• Journal of East-Asian Urban History
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• v.2 no.1
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• pp.7-26
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• 2020

Urban pollution has been a problem in China since ancient times. In modern times, pollution was aggravated by industrialization and urbanization and became closely related to people's lives. Shanghai was the industrial center and the most urbanized place of modern China. As a price, it needed to face extremely serious urban pollution, and the treatment of this problem involved all aspects of social life. Noise pollution let foreigners to interpret the Chinese people and the city of Shanghai from a cultural perspective, and let Chinese residents to understand Shanghai and the nation from a civilized perspective. Pollution regulation made Shanghai the first city in modern China to implement overall pollution control and levy environmental protection fees. It also enabled the Chinese to gradually fight for their rights in urban governance. Urban pollution also brought business opportunities; in the highly commercial city of Shanghai, it promoted the development of some industries. The experience of urban pollution and its treatment prompted the people of Shanghai to rethink and re-recognize modern civilization, and also promoted the formation of Shanghai urban community.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.1749-1752
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• 2012

Colorectal cancer (CRC), now the third most common cancer across the world, is known to aggregate in families. USP7 is a very important protein with an important role in regulating the p53 pathway, which is critical for genomic stability and tumor suppression. We here genotyped eight SNPs within the USP7 gene and conducted a case-control study in 312 CRC patients and 270 healthy subjects in the Chinese Han population. No significant associations were found for any single SNP and CRC risk. Our data eliminate USP7 as a potential candidate gene towards for CRC in the Han Chinese population.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.3
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• pp.743-752
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• 2012

Hepatocellular carcinoma is a common disorder worldwide which ranks 5th and 7th most common cancer among men and women. In recent years, different incidence trends have been observed in various regions, but the reasons are not completely understood. However, due to the great public efforts in HCC prevention and alternation of lifestyle, the roles of some well documented risk factors played in hepatocarcinogenesis might have changed. This paper summarizes both the environmental and host related risk factors of hepatocellular carcinoma including well established risk factors such as hepatitis virus infection, aflatoxin and alcohol, as well as possible risk factors such as coffee drinking and other dietary agents.

• 대한핵의학회:학술대회논문집
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• 2000.05a
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• pp.80.2-80.2
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• 2000

• Molecules and Cells
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• v.46 no.4
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• pp.219-230
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• 2023

Down syndrome (DS) is the most common autosomal aneuploidy caused by trisomy of chromosome 21. Previous studies demonstrated that DS affected mitochondrial functions, which may be associated with the abnormal development of the nervous system in patients with DS. Runt-related transcription factor 1 (RUNX1) is an encoding gene located on chromosome 21. It has been reported that RUNX1 may affect cell apoptosis via the mitochondrial pathway. The present study investigated whether RUNX1 plays a critical role in mitochondrial dysfunction in DS and explored the mechanism by which RUNX1 affects mitochondrial functions. Expression of RUNX1 was detected in induced pluripotent stem cells of patients with DS (DS-iPSCs) and normal iPSCs (N-iPSCs), and the mitochondrial functions were investigated in the current study. Subsequently, RUNX1 was overexpressed in N-iPSCs and inhibited in DS-iPSCs. The mitochondrial functions were investigated thoroughly, including reactive oxygen species levels, mitochondrial membrane potential, ATP content, and lysosomal activity. Finally, RNA-sequencing was used to explore the global expression pattern. It was observed that the expression levels of RUNX1 in DS-iPSCs were significantly higher than those in normal controls. Impaired mitochondrial functions were observed in DS-iPSCs. Of note, overexpression of RUNX1 in N-iPSCs resulted in mitochondrial dysfunction, while inhibition of RUNX1 expression could improve the mitochondrial function in DS-iPSCs. Global gene expression analysis indicated that overexpression of RUNX1 may promote the induction of apoptosis in DS-iPSCs by activating the PI3K/Akt signaling pathway. The present findings indicate that abnormal expression of RUNX1 may play a critical role in mitochondrial dysfunction in DS-iPSCs.

• 한국균학회소식:학술대회논문집
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• 2009.10a
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• pp.38-40
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• 2009

• Proceedings of the Korean Magnestics Society Conference
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• 2008.12a
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• pp.60.1-60.1
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• 2008

• Proceedings of the KOR-KST Conference
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• 1996.06a
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• pp.131-137
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• 1996

This paper discusses the necessity, strategy and objectives of the rail transportation recently developed in Shanghai. The objective should not be regarded just as a term project, but should be taken as an urgent mission with the 21st century, Shanghai should possess a network of about 100km of rail transport lines. To this end, the following measures are suggested : grade separation of all lines on elevated structures ; developing the rail car industries ; full utilization of all available transportation facilities ; optimizing the use of the space resources of highways ; bringing into play the initiatives of all parties concerned. Recently, it has become a popular consensus that the development of high-speed, safe, punctual, comfortable, non-pollution rail transport with large capacity is the best and only solution to Shanghai urban transportation. In this respect, this dissertation deals with the development strategy for current Shanghai rail construction, together with the infractructure in Shanghai, positioning the developing target; meanwhile, some proposals and solutions to hit this target will be put forward for the reference of leaders and experts.

• Journal of Microbiology and Biotechnology
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• v.24 no.9
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• pp.1162-1169
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• 2014

Glyphosate is the active component of the top-selling herbicide, the phytotoxicity of which is due to its inhibition of the shikimic acid pathway. 5-Enolpyruvylshikimate-3-phosphate synthase (EPSPS) is a key enzyme in the shikimic acid pathway. Glyphosate tolerance in plants can be achieved by the expression of a glyphosate-insensitive aroA gene (EPSPS). In this study, we used a PCR-based two-step DNA synthesis method to synthesize a new aroA gene ($aroA_{R.\;leguminosarum}$) from Rhizobium leguminosarum. In vitro glyphosate sensitivity assays showed that $aroA_{R.\;leguminosarum}$ is glyphosate tolerant. The new gene was then expressed in E. coli and key kinetic values of the purified enzyme were determined. Furthermore, we transformed the aroA gene into Arabidopsis thaliana by the floral dip method. Transgenic Arabidopsis with the $aroA_{R.\;leguminosarum}$ gene was obtained to prove its potential use in developing glyphosate-resistant crops.

• Current Optics and Photonics
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• v.4 no.1
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• pp.1-8
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• 2020

We research a system of compressed-sensing computational ghost imaging (CSCGI) based on the intensity fluctuation brought by turbulence. In this system, we used the gamma-gamma intensity-fluctuation model, which is commonly used in transmission systems, to simulate the CSCGI system. By setting proper values of the parameters such as transmission distance, refractive-index structure parameter, and sampling rates, the peak signal-to-noise ratio (PSNR) performance and bit-error rate (BER) performance are obtained to evaluate the imaging quality, which provides a theoretical model to further research the ghost-imaging algorithm.