• 한국공작기계학회논문집
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• 제15권6호
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• pp.114-120
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• 2006

Front-end side members of vehicles are structures with the greatest energy absorbing capability in a front-end collision of vehicles. This paper was undertaken to analyze the energy absorption characteristics of spot welded hat and double hat-shaped section members under the axial collapse. The experiments were performed with respect to the various collapse velocities. It was expected that para-closed sections would show collapse characteristics which be quite different from those of perfectly closed sections. The collapse velocities were selected as follows: the velocities in the hat-shaped section members were 0.00017m/sec, 0.017m/sec, 4.7m/sec, 6.5m/sec, 6.8m/sec, 7.2m/sec, and 7.3m/sec those in the double hat-shaped section members were 0.00017m/sec, 0.017m/sec, 6.5m/sec, 6.8m/sec, 7.2m/sec 7.3m/sec, and 7.9m/sec. In the program system presented in this study, an explicit finite element code, LS-DYNA3D, is adopted for simulating complicated collapse behavior of the hat and double hat-shaped section members under the same condition of the collapse test. The validity of simulation was confirmed by the comparison between the simulation result and the collapse experiment.

• 성인간호학회지
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• 제12권4호
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• pp.497-506
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• 2000

The purpose of this phenomenological study was to explore and describe the experience of people with HIV/AIDS. Three men and three women with HIV/AIDS participated in the study. They were asked open-ended and descriptive questions in order for them to talk about their experience in their own terms. Interviews were audiotaped and transcribed to maintain data integrity and to reduce perceptual bias. The transcripts were analyzed by the Colaizzi method. Member checks from the participants were used to validate the emergent themes. Seven themes emerged from the analysis. 1. People with HIV/AIDS have a strong impact and emotional reaction when receiving positive HIV test results. 2. All people with HIV/AIDS attempt to conceal HIV infection because of fear of stigma or rejection. 3. After the initial brief traumatic reaction to HIV/AIDS diagnosis, all participants feel lonely because they had no one to express or share their own experiences. 4. People with HIV/AIDS reflect on their life, think about the death and dying process and they become depressed. 5. Most participants feel that the family members who know his/her diagnosis are a big source of support. 6. According to the normativeness of infection route of HIV, the degree of guilty feeling differs among participants. 7. Although all participants think medication is a lifeline, the adherence to medication is not maintained because of side effects, denial and concealment of HIV/AIDS. The results of this study may help nurses and other health care workers to implement more efficient nursing strategies for people with HIV/AIDS by more deeply understanding their experience.

• 정보관리학회지
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• 제18권2호
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• pp.165-186
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• 2001

이 연구의 목적은 웹상에서 정보검색시스템과 상호대차시스템을 연계하여 이용할 수 있는 현실적 방안을 모색하는 것이다. 이를 위해 상호대차가 가장 활발하게 수행되고 있는 의학 도서관을 대상으로 상호대차현황을 조사, 분석하였고, 상호대차가 처리되는 과정을 단계적으로 분석하였다. 정보검색과 동시에 문헌을 신청할 수 있는 방안을 찾기 위하여 PubMed와 종합목록, 상호대차시스템이 연동될 수 있는 방안을 모색하였다. 연구결과 정부검색시스템의 결과물을 MEDLINE,XML/SGML 형태로 저장할 수 있어서 이를 활용할 수 있었고, 종합목록시스템 유지관리는 모든 도서관이 공동관리하고, 서버와 클라이언트에서 모두 검색되는 방안이 효율적으로 나타났다. 또한 상호대차시스템은 이용자사항은 IP 체크로, 신청내용은 정보검색결과를 저장하여 이것을 상호대차시스템에 그대로 이용하는 방안이 현실적 실현가능성이 있는 방안으로 모색되었다.

