• Molecules and Cells
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• v.45 no.1
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• pp.6-15
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• 2022

Phase separation is a thermodynamic process leading to the formation of compositionally distinct phases. For the past few years, numerous works have shown that biomolecular phase separation serves as biogenesis mechanisms of diverse intracellular condensates, and aberrant phase transitions are associated with disease states such as neurodegenerative diseases and cancers. Condensates exhibit rich phase behaviors including multiphase internal structuring, noise buffering, and compositional tunability. Recent studies have begun to uncover how a network of intermolecular interactions can give rise to various biophysical features of condensates. Here, we review phase behaviors of biomolecules, particularly with regard to regular solution models of binary and ternary mixtures. We discuss how these theoretical frameworks explain many aspects of the assembly, composition, and miscibility of diverse biomolecular phases, and highlight how a model-based approach can help elucidate the detailed thermodynamic principle for multicomponent intracellular phase separation.

• Korean Chemical Engineering Research
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• v.53 no.1
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• pp.22-30
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• 2015

So far, most of research activities on modeling of membrane separation processes have been focused on binary feed mixture. But, in actual separation operations, binary feed is hard to find and most separation processes involve multicomponent feed mixture. In this work models for membrane separation processes treating multicomponent feed mixture are developed. Various model types are investigated and validity of proposed models are analysed based on experimental data obtained using hollowfiber membranes. The proposed separation models show quick convergence and exhibit good tracking performance.

• Structural Engineering and Mechanics
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• v.43 no.4
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• pp.503-526
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• 2012

Pounding between closely located adjacent buildings is a serious issue of dense cities in the earthquake prone areas. Seismic responses of adjacent buildings subjected to earthquake induced pounding are numerically studied in this paper. The adjacent buildings are modeled as the lumped mass shear buildings subjected to earthquake acceleration and the pounding forces are modeled as the Kelvin contact force model. The Kelvin model is activated when the separation gap is closed and the buildings pound together. Characteristics of the Kelvin model are extensively explored and a new procedure is proposed to determine its stiffness. The developed model is solved numerically and a SDOF pounding case as well as a MDOF pounding case of multistory adjacent buildings are elaborated and discussed. Effects of different separation gaps, building heights and earthquake excitations on the seismic responses of adjacent buildings are obtained. Results show that the seismic responses of adjacent buildings are affected negatively by the pounding. More stories pound together and pounding is more intense if the separation gap is smaller. When the height of buildings differs significantly, the taller building is almost unaffected while the shorter building is affected detrimentally. Finally, the buildings should be analyzed case by case considering the potential earthquake excitation in the area.

• Journal of Institute of Control, Robotics and Systems
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• v.9 no.2
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• pp.99-106
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• 2003

A new reconfigurable model following flight control method based on direct adaptive scheme is presented. Using the timescale separation principle, both the inner-loop and the outer-loop states are controlled simultaneously. For the timescale separation assumption to be satisfied, the inner-loop model dynamics is set to be fast whereas the outer-loop model dynamics is set to be relatively slow. The stability and convergence of the proposed control law is proved by Lyapunov theorem. One of the merits of the proposed reconfigurable controller is that the FDI process and the persistent input excitation are not necessary, which is suitable for the flight control system. To evaluate the reconfiguration performance of the proposed control method, numerical simulation is performed using six degree-of-freedom nonlinear dynamics.

• 연구논문집
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• s.30
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• pp.67-77
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• 2000

This study was performed to investigate the characteristics and performance of model Decanter for separating swine wastewater to solid and liquid which is slurry state with 12.6% TS. Swine wastewater of the slurry tank was pumped into model Decanter which capacity was $2m^3$/hr in 10% TS Slurry inside of bowl was separated to solid-liquid by centrifugal acceleration. Sampling was done in the section of slurry feed pipe, supernatant outflow pipe, cake discharge pipe. After solid-liquid separation TS, $COD_cr$ and slurry volume reduction effect represented 38%, 40%, 19.6% respectively. Relation factor of model Decanter operation slurry concentration, optimum retention time of slurry, overflow velocity of supernatant, supernatant concentration, sludge removal rate etc. Optimal operation conditions can be set and evaluated efficiency based on the experimental results in the case of Decanter adopted for solid-liquid separation in highly concentrated swine wastewater.

