• The Korean Journal of Physiology and Pharmacology
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• v.23 no.5
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• pp.317-328
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• 2019

It is known that top-down associative inputs terminate on distal apical dendrites in layer 1 while bottom-up sensory inputs terminate on perisomatic dendrites of layer 2/3 pyramidal neurons (L2/3 PyNs) in primary sensory cortex. Since studies on synaptic transmission in layer 1 are sparse, we investigated the basic properties and cholinergic modulation of synaptic transmission in layer 1 and compared them to those in perisomatic dendrites of L2/3 PyNs of rat primary visual cortex. Using extracellular stimulations of layer 1 and layer 4, we evoked excitatory postsynaptic current/potential in synapses in distal apical dendrites (L1-EPSC/L1-EPSP) and those in perisomatic dendrites (L4-EPSC/L4-EPSP), respectively. Kinetics of L1-EPSC was slower than that of L4-EPSC. L1-EPSC showed presynaptic depression while L4-EPSC was facilitating. In contrast, inhibitory postsynaptic currents showed similar paired-pulse ratio between layer 1 and layer 4 stimulations with depression only at 100 Hz. Cholinergic stimulation induced presynaptic depression by activating muscarinic receptors in excitatory and inhibitory synapses to similar extents in both inputs. However, nicotinic stimulation enhanced excitatory synaptic transmission by ~20% in L4-EPSC. Rectification index of AMPA receptors and AMPA/NMDA ratio were similar between synapses in distal apical and perisomatic dendrites. These results provide basic properties and cholinergic modulation of synaptic transmission between distal apical and perisomatic dendrites in L2/3 PyNs of the visual cortex, which might be important for controlling information processing balance depending on attentional state.

• The Journal of Korean Academy of Sensory Integration
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• v.6 no.1
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• pp.63-69
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• 2008

Introduction : This study presents a case report of a child with sensory integration dysfunction(mixed sensory modulation disorder and dyspraxia), and describes strategy of the sensory integration intervention to encourage child's inner drive and the change of adaptive response. Main Subject : The subject was a boy, age 5 years and 10 months, who participated in short-term intensive sensory integration therapy program which was provided in a 2008 sensory integration treatment course. Based on results of assessment to the child, This study identifies the treatment goals, contents of treatment and analyze adaptive response' change of four therapy sessions. Conclusion : This case report demonstrates improvement of the adaptive response by sensory integration intervention and impotent to encourage the child's inner drive. However, subjective date, which is sensory integration may produce an effect that is evident during treatment sessions and in home environment have suggested.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2012.05a
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• pp.1303-1304
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• 2012

• The Journal of Korean Academy of Sensory Integration
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• v.6 no.1
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• pp.25-33
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• 2008

Objective : To identify the effectiveness of a short-term intensive intervention program on the improvement of adaptive response of a child with mixed sensory integration disorder. Method : Four and half years old boy who has been diagnosed of PDD received 40 min of one intervention session and 50 min of 3 intervention sessions. The intervention was a part of the 2008 Sensory Integration Treatment Course developed by the Korean Academy of Sensory Integration (KASI) and all sessions were implemented under supervision by experts. Result : Adaptive responses of the child were enhanced throughout the intervention process in terms of postural response and peer interaction. His oral defensiveness is improved. As the intervention progressed, he exhibited more active movements, louder voice, and coherence within peer group. Conclusion : This case report demonstrates effectiveness of a short-term intensive intervention program in terms of improving adaptive response. To enrich the effectiveness, tt is suggested to educate parents about neurological base of the child's behaviors so the they understand the importance of various sensory experience within play.

• Sleep Medicine and Psychophysiology
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• v.1 no.2
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• pp.156-162
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• 1994

Objectives: Eyeblinking varied depending on individual cognitive abilities or personality traits thought to related to brain mechanisms of sensory modulation. This study explored whether personality traits are related to the rate of eye blinks and how eyeblink and evoked potential augumenting-reducing(EPAR) interact Methods: Forty four students were studied with EPAR topography to explore how eyeblinks, personality and EPAR interact The Zuckerman Sensation Seeking Scale(SSS) and Eysenck Personality Questionnaire(EPQ) were used as personality measured by a stimulus response program during EP study. Results: Rate of blink increased as intensity of light increased. The General(GEN), Thrill and Adventure Seeking(TAS), Experience Seeking(ES) and Disinhibition(DS) subscales in SSS and Extraversion-Introversion(E) subscale in EPQ showed significant negative correlations with number of eyeblinks in the hightest intensity of light, whereas Neuroticism(N) subscales in EPQ showed a positive correlation. Correlation between number of eyeblinks with the brightest light and EPAR slope varied topographically. The strongest positive correlation was noted in right posterior temporal area. Conclusion: High sensation seekers blinked significantly fewer times than lower sensation seeker did. Higher personality correlations with eyeblink than with EP may imply that the eyeblink works as a primary filter since it is more directly related to central mechanisms of sensory modulation than EP. The right posterior temporal area may play an important role in modulation of visual stimuli.

