• Journal of Nutrition and Health
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• v.38 no.6
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• pp.411-418
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• 2005

To elucidate the effect of soy isoflavone supplementation and exercise on serum lipids in normolipidemic and mildly hyperlipidemic postmenopausal period, 54 women residing in Seoul area were recruited. The subjects were divided into 4 groups: control group (n=13), isoflavone group (n=14), exercise group (n=14), isoflavone + exercise group (n=13). The control group was given placebo capsules, isoflavone group was given soy isoflavone supplements (90 mg/day), exercise group was given placebo capsules and exercised 3 times/week, over 30 min/time, and isoflavone + exercise group took soy isoflavone supplement and exercised. The duration of study were 8 weeks. The average age of the subjects was 57.0 years, 56.0 years, 54.4 years, and 55.2 years, respectively. There were no significant differences among the four groups in terms of height, weight, and body mass index. There were no significant differences among the four groups in terms of serum, total cholesterol, HDL-cholesterol. But the subjects indicated a significant difference in serum LDL-cholesterol (110.5 mg/day in before versus 74.6 mg/day in after) in the isoflavone + exercise group at the levels of p<0.05. In conclusion, the isoflavone supplementation and exercise may be helpful to decrease serum lipids of normolipidemic and mildly hyperlipidemic postmenopausal women.

• Journal of Nutrition and Health
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• v.32 no.1
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• pp.24-29
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• 1999

This study was conducted of investigate the antioxidant vitamins and serum lipids status of 23 healthy female subjects and 22 female patients suffering from cerebrovascular disease hospitalized at any of three of general hospitals in Taegu. The systolic blood pressure of patients suffering from cerebrovascular disease(151.4$\pm$30.2mmHg) was significantly higher than healthy controls(129.7$\pm$17.8mmHg). The frequency of drinking alcohol and smoking in patients was also higher. Analysis of patient and control dietary intakes revealed that all subjects were consuming the minimed recommended energy-nutrient levels. HDL-cholesterol(26.15 vs 37.74mg/dl), serum vitamin E(12.69 vs 17.74mg/l) and vitamin C(65.59 vs 152.50ug/dl) levels were significantly lower, but triglyceride(221.01 vs 87.30 mg/dl) and total-cholesterol / HDL-cholesterol levels(5.98 vs 4.89)were significantly higher in the patient group. According to the results of this study, it is expercted that refraining from smoking and drinking alcohol, cultivating healthy living habits which can decrease stress, and maintaining suitable levels of serum antioxidant vitamins can prevent the occurrence of cerebrovascular disease.

• The Journal of Internal Korean Medicine
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• v.27 no.3
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• pp.706-714
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• 2006

Object : This study was carried out to investigate the correlation between homocysteine and serum lipids which are known risk factors of stroke. Methods : The subjects were a total of 60 patients divided into a control group (n =30) and a sample group (n =30). The control group was normal homocysteine level without clinical symptoms, and the sample group was high homocysteine level with headache, dizziness, hypertension and so on. clinical symptoms, Each group was measured and compared for serum homocysteine, total cholesterol, triglyceride(TG), low density lipoprotein(LDL), and high density lipoprotein(HDL). Results : Total cholesterol, TG, and LDL were significantly increased and HDL was significantly decreased in the sample group. which was a high homocysteine level group compared with the control group, which was a normal homocysteine level group. Conclusion : In these results. it was suggested that increase of homocysteine leads to increase of serum total cholesterol, TG, LDL, but causes decrease of HDL. It seemed that risk of stroke is more at high homocysteine level than normal.

• Journal of Nutrition and Health
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• v.30 no.6
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• pp.648-657
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• 1997

This study was to investigate the ultrasonographic liver fat density , obesity index, and serum lipids. One hundred and one (43 males, 58 females)healthy adult subjects were examined using anthropometric indices, biochemical measurements and ultrasonography. The average levels of ULFD, TC, TG, HDL-C, LDL-C were 122.4mg/dl, 201.1mg/dl, 144.9mg/dl, 49.8mg/dl 122.3mg/dl, respectively for males and 117.9mg/dl, 199.1mg/dl, 130.6mg/dl, 50.6mg/dl, 122.3mg/dl, respectively for females. Males had higher levels of ULFD, TC , TPH, LPH and AI than the females but the differences were not significantly. LDL-C, TC , LPH, TPH and AI of obese groups by KI were significantly higher than those of nonobese groups. Ultrasonnographic liver fat density showed positive correlation with BW, W/H and TG. Objective measurement of ultrasonographic liver fat density is useful for the parameter of obesity.

