• Title/Summary/Keyword: Side Reaction

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Effect of All-out Condition on Physical Balance, Agility and Power (최대 지친상태가 신체의 평형성, 민첩성, 순발력에 미치는 영향)

  • Huh, Man-Dong;Bang, Chang-Hoon
    • Fire Science and Engineering
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    • v.24 no.2
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    • pp.120-125
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    • 2010
  • The aim of study intends to investigate effect of All-out condition on physical balance, agility and power and to provide the base data for the safety of firefighter. The results of the study are as follows. For power estimation, the sargent jump is $41.0{\pm}3.2cm$ before estimation and $42.2{\pm}6.02cm$ after estimation as All-out condition. For static balance estimation, the closed-eyes foot balance is $40.3{\pm}36.8$sec before estimation and $27.5{\pm}27.18$sec after estimation. For dynamic balance estimation, the beam walking is $6.2{\pm}1.22$sec before estimation and $6.4{\pm}1.57$sec after estimation. The results are statistically significant. For agility estimation, the side step is $40.3{\pm}3.40$rep/20sec before estimation and $43.3{\pm}2.50$rep/20sec after estimation. The results are statistically significant. The wholebody reaction time is $0.21{\pm}0.05$sec before estimation and $0.18{\pm}0.02$sec after estimation.

Two Cases of Pulmonary Complications Following Intravesical Bacillus Calmette-Guerin Immunotherapy in Patients with Superficial Bladder Cancer (표재성 방광암 환자에서 방광내 BCG 주업치료 후 발생한 폐합병증 2예)

  • Lee, Gyeoi-Seong;Lee, Gi-Yong;Yoon, Jae-Cheol;Na, Dong-Jib;Jeong, Seong-Su;Sul, Chong-Koo;Kim, Sun-Young;Kim, Ju-Ock
    • Tuberculosis and Respiratory Diseases
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    • v.46 no.6
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    • pp.869-878
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    • 1999
  • Intravesical instillation of the bacillus Calmentte-Gu$\acute{e}$rin(BCG), an attenuated strain of Mycobacterium bovis, is an approved method for the treatment of superficial bladder cancer. Because BCG is a living organism, the potential for infection exists. BCG is generally well tolerated, with complications in less than 5% of those treated with use of current practices. The most frequent symptoms of toxicity associated with intravesical BCG immunotherapy include bladder irritation, frequency, and dysuria. Systemic reactions are less common but more serious than local side effects, and include fever, chills, malaise, rash, hepatitis, pneumonitis, arthritis and sepsis. In rare cases, BCG treatment can result in a systemic infection that requires antituberculous therapy. The pulmonary toxicity that results from intravesical BCG treatment is generally characterized by one of two types : systemic allergic reaction with pulmonary reticulonodular opacities depicted on chest radiographs with cellular findings consisting of activated lymphocytes, and actual BCG mycobacteremia with a miliary pattern depicted on chest radiographs and granuloma formation which rarely results in positive acid-fast stain or culture results. Recently we experienced two types of pulmonary complications following intravesical BCG immunotherapy in patients with superficial bladder cancer. We report two cases with a review of literatures.

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Measures of Underlying Inflation and Evaluation of Inflation Targeting with Global Crisis in Korea (글로벌 금융위기와 물가안정목표제 평가: 근원인플레이션을 중심으로)

  • Park, Won-Am
    • KDI Journal of Economic Policy
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    • v.32 no.3
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    • pp.1-32
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    • 2010
  • The global financial crisis has exerted enormous impacts on the attainment of inflation target in Korea. The annual average CPI inflation was 3.3% during the targeting period of 2007-2009 and the target was $3.0{\pm}0.5%$. Thus Korea has succeeded in keeping annual average CPI inflation just below the upper limit of the 2007-2009 target under the global crisis. This paper intends to evaluate the performance of the inflation targeting system in Korea. First, it estimates the conventional call rate reaction equation under the global crisis and finds that the policy interest rates never reacted to expected inflation, output gap, and won/dollar exchange rate, as expected by theory. Second, it identifies the shock of global financial crisis into core and non-core, applying the structural VAR model. The core shock was defined to have no (medium- to) long-run impact on real output. The core shock was identified to have the character of the demand shock, since it has the positive impact on the inflation and output in the short run. The structural core inflation due to core shock was an attractor of headline inflation, not vice versa. Therefore, the structural core inflation that reflects the demand-side shock would be the better intermediate target for the final headline inflation target than the official core inflation that excludes the volatile inflation of agricultural and oil-related products. During the inflation targeting period of 2007-2009, the structural core inflation was more volatile than the official core inflation, because the global crisis has very large negative impacts on the domestic demand as well as the prices of agricultural and oil-related products. This paper shows that the negative core shock during the fourth quarter of 2008 was larger than that in the financial crisis in 1998. But the core shock turned into positive very quickly in 2009, as the Korean economy recovered very quickly from crisis. The volatile changes in structural core inflation suggests that the Bank of Korea barely managed to attain the 2007-2009 inflation target, owing to the very large negative impacts of the global financial crisis on the domestic demand. It also suggests that the rapid rise in core inflation with the rapid recovery of the Korean economy will lead to rapid rise in headline inflation.

