to discribe the situation using the multi-job machine. But this paper proposed the model of Group Technology using the multi-job machin, taking the method of making practical application of principle of similarity coefficient.

• Journal of the Korean Operations Research and Management Science Society
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• v.16 no.2
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• pp.137-137
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• 1991

This paper compares and evaluates the performances of the two types of mathematical programming models for solving the machine-part cell formation problem in group technology manufacturing : indirect formulation relying on surrogate measure such as similarity coefficient and direct formulation seeking to minimize the number of exceptional elements. New indirect formulation, called the generalized p-median model. is proposed. Unlike existing p-median formulations, proposed formulation includes the classical cell formation problem in which only one process plan exsits for each part as a special case. The proposed new formulation can also deal with the cell formation problem in which alternative process plans exist for a part. The indirect formulation is compared with a new direct formulation which needs much fewer extra variables and constraints than existing direct formulations. Some significant findings from comparative experiment are discussed.

• Korean Management Science Review
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• v.16 no.2
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• pp.137-147
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• 1999

This paper compares and evaluates the performances of the two types of mathematical programming models for solving the machine-part cell formation problem in group technology manufacturing : indirect formulation relying on surrogate measure such as similarity coefficient and direct formulation seeking to minimize the number of exceptional elements. New indirect formulation, called the generalized {{{{ { p}_{ } }}-median model. is proposed. Unlike existing {{{{ { p}_{ } }}-median formulations, proposed formulation includes the classical cell formation problem in which only one process plan exsits for each part as a special case. The proposed new formulation can also deal with the cell formation problem in which alternative process plans exist for a part. The indirect formulation is compared with a new direct formulation which needs much fewer extra variables and constraints than existing direct formulations. Some significant findings from comparative experiment are discussed.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.10a
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• pp.105-110
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• 2005

The penalty method has been widely applied to analyses of incompressible fluid flow. However, we have not yet found any prior studies that employed penalty method to analyze compressible fluid flow. In this study, with an eye on the apparent similarity between the slight compressible formulation and the penalty formulation, we have proposed a modified approximate approach that can analyze compressible packing process using the penalty parameter, which is an improvement on an earlier formulation (KSME, 2004B). Based on the assumption of the isothermal flow, a set of reference solutions was obtained to verify the validity of the proposed scheme. Furthermore, we have applied the proposed scheme to the analysis of the packing process of different cases.

• Archives of Pharmacal Research
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• v.24 no.6
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• pp.568-571
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• 2001

The purpose of this work was to study the effect of storage time and temperature on the in vitro release kinetics of a commercial sustained-release dosage form of theophylline, at different pHs of the dissolution medium. The formulation was stored at $35^{\circ}C$ for 16 months and at $45^{\circ}C$ for 8 months, with a relative humidity of 60%. The in vitro release tests were performed at pHs 2, 4, 6 and 7.4. The mean values of the transport coefficient n, were close to 0.5 in all the conditions tested, which indicates that the transport system is not modified after storage of the formulation at $35^{\circ}C$ and $45^{\circ}C$. The mean values of the dissolution rate constant ranged from 0.036 to 0.043 $min^{-n}$, under all the conditions tested. Significant differences (${\alpha}=0.05$) were found between pHs 2, 4 and 6, 7.4 for all the model-independent parameters studied. When the formulation was kept at $35^{\circ}C$ for 16 months, the mean percentage of drug dissolved at 8 hours was 25.61% (pHs 2, 4) and, 36.12% (pHs 6, 7.4), representing a 26% and 24% reduction, respectively. Simitar results were obtained after storing the formulation at $45^{\circ}C$ for 8 months, corresponding to 33.3% (pHs 2, 4) and, 22.5% (pHs 6, 7.4) diminution, respectively. The values of the similarity factory $f_2$, obtained were lower than 50, which indicates the lack of similarity among the dissolution profiles, after storing the formulation under the experimental Conditions tested.

• Proceedings of the KSME Conference
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• 2004.11a
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• pp.916-921
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• 2004

The penalty method has been widely applied to analyses of incompressible fluid flow. However, we have not yet found any prior studies that employed penalty method to analyze compressible fluid flow. In this study, with an eye on the apparent similarity between the slight compressible formulation and the penalty formulation, we have proposed a new approximate approach that can analyze compressible packing process using the penalty parameter l. Based on the assumption of the isothermal flow, a set of reference solutions was obtained to verify the validity of the proposed scheme. Furthermore, we have applied the proposed scheme to the analysis of the packing process of different cases.

• Journal of Pharmaceutical Investigation
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• v.40 no.5
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• pp.297-304
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• 2010

The present work focuses on preparation of olanzapine, orally dispersing tablets by direct compression method. Effect of super disintegrant crospovidone, disintegration time, drug content on in vitro release has been studied. A factorial design was employed in formulating a prompt dispersible tablet. The selected independent variables crospovidone and fmelt showed significant effect on dependent variables i.e. disintegration time and percent drug dissolved. Disintegration time and percent drug dissolved decreased with increase in the level of crospovidone. The similarity factor $f_2$ was found to be 97.48 for the developed formulation indicating the release was similar to that of the marketed formulation. Pharmacokinetics of olanzapine after single-dose oral administration of orally disintegrating tablet in normal volunteers were evaluated and the results showed that PK parameters (Cmax, Tmax, AUC) of the designed ODT matrix were similar to those of commercial product, Zyprexa Zydis$^{(R)}$ as a reference.

• Communications for Statistical Applications and Methods
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• v.13 no.3
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• pp.719-732
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• 2006

A set of clustering algorithms with proper weight on the formulation of distance which extend to mixed numeric and multiple binary values is presented. A simple matching and Jaccard coefficients are used to measure similarity between objects for multiple binary attributes. Similarities are converted to dissimilarities between i th and j th objects. The performance of clustering algorithms with balancing weight on different similarity measures is demonstrated. Our experiments show that clustering algorithms with application of proper weight give competitive recovery level when a set of data with mixed numeric and multiple binary attributes is clustered.

• Journal of the Korean Society for Precision Engineering
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• v.19 no.12
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• pp.142-149
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• 2002

In this paper, the metal forming process is caused of rise of the unit cost of production in increase of the lead-time and cost because of manufacturing final product through a few the number of processes. Flow control complex forming is proposed to put into formulation in order to apply cold forging from conventional approximate similarity theory, and the forming loads of the real material(AISI 1008) can be calculated by put at the new similarity formula the load by plasticine model material experiment through hub clutch. In order to reduce lead-time and cost the technology is used to manufacture with lower die of this product. By the application synthetic resin as the raw material, it is have the merit such short lead-time, low cost, good surface finish etc., as compared with the machine work.

• Journal of the Korean Society for Precision Engineering
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• v.8 no.4
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• pp.95-106
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• 1991

A numerical computation of turbulent wirling flow in a stationary pipe is presented in this work. Major concerns of this study are: 1) To approve similarity laws which were verified experimentally. 2) To investigate the effects of curvature modification for the K- .epsilon. model. To account for effects of swirl, Rodi's curvature correction and Kim & Chung's are applied. The governing differential equations for eliptic flow are discretized by control volume formulation method, and the discretized equations are calculated ay line by line TDMA and SIMPLE algorithm. The computational results also satisfy similarity laws which are based on swirl angle as in experiments. And the curvature modification of Rodi improves compuational accuacy than the standard K- .epsilon. model. But such lower order closure models are not adequate for the prediction of this complex flow.