• The Korean Journal of Physiology
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• v.28 no.1
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• pp.99-103
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• 1994

Single neuronal activities were recorded in the cuneate nucleus of awake rats during rest and running behavior. Movement-induced changes in somatic sensory transmission were tested by generating post-stimulus time histograms of these neurons' responses to stimulation through eleetrodes chronically implanted under the skin of the forepaw, during control resting behavior and during two standardized speeds of locomotor movement: slow (1.0 steps/s), fast (2.0 steps/s). The magnitudes of firing during these responses were measured and normalized as percentage increases over background firing. The averaged evoked unit responses were facilitated by $+59.3{\pm}12.5%\;and\;+25.6{\pm}5.4%$ (SEM) as compared with resting behavior, during slow and fast movement respectively. This is to be compared with the movement-induced sensory suppressions observed previously in the ventrobasal thalamus $(-31.0%{\pm}1.9%)$ and in the primary somatosensory cortex $(-71.2%{\pm}3.8%)$ of slowly running rats. These results suggest that afferent somatosensory information may be uniquely modulated at each sensory relay, such that it may be facilitated at brainstem level and then subjected to suppression at higher somatosensory nuclei during movement.

• Journal of the Korean Society for Precision Engineering
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• v.29 no.7
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• pp.711-716
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• 2012

The purpose of this study was to investigate how the modulation method affects the effectiveness of eliciting tactile sensations by electrical stimulation. Two methods were employed and the results were compared and analyzed; pulse amplitude modulation (PAM) and pulse width modulation (PWM). Thirty-five healthy subjects participated in the experiments to measure the stimulation intensity that began to elicit a tactile sensation - activation threshold (AT). Constant-current monophasic rectangular pulse trains were employed, and the stimulation intensity was varied from zero until the subject felt any uncomfortable sensation. The step size of the stimulation intensity was 100nC/pulse. After each experiment, the subject described the sensation both quantitatively and qualitatively. The two modulation methods did not make a significant difference as far as the AT values were concerned, but most of the subjects showed 'intra-individual' consistency. Also, it was confirmed that our range of the stimulation parameters enabled us to obtain three major tactile sensations; tickling, pressure and vibration. The results suggested that the stimulation parameters and the modulation type should be selected for each individual and that selective electrical stimulation of the mechanoreceptors needs more diversified researches on the electrode design, multi-channel stimulation protocol, waveforms of the pulse train, etc.

• The Journal of Korean society of community based occupational therapy
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• v.1 no.2
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• pp.71-79
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• 2011

Objective : This study aimed to systematically reviewed to identify, evaluate, synthesize the research literature and suggested to the research direction on the effectiveness of occupational therapy using a sensory integration approach. Methods : We analyzed 10 studies that identified the effectiveness of occupational therapy using a sensory integration approach for children and adolescents offering in MEDLINE/PubMed and http://ajot.aotapress.net between 1993 and 2011. Results : The subjects were the sensory modulation disorder and autism spectrum. The different intervention strategies were similar to a previous studies. Intervention dosage was over 20 sessions, 2~3days per week more than 10weeks. Occupational therapy using a sensory integration approach may result in positive outcome in motor performance, behavioral outcomes, academic and psychoeducational outcomes and tried to currently identify the effect of intervention outcomes in sensory processing and occupational performance using the GAS. Conclusion : Clinicians have a minimal idea planing a research design and a evidence running a study.

• The Journal of Korean Academy of Sensory Integration
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• v.18 no.2
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• pp.55-68
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• 2020

Objective : The purpose of this study is to summarize the best-available intervention evidence for children's sensory integration therapy, drawn from studies published domestically in Korea over the last 10 years. Methods : The articles evaluated in this study were collected from the RISS and DBpia databases using the search terms "sensory integration," "sensory processing," and "Ayres Sensory Integration (ASI)". A total of 19 papers were analyzed. The selected studies