The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지

A Comparative study on the inhibitory effect on contraction of isolated organs, anti-ulcer, secretion of gastric juice, secretion of gastrin in serum, transport ability of intestine, analgesic effect and sedative effect of the Bosimgunbitang(補心健脾湯) and ungjungamiijintang(正傳加味二陳湯)

보심건비탕(補心健脾湯)과 정전가미이진탕(正傳加味二陳湯)의 적출장기(摘出臟器), 항궤양(抗潰瘍), 위액(胃液)·gastrin 분비(分泌), 장관수송능(腸管輸送能) 및 진통(鎭痛).진경작용(鎭痙作用)에 대한 비교(比較) 연구(硏究)

  • Ryu, Bong-Ha (Department of the 3rd Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Park, Dong-Won (Department of the 3rd Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Ryu, Ki-Won (Department of the 3rd Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Yin, Chang-Jina (Department of the 3rd Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Kim, Jin-Seong (Department of the 3rd Internal Medicine, College of Oriental Medicine, Kyung Hee University)
  • 류봉하 (경희대학교 한의과대학 비계내과학교실) ;
  • 박동원 (경희대학교 한의과대학 비계내과학교실) ;
  • 류기원 (경희대학교 한의과대학 비계내과학교실) ;
  • 윤상건 (경희대학교 한의과대학 비계내과학교실) ;
  • 김진성 (경희대학교 한의과대학 비계내과학교실)
  • Published : 2000.08.30
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Abstract

Objectives : This is the experimetal paper to evaluate and compare the effects of Bosimgunbitang(補心健脾湯) with those of Jungjungamiyijintang(正傳加味二陳湯) on contraction of isolated organs, anti-ulcer, secretion of gastric juice, secretion of gastrin in serum, transport ability of intestine, analgesic effect and sedative effect Methods : We used mice and rats administered with the extract of the above herbs. Results: Bosimgunbitang and jungjungamiijintang showed the inhibitory effect on the smooth muscle contraction of the isolated ileum induced by acethylcholine chloride and barium chloride in mice. transport ability of intestine. Bosimgunbitang and jungjungamiijintang showed the inhibitory effect on the contraction of the fundus-strip induced by acethylcholine chloride and barium chloride in rats. The preventive effect on pyloric ulcer, indomethacin induced ulcer and ethanol-HCl induced ulcer bf mice was significant. The inhibitory effect of Bosimgunbitang on gastric free acidity, total acidity in Shay rats was significant. The inhibitory effect of on gastrin secretion in serum was significant after only 1 hour when the Bosimgunbitang and jungjungamiijintang was administered. The promoting effect of the jungjungamiijintang on the transport ability of small intestine was significant in the high concentration. The promoting effect of the Bosimgunbitang and jungjungamiijintang on the transport ability of large intestine was significant. The analgesic and the sedative effect were recognized. It meaned that Bosimgunbitang and jungjungamiijintang effected on the C.N.S.. Conclusion : Bosimgunbitang and jungjungamiijintang have the inhibitory effect on the smooth muscle abnormal contraction of the isolated ileum and the anti-ulcer effect to prevent, secretion of gastric juice and gastrin in serum. And they also have to increase a transport ability of intestine, analgesic effect and sedative effect. Jungjungamiijintang especially is eminent for analgesic effect while Bosimgunbitang has excellent sedative effect.

Keywords

References

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