• The Journal of Korean Obstetrics and Gynecology
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• v.26 no.1
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• pp.121-134
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• 2013

Objectives: The purpose of this study is to evaluate the effects of Shihogayonggolmoryo-tang on climacteric symptoms. Methods: We studied 5 climacteric symptoms patients who visited Oriental Hospital of OO University from March 2012 to September 2012. We treated them with Shihogayonggolmoryo-tang, acupuncture and moxibustion. The patients of climacteric symptoms had been estimated with Kupperman's index. Results: After treatment, climacteric symptoms were improved and mean score of Kupperman's index was reduced(the first case reduce from 82 to 13 during 3 months, the second case reduce from 81 to 19 during 2 months, the third case reduce from 80 to 21 during 2 months, the fouth case reduce from 50 to 9 during 2 months, the fifth case reduce from 66 to 17 during 1 month). Conclusions: This study suggests that Shihogayonggolmoryo-tang is significantly effective on climacteric symptoms patients.

• The Journal of Internal Korean Medicine
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• v.43 no.2
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• pp.144-151
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• 2022

Objective: The purpose of this study is to report the effects of Shihogayonggolmoryo-tang on elderly delirium. Methods: A patient suffering from delirium was treated with Shihogayonggolmoryo-tang herbal therapy for 35 days. To evaluate the therapeutic effects, the Korean version of the Mini Mental State Examination (MMSE-K) and the Korean Nursing Delirium Screening Scale (nu-DESC) were used twice a week. Results: After treatment, the patient's MMSE-K score increased from 0 to 12, and the nu-DESC results decreased 4 to 0. Conclusion: These scores suggest that therapy with Shihogayonggolmoryo-tang has a positive effect on elderly delirium.

• The Journal of Internal Korean Medicine
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• v.43 no.3
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• pp.485-492
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• 2022

Objective: The aim of this case report is to report the effect of Korean medicine treatment, including Shihogayonggolmoryo-tang, on anxiety and abdominal pulsation in a patient diagnosed with functional dyspepsia. Method: The patient was treated with Shihogayonggolmoryo-tang, including acupuncture, moxibustion, and cupping therapy. Changes in symptoms were evaluated using a self-reported numerical rating scale (NRS) score every morning. The gastrointestinal symptom score (GIS) was checked on admission and discharge day. Results: After 6 days, the NRS scores for anxiety, abdominal pulsation, abdomen discomfort, and GIS all decreased. Conclusion: The results suggest that Shihogayonggolmoryo-tang with Korean medicine could be effective for treating anxiety, abdominal pulsation, and accompanying abdomen symptoms. However, further evaluation is needed to clarify the relationship between the treatment's effect and Shihogayonggolmoryo-tang.

• Herbal Formula Science
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• v.20 no.1
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• pp.159-166
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• 2012

Objectives : This study was carried out to investigate trends of using Shihogayonggolmoryo-tang granule on neuropsychiatry fields. And suggest that using herbal extracts change non-prescription medicine to prescription medicine. Methods : I researched 86 outpatients who treated with Shihogayonggolmoryo-tang granule at oriental medicine hospital. And I analyzed their medical records of chart review study. Results : 1. Average medication time in this research was 14.9 days and the main usage was supplementary to herbal medicine, such cases amounted to 62%. 2. There are 52 patients out of 86 who are much better, such cases amounted to 55%. 3. The improved diagnosis is Syndrome of heart-fire flaring up, Syndrome of upper energizer dryness-heat, headache, and tinnitus. The improved symptom is anxiety, headache, dizziness, tic disorders, and chest discomfort. Conclusions : I expect to using herbal extracts change non-prescription medicine to prescription medicine based on this study.

• The Journal of Internal Korean Medicine
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• v.37 no.4
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• pp.601-608
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• 2016

Objectives: The purpose of this study was to investigate the efficacy of Shihogayonggolmoryo-tang (SYT) in combatting excessive sweating.Methods: The electronic medical records (EMR) of patients who attended the Department of Korean Internal Medicine, Stroke and Neurological Disorders Center from December 2014 to April 2016 were reviewed. Excessive sweating was graded and compared before and after the administration of SYT in 32 patients.Results: The average grade for excessive sweating of the 32 patients significantly decreased from 2.47±0.62 to 1.03±0.86 after the SYT treatment.Conclusions: These results provide evidence that SYT may be effective in combatting excessive sweating.

• Journal of Physiology & Pathology in Korean Medicine
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• v.35 no.1
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• pp.8-14
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• 2021

Shihogayonggolmoryo-tang (ST) is a Korean medical herb cocktail which has been used to treat anxiety induced insomnia. In this study, we will examine sleep-promoting and anti-anxiety effects of ST, and investigate its mechanism. ICR mice were divided into three groups for the first examination : control group (n=11), ST50 group (50 mg/kg, po, n=11), ST200 group (200 mg/kg, po, n=11). Sleep-promoting effect was confirmed by measuring the sleeping duration time and sleeping onset time after thiopental sodium treatment (50 mg/kg, ip). ICR mice were divided into five groups for the second examination : control group (n=11), ST200 group (200 mg/kg, po, n=11), ST200+Flumazenil group (ST 200 mg/kg, po, flumazenil 0.3 mg/kg, ip, n=11), diazepam group (1 mg/kg, ip, n=11), diazepam+flumazenil group (diazepam 1 mg/kg, ip, Flumazenil 0.3 mg/kg, ip, n=11). Anxiety behavior and sleep-promoting effect was confirmed by open field test and measuring the sleeping duration time and sleeping onset time. Expression levels of c-fos in tuberomammillary nucleus (TMN) and ventrolateral preoptic nucleus (VLPO) were analyzed by immunohistochemistry. ST treated group showed significantly decreased anxiety behavior and enhanced sleeping duration time and sleeping onset time concentration dependently. The expression of c-fos was significantly upregulated in VLPO as sleep-inducing center and TMN as downregulated in arousal center by ST treatment. In addition, all effects of ST were reversed by flumazenil. Our results suggest that ST has sleep-promoting and anti-anxiety effects through regulating arousal center (TMN) and sleep-inducing center (VLPO).