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Structural characteristics of a red ginseng acidic polysaccharide rhamnogalacturonan I with immunostimulating activity from red ginseng

  • Lee, Sue Jung;In, Gyo;Han, Sung-Tai;Lee, Mi-Hyang;Lee, Jong-Won;Shin, Kwang-Soon
    • Journal of Ginseng Research
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    • v.44 no.4
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    • pp.570-579
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    • 2020
  • Background: Many researchers reported that the various immune activities of red ginseng are due to acid polysaccharides. But, the exact structural characteristics of the acidic polysaccharide in red ginseng have not been fully elucidated. Therefore, we isolated the acidic polysaccharide from red ginseng and characterized the structural property of the active moiety of this polysaccharide, which contributes to the immunostimulatory activity of red ginseng. Methods: A polysaccharide (RGP-AP-I) was purified from red ginseng via size-exclusion chromatography using Sephadex G-100. Immunostimulatary activity of RGP-AP-I was investigated via anti-complementory and macrophage stimulatory activity. The structure of RGP-AP-I was characterized by HPLC, sugar composition, β-glucosyl Yariv reagent and methylation analysis. Results: Peritoneal macrophages stimulated using RGP-AP-I significantly augmented the production of various cytokines such as interleukin (IL)-6, IL-12, and tumor necrosis factor (TNF)-α. The primary structure of RGP-AP-I was elucidated by assessing its sugar composition and methylation analysis. RGP-AP-I is a 96 kDa acidic polysaccharide, and comprises nine different monosaccharides, which mainly include sugars such as rhamnose (Rha, 9.5%), galacturonic acid (GalA, 18.4%), galactose (Gal, 30.4%), and arabinose (Ara, 35.0%). RGP-AP-I exhibited an considerable reaction with the β-glucosyl Yariv reagent, revealing the presence of arabino-β-3,6-galactan. Methylation analysis indicated that RGP-AP-I comprises 21 different glycosyl linkages, such as 3-, 4-, 6- and 3,6-linked Galp; 5-linked Araf; 2,4-linked Rhap; and 4-linked GalAp, which are characteristics of rhamnogalacturonan I (RG-I). Conclusion: we assumed that the immunostimulatory activity of RGP-AP-I may be due to the RG-I structure, which comprises a main chain with a repeating linkage unit, [→2)-Rhap-(1→4)-GalAp-(1→] and three groups of side chains such as (1→5)-linked arabinan, (1→4)-linked galactan, and arabino-β-3,6-galactan, which branch at the C(O)4 positions of Rha residues in the main chain of RGP-AP-I.

A Sasang Constitutional Study on the Myunghyun Symptom (명현현상(瞑眩現狀)에 대한 사상의학적(四象醫學的) 고찰(考察))