• 대한수의학회지
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• 제44권2호
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• pp.195-200
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• 2004

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family and potent inducer of apoptosis. TRAIL has been shown to effectively limit tumor growth in vivo without detectable cytotoxic side effects. Interferon (IFN)-${\gamma}$ often modulates the anti-cancer activities of TNF family members including TRAIL. We previously reported that IFN-${\gamma}$ enhanced TRAIL-induced Apoptosis in HeLa cells without the unknown mechanism. In this study, we investigated whether IRF-1 involves in IFN-${\gamma}$-enhanced TRAIL-induced apoptosis. We exposed HeLa cells to IFN-${\gamma}$ for 12 hours and then treated with recombinant TRAIL protein. No apoptosis was induced in cells pretreated with IFN-${\gamma}$, and TRAIL only induced 30% apoptosis after 3 hours treatment. In HeLa cells pretreated with IFN-${\gamma}$, TRAIL induced cell death to more than 75% at 3 hours, showed that IFN-${\gamma}$-pretreatment enhanced HeLa cell death to TRAIL-induced apoptosis. To investigate the functional role of IRF-1 in IFN-${\gamma}$-enhanced TRAIL-induced apoptosis, IRF-1 was overexpressed by using an adenoviral vector AdIRF-1. IRF-1 overexpression increased apoptotic cell death and significantly enhanced apoptotic cell death induced by TRAIL when infected cells were treated with TRAIL. Our findings show that IFN-${\gamma}$ enhances TRAIL-induced apoptosis by IRF-1 in HeLa cells.

• 한국미생물·생명공학회지
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• 제33권2호
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• pp.90-95
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• 2005

An Actinomycetes producing an anti-VRSA (vancomycin-resistant Staphylococcus aureus) substance was isolated from soil. The cultural, morphological, physiological and phylogenetic analyses of an isolated strain were investigated for identification. Cultural characteristics based on ISP (International Streptomyces Project) were as follows: white aerial mycelium, yellow reverse side, and good growth on various medium. Also, the isolate did not produce the soluble pigment. Morphological characteristics were showed cylindrical spore chain and smooth spore surface by SEM (Scanning Electron Microscope). Physiological characteristics were showed LL-type by DAP isomer analysis and detected glycine, glutamic acid and alanine. A phylogenetic analysis of the 16S rDNA provided a clue that the isolated strain was actually a member of the genus Streptomyces, because the determined sequence exhibited a higher homology with Streptomyces echinatus. The isolate was identified to be a genus of Streptomyces sp.. The optimal culture conditions for the maximum production of anti-VRSA substance by Streptomyces sp. were attained in a culture medium composed of $2.0\%$ (w/v) glucose, and $0.4\%$ (w/v) yeast extract. The anti-VRSA substance was highly produced after 5 days of culture. Optimal pH and temperature conditions for the production of anti-VRSA substance were pH 7.0 and $28^{\circ}C$, respectively.

• 전산구조공학
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• 제9권2호
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• pp.121-131
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• 1996

본 연구는 부재의 응력, 절점의 횡변위 등 거동적 제약과 설계변수에 가해지는 부차적 제약을 받는 평면뼈대 구조물의 설계에 적용할 수 있는 최적규준을 제안하고자 하는 것이다. 변위 및 응력제약 모두에 1차 근사법을 적용하며 이는 전응력 설계방법과 다른 점이다. 비선형인 제약조건식을 푸는데 Newton-Raphson방법을 이용하고 최소치수 제약과 관련하여 설계공간을 축소하는 등 수학적으로 엄밀한 방법으로 재설계 알고리즘을 유도하였다. 적용 예를 통하여 이 방법이 정확한 방법임이 입증되었으며 전응력 설계가 최적설계가 되지 못하는 경우도 종종 발견되었다. 이 방법은 복잡한 계산과정 만큼 그 이용가치가 있으며 단순한 응력비 알고리즘을 이용하는 대부분의 최적규준 방법에 대치되어야 할 것이다. 특히, Computer의 지속적인 발전은 이 방법의 보편적인 이용을 가능하게 할 것이다.

• 한국안전학회지
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• 제20권4호
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• pp.54-62
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• 2005

This Study is to find out how RC beam mixed with sawdust acts comparing with normal beam without sawdust mixture, and how they can be applied to the actual structural frame, despite a Int that they are mixed with waste material : saying sawdust. ED3H1, ED3H2, ED5H1, ED5H2, ED3H1UB, ED5H1UB, ED3H2L, ED5H2L and Normal without sawdust mixture are main factor to be tested here in order to apply them to the actual case. D and H means diameter 3cm or 5cm, and holes one and two respectively. And all variables are tested with each two for one variables. Test results are compared using crack diagrams and strain & loads. There are eleven(11)% capacity decrease between ED 3H1 and ED5H1 in rebar, strain. Left and right side crack shapes are much similar in variable ED3H2L having maximum capacity 14.5 tone. ED5H2L having maximum capacity thirteen(13)tone, in case of normal 19.6 tone. Two holes in beam rather on the longitudinal direction than on the forcing direction can be more effective to keep the original capacity of the beam because this case can distribute load more uniformly. There is 33% capacity decreased in case of diameter five(5)cm, compared to diameter three(3)cm. Two holes give thirty nine(39) percent capacity decrease than one of diameter three(3)cm.