• Journal of Nutrition and Health
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• v.25 no.7
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• pp.578-585
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• 1992

This study was undertaken to investigate effects of alcohol and dietary protein levels on serum lipids and enzyme activities in 15 week-old male rats given a normal diet. Rats were divided into 8 groups : control group (16% protein 16PC) and 8%(8PE) 16%(16PE) and 24% protein groups(24PE) to which was given 5% ethanol mixed into their drinking water after 4 weeks and 10 weeks. Body weight organ weight and various blood components were determined at 4 and 10 weeks. Body weight gain organ weight hemoglobin concentration and hematocrit value were not influenced by ethanol and dietary protein levels. The levels of total cholesterol HDL-cholesterol and phospholipid in serum were not affected by ethanol consumption. Serum triglyceride concen-trations after 10 weeks were significnatly increased ethanol-treated group compared with that of control group and the effect was greater in low protein group than control group. Serum ALP activity was significantly higher in 8PE group than other group but there was no influence by ethanol consumption.

• Journal of agricultural medicine and community health
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• v.28 no.2
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• pp.123-133
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• 2003

Objectives: To examine the association between serum gamma-glutamyltransferase(GGT) activity level and blood pressure, serum lipids in the male residents of rural area, we analyzed cross-sectionally the data of 379 male health examinees aged 40 years and older from rural areas in Gyeongsangnam-do prefecture in Korea. Methods: Blood pressure and concentration of serum lipids were compared between high and low level of serum GGT activity by t-test or Wilcoxon rank sum test. Possible confounding effects of age, body mass index and coffee drinking were adjusted by analysis of covariance. Results: Adjusted values of systolic and diastolic blood pressure were higher in the group of high level of serum GGT activity in non-drinkers(P=0.055 and P=0.074 respectively) and drinkers(P=0.284 and P=0.398) of alcohol. Adjusted serum total cholesterol level was also higher in the group of high level of serum GGT activity in non-drinkers(P=0.052) but not in drinkers(P=0.981) of alcohol. In serum triglyceride, adjusted level was significantly higher in the group of high level of serum GGT activity in both non-drinkers(P=0.035) and drinkers(P=0.002) of alcohol. Conclusions: These results suggest the association of serum GGT activity and serum triglyceride, total cholesterol, or blood pressure in non-drinkres of alcohol.

• Journal of Preventive Medicine and Public Health
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• v.30 no.1 s.56
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• pp.45-59
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• 1997

It has been known that there is a tracking phenomenon in the level of serum lipids. However, no study has been performed to examine the change and tracking of serum lipids in Korean adolescents. The purpose of this study is to examine the changes of serum lipids in Korean adolescents from 12 to 16 years of age, and to examine whether or not there is a tracking phenomenon in serum lipids level during the period. In 1992 serum lipids(total cholesterol(TC), triglyceride(TG), LDL cholesterol(LDL-C), HDL cholesterol(HDL-C)) were measured in 318 males, 365 females who were 12 years of age in Kangwha county, Korea. These participants have been followed up to 1996 and serum lipids level were examined in 1994 and 1996. Among the participants 162 males and 147 females completed all three examinations in fasting state. To examine the effect of eliminating adolescents with incomplete data, we compared serum lipids, blood pressure and anthropometric measures at baseline between adolescents with complete follow-up and adolescents who were withdrawn. To examine the change of serum lipids we compared mean values of serum lipids according to age in males and females. Repeated analysis of variance was used to test the change according to age. We used three methods to examine the existence of tracking. First, we analyzed the trends in serum lipids over 4-year period within quartile groups formed on the basis of the first-year serum lipids level to see whether or not the relative ranking of the mean serum lipids among the quartile groups remained in the same group for 4-year period. Second, we quantified the degree of tracking by calculating Spearman's rank correlation coefficient between every tests. Third, the persistence extreme quartile method was used. This method divides the population into quartile groups according to the initial level of blood lipids and then calculates the percent of the subjects who stayed in the same group at follow-up measurement. The decreases in levels were noted during 4 years for TC, LDL-C, primarily for boys. The level of HDL-C decreased between baseline and first follow-up for both sexes. Tracking, as measured by both correlation coefficients and persistence extreme quartiles, was evident for all of the lipids. The correlation coefficients of TC between baseline and 4 years later in boys and girls were 0.55 and 0.68, respectively. And the corresponding values for HDL-C were 0.58 and 0.69. More than 50% of adolescents who belonged to the highest quartile group in TC, HDL-C and LDL-C at the baseline were remained at the same group at the examination performed 2 years later for both sexes. The probabilities of remaining at the same group were more than 35% when examined 4 years later. The tracking phenomenon of TG was less evident compared with the other lipids. Percents of girls who stayed at the same group 2 years later and 4 years later were 42.9% and 25.7%, respectively. It was evident that serum lipid levels tracked in Korean adolescents. Researches with longer follow-up would be needed in the future to investigate the long-term change of lipids from adolescents to adults.