  • Jeong, Yong-Jae;Lee, Jun-Hee;Lee, Soo-Kyung;Kim, Dal-Rae;Koh, Byung-Hee
    • Journal of Sasang Constitutional Medicine
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    • v.21 no.1
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    • pp.20-27
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    • 2009
  • 1. Objects Myunghyun Symptom(瞑眩現狀) is widely regarded as 'symptoms of discharge the accumulated poison in body', 'symptoms in the process of healing' apart from any other side effects of drugs. Recently, Natural Medicine of Europe and the U.S.A named it 'healing crisis'. However, this tends to be used indiscriminately. I took a look at the meaning of the Myunghyun Symptom correctly, and the meaning at a point of Sasang Constitutional view 2. Methods It was researched on the literal study about the meaning of the Myunghyun Symptom on the book "Seokyung"(書經), "Dongeuibogam(東醫寶鍵)", "Dongyi Suse Bowon(東醫壽世保元)", "Yakjing(藥徵)", and the meaninig at a point of Sasang Constitutional view through the "Dongyi Suse Bowon(東醫壽世保元)", "Dongyi Suse Bowon Sasang Chobonguen(東醫壽世保元 四象草本卷)". 3. Results and Conclusions 1. The original meaning of the Myunghyun symptom is 'dizziness by the use of massive effective drugs'. 2. Yoshimasu Todo interprεtated broadly the Myunghyun symptoms as the discharge of the accumulated poison in body, the symptoms in the process of healing. 3. Dongmu recognized the Myunghyun symptom as dizziness by massive effective drugs and shun the use of massive effective drugs. 4. Dongmu established the concept of 'Jang-gi(臟氣) and 'Yak-gi(藥氣)' and esteemed Jang-gi more than Yak-gi. So he contended that When there is no disease does not use drugs, even if the illness prioritized the use of mild drug, use the massive effective drugs a little while when there is an acute disease. 5. When the Sasnag Constututional Drugs help the Bomyungjiju(보명지주), Sometimes the Myunghyun Symptom is appeared. it is the process of Tongoi by Taeum Drugs, Chungjang by Soyang Drugs, Gojung by Tayang Drugs, Onri by Soeum Durgs. 6. Myunghyun symptoms which used indiscriminately in present is stopped and needs a clear observation and description about the drug reactions to the patient's condition.

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A Case Study on the TEMAZ Explosion Accident in Semiconductor Process (반도체 공정에서 TEMAZ폭발사고 사례연구)

  • Yang, Won-Baek;Rhim, Jong-Kuk;Hong, Seong-Min
    • Journal of the Korean Institute of Gas
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    • v.21 no.6
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    • pp.52-60
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    • 2017
  • In diffusion process exhaust line during semiconductor manufacturing process, In order to improve the transportation efficiency in the piping by removing "The reaction by-product, $ZrO_2$ and The unreacted material, TEMAZ, TMA, $O_3$, etc" and "Powder being deposited", the piping temperature was raised to $80^{\circ}C$ or more by using the heater jacket, and the bellows at the rear end of the vacuum pump ruptured. So conducted a case study and try to prevent the similar accidents from occurring through case studies. The causes of the accident were analyzed as follows: the inflow of outside air due to the generation of a gap on the suction side of the vacuum pump and heating the pipe with the heater jacket resulted in the overpressure in the pipe due to the volumetric expansion of the gas generated by decomposition of the unreacted TEMAZ, It can be assumed that the most vulnerable bellows of the piping has been ruptured. In order to prevent such accidents, This study is aimed to identify the cause of pipeline rupture accident and to establish safety measures for the prevention of similar accidents by evaluating physical hazards of TEMAZ, which is assumed to be the cause of pipe rupture accident.

The New Technology Development Strategy of Cosmeceuticals with Use Advanced Materials Resources (신소재 자원을 활용한 기능성화장품의 신기술 개발전략)

  • Kim Ju-Duck
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.30 no.3 s.47
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    • pp.427-438
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    • 2004
  • Cosmeceuticals products we not the products simply for moisturizing and protecting skin but the ones for encouraging to make improvements on wrinkles and helping to whiten, tan, and protect skin against ultraviolet light. In a broader sense, they refer to products with aiming to maintain healthy condition of skin such that skin troubles could be improved or aging of skin could be delayed. However, cosmeceuticals should not have any side effects because they are applied to the whole body for a long period of time differing from medical products which are used on specific areas for a short time. The number of such cosmeceuticals has increased from 500 in 2001 to 2300 in 2003. In order to develop and broaden the scope of cosmeceuticals, the concept of cosmetics needs to be changed from caring skin to delaying aging of the skin and reviving cells. For this purpose, high-valued materials should be developed through basic researches related to the biological function of skin, in vivo experiment and reaction of skin in response to various stimuli using biotechnologies and bioengineering methods. At the same time, it should be proceeded to develop new nano materials for overcoming skin barriers and transfer matericals for helping to absorb effective substances and maintaining stability.