• The Journal of Internal Korean Medicine
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• v.44 no.2
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• pp.117-128
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• 2023

Objective: This study reported the improved symptoms of integrative Korean medicine-based treatment in a patient diagnosed with Systemic Lupus Erythematosus (SLE) who persistently complained of fatigue and chest tightness. Methods: A 51-year-old female SLE patient persistently complaining of fatigue and chest tightness underwent an 18-day treatment with Kracie Shihogayonggolmoryo-tang, Cheongpajeon-H, Gwanjeol-go, acupuncture, pharmacopuncture, cupping therapy, deep tissue meridian hot pack therapy, manual therapy, Interferential Current Therapy, and Extracorporeal Shock Wave Therapy. The Brief Fatigue Inventory (BFI) and Numeric Rating Scale (NRS) for each symptom were measured on admission, at one week, two weeks of hospitalization, and upon discharge. Clinical outcomes were assessed using these two figures. Results: After treatment, there was a reduction in the BFI score (7 to 3). The NRS score of chest tightness with hot flashes decreased from 8 to 5, neck pain lessened from 7 to 5, pain in both ankles diminished from 6 to 4, the cold hypersensitivity of both feet fell from 6 to 4, and heartburn decreased from 5 to 2. In order, the biggest clinical improvement was to heartburn, fatigue, and chest tightness with hot flashes. Conclusion: This case study shows that integrative Korean medicine-based treatment can improve symptoms of a Systemic Lupus Erythematosus patient persistently complaining of fatigue and chest tightness with hot flashes and suggests that Shihogayonggolmoryo-tang may be an effective option for managing and treating SLE patients.

• The Journal of Internal Korean Medicine
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• v.41 no.2
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• pp.186-193
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• 2020

Objectives: This study aimed to report a case that showed improvements in the symptoms of patients with alcoholic hepatitis without any indication of deterioration of the disease. Methods: Western medicine with Urusa tablets and Godex capsules and Korean medicine therapeutic approaches, including Shihogayonggolmoryo-tang, acupuncture, and moxibustion, were administered to a patient during the period of treatment. Blood tests were used to determine levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), AST/ALT ratio, alkaline phosphatase (ALP), gamma glutamyltransferase (GGT), total bilirubin, direct bilirubin, and total cholesterol. Fatigue was measured using the numeric rating scale (NRS), and the patient's total sleeping time was checked, daily. Results: After the combined treatment, the AST/ALT ratio and the AST, ALT, ALP, GGT, total cholesterol, and direct bilirubin levels were decreased. Through Oriental medicine for the purpose of improving symptoms, NRS of fatigue decreased from 10 to 5, and the amount of sleeping time increased from 2 to 5 hours. Conclusions: The herbal medicine had no effect on the hepatoprotective drugs such as Urusa tablets and Godex capsules used to treat alcoholic hepatitis, and no adverse reaction from the combined administration was observed. To reduce fatigue and insomnia in patients with alcoholic hepatitis, it might be helpful to combine Western medications with Korean medicine treatments, including acupuncture, moxibustion, and Shihogayonggolmoryo-tang.

• Journal of Haehwa Medicine
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• v.16 no.1
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• pp.69-79
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• 2007

Background : Tremor is a rhythmic, involuntary muscular contraction characterized by oscillations (to-and-fro movements) of a part of the body. Tremor is the common symptom clinically. Objectives : The purpose of this study is to show a case of patient with tremor improved by medication of Bok-jin-centered. Patients & Methods : The patient was 60-year-old woman who complained Cephalic and cheilo tremor. She was treated by oriental medicine with acupuncture, herb medication, physical therapy through the abdominal diagnosis, Bok-Jin. Results : The Cephalic and cheilo tremor was reduced after oriental medical therapy. Conclusion : After the treatment, tremor and other symptoms were improved. This result suggested that Bok-jin is the significant diagnosis and medication of Bok-jin-centered is recommanded.

• The Journal of Korean Medicine
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• v.38 no.2
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• pp.73-77
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• 2017

Objectives: To inform a clinical case of a refractory levator ani syndrome, that was improved by treatments of traditional Korean medicine (TKM). Methods: A 55-years old female had complained severe anorectal pain which didn't respond to Western medicine therapeutics during 5 months including 45-day hospitalization. Whereas the symptom was rapidly resolved by the treatment in a Korean medicine hospital, and the clinical outcome was monitored. Result: There was no abnormality explaining the anorectal pain from blood tests, gastrointestinal endoscopy, sonogram and computed tomography for abdomen and pelvis. The patient was diagnosed with a levator ani syndrome. Based on the typical feature of tenderness of lower abdomen as well as beating sign around belly, an herbal drug, Shihogayonggolmoryo-tang (柴胡加龍骨牡蠣湯) was prescribed. In addition, the warm acupuncture at BL 31 to BL 33 and moxibustion on lower abdomen were given to the patient. The anorectal pain was radically reduced from treatment 7-day, and it almost disappeared within treatment 25-day. Conclusion: This case report would provide information for the potential of TKM therapies focused on the refractory levator ani syndrome which no satisfactory therapy exist.