Browse > Article

Cytotoxic Sesquiterpene Lactones from Saussurea calcicola  

Choi, Sang-Zin (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University)
Choi, Sang-Un (Korea Research Institute of Chemical Technology)
Lee, Kang-Ro (Natural Products Laboratory, College of Pharmacy, Sungkyunkwan University)
Publication Information
Archives of Pharmacal Research / v.28, no.10, 2005 , pp. 1142-1146 More about this Journal
Abstract
Seven sesquiterpene lactones were isolated by the chromatographic separation of the MeOH extract of the aerial parts of Saussurea calcicola (Compositae). Their structures were determined spectroscopically to be cynaropicrin (1), arguerin B (2), cebellin F (3), 8${\alpha}$-hydroxy-11${\alpha}$, 13-dihydrozaluzanin C (4), desacylcynaropicrin (5), 3${\beta}$-hydroxy-8${\alpha}$-epoxymethylacriloiloxy-4(15), 10(14), 11(13)-trien-guaian-6, 12-olide (6), and kandavanolide (7). Compounds 1 and 2 showed significant cytotoxicity against five cultured human tumor cell lines with $ED_{50}$ values ranging from $0.23{\~}1.72\;{\mu}g/mL$.
Keywords
Saussurea calcicola; Compositae; Sesquiterpene lactone; Cytotoxicity;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 9  (Related Records In Web of Science)
Times Cited By SCOPUS : 4
연도 인용수 순위
1 Ha, T. J., Jang, D. S., Lee, J. R., Lee, K. D., Hwang, S. W., Jung, H. J., Nam, S. H., Park, K. H., and Yang, M. S., Cytotoxic effects of Sesquiterpene lactones from the flowers of Hemisteptia lyrata B. Arch. Pherm. Res., 26, 925-928 (2003)   DOI   ScienceOn
2 Marco, J. A., Sanz-cervera, J. F., Garcia-liiso, V., Susanna, A., and Garcia-Jacas, N., Sesquiterpene lactones, lignans, and aromatic esters from Cheirolophus species. Phytochemistry, 37, 1101-1107 (1994)   DOI   ScienceOn
3 Skehan, P., Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D., Warren, J. T., Bokesch, H., Kenney, S., and Boyd, M. R., New colorimetric cytotoxicity assay for anticancer-drug screening. J. Natl. Cancer lnst., 82, 1107-1112 (1990)   DOI   PUBMED
4 Bensky, D. and Gamble, A., 'Chinese herbal medicine (Material medica)', Eastland Press, Seattle, pp. 339-340 (1986)
5 Marco, J. A., Sanz-Cervera, J. F., Yuste, A., and Oriola, M. C., Sesquiterpene lactones and dihydroflavonols from Andryala and Urospermum species. Phytochemistry, 36, 725-729 (1994)   DOI   ScienceOn
6 Kisiel, W., 8-Epidesacylcynaropicrin from Crepis capillaris. Planta Med., 49, 246-247 (1983)   DOI   ScienceOn
7 Matsuda, H., Kageura, T., Inoue, Y., Morikawa, T., and Yoshikawa, M., Absolute stereostructures and syntheses of Saussureamines A, S, C, D, and E, amino acid-sesquiterpene conjugates with gastroprotective effect, from the roots of Saussurea lappa. Tetrahedron, 56, 7763-7777 (2000)   DOI   ScienceOn
8 Bohlmann, F. and Gupta, R. K., Further ineupatorolide like germacranolides from Inula cuspidate. Phytochemistry, 21, 157-160 (1982)   DOI   ScienceOn
9 Youssef, D. and Frahm, A. W., Circular dichroism of C-7, C-6 trans-fused Gualanolides of Centaurea scoparia. Phtyochemistry, 41, 1107-1111 (1993)
10 Cho, J. Y., Baik, K. U., Jung, J. H., and Park, M. H., In vitro antiinflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa. Eur. J. Pharm., 398, 399-407 (2000)   DOI   ScienceOn
11 Marco, J. A., Sanz, J. F., Albiach, R., Rustaiyan, A., and Habibi, Z., Bisabolene derivatives and sesquiterpene lactones from Cousinia species. Phytochemistry, 32, 395-400 (1993)   DOI   ScienceOn
12 Fernandez, I., Garcia, B., Grancha, F. J., and Pedro, J. R., Two guaianolides from Centaurea collina. Phytochemistry, 26, 2403-2405 (1987)   DOI   ScienceOn
13 Fernandez, I., Garcia, B., Grancha, F. J., and Pedro, J. R., Sesquiterpene lactones, f1avonoids and coumarins from Centaurea collina. Phytochemistry, 28, 2405-2407 (1989)   DOI   ScienceOn
14 Chhabra, B. R., Gupta, S., Jain, M., and Kalsi, P. S., Sesquiterpene lactones from Saussurea lappa. Phytochemistry, 49, 801-804 (1998)   DOI   ScienceOn
15 Li, Y. and Jia, Z. J., Guaianolides from Saussurea involucrate. Phytochemistry, 28, 3395-3397 (1989)   DOI   ScienceOn
16 Dai, J., Zhao, C., Zhang, Q., Liu, Z. L., Zheng, R., and Yang, L., Taraxastane type triterpenoids from Saussurea petrovii. Phytochemistry, 58, 1107-1111 (2001)   DOI   ScienceOn
17 Singhal, A. K., Chowdhury, P. K., and Sharma, R. P., Guaianolides from Tricholepis glaberrima. Phytochemistry, 21, 462-463 (1982)   DOI   ScienceOn
18 Zdero, C., Bohlmann, F., and Wasshausen, D. C., Guaianolides from Brachylaena species. Phtyohemistry, 30, 3810-3811 (1991)   DOI   ScienceOn
19 Rustaiyan, A., Niknejad, A., Zdero, C., and Bohlmann, F., A guaianolide from Centaurea benen. Phytochemistry, 20, 2427-2429 (1981)   DOI   ScienceOn
20 Gonzalez, A. G., Amaro, J., Fraga, B. M., and Luis, J., 3-Oxo-6B-hydroxyolean-18-enoic acid from Orthopterygium huancuy. Phytochemistry, 22, 1828-1830 (1983)   DOI   ScienceOn
21 Helal, A. M., Nakamura, N., Meselhy, M. R., EI-Fishawy, A.M., Hattori, M., and Mahran, G. H., Guaianolides from Centaurea scoparia. Phytochemistry, 45, 551-554 (1997)   DOI   ScienceOn