• 제목/요약/키워드: Serum gastrin

검색결과 43건 처리시간 0.029초

단삼보혈탕(丹蔘補血湯)이 혈청(血淸) gastrin, secretin 및 중추신경계(中樞神經系)에 미치는 영향(影響) (Effects of Dansambohyultang on serum gastrin, secretin release and CNS)

  • 여은경;윤상협;류봉하;박동원;류기원
    • 대한한방내과학회지
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    • 제19권2호
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    • pp.233-248
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    • 1998
  • This study was conducted to investigate effects of Dansambohyultang on serum gastrin, secretin release and CNS in rats and mice. One group of seven rats was intactly in normal condition, the other group of seven rats was respectively heated, starved, and stressfully immobilized. The third group of seven rats was provided with Dansambohyultang before the stress, and the forth one after the stress. And, gastrin concentration and secretin concentration were measured. Mice were studied with regard to convulsion time, total sleep time and analegic effects on cental nerve system. The results were as follows: 1. Gastrin concentration was significantly decreased, and secretin concentration was significantly increased. 2. Analegic effect by acetic acid method was recognizably observed. 3. Effect of total sleep time done by pentobarbital-Na was recognizably observed. 4. Anti-convulsion effects induced by strychnine, picrotoxin and caffeine were recognizable. It is inferred from above results that Dansambohyultang inhibits gastin release, stimulates secretin release and palliate the pain.

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The Effects of Interferential Current Therapy on Functional Dyspepsia

  • Koo, Ja Pung;Shin, Hee Joon;Kim, Nyeon Jun;Jeon, Hye Mi;Park, Joo Hyun;Yun, Young Dae;Lee, Joon Hee;Lim, Sang Wan;Um, Ki Mai;Kim, Ji Sung
    • 국제물리치료학회지
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    • 제4권1호
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    • pp.499-504
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    • 2013
  • This study aims to address the effect of interferential current therapy and thereby to provide basic resources to physical therapies for internal medicine by identifying symptoms for functional dyspepsia and serum gastrin level that shows gastric motility. Following results were obtained by performing interferential current therapy to 16 subjects composed of 8 for functional dyspepsia group and 8 for control group for 20 minutes a day, 3 days a week, for 6 weeks. In control group, serum gastrin level was significantly( p<.01), lowered after the therapy whereas there was no significant difference observed in all questions from questionnaire for symptoms of functional dyspepsia between before and after the therapy. In functional dyspepsia group, serum gastrin level was significantly(p<.01), lowered after the therapy and there was also significant(p<.01) reduction in every question from questionnaire for symptoms of functional dyspepsia between before and after the therapy. There was more significant decrease in serum gastrin level and reduction in questionnaire for symptoms of functional dyspepsia in the functional dyspepsia group compared to the control group(p<.01). This study confirms the interferential current therapy as an effective therapeutic method for internal diseases including functional dyspepsia since it not only improves the symptoms of functional dyspepsia but also allows the gastric motility close to normal.

포도당 및 Casein 액 단일투여에 의한 조기 Gastrin 반응 (Early Gastrin Response to Single Glucose and Casein Feeding)

  • 성호경;남기용
    • The Korean Journal of Physiology
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    • 제15권2호
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    • pp.97-101
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    • 1981
  • The early plasma gastrin responses to single oral glucose or casein solution were studied in the same normal subjects on different days. After an overnight fast, glucose or casein solution was ingested within few minutes at the breakfast time. The plasma gastrin responses to these solutions were compared and contrasted with the concentration when the subjects received glucose solution intravenously. Results were as follows: 1) Rapid intravenous glucose infusion did not produce any changes in the plasma gastrin concentration. 2) Plasma gastrin concentration rose and peaked within 10 minutes after an oral liquid ingestion and then decreased substantially by 15 minutes, but remained slightly above fasting levels at 60 minutes. 3) There was no significant difference between the mean plasma gastrin concentrations after glucose of casein ingestion, but each fluid produced a significant increase in serum gastrin above fasting levels. 4) The subjects who produced high plasma gastrin response to glucose solution did so to casein solution. Conversely a low response to one solution reflected a low response to the other solution. 5) From the above results, authors discussed that individual responsibility rather than the sorts of meals is the factor in the determination of the magnitude of the early gastrin response.