THE mRNA EXPRESSION OF MMP-1, TIMP-1, $TGF-{\beta}_1$ IN GINGIVAL KERATOCYTES FROM GINGIVAL HYPERPLASIA INDUCED BY CYCLOSPORINE A (정상 치은 조직에서 배양된 각화세포에서 Cyclosporine A에 의한 MMP-1, TIMP-1, $TGF-{\beta}_1$의 발현에 관한 연구)

  • Kang, Hag-Soo;Lee, Jae-Sun;Bing, Jung-Ho;Park, Chang-Joo;Im, Jae-Jung;Hwang, Kyung-Gyun;Shim, Kwang-Sup
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.34 no.4
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    • pp.405-411
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    • 2008
  • Purpose : Cyclosporine A (CsA) is a versatile immunosuppresive agent used to prevent graft rejection syndrome and treat autoimmune disease. One of the major side effects associated with CsA is the abnormal gingival hyperplasia. The purpose of this study was to investigate the relationship between the mRNA expression of the MMP-1, TIMP-1, and $TGF-{\beta}_1$ and the concentration of CsA in cultured human gingival keratinocytes. Materials & Methods : Gingival keratocytes were obtained from gingival tissues of 4 healthy donors. The cultured gingival keratocytes were incubated with increasing concentrations of CsA (0-2000 ng/ml) for 24 hours and the expression of MMP-1, TIMP-1, and $TGF-{\beta}_1$ were determined by reverse transcription-polymerase chain reaction (RT-PCR). Results : The expressions of MMP-1 and $TGF-{\beta}_1$ were not significantly different according to the concentrations of CsA. The expression of TIMP-1 was significantly increased at the CsA concentration of 500 ng/ml. Conclusion : We concluded that the gingival hyperplasia induced by CsA was more related with TIMP-1 than MMP-1 or $TGF-{\beta}_1$ on gingival collagen metabolism in patients treated with CsA.

Characteristics of Strong Alkaline Electrolyzed Water Produced in All-in-one Electrolytic Cell (일체형 전해조에서 생산된 강알카리성 전해수의 특성)

  • Lee, Ho Il;Rhee, Young Woo;Kang, Kyung Seok
    • Clean Technology
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    • v.18 no.4
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    • pp.446-450
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    • 2012
  • Strong alkaline electrolyzed water which is produced in cathode by electrolyzing the solution where electrolytes (NaCl, $K_2CO_3$ etc.) are added in diaphragm electrolytic cell, is eco-friendly and has cleaning effects. So, it is viewed as a substitution of chemical cleaner. In addition, strong alkaline electrolyzed water is being used by some Japanese automobile and precision parts manufacturing industries. When strong alkaline electrolyzed water is produced by using diaphragm electrolytic cell, it is necessarily produced at the anode side. Since strong acidic electrolyzed water produced is discarded when its utilization cannot be found, production efficiency of electrolyzed water is consequently decreased. Also, there is a weakness electrolytic efficiency is decreasing due to the pollution of diaphragm. In order to overcome this, non-diaphragm all-in-one electrolytic cell integrated with electrode reaction chamber and dilution chamber was applied. Strong alkaline electrolyzed water was produced for different composition of electrolytes, and their properties and characteristics were identified. In comparing the properties between strong alkaline electrolyzed water produced in diaphragm electrolytic cell and that produced in all-in-one electrolytic cell, the differences in ORP and chlorine concentration were found. In emulsification test to confirm surface-active capability, similar results were obtained and strong alkaline electrolyzed water produced in non-diaphragm all-in-one electrolytic cell was identified to be useable as a cleaner like strong alkaline electrolyzed water produced in diaphragm electrolytic cell. Strong alkaline electrolyzed water produced in non-diaphragm all-in-one electrolytic cell is thought to have sterilizing power because it has active chlorine which is different from strong alkaline electrolyzed water produced in diaphragm electrolytic cell.

A Study of Structural Analysis Simulation for Squat Exercise Foot Plate (스쿼트운동장치의 풋플레이트 구조해석에 관한 연구)

  • Jung, Byung-Geun;Kim, Ji-won;Jeong, Byeong-Ho
    • Journal of the Korea Convergence Society
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    • v.8 no.9
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    • pp.365-372
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    • 2017
  • Squat exercise is one of the important free weight exercises that can safely and effectively expect the athletic performance by establishing the rationale. Therefore, it is necessary to study the side effects caused by incorrect exercise, scientific countermeasures and to develop a exercise estimation model. It is effective and accurate to use a variety of assistive devices to calibrate athletic posture. The issues of the structural analysis for designing a foot plate for squat exercise is to model the behavior by the dynamic behavior. It should be consider that the center of gravity of each segmented body is different when the maximum load is applied. It is applied to complete system design through simulation method with kinematic dynamic, ground reaction force and load analysis for the free weight exercise equipment, VR device, and safety foot plate. In this paper, the authors propose the design method for the vertical load distribution applied in the design of the foot plate used for the squat exercise mechanism, and based on these results, design make the more safe and reliable free weight exercise equipment system.