• Title/Summary/Keyword: Sesquiterpene

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Comparison of Sesquiterpenes in Korean and American Ginsengs (한국인삼과 북미산 서양상의 Sesquiterpene 성분 비교)

  • 위재준;신지영
    • Journal of Ginseng Research
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    • v.21 no.3
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    • pp.209-213
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    • 1997
  • Sesquiterpenes of Korean ginseng (Panax ginseng C.A. Meyer, KG) and American ginseng (Panax quinquefolium, AG) were Isolated by simultaneous distillation and extraction (SDE) with 30% methanol and n-hexane or adsorption using C18 Sep-Pak . The sesquiterpenes in KG and AG were compared each other by using TLC and GC/MS. Thin layer chromatogram of KG gave 4~5 spots of terpenes colored by vanillin-sulfuric acid, while AG did one major spot. Total ion chromatogram of KG showed about 30 peaks of sesquiterpene having molecular weight 204. Among these, 9 components such as alloaromadendrene, germacrene B, isocaryophyllene, $\alpha$-neoclovene, ${\gamma}$-muurolene and $\beta$-panasinsene together occupied 81.5% of total sesquiterpenes identified. In AG, however, only 3 components, i.e., isocaryophyllene, $\beta$-bisabolene, $\beta$-sesquiphellandrene occupied 79.3% of total sesquiterpenes identified. Especially isocaryophyllene was a dominant component of AG occupying 56.6%. Eight sesquiterpenes, including alloaromadendrene, germacrene B and $\alpha$-humulene, were not detected in AG. These results indicate that sesquiterpenes could be used as indices for the chemical difference between KG and AG.

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Cytotoxic and Cytotoxicity-Potentiating Effects of the Curcuma Root on L1210 Cell

  • Ahn, Byung-Zun;Lee, Jeong-Hyung
    • Korean Journal of Pharmacognosy
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    • v.20 no.4
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    • pp.223-226
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    • 1989
  • A cytotoxic sesquiterpene against L1210 cell has been isolated from the root of Curcuma domestica. Its structure was identified as ${\beta}-sesquiphellandrene$. The cytotoxicity-potentiating substance was (+)-ar-turmerone. (+)-ar-Turmerone potentiated the cytotoxicity of ${\beta}-sesquiphellandrene$(5 fold in $ED_{50}$ value) and an unknown sesquiterpene which was isolated from the root as well, and that of aurapten(6.3 fold) isolated from the unripe fruit of Poncirus trifoliata. Moreover, it potentiated the cytotoxic activities of MeCCNU 10 fold and cyclophosphamide 10 fold. Except the fact that all the effective cytotoxic substances possess relatively good lipophilicity, no relationship between structures of the cytotoxic substances and the cytotoxicity-enhancing effect of (+)-ar-turmerone could be observed.

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Cytotoxic Sesquiterpene Lactones from Saussurea calcicola

  • Choi, Sang-Zin;Choi, Sang-Un;Lee, Kang-Ro
    • Archives of Pharmacal Research
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    • v.28 no.10
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    • pp.1142-1146
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    • 2005
  • Seven sesquiterpene lactones were isolated by the chromatographic separation of the MeOH extract of the aerial parts of Saussurea calcicola (Compositae). Their structures were determined spectroscopically to be cynaropicrin (1), arguerin B (2), cebellin F (3), 8${\alpha}$-hydroxy-11${\alpha}$, 13-dihydrozaluzanin C (4), desacylcynaropicrin (5), 3${\beta}$-hydroxy-8${\alpha}$-epoxymethylacriloiloxy-4(15), 10(14), 11(13)-trien-guaian-6, 12-olide (6), and kandavanolide (7). Compounds 1 and 2 showed significant cytotoxicity against five cultured human tumor cell lines with $ED_{50}$ values ranging from $0.23{\~}1.72\;{\mu}g/mL$.

Cytotoxic Peroxides from Artemisia stolonifera

  • Kwon, Hak-Cheol;Choi, Sang-Un;Lee, Kang-Ro
    • Archives of Pharmacal Research
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    • v.23 no.2
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    • pp.151-154
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    • 2000
  • Two sesquiterpene endoperoxides, 1S, 4R, 6R-1, 4-endoperoxy-bisabola-2, 10-diene (1), 1R, 4S, 6R-1, 4-endoperoxy-bisabola-2, 10-diene (II), and a sesquiterpene hydroperoxide, 1$\beta$-hydroperoxygermacra-4 (15), 5, 10 (14)-triene (III) were isolated from the aerial parts of Artemisia stolonifera (Compositae). Their chemical structures were assigned by spectral evidences. Compounds I and II exhibited cytotoxicity against five human tumor cell lines with their $\ED_50 values ranging from 0.20 to 5.43 ${\mu}g/m\ell$ and from <0.1 to 0.87 ${\mu}g/m\ell$, respectively.