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전침(電鍼)의 Prameters에 대한 실험(實驗)적 연구-자극시간(刺戟時間), 시술(施術)기간, 자극(刺戟)깊이를 중심으로- (Experimental Study of Electro-Acupuncture's Parameters at ST36 on the Serum Gastrin Level in Rats)

  • 윤정안;유윤조;김강산;김경식;김홍훈;김대중;조남근
    • Journal of Acupuncture Research
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    • 제22권1호
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    • pp.145-153
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    • 2005
  • 침(鍼) 치료효과(治療效果)에 영향을 주는 자극(刺戟) 시간(時間)과 자침(刺鍼) 깊이 및 시술(施術) 기간(期間)에 따른 효과차리(效果差異)를 관찰하기 위하여 족삼리(足三里)에 전침(電鍼)을 사용하여 위산분비를 촉진시키는 호르몬인 혈중 gastrin 농도의 변화를 관찰하여 다음과 같은 결과를 얻었다. 1. 자침 시간의 비교에서 10분, 30분 실험군에서는 대조군에 비하여 혈중 gastrin 농도를 유의하게 증가시켰으나, 60분 실험군에서는 변화를 관찰할 수 없었다. 2. 시술 기간의 비교에서 5일과 10일 실험군에서는 대조군에 비하여 혈중 gastrin 농도를 유의하게 증가시켰으나, 1일 실험군에서는 변화를 관찰할 수 없었다. 3. 자침 깊이의 비교에서 전체자극군과 피부자극군에서는 대조군에 비해 혈중 gastrin 농도를 유의하게 증가시켰으나, 심부자극군에서는 변화를 관찰할 수 없었다. 이상의 결과로 미루어 침 치료효과를 실질적으로 향상시키기 위해서는 영향을 줄 수 있는 다양한 인자들에 대한 실험적, 임상적 비교 연구가 진행되어 임상과 기초이론에 활용할 수 있는 자료가 구축되어야 할 것으로 사료된다.

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만성신부전에 수반된 각종 내분비기능 변화에 관한 연구 (A Study on the Abnormalities of the Various Endocrine Functions Associated with Chronic Renal Failure)

  • 홍찬표;김만우;노방수;장경식;이민형;오현관
    • 대한핵의학회지
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    • 제16권1호
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    • pp.7-14
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    • 1982
  • In an attempt to evaluate the various serum hormonal changes in terminal renal failure, the fasting $T_4,\;T_3,\;rT_3$, gastrin, secretin prolactin, and aldosterone were measured by radioimmunoassay in 12 patients with chronic renal failure, who were admitted to Chosun University Hospital from January to June, 1981. From the analysis the following results were obtained. 1. Mean values of serum hormonal concentration in 10 normal control were as follows: $T_4,\;12.93{\pm}2.00ug/ml$; $T_3,\;113.0{\pm}28.7ng/ml$; $rT_3,\;0.11{\pm}0.10ng/ml$; gastrin, $100.0{\pm}47.1pg/ml$; secretin, $32.46{\pm}11.45pg/ml$; prolactin, $11.0{\pm}3.6ng/ml$; aldosterone, $137.0{\pm}58.5pg/ml$, 2. Mean values of serum hormonal concentration in 12 chronic renal failure were as follows: $T_4,\;7.34{\pm}2.43ug/ml$; $T_3,\;71.0{\pm}19.1ng/ml$; reverse $T_3,\;0.38{\pm}0.19ng/ml$; gastrin, $162.5{\pm}40.2pg/ml$; secretin, $107.50{\pm}20.48pg/ml$; prolactin, $34.0{\pm}17.2ng/ml$; Aldosterone, $86.5{\pm}19.8pg/ml$. 3. In chronic renal failure group, serum T 4, T 3 and adosterone level were significantly lower than those of the control group, but serum $rT_3$, gastrin, secretin and prolactin were significantly higher than those of the control group. 4. In the view of the correlation between serum hormonal concentions and serum creatinine levels in patients with chronic renal failure, $rT_3$, gastrin, secretin and prolactin showed increasing tendency(positive correlations), whereas $T_4,\;T_3$ and aldosterone showed decreasing tendency (negative correlations) with increment of serum cteatinine levels. And so, we observed the negative correlation between $T_3\;and\;rT_3$.

