• The Korean Journal of Physiology and Pharmacology
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• 제16권2호
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• pp.139-144
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• 2012

It has been reported that activation of metabotropic glutamate receptor 1 (mGluR1) can mediate endocannabinoid-induced short-term depression of synaptic transmission in cerebellar parallel fiber (PF)-Purkinje cell (PC) synapse. mGluR1 has signaling pathways involved in intracellular calcium increase which may contribute to endocannabinoid release. Two major mGluR1-evoked calcium signaling pathways are known: (1) slow-kinetic inward current carried by transient receptor potential canonical (TRPC) channel which is permeable to $Ca^{2+}$; (2) $IP_3$-induced calcium release from intracellular calcium store. However, it is unclear how much each calcium source contributes to endocannabinoid signaling. Here, we investigated whether calcium influx through mGluR1-evoked TRPC channel contributes to endocannabinoid signaling in cerebellar Purkinje cells. At first, we applied SKF96365 to inhibit TRPC, which blocked endocannabinoid-induced short-term depression completely. However, an alternative TRP channel inhibitor, BTP2 did not affect endocannabinoid-induced short-term depression although it blocked mGluR1-evoked TRPC currents. Endocannabinoid signaling occurred normally even though the TRPC current was mostly blocked by BTP2. Our data imply that TRPC current does not play an important role in endocannabinoid signaling. We also suggest precaution in applying SKF96365 to inhibit TRP channels and propose BTP2 as an alternative TRPC inhibitor.

• 대한간호학회지
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• 제42권1호
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• pp.28-35
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• 2012

Purpose: This study was done to evaluate the effects of a short-term life review on spiritual well-being, depression, and anxiety in patients with terminal cancer. Methods: The study used a pre posttest quasi experimental design with a nonequivalent control group. Measurement instruments included the Functional Assessment of Chronic Illness Therapy-Spiritual scale (FACIT-Sp12) and the Hospital Anxiety and Depression Scale (HADS). Participants were 32 patients with terminal cancer who were receiving chemotherapy or palliative care at hospitals or at home. Eighteen patients were assigned to the experimental group and 14 to the control group. A sixty minute short-term life review session was held twice a week as the intervention with the experimental group. Results: There was a statistically significant increase in spiritual well-being in the experimental group compared to the control group. There were also significant decreases in depression and anxiety in the experimental group compared to the control group. Conclusion: The results indicate that a short-term life review can be used as a nursing intervention for enhancing the spiritual well-being of patients with terminal cancer.

• The Korean Journal of Physiology and Pharmacology
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• 제7권6호
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• pp.303-306
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• 2003

Metabotropic glutamate receptors (mGluRs), classified into three groups (group I, II, III), play a critical role in modulation of synaptic transmission at central and peripheral synapses. In the present study, extracellular field potential recording techniques were used to investigate effects of mGluR agonists on excitatory synaptic transmission at thalamic input synapses onto the lateral amygdala. The non-selective mGluR agonist t-ACPD ($100{\mu}M$) produced reversible, short-term depression, but the group III mGluR agonist L-AP4 ($50{\mu}M$) did not have any significant effects on amygdala synaptic transmission, suggesting that group I and/or II mGluRs are involved in the modulation by t-ACPD. The group I mGluR agonist DHPG ($100{\mu}M$) produced reversible inhibition as did t-ACPD. Unexpectedly, the group II mGluR agonist LCCG-1 ($10{\mu}M$) induced long-term as well as short-term depression. Thus, our data suggest that activation of group I or II mGluRs produces short-term, reversible depression of excitatory synaptic transmission at thalamic input synapses onto the lateral amygdala. Considering the long-term effect upon activation of group II mGluRs, lack of long-term effects upon activation of group I and II mGluRs may indicate a possible cross-talk among different groups of mGluRs.

• Journal of Korean Biological Nursing Science
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• 제22권2호
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• pp.111-118
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• 2020

Purpose: The purpose of this study was to understand the impact of long- and short-term energy drinks on anxiety-like, depressionlike, and cognitive behavior in adolescent rats. Methods: Adolescent rats (age six weeks) were randomly classified into a control group (CON), a long-term administration group (LT), and a short-term administration group (ST). The LT group was orally administered 1.5 mL/100 g (body weight) of energy drink twice daily for 14 days, the ST group was orally administered for one day, and the control group applied the same amount of normal saline. Later, an open-field test, a forced swim test, novel object recognition test, and an 8-arm radial maze test was conducted to assess the rats' anxiety, depression, and cognitive function. Results: There were different effects in the long- and short-term groups of energy drink administration. In the LT group, anxiety- and depressive-like behavior increased because of increased movement in the side corner and decrease of immobility time. Also, the time to explore novel objects decreased, and the number of correct responses was reduced, indicating a learning and memory function disorder. However, the ST group was not different from the control group. Conclusion: These results indicate that long-term consumption of energy drinks can increase anxiety-like, depression-like behavior, and this can lead to decrease in learning and memory functions. Thus, nurse and health care providers should understand the impact of energy drink consumption in adolescence to provide appropriate practices and education.

• 대한가정학회지
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• 제49권9호
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• pp.59-72
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• 2011

This study examined whether there are underlying latent classes of growth trajectories of maternal depression in the Korean population. Data from the first phase of the Panel Study of Korean Children (PSKC) of the Institute of Child Care and Education (KICCE) were used for this study. The final sample of participants included 1,471 mothers, who completed three interviews: at birth, at one month, and at four months. A two-class model consisting of depression (12.3%) and non-depression (87.7%) was considered the best-fitting solution using Mplus 3.13. The changes in postnatal depression in the Korean population within four weeks after childbirth, which is the period of "postpartum onset", seem to be important. Logistic regression analysis showed that duration of breast-feeding and planned pregnancy effects were significantly associated with trajectory class membership.

