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A New Sesquiterpene Hydroperoxide from the Aerial Parts of Aster oharai  

Choi, Sang-Zin (Natural Products Laboratory, College of Pharmacy, SungKyunKwan University)
Lee, Sung-Ok (Natural Products Laboratory, College of Pharmacy, SungKyunKwan University)
Choi, Sang-Un (Korea Research Institute of Chemical Technology)
Lee, Kang-Ro (Natural Products Laboratory, College of Pharmacy, SungKyunKwan University)
Publication Information
Archives of Pharmacal Research / v.26, no.7, 2003 , pp. 521-525 More about this Journal
Abstract
Phytochemical works on the aerial parts of Aster oharai (Compositae) led to the isolation of a new sesquiterpene hydroperoxide, 7$\alpha$-hydroperoxy-3, 11-eudesmadiene (2) and seven known compounds, teucdiol B (1), $\alpha$-spinasterol (3), oleanolic acid (4), $\alpha$-spinasterol 3-Ο-$\beta$-D-glucopyranoside (5), methyl 3,5-di-Ο-caffeoyl quinate (6), 3,5-di-Ο-caffeoylquinic acid (7), 3,4-di-Ο-caffeoylquinic acid (8). The chemical structures of 1-8 were established by chemical and spectroscopic methods. Compound 2 showed cytotoxicity against cultured human tumor cell lines in vitro, SK-OV-3 (ovarian), SK-MEL-2 (skin melanoma), and HCT15 (colon) with $ED_{50}$ values ranging from 3.86-17.21 $\mu$g/mL.
Keywords
Aster oharai; Compositae; Sesquiterpene hydroperoxide; Quinic Acid; Cytotoxicity;
Citations & Related Records

Times Cited By Web Of Science : 15  (Related Records In Web of Science)
Times Cited By SCOPUS : 9
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