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Screening of Precancerous Gastric Lesions by Serum Pepsinogen, Gastrin-17, Anti-Helicobacter Pylori and Anti-Caga Antibodies in Dyspeptic Patients over 50 years Old in Guilan Province, North of Iran

  • Mansour-Ghanaei, Fariborz;Joukar, Farahnaz;Rajpout, Yaghoub;Hasandokht, Tolou
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권18호
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    • pp.7635-7638
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    • 2014
  • Background: The aim of this study was to investigate the value of serum gastric markers to differentiate between patients with precancerous lesions and nonatrophic chronic gastritis. Materials and Methods: Serum samples of 128 patients with dyspepsia who were candidates for endoscopic examination were tested for pepsinogen (PG I and PG II), PG I/II ratio, gastrin 17(G-17), anti-Helicobacter pylori (anti-H pylori ) and anti-CagA antibodies. Two sample t-tests, chi-square tests and Pearson's correlation analyses were used for analysis using SPSS (version 20). Results: PGI, PG I/II ratio values were decreased significantly in the precancerous lesion group (0.05, 0.001 respectively). The frequency of H pylori infection was significantly (p=0.03) different between the two groups ofthe study. Conclusions: We suggest PGI and the PG I/II ratio as valuable markers for screening of premalignant gastric lesions.

보심건비탕(補心健脾湯)과 정전가미이진탕(正傳加味二陳湯)의 적출장기(摘出臟器), 항궤양(抗潰瘍), 위액(胃液)·gastrin 분비(分泌), 장관수송능(腸管輸送能) 및 진통(鎭痛).진경작용(鎭痙作用)에 대한 비교(比較) 연구(硏究) (A Comparative study on the inhibitory effect on contraction of isolated organs, anti-ulcer, secretion of gastric juice, secretion of gastrin in serum, transport ability of intestine, analgesic effect and sedative effect of the Bosimgunbitang(補心健脾湯) and ungjungamiijintang(正傳加味二陳湯))

  • 류봉하;박동원;류기원;윤상건;김진성
    • 대한한방내과학회지
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    • 제21권1호
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    • pp.87-99
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    • 2000
  • Objectives : This is the experimetal paper to evaluate and compare the effects of Bosimgunbitang(補心健脾湯) with those of Jungjungamiyijintang(正傳加味二陳湯) on contraction of isolated organs, anti-ulcer, secretion of gastric juice, secretion of gastrin in serum, transport ability of intestine, analgesic effect and sedative effect Methods : We used mice and rats administered with the extract of the above herbs. Results: Bosimgunbitang and jungjungamiijintang showed the inhibitory effect on the smooth muscle contraction of the isolated ileum induced by acethylcholine chloride and barium chloride in mice. transport ability of intestine. Bosimgunbitang and jungjungamiijintang showed the inhibitory effect on the contraction of the fundus-strip induced by acethylcholine chloride and barium chloride in rats. The preventive effect on pyloric ulcer, indomethacin induced ulcer and ethanol-HCl induced ulcer bf mice was significant. The inhibitory effect of Bosimgunbitang on gastric free acidity, total acidity in Shay rats was significant. The inhibitory effect of on gastrin secretion in serum was significant after only 1 hour when the Bosimgunbitang and jungjungamiijintang was administered. The promoting effect of the jungjungamiijintang on the transport ability of small intestine was significant in the high concentration. The promoting effect of the Bosimgunbitang and jungjungamiijintang on the transport ability of large intestine was significant. The analgesic and the sedative effect were recognized. It meaned that Bosimgunbitang and jungjungamiijintang effected on the C.N.S.. Conclusion : Bosimgunbitang and jungjungamiijintang have the inhibitory effect on the smooth muscle abnormal contraction of the isolated ileum and the anti-ulcer effect to prevent, secretion of gastric juice and gastrin in serum. And they also have to increase a transport ability of intestine, analgesic effect and sedative effect. Jungjungamiijintang especially is eminent for analgesic effect while Bosimgunbitang has excellent sedative effect.

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가미귀비탕(加味歸脾湯)이 흰쥐의 위궤양(胃潰瘍)에 미치는 영향(影響) (Studies on the effect of Kamikuibitang on the Gastric Ulcer in Rats)

  • 백동진
    • 대한한의학회지
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    • 제17권2호
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    • pp.277-290
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    • 1996
  • This study was aimed to evaluate the anti-pain effect of Kamikuibitang in acetic acid method and the anti-ulceration effect of Kamikuibitang in indomethacin, aspirin and immobilization stress method in rats. The results were follows; 1. The anti-pain effects of Kuibitang and Kamikuibitang were decreased compared with those of control group. 2. In indomethacin and aspirin method, the anti-ulcerative effects of experimental groups were shown compared with those of control group. 3. In immobilization stress method, the anti-ulcerative effect of experimental groups was significantly shown compared with that of control group. 4. The serum gastrin levels of Kuibitang groups showed very significant decrease in indomethacin-induced and immobilization stress-induced ulcers. The serum gastrin levels of Kamikuibitang groups showed very significant decrease in indomethacin-induced, aspirin- induced and immobilization stress-induced ulcers. 5. The serum $V_{B12}$ levels of Kuibitang groups showed very significant increase in both indomethacin-induced and immobilization stress-induced ulcers. The serum $V_{B12}$ levels of Kamikuibitang groups showed significant increase in aspirin-induced and immobilization stress-induced ulcers whereas very significant increase in indomethacin-induced ulcer. According to the above results, it was concluded that Kamikuibitang had very significant anti-ulceration effect as well as anti-pain effect on gastric ulcer in rats.

