• Journal of Nutrition and Health
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• 제53권4호
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• pp.381-389
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• 2020

본 연구는 국내 비만과 고도비만 여성의 혈청 영양소 수준을 관찰하고자 시행하였다. 본 연구 결과를 통해 비만인과 고도비만인의 비만 예방 및 관리 지표로서의 혈청 영양소와의 관련성을 파악하고자 하였다. 본 연구의 대상자의 연령은 만18세 이상에서 59세 이하 성인 여성이며 서울 B 외과의원 비만클리닉에서 제공된 ID에 의하여 판별되는 2차 가공된 자료로 병원에서 환자의 동의를 받고 후향적으로 자료를 분석하여 총 44명을 대상자로 선정하였다. 본 연구는 BMI의 지표를 활용하여 BMI가 25.0-29.9 kg/㎡의 비만을 비만군, 30.0 kg/㎡ 이상의 고도 비만을 고도비만군으로 구분하여 비만군 23명, 고도비만군 21명을 분석하였다. 연구 대상자들의 신장과 체중, BMI, SMM, BFM, PFM을 체성분 분석을 통해 조사하였고, 혈중 생화학적 지표와 엽산, 비타민 B₁₂, 25(OH)D₃, 철, 페리틴 수준을 분석하였다. 비만군과 고도 비만군의 연령, 체중, BMI 및 체조성 중 체지방량, 체지방률은 비만군이 유의적으로 낮게 나타났으며 신장은 고도 비만군에서 유의적으로 낮게 나타났다. 생화학적 지표 검사결과 AST, ALT, 당화혈색소, 총 콜레스테롤, 중성지방은 대부분 정상 범위에 해당하였으며 두 군 사이의 유의적 차이가 나타나지 않았다. 비만과 관련된 혈청 영양소 수준을 조사한 결과 혈청 엽산, 비타민 B₁₂, 25(OH)D₃, 철, 페리틴의 수치는 대부분 정상 범위에 해당하며 두 군 간의 유의적인 차이는 없었다. 본 연구에서 비만과 고도비만 성인 여성의 혈청 영양소 수준은 유의적 차이가 없는 것으로 나타났다. 국내에서 비만 예방이나 치료를 위한 근거를 마련하기 위해서 비만과 영양소의 관련성에 대해 보다 심도 깊은 전향적 연구가 필요할 것으로 사료된다.

• 한국학교ㆍ지역보건교육학회지
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• 제9권1호
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• pp.33-46
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• 2008

Objectives: The aim of this study was to investigate the correlation between the obesity rate in elementary school students in Daejeon and the relevant factors such as social-demographical factors, genetic factors, birth factors, diet factors and intelligence factors. Methods: For the research, 443 fourth grade students, 405 fifth grade students and 417 sixth grade students from six elementary schools in Daejeon Metropolitan City Participated in this study and classified into three groups: normal-weight group, mild obesity group, and moderate or severe obesity group. Results: The total obesity rate of the elementary school students in the school district of Daejeon Metropolitan City was 14.2%; the rate of mild obesity was 7.2%; the rate of moderate obesity was 5.5%; and the rate of severe obesity was 1.5%. The obesity rate of surveyed boys was 16.9%, and the obesity rate of girls was 11.1%. The significant factors for girls' obesity were fathers' EMI, mothers' EMI, living standards, constant demand of foods, preference for greasy foods, frequency of eating snacks, and daily walking hours. It was found that students' subjective mind and objective health index were related to obesity. In the case of obese students, they had more concern about their health and more stress from the dissatisfaction of their physical appearance than normal students. Conclusions: From the above evidences, it is apparent that the obesity of elementary school students has strong relations with eating habits rather than physical activities. It is to be hoped that obesity prevention programs such as effective meal guidance. parental guidance for watching TV, and intense physical activities will be included in the curriculums of health education for elementary school students.