• Journal of Nutrition and Health
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• v.31 no.1
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• pp.72-79
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• 1998

This study was intended to figure out the difference of the blood lipids, insulin and nutrients intake by fat distribution among the obese young male in Korean. Twenty-eight male college students participated in this study, whose to find out body fat distributions were classified on the basis of Waist /hip ratio (WHR) into three groups-upper body type (UBTM), intermediate body type(IBTM) and lower body type (LBTM). To conduct this study, anthropometric measurements , blood pressure, serum lipids and insulin levels, and daily nutrients intake were analized . The results are as follows : The three body type groups showed significant differences each other in waist circumference(p<0.05), WTR(p<0.001) and body fat percentage (p<0.05). Also they showed significant difference each other in the daily construction in the daily energy intake. But they did not show significant differences in the blood pressure, serum lipids and insulin levels. From the above results, we could concluded that the body fat distribution in obese the young men could affect nutrients intake pattern.

• Journal of the Korean Applied Science and Technology
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• v.1 no.1
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• pp.11-21
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• 1984

The purpose of the study was to find an effect of medium chain triglyceride (MCT)diet on the serum lipids and lipoprotein of Sprague-Dawley rats when the were fed with cholesterol. All experiment-groups were fed with different diet such as soybean oil, shortening,MCT and MCT mixed with oil respectively. After fed to each group, the levels of serum lipids and lipoprotein among fed rats were examined and the data from the experiment were compared with a control group. The results obtained from the study are as follows : (1) The average boby weight gain in MCT diet and soybean oil diet groups were lighter than that of the control group, while the food efficiency ratio in each experimental diet group was almost same as than in the control group. (2) Total cholesterol levels in serum of all experimental diet groups were lower than that of the control group except the level in shortening diet group. Especially, the levels of total cholesterol in MCT diet and soybean oil diet groups were significantly lower than that of the control group. (3) VLDL, LDL-cholesterol levels of all experimental groups were almost same except the case of the MCT diet and soybean oil diet group which was significantly low. (4) The ratio of VLDL, LDL-cholesterol to HDL-cholesterol, so called, atherogenic index in serum of MCT and soybean oil diet groups were significantly lower than that of the control group. (5) The ratio of total cholesterol to phospholipids in serum of MCT diet group was decreased, because total cholesterol levels were decreased more than phospolipid levels. (6) The ratio of the serum VLDL, LDL to HDL in MCT diet group. in MCT and soybean oil mixed diet group, and in soybean diet group was decreased. In other wards, it means that the decrease of the serum VLDL, LDL in each group and the increase of the serum HDL.

• YAKHAK HOEJI
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• v.28 no.2
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• pp.79-87
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• 1984

Lipid consumption in early life has been implicated with arteriosclerosis in later life. It has been also claimed that lipid contents of serum in early life would reflect coronary atherosclerosis in later life. Present study has been undertaken to look for serum lipid contents of mother and newborn simultaneously to determine the difference of various lipid classes. Lipids were extracted by Folch method. Total lipid was determined gravimetrically; cholesterol by Zak's method, phospholipids by Fiske-Subba-Row's method, and triglycerides by Sugiura's method. Fatty acids were analysed by gas liguid chromatography. Values of the total lipids of mother was significantly higher than those of newborn. HDI-cholesterol/total cholesterol ratio of newborn's was higher than mother's. The amount of saturated fatty acids in the serum cholesteryl ester of newborn was significantly higher than mother's.