• Journal of Korean Society of Transportation
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• v.12 no.3
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• pp.15-27
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• 1994

A mathematical model and its solution algorithm are proposed for computing the capacity of terminal control area. The model is built based on dynamics of aircraft flying on pre-established approach path and its solution algorithm employs a numerical method. The model computes the minimum separation of two aircraft at the entry fix of the terminal control area, which assures that air traffic separation rules are not violated during the approach phase, thereby computes the capacity. The model might be applied for designing approach paths for a new airport, for rearranging paths of an existing airport or establishing approach control procedures.

• Journal of the Korean Data and Information Science Society
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• v.13 no.2
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• pp.129-138
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• 2002

This paper deals with logistic regression models for analysing separation rates from majors. The model building procedure shows how to incoporate the effects of some factors causing from three-way nested sampling scheme and discusses what type of characteristics as independent variables directly affecting the rates should be considered.

• Journal of the Institute of Convergence Signal Processing
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• v.15 no.3
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• pp.91-96
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• 2014

For Sound source direction and separation method, Frequency Domain Binaural Model(FDBM) shows low computational cost and high performance for sound source separation. This method performs sound source orientation and separation by obtaining the Interaural Phase Difference(IPD) and Interaural Level Difference(ILD) in frequency domain. But the problem of reflection occurs in practical environment. To reduce this reflection, a method to simulate the sound localization of a direct sound, to detect the initial arriving sound, to check the direction of the sound, and to separate the sound is presented. Simulation results show that the direction is estimated to lie close within 10% from the sound source and, in the presence of the reflection, the level of the separation of the sound source is improved by higher Coherence and PESQ(Perceptual Evaluation of Speech Quality) and by lower directional damping than those of the existing FDBM. In case of no reflection, the degree of separation was low.

• Convergence Security Journal
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• v.21 no.1
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• pp.45-53
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• 2021

When the security monitoring system is performed in a separation network, there is little normal anomaly detection in internal networks or high-risk sections. Therefore, after the establishment of the security network, a model is needed to evaluate state-of-the-art cyber threat anomalies for internal network in separation network to complete the optimized security structure. In this study, We evaluate it by generating datasets of cyber vulnerabilities and malicious code arising from general and separation networks, It prepare for the latest cyber vulnerabilities in internal network cyber attacks to analyze threats, and established a cyber security test evaluation system that fits the characteristics. The study designed an evaluation model that can be applied to actual separation network institutions, and constructed a test data set for each situation and applied a real-time security assessment model.

• Journal of the korean society of oceanography
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• v.34 no.1
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• pp.1-21
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• 1999

A two-layer quasi-geostrophic numerical model is used to investigate the temporal variability of the East Korea Warm Current (EKWC), especially the separation from the Korean coast and the generation of warm eddies. An attention is given on the active role of the nonlinear boundary layer process. For this, an idealized flat bottom model of the East Sea is forced with the annual mean wind curl and with the inflow-outflow specified at the Korea (Tsushima) and Tsugaru Straits. Two types of separation mechanisms are identified. The first one is influenced by the westward movement of the recirculating leg of the EKWC (externally driven separation),the second one is solely driven by the boundary layer dynamics (internally driven separation). However, these two processes are not independent, and usually coexist. It is hypothesized that 'internally driven separation' arises as the result of relative vorticity production at the wall, its subsequent advection via the EKWC, and its accumulation up to a critical level characterized by the separation of the boundary flow from the coast. It is found that the sharp southeastern corner of the Korean peninsula provides a favorable condition for the accumulation of relative vorticity. The separation of the EKWC usually accompanies the generation of a warm eddy with a diameter of about 120 km. The warm eddy has a typical layer-averaged velocity of 0.3 m/s and its lifespan is up to a year. In general, the characteristics of the simulated warm eddy are compatible with observations. A conclusion is therefore drawn that the variability of the EKWC is at least partially self-excited, not being influenced by any sources of perturbation in the forcing field, and that the likely source of the variability is the barotropic instability although the extent of contribution from the baroclinic instability remains unknown. The effects of the seasonal wind curl and inflow-outflow strength are also investigated.