• 근관절건강학회지
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• 제4권2호
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• pp.249-261
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• 1997

The purpose of this study was to explore the effect of short term selp-help education on pain, depression, self-efficacy, and quality of life in patients having chronic arthritis. This program was carried out 3 hrs per week for 4 weeks by 3 small groups among 10 patients. Research design was a quasi-experimental study of nonequivalent control group pretest-posttest design. The subject of this study were 10 of experimental group and 10 of control group. Before and after 4 weeks program, quality of life, self-efficacy, depression, pain, ADL were measured. As a result, it was confirmed the self-help education was effective to increase quality of life, but self-efficacy, depression, pain, ADL were not improved. This suggests the replicate study to examine the effect of self-help education with the large samples of subjects having chronic arthritis.

• 한국노년학
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• 제31권3호
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• pp.553-571
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• 2011

본 논문의 목적은 4개 국가에서 이뤄진 60세 이상 노인을 대상으로 한 우울증 관리 프로그램의 전체, 단·장기 효과성의 메타 비교 분석을 통해 효과적인 한국의 노인 우울증 관리 프로그램 개발에 정책적 함의를 제공하는 것이다. 분석 자료는 AMED, EMBASE, Ovid Medline, PsycInfo에서 두 차례에 걸쳐 체계적 검토 방법을 통해 추출된 총 10건의 RCT 연구 논문이다. Review Manager를 사용한 메타 분석 결과, 첫째, 노인 우울증 관리 프로그램은 전체적으로 효과적이었고(OR=0.47, 신뢰도 95%, 신뢰구간 0.36-0.61), 둘째, 단기적으로도 효과적이었으며(OR=0.37, 신뢰도 95%, 신뢰구간 0.26-0.54), 셋째, 장기적으로도 효과적이었다(OR=0.61, 신뢰도 95%, 신뢰구간 0.41-0.89). 본 논문의 분석 결과는 한국의 노인을 위한 효과적인 우울증 관리 프로그램 개발에 세 가지 정책적 함의를 제공해 주고 있다. 첫째, 전체적으로 높은 성공률(53%)이 입증된 외국의 노인 우울증 관리 프로그램의 한국적 응용을 모색하면서 장기적 효과성이 담보되지 못함(24% 감소)에 주의하여 한국의 노인을 위한 우울증 관리 프로그램은 장기적 효과성도 담보 될 수 있는 요소가 고려되어야 한다. 둘째, 장기적 효과성이 담보된 노인 우울증 관리 프로그램을 적용할 때 남성 노인에게는 전반기에, 여성 노인에게는 후반기 적용에 보다 더 큰 관심이 요구된다. 끝으로, 새로운 노인 우울증 관리 프로그램은 기존의 의료적 모델에 사회적 지지 모델의 핵심 요소들을 결합한 형태로 이뤄져야 할 것이다.

• 동서간호학연구지
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• 제10권1호
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• pp.53-60
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• 2004

The purpose of this study was to examine the effects of the short term education and reinforcement program to health promotion in women in mid-life. This study has been done between February and April, 2004 and the subjects of the study were 26 women in mid-life. The treatment intervention was applied during total 8 weeks as 5 days for the short term education and 7 weeks for reinforcement with 1 time per a week. The short term education included health education for menopause, effect of exercise, healthy diet, management of stress and management of chronic illness and stretching exercise and recreation. The collected data were processed using the SPSS Win(12.0) program and analyzed using Wilcoxon Signed Ranks Test. The result of this study are as follows : 1. The short term education and reinforcement program significantly effected on the total cholesterol, HDL-cholesterol, triglyceride. 2. The short term education and reinforcement program significantly effected on the anxiety, but not depression. 3. The short term education and reinforcement program non significantly effected on the sleep disturbance and self-efficacy of exercise. 4. The short term education and reinforcement program significantly effected on the practice of healthy life. In conclusion, the short term education and reinforcement program effected on the physical health index, anxiety and practice of healthy life.

• 근관절건강학회지
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• 제18권1호
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• pp.28-38
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• 2011

Purpose: This paper was aimed to investigate the effect of laugher therapy on the pain, depression and sleep disturbance in elderly patients who admitted in long term care facility. Method: This study used a nonequivalent control group pretest-posttest design. A sample of 40 elderly patients (20: experimental group, 20: control group, 65 or older) were recruited. Visual analogue scale was used to measure level of pain level, Geriatric Depression Scale Short Form Korea Version (GDSSF-K) for depression. Sleep Scale for sleep. The laugher therapy was given twice a week for four weeks (8 times). Each therapy consists of preparatory, action and finishing stage. Data were analyzed by PASW 18.0. Results: The pain score in experimental group was significantly different from that in control group (t=4.17, p<.001). The level of depression in experimental group was significantly different from that in control group (Z=4.12, p<.000). The level of sleep in experimental group was not significantly different from that in control group (Z=-1.43, p<.152). Conclusion: A laugher therapy is expected to be practical used an efficient method of a nursing intervention to elderly patients in long term care facility.

• Clinical and Experimental Pediatrics
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• 제48권5호
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• pp.469-475
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• 2005

Mother-infant interaction is a crucial component of an infant's cognitive, emotional and behavioral development. Most people are preoccupied with fetal education, the physical conditions of the postpartum mother and baby, and emphasizing an early start in the child's education. However, the effects of a mother's postnatal emotional state on the development of the infant are often overlooked. Postpartum depression is a significant health problem affecting 10-20 percent of new mothers. Recent research findings indicate that the suffering caused by postpartum depression is not limited to these mothers alone; their babies and close family members are vulnerable to short-term and long-term effects as well. This review summarizes the findings of recent research works, in the light of publications within the last seven years.