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http://dx.doi.org/10.7314/APJCP.2012.13.5.1749

No Association Between the USP7 Gene Polymorphisms and Colorectal Cancer in the Chinese Han Population  

Li, Xin (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University)
Wang, Yang (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University)
Li, Xing-Wang (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University)
Liu, Bao-Cheng (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University)
Zhao, Qing-Zhu (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University)
Li, Wei-Dong (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University)
Chen, Shi-Qing (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University)
Huang, Xiao-Ye (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University)
Yang, Feng-Ping (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University)
Wang, Quan (Department of General Surgery, The Affiliated Shanghai First People's Hospital of Shanghai Jiao Tong University)
Wang, Jin-Fen (Shanxi Cancer Hospital)
Xiao, Yan-Zeng (Shanxi Cancer Hospital)
Xu, Yi-Feng (Shanghai Institute of Mental Health, The Affiliated Shanghai First People's Hospital of Shanghai Jiao Tong University)
Feng, Guo-Yin (Shanghai Institute of Mental Health, The Affiliated Shanghai First People's Hospital of Shanghai Jiao Tong University)
Peng, Zhi-Hai (Department of General Surgery, The Affiliated Shanghai First People's Hospital of Shanghai Jiao Tong University)
He, Lin (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University)
He, Guang (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.13, no.5, 2012 , pp. 1749-1752 More about this Journal
Abstract
Colorectal cancer (CRC), now the third most common cancer across the world, is known to aggregate in families. USP7 is a very important protein with an important role in regulating the p53 pathway, which is critical for genomic stability and tumor suppression. We here genotyped eight SNPs within the USP7 gene and conducted a case-control study in 312 CRC patients and 270 healthy subjects in the Chinese Han population. No significant associations were found for any single SNP and CRC risk. Our data eliminate USP7 as a potential candidate gene towards for CRC in the Han Chinese population.
Keywords
Association; USP7 gene; colorectal cancer; Chinese Han population;
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1 Aaltonen L, Johns L, Järvinen H, Mecklin JP, Houlston R (2007). Explaining the familial colorectal cancer risk associated with mismatch repair (MMR)-deficient and MMR-stable tumors. Clin Cancer Res, 13, 356-61.   DOI
2 Ashcroft M, Vousden KH (1999). Regulation of p53 stability. Oncogene, 18, 7637-43.   DOI
3 Becker K, Marchenko ND, Palacios G, Moll UM (2008). A role of HAUSP in tumor suppression in a human colon carcinoma xenograft model. Cell Cycle, 7, 1205-13.   DOI
4 Cummins JM, Rago C, Kohli M, et al (2004). Disruption of HAUSP gene stabilizes p53. Nature, 428, 1 p following 486.
5 de Bie P, Zaaroor-Regev D, et al (2010). Regulation of the Polycomb protein RING1B ubiquitination by USP7. Biochem Biophys Res Commun, 400, 389-95.   DOI
6 Everett RD, Meredith M, Orr A, et al (1997). A novel ubiquitinspecific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein. EMBO J, 16, 1519-30.   DOI
7 Fang F, Yu XJ, Yu L, Yao L (2010). MDM2 309 T/G polymorphism is associated with colorectal cancer risk especially in Asians: a meta-analysis. Med Oncol, 28, 981-5.
8 Faul F, Erdfelder E, Lang AG, Buchner A (2007). G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods, 39, 175-91.   DOI
9 Houlston RS, Peto J (2004). The search for low-penetrance cancer susceptibility alleles. Oncogene, 23, 6471-6.   DOI   ScienceOn
10 Hu M, Li P, Li M, et al (2002). Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. Cell, 111, 1041-54.   DOI
11 Hyodo I, Suzuki H, Takahashi K, et al (2010). Present status and perspectives of colorectal cancer in Asia: Colorectal Cancer Working Group report in 30th Asia-Pacific Cancer Conference. Jpn J Clin Oncol, 40, i38-43.   DOI
12 Kessler BM, Fortunati E, Melis M, et al (2007). Proteome changes induced by knock-down of the deubiquitylating enzyme HAUSP/USP7. J Proteome Res, 6, 4163-72.   DOI
13 Lichtenstein P, Holm NV, Verkasalo PK, et al (2000). Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med, 343, 78-85.   DOI
14 Pasche B, Yi NJ (2010). Candidate gene association studies: successes and failures. Curr Opin Genet Dev, 20, 257-61.   DOI
15 Li M, Chen D, Shiloh A, et al (2002). Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature, 416, 648-53.   DOI   ScienceOn
16 Maertens GN, El Messaoudi-Aubert S, Elderkin S, Hiom K, Peters G (2010). Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor. EMBO J, 29, 2553-65.   DOI
17 Meulmeester E, Pereg Y, Shiloh Y, Jochemsen AG (2005). ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation. Cell Cycle, 4, 1166-70.   DOI
18 Qin W, Leonhardt H, Spada F (2010). Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1. J Cell Biochem, 112, 439-44.
19 Shi YY, He L (2005). SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res, 15, 97-8.   DOI
20 Tang NP, Wu YM, Wang B, Ma J (2010). Systematic review and meta-analysis of the association between P53 codon 72 polymorphism and colorectal cancer. Eur J Surg Oncol, 36, 431-8.   DOI
21 Tang J, Qu L, Pang M, Yang X (2010). Daxx is reciprocally regulated by Mdm2 and Hausp. Biochem Biophys Res Commun, 393, 542-5.   DOI
22 van der Horst A, de Vries-Smits AM, Brenkman AB, et al (2006). FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP. Nat Cell Biol, 8, 1064-73.   DOI