• 한방비만학회지
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• 제22권1호
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• pp.77-85
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• 2022

While the Coronavirus disease 2019 (COVID-19) pandemic is gradually turning into an endemic disease, concerns about post COVID-19 conditions (Long COVID) are emerging. Obesity is a major risk factor for severe complications of COVID-19, and COVID-19 has a wide range of effects on obesity and metabolic function. This paper aims to examine the interaction between COVID-19 and obesity, the effects and mechanisms of long COVID on obesity, and the role of Korean medicine on long COVID-related obesity. Obesity may worsen with cardiometabolic damage and psychosocial insecurity during COVID-19 and long COVID-induced neuroinflammation, systemic inflammation, mitochondrial dysfunction, and hypoxia also may aggravate obesity. Korean Medicine treatments, which have been widely used to treat obesity, have the potential to improve obesity in the era of long COVID by intervening in these mechanisms.

• 대한지역사회영양학회지
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• 제20권4호
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• pp.281-290
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• 2015

Objectives: Obesity is known to influence physical and mental health as well as the general quality of life. The aim of this study was to evaluate the effect of obesity related quality of life on selecting a goal for weight management in overweight and obese female patients. Methods: A total of 140 overweight or obese (Body mass index $23kg/m^2$) female outpatients aged ${\geq}20$ and ${\leq}60$ years from one clinic participated in this study. Patients' desired weight (goal weight, ideal weight, satisfactory weight, acceptable weight and disappointed weight) and obesity related quality of life measures were evaluated. Univariate and multivariate analysis were performed to evaluate the effect of obesity related quality of life on goal weight reduction (%) and goal body mass index (BMI). Results: Mean BMI of overweight group, mild obesity group and severe obesity group were $62.0{\pm}4.8kg$, $68.5{\pm}5.5kg$ and $83.5{\pm}9.6kg$, respectively. Mean weight loss expectations of the three groups were $16.4{\pm}4.7%$, $19.5{\pm}5.3%$ and $30.2{\pm}6.8%$, respectively and goal weight was significantly different among the three groups. Severe obesity group had a lower total quality of life score including physical, work-related, daily living domains than overweight or mild obesity groups. In univariate and multivariate regression analysis, psychosocial domain of quality of life had an effect on goal weight reduction (%) and goal BMI. Conclusions: The results of this study demonstrated that the obese patients with poorer quality of life and psychosocial health tended to choose higher goal weight reduction and lower goal BMI.

• 대한수의학회지
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• 제56권4호
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• pp.205-208
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• 2016

The aim of the present study is to investigate the potential influence of obesity as a factor in 5-hydroxytryptamine (5-HT) concentration in myxomatous mitral valve disease (MMVD) dogs. Fifty-five client-owned dogs were enrolled in a randomized trial. Dogs were classified by echocardiography into healthy (control), mild, and moderate to severe MMVD groups. Each group was subclassified by using a 9-point body condition score (BCS); lean (BCS 5-6/9) and obese groups (BCS 7.5-9/9). Dogs with moderate to severe MMVD had lower serotonin (5-HT) concentrations than the control group (p = 0.03). Dogs with moderate to severe MMVD (p = 0.017) had lower serum 5-HT concentrations than the control group in the obese group (BCS 7.5-9/9). Significant difference was found between the lean and obese groups (p = 0.015) which are not consider severe in the MMVD group. These results suggested that 5-HT concentration was decreased with the increasing severity of MMVD, and obesity might be taken into consideration when interpreting the serotonin concentration in MMVD dogs.

• Clinical and Experimental Pediatrics
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• 제64권10호
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• pp.511-518
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• 2021

The prevalence of childhood obesity is increasing worldwide at an alarming rate. While obesity is known to increase a variety of cardiovascular and metabolic diseases, it also acts as a risk factor for the development and progression of chronic kidney disease (CKD). During childhood and adolescence, severe obesity is associated with an increased prevalence and incidence of the early stages of kidney disease. Importantly, children born to obese mothers are also at increased risk of developing obesity and CKD later in life. The potential mechanisms underlying the association between obesity and CKD include hemodynamic factors, metabolic effects, and lipid nephrotoxicity. Weight reduction via increased physical activity, caloric restriction, treatment with angiotensin-converting enzyme inhibitors, and judicious bariatric surgery can be used to control obesity and obesity-related kidney disease. Preventive strategies to halt the obesity epidemic in the healthcare community are needed to reduce the widespread deleterious consequences of obesity including CKD development and progression.