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전침자극(電針刺戟)이 말의 위장관운동관련 내분비물질(內分泌物質)의 혈중농도(血中濃度)에 미치는 영향 (The effects of electroacupuncture on blood concentration of gastrointestinal motility-related endocrine substances in horses)

  • 김병선;최희인
    • 대한수의학회지
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    • 제38권3호
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    • pp.614-628
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    • 1998
  • The effects of electroacupuncture(EA) on blood concentration of endocrine substances were investigated in 6 horses. Three acupuncture points ; Guan Yuan Shu(BL-26), Wei Shu(BL-21) and Da Chang Shu(BL-25) were stimulated for 20 minutes by EA at separate occasions under varying condition ; 2V-1Hz, 2V-5Hz, 2V-30Hz, 4V-1Hz, 4V-5Hz and 4V-30Hz. Plasma levels of adrenocorticotropic hormone(ACTH), ${\beta}$-endorphin, epinephrine, norepinephrine and serum levels of gastrin were analysed. Blood samplings were carried out before, 0, 20 and 40 minutes after the EA stimulation. The serum gastrin levels were increased by 2V-5Hz stimulation on the Wei Shu. Plasma ACTH levels were decreased by 2V-1Hz stimulation on the Wei Shu, but largely increased by 4V-30Hz stimulation on the Guan Yuan Shu. Plasma ${\beta}$-endorphin levels were slightly increased or decreased by 2V-1Hz stimulation, but largely increased by 4V-30Hz stimulation on the Guan Yuan Shu. Plasma levels of epinephrine and norepinephrine were not so much changed by 2V-1Hz or 5Hz stimulation, but tended to increase by 4V-30Hz stimulation on Guan Yuan Shu. These results suggest that the low voltage-low frequence EA stimulation increased blood concentration of gastrin, but decreased ACTH, ${\beta}$-endorphin, epinephrine and norepinephrine, whereas high voltage-high frequence EA stimulation induced opposite results. Accordingly, there appears to be a close relationship between the changes of gastrointestinal motility and the changes of blood concentration of endocrine substances by EA stimulation.

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상완, 중완, 하완 구요법과 사관 침요법의 혼합사용이 정상 백서 위 기능에 미치는 영향 (Effect of Combined Acupuncture at Hefu(LI4), Taichong(LR3) and Moxibustion at Shangwan(CV13), Zhongwan(CV12), Xiawan(CV10) on the Serum Gastrin Level in Rats)

  • 한상묵;황태준;김홍재;정상구;조승묵;유윤조;김명동
    • 동의생리병리학회지
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    • 제19권5호
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    • pp.1238-1242
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    • 2005
  • Shangwan(CV13), Zhongwan(CV12), Xiawan(CV10), Hefu(L14) and Taichong(LR3) which belong to Conception Vessel and stomach meridian are acupuncture points frequently used for healing gastrointestinal desease in oriental medicine. The present study was conducted to see the effects produced by combined acupuncture(A), electro-acupuncture(EA) and moxibustion using five acupoints which belongs to different meridians on serum gastrin level in rats. Electro-acupuncture (2 Hz, intensity; 10 times muscle twitch threshold) was applied for 30 minutes to Hefu(LI4), Taichong(LR3) under halothane anesthesia. Moxibustion ($1.6{\pm}0.3\;mg$, 5 times of a day) was applied during 3 days to CV10, CV12, CV13 under halothane anesthesia. Combined stimuli of acupuncture at Hefu(LI4), Taichong(LR3) and moxibustion at CV13, CV12 increased serum gastrin level significantly eventough combined simulus of moxibustion on CV 10 was not shown any change. And combined stimul of EA and moxibustion at experimental all groups were not shown any effects. These data suggest that effects of acupuncture and moxibustion are depentent with used acupoints and combination stimuli method.