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Some Effects of Inula Sesquiterpene Lactones on the Growth and the Stem Anatomy of Phaseolus vulgaris L. (Inula Sesquiterpene Lactone이 Phaseolus vulgaris L.의 조직변화와 생장에 미치는 영향)

  • 권영명
    • Journal of Plant Biology
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    • v.16 no.1_2
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    • pp.12-16
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    • 1973
  • The inhibitory effect of Inula sesquiterpene lactones on the growth of Phaseolus vulgaris was tested and the abnormality of the stem organization caused by the lactones was also examined. The longitudinal growth of the young stem and the expansion of the young leaf were stopped by the application of the lactones. However, this inhibitory effect was appeared and strictly restricted within the treated area. So the young shoot was observed for possible bending as a result of the unilateral application of the lactones. When the application of the lactones into the medium, the growth of the plant was entirely repressed. However, the growth of shoot and re-initiation of root were started after the plant was transfered to the lactone free medium. And partial reversal of inhibition of the stem growth was achieved by the additions of gibberelline and the lactones.

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Sesquiterpene Lactones from Saussurea lappa and Their Cell Proliferation Effects on Human Breast Cell Lines (목향(木香)으로부터 분리된 Sesquiterpene 화합물의 암세포 생육저해에 대한 활성)

  • Park, Hyun-Sun;Choi, Eun-Jeong;Lee, Yong-Soo;Kim, Gun-Hee
    • YAKHAK HOEJI
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    • v.51 no.2
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    • pp.145-149
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    • 2007
  • Saussurea Radix, the dried roots of Saussurea lappa Clark (Compositae), has been used in oriental traditional medicine for aromatic stomachic. Present study was carried out for the anticancer effect of Saussurea Radix. Bioassay-directed fractionation of Saussurea Radix led to the isolation of two sesquiterpenes, dehydrocostuslactone (1) and costunolide (2). The structures of 1 and 2 were elucidated by spectral methods (MS, IR, $^1$H and $^{13}$C NMR). These compounds showed a potent cell proliferation activity against human breast cancer cell MCF-7 and MDA-MB-453.

Pubetalin, the Cytotoxic Principle of Siegesbeckia pubescenes Makino against L1210 Cell (털진득찰의 L1210 세포독성물질 Pubetalin의 분리)

  • Kim, Seon-Hee;Ahn, Byung-Zun
    • Korean Journal of Pharmacognosy
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    • v.19 no.4
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    • pp.251-255
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    • 1988
  • A cytotoxic sesquiterpene against L1210 cell, named pubetalin. was isolated from the herb of Siegesbeckia pubescens Makino. Its structure was identified as $6-formyl-2,\;3,\;3{\alpha},\;4,\;5,\;8,\;9,\;11{\alpha}-octahydro-10-hydroxymethyl-5-methoxy-3-methylene-2-oxocyclodeca[{\beta}]\;furan-4-ylester$ of 2-methyl-2-propenoic acid.

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The Insecticide Constituents of Several Celastraceae Plants

  • Wang, MingAn;Wu, WenJun
    • The Korean Journal of Pesticide Science
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    • v.6 no.1
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    • pp.9-15
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    • 2002
  • The insecticide constituents of several Celastraceae family plants including Celastrus angulatus, Celastrus orbiculatus, Celastrus flagellaris, Euonymus verrucosides, Euonymus forunei and Euonymus phellomana were studied by bioassay-guided fractionation. All structures of sesquiterpene polyol esters and alkaloids have been elucidated by UV, IR, MS, NMR and x-ray diffraction evidences. These compounds exhibited insecticidal, antifeedant and narcotic activities against Mythimna separata.

Studies on Tissue Culture of Perilla Species (자소(紫蘇)의 조직배양에 관한 연구(II))

  • Shin, Soon-Hee
    • Korean Journal of Pharmacognosy
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    • v.17 no.1
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    • pp.7-11
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    • 1986
  • The young leaf of Perilla species was cultured by two stage culture system using the medium containing mevalonic acid lactone. The growth rate and productivity of essential oil of callus were increased. The essential oil from intact plant and callus was also analysed. Sesquiterpene hydrocarbons and one sesquiterpene alcohol were identified in essential oils of callus.

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