• Journal of Yeungnam Medical Science
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• 제39권4호
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• pp.285-293
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• 2022

Background: This study was conducted to analyze the effects of low skeletal muscle mass index (SMI) and obesity on aging-related osteoarthritis (OA) in the Korean population. Methods: A total of 16,601 participants who underwent a dual-energy X-ray absorptiometry and 3,976 subjects with knee X-rays according to the modified Kellgren-Lawrence (KL) system were enrolled. Knees of ≥KL grade 2 were classified as radiologic OA. The severity of joint space narrowing (JSN) was classified by X-rays as normal, mild-to-moderate, and severe JSN in radiologic OA. The subjects were grouped as normal SMI (SMI of ≥-1 standard deviation [SD] of the mean), low SMI class I (SMI of ≥-2 SDs and <-1 SD), and low SMI class II (SMI of <-2 SDs). Obesity was defined as a body mass index (BMI) of ≥27.5 kg/m². Results: The modified KL grade and JSN severity were negatively correlated with the SMI and positively correlated with BMI and age. The SMI was negatively correlated with age. JSN severity was significantly associated with a low SMI class compared to a normal SMI, which was more prominent in low SMI class II than class I. Obesity was significantly associated with more severe JSN, only for obesity with a low SMI class. Furthermore, patients with a low SMI class, regardless of obesity, were prone to having more severe JSN. Conclusion: This study suggested that a low SMI class was associated with aging and that an age-related low SMI was more critically related to the severity of JSN in OA.

• The Korean Journal of Pain
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• 제31권4호
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• pp.268-276
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• 2018

Background: Although a variety of instruments implement body maps for the precise identification of pain symptoms, no instrument has been validated for use in people with obesity. This study reports the adaptation and validation of body maps for musculoskeletal pain location in people with obesity. Methods: Nine key anatomical regions were highlighted based on the original images of the Nordic Musculoskeletal Questionnaire body maps. Adult silhouettes were generated from photographs of men and women with obesity. The body dimensions were adjusted to take into account the different body fat distribution patterns of people with obesity. The validity of the images was assessed by 12 experts. Subsequently, a data collection stage was performed with 58 patients with severe obesity from both sexes. The reproducibility of the images was tested by comparison with the original images. Results: The results of the validation pilot study indicated that the adapted images facilitated the location of musculoskeletal pain in men and women with obesity. The reproducibility of the original and adapted versions of the body maps indicated good agreement for pain over the last 12 months and 7 days (80% vs. 79.7%). Pain scores in the last 12 months indicated good and high sensitivity and specificity for all body areas (60.9% vs. 89.1%). Considering pain in the last 7 days, high sensitivity and specificity for all areas of the body (85.1% vs. 70.1%). Conclusions: The body maps developed in this study are reliable and valid to identify the location of pain in people with obesity.

• 한방비만학회지
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• 제21권2호
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• pp.105-111
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• 2021

This study is reporting the clinical effect of herbal medicine for Class III obesity. A 34-year-old man with body mass index (BMI) 44.1 kg/m² was diagnosed to Class III obesity. We prescribed herbal medicine (Gambi-hwan) for 60 days. Self controlled low calorie diet and slight aerobic exercise were concomitantly performed during the treatment period. Body weight decreased from 152.4 kg to 128.1 kg. BMI decreased from 44.1 kg/m² to 37.0 kg/m². Visceral fat area decreased from 276 cm² to 195 cm². Percent of excess weight loss was 58.40% after treatment. A Class III obesity patient showed significant weight loss with herbal medicine as single Korean medicine treatment.

• 한국응용과학기술학회지
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• 제30권4호
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• pp.622-634
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• 2013

The multi-origin of obesity and its associated diseases made it's a complex area of biomedical science research and severe health disorder. From the 1970s to onwards this health problem turned to an epidemic without having any report of declining yet and it created a red alert to the health sector. Meanwhile, many animal models have been developed to study the lethal effect of obesity. In consequence, many drugs, therapies and strategies have already been adopted based on the findings of those animal models. However, many complicated things based on molecular and generic mechanism has not been clarified to the date. Thus, it is important to develop a need based animal model for the better understanding and strategic planning to eliminate/avoid the obesity disorder. Therefore, the present review would unveil the pros and cons of presently established animal models for obesity research. In addition, it would indicate the required turning direction for further obesity and obesity based disease research.