• ETRI Journal
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• v.35 no.1
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• pp.41-50
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• 2013

Network Mobility (NEMO) handles mobility of multiple nodes in an aggregate manner as a mobile network. The standard NEMO suffers from a number of limitations, such as inefficient routing and increased handoff latency. Most previous studies attempting to solve such problems have imposed an extra signaling load and/or modified the functionalities of the main entities. In this paper, we propose a more secure and lightweight route optimization (RO) mechanism based on exploiting the firewall in performing the RO services on behalf of the correspondent nodes (CNs). The proposed mechanism provides secure communications by making an authorized decision about the mobile router (MR) home of address, MR care of address, and the complete mobile network prefixes underneath the MR. In addition, it reduces the total signaling required for NEMO handoffs, especially when the number of mobile network nodes and/or CNs is increased. Moreover, our proposed mechanism can be easily deployed without modifying the mobility protocol stack of CNs. A thorough analytical model and network simulator (Ns-2) are used for evaluating the performance of the proposed mechanism compared with NEMO basic support protocol and state-of-the-art RO schemes. Numerical and simulation results demonstrate that our proposed mechanism outperforms other RO schemes in terms of handoff latency and total signaling load on wired and wireless links.

• Proceedings of the IEEK Conference
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• 2002.07a
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• pp.568-570
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• 2002

With the development of Wavelength Division Multiplexing (WDM) and Optical Cross-Connect (OXC) systems, an efficient integration of IP and WDM has been focused. The Optical Internetworking Forum (OIF) proposes a new model that is called Overlay model for the integration of IP and WDM. In the Overlay model, UNI 1.0 signaling is adopted to establish signaling interface between Optical and IP network. UNI 1.0 signaling consists of a lot of functions; especially, reliability, light traffic, and etc. For that reason, Srefresh and ACK messages in UNI signaling support reliable messaging and reduce the amount of information that must be transmitted and processed in order to maintain RSVP states and processing time. This paper focuses on an implementation of Srefresh and ACK messages based on UNI 1.0 signaling and comparison between before and after implementing. The results show that Srefresh and ACK messages improve intelligence in the control plane of the optical network, which will make them more survivable, flexible, reliable, and controllable.

• Proceedings of the KSR Conference
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• 2011.10a
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• pp.2795-2803
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• 2011

Due to speed acceleration, higher requirements have been put forward to high speed railway communication and signaling system. The railway applications, including intra-train, train to ground and trackside networks, demand larger bandwidth, higher reliability and shorter response time from railway communication networks to ensure security operation and passenger communication. However, the current railway communication and signaling system has lagged behind the railway development, so advanced communication technologies are needed to improve the current situation. This paper presents high speed railway communication and signaling system based on 4G LTE technology, introduces its network architecture, key technology and analyzes its technical advantages compared with GSM-R system. According to analysis, LTE based high-speed railway communication network is more effective and reliable.

• IMMUNE NETWORK
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• v.11 no.5
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• pp.245-252
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• 2011

Antimicrobial peptides/proteins are ancient and naturally-occurring antibiotics in innate immune responses in a variety of organisms. Additionally, these peptides have been recognized as important signaling molecules in regulation of both innate and adaptive immunity. During mycobacterial infection, antimicrobial peptides including cathelicidin, defensin, and hepcidin have antimicrobial activities against mycobacteria, making them promising candidates for future drug development. Additionally, antimicrobial peptides act as immunomodulators in infectious and inflammatory conditions. Multiple crucial functions of cathelicidins in antimycobacterial immune defense have been characterized not only in terms of direct killing of mycobacteria but also as innate immune regulators, i.e., in secretion of cytokines and chemokines, and mediating autophagy activation. Defensin families are also important during mycobacterial infection and contribute to antimycobacterial defense and inhibition of mycobacterial growth both in vitro and in vivo. Hepcidin, although its role in mycobacterial infection has not yet been characterized, exerts antimycobacterial effects in activated macrophages. The present review focuses on recent efforts to elucidate the roles of host defense peptides in innate immunity to mycobacteria.

• ETRI Journal
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• v.30 no.5
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• pp.685-695
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• 2008

The Network Mobility (NEMO) and IPv6 over Low power WPAN (6LoWPAN) protocols are the two most important technologies in current networking research and are vital for the future ubiquitous environment. In this paper, we propose a compressed packet header format to support the mobility of 6LoWPAN. Also, a Lightweight NEMO protocol is proposed to minimize the signaling overhead between 6LoWPAN mobile routers and 6LoWPAN gateways by using a compressed mobility header. Performance results show that our Lightweight NEMO protocol can minimize total signaling costs and handoff signaling delay.

• IMMUNE NETWORK
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• v.13 no.5
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• pp.184-193
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• 2013

Co-signaling molecules are surface glycoproteins that positively or negatively regulate the T cell response to antigen. Co-signaling ligands and receptors crosstalk between the surfaces of antigen-presenting cells (APCs) and T cells, and modulate the ultimate magnitude and quality of T cell receptor (TCR) signaling. In the past 10 years, the field of co-signaling research has been advanced by the understanding of underlying mechanisms of the immune modulation led by newly identified co-signaling molecules and the successful preclinical and clinical trials targeting co-inhibitory molecules called immune checkpoints in the treatment of autoimmune diseases and cancers. In this review, we briefly describe the characteristics of well-known B7 co-signaling family members regarding the expression, functions and therapeutic implications and to introduce newly identified B7 members such as B7-H5, B7-H6, and B7-H7.

• BMB Reports
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• v.41 no.7
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• pp.485-494
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• 2008

The Wnt signaling network, which is composed of Wnt ligands, receptors, antagonists, and intracellular signaling molecules, has emerged as a powerful regulator of cell fate, proliferation, and function in multicellular organisms. Over the past two decades, the critical role of Wnt signaling in embryonic cartilage and bone development has been well established, and much has been learnt regarding the role of Wnt signaling in chondrogenesis and cartilage development. However, relatively little is known about the role of Wnt signaling in adult articular cartilage and degenerative cartilage tissue. This review will briefly summarize recent advances in Wnt regulation of chondrogenesis and hypertrophic maturation of chondrocytes, and review data concerning the role of Wnt signaling in the maintenance and degeneration of articular chondrocytes and cartilage.

• The Korea Journal of Herbology
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• v.38 no.6
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• pp.73-91
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• 2023

Objectives : This study used a network pharmacology approach to elucidate the efficacy and molecular mechanisms of Daehwangmokdanpitang (DHMDPT) on Psoriasis. Methods : Using OASIS databases and PubChem database, compounds of DHMDPT and their target genes were collected. The putative target genes of DHMDPT and known target genes of psoriasis were compared and found the correlation. Then, the network was constructed using Cytoscape 3.10.1. The key target genes were screened by Analyzer network and their functional enrichment analysis was conducted based on the Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathways to predict the mechanisms. Results : The result showed that total 30 compounds and 439 related genes were gathered from DHMDPT. 264 genes were interacted with psoriasis gene set, suggesting that the effects of DHMDPT are closely related to psoriasis. Based on GO enrichment analysis and KEGG pathways, 'Binding', 'Cytokine Activity', 'Receptor Ligand Activity' 'HIF-1 signaling pathway', 'IL-17 signaling pathway', 'Toll-like receptor signaling pathway', and 'TNF signaling pathway' were predicted as functional pathways of 16 key target genes of DHMDPT on psoriasis. Among the target genes, IL6, IL1B, TNF, AKT1 showed high correlation with the results of KEGG pathways. Additionally, Emodin, Acetovanillone, Gallic acid, and Ferulic acid showed a high relevance with key genes and their mechanisms. Conclusion : Through a network pharmacological method, DHMDPT was predicted to have high relevance with psoriasis. This study could be used as a basis for studying therapeutic effects of DHMDPT on psoriasis.

• Proceedings of the IEEK Conference
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• 1998.10a
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• pp.207-210
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• 1998

Providing the connectivity interworking between the lightweight signaling function using in VOD set-top box and the broadband signaling function In the access node system, it can diminish the cost-burden of user about set-top box and we shall use efficiently the network resources. Therefore, In this paper, we shall design the signaling brokerage agent function for the connectivityinterworking in access node system and discuss the result applied its function to the real-time VOD service.

• International Journal of Computer Science & Network Security
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• v.22 no.3
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• pp.236-244
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• 2022

Network Mobility Basic Support (NEMO BS) protocol has been accredited and approved by Internet Engineering Task Force (IETF) working group for mobility of sub-networks. Trains, aircrafts and buses are three examples of typical applications for this protocol. The NEMO BS protocol was designed to offer Internet access for a group of passengers in a roaming vehicle in an adequate fashion. Furthermore, in NEMO BS protocol, specific gateways referred to Mobile Routers (MRs) are responsible for carrying out the mobility management operations. Unfortunately, the main limitations of this basic solution are pinball suboptimal routing, excessive signaling cost, scalability, packet delivery overhead and handoff latency. In order to tackle shortcomings of triangular routing and Quality of Service (QoS) deterioration, the proposed scheme (Diff-FH NEMO) has previously evolved for end-users in moving network. In this sense, the article focuses on an exhaustive analytic evaluation at Home Agent (HA) entity of the proposed solutions. An investigation has been conducted on the signaling costs to assess the performance of the proposed scheme (Diff-FH NEMO) in comparison with the standard NEMO BS protocol and MIPv6 based Route Optimization (MIRON) scheme. The obtained results demonstrate that, the proposed scheme (Diff-FH NEMO) significantly improves the signaling cost at the HA entity in terms of the subnet residence time, number of mobile nodes, the number of DMRs, the number of LFNs and the number of CNs.