• 한국강구조학회 논문집
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• 제18권2호
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• pp.261-270
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• 2006

본 논문은 기존의 철근콘크리트의 단점을 개선한 Lip형 모듈단면 MSC보의 휨거동에 대하여 실험값과 이론값을 비교 분석하여 MSC보의 적용에 대한 기초적인자료를 제시하고자하였다. 기존의 SC보는 제작과정에서 절단 및 용접 등 많은 노동력을 필요로 하지만 MSC보는 박판강재를 측면모듈과 하부모듈의 2가지 형태로 모듈화 하여 필요한 크기의 SC보를 손쉽게 제작할 수 있는 프리패브의 개념을 도입하였다. 실험결과 모듈간의 결합방법 및 콘크리트와의 합성방법에 개선이 필요성이 나타났으며 추후 연구를 통해 모듈간의 결합력강화 및 강재와 콘크리트의 합성율을 높인다면 새로운 구조부재로 사용이 가능하다고 판단된다.

• 근관절건강학회지
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• 제3권1호
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• pp.4-22
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• 1996

Purposes of this study were to identify a hospital-based home care model and to improve the physical, emotional and economical effectiveness of arthritic patients through medical and nursing team approach. The design in nonequivalent control group pretest-posttest design with matched samples in terms of age, sex and disease severity. Fifty two patients in each group were assigned in Seoul, Kyunggi, Kangwon and Kwangju. Before and after 6-month period of home care, level of pain, duration of morning stiffness, Richie Index, ADL, self efficacy, depression, cost expenditure were measured. Nine patients were excluded from the control group in the period of study because of denial of participation. Contents of home care provided to the experimental group include mainly distribution of prescribed drugs, 'assessment of patients' condition and side-reactions of drug. All of the information related to the home care patient were reported to the physician. On the bases of these data, the physician prescribe the specific drugs to each patient. Each patient visited the physician every 2 or 3 month for laboratory test. Patients assigned to the control group visited the outpatient clinic once a month as usual. Null hypotheses were selected because physicians concerned about the ineffective change of patients' conditions due to indirect communication with patients through nurses. Level of pain, Richie index, ADL, self-efficacy, depression, duration of morning stiffness and direct medical cost were the home care provided to them. If a family member accompany in a home care group can save 10,676 Won/month in Seoul, 34,000 Won/month in other districts. Other in-direct cost for transportation and meal can also be saved. In conclusion, those patients with low level of ADL, high level of pain and Richie index, living in the remote area definitely need the home care.

• 대한약침학회지
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• 제22권1호
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• pp.16-27
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• 2019

Generative and vegetative parts of the cactuses have had a long-lasting position in folk medicine and their effects could partly be confirmed in scientific experiments. Nowadays, the cactus, fruits, and cladodes are the focus of many studies because of their desirable properties. Therefore, the summarized reports of valuable properties of medicinal plants may be a good way to familiarize researches with a new source of drugs with lower side effects and higher efficacy. Opuntia dillenii, a well-known member of the Cactaceae family, is used as a medicinal plant in various countries and grows in the desert, semi-desert, tropical and sub-tropical areas. It shows diverse pharmacological activities such as: antioxidant, anti-inflammatory, anti-tumor, neuroprotective, hepatoprotective, hypotensive etc. OD fruit also possesses valuable constitutes for instance: betalains, ascorbic acid, total phenol, protein as well as essential elements which suggest the significant potential of this plant as a complementary therapy against several pathological conditions. This review describes experimental evidence about pharmacological and therapeutic potential of OD in order to give the basis of its application in the prevention and treatment of some chronic diseases. More studies on OD can help better understanding of its pharmacological mechanism of action to explain its traditional uses and to identify its potential new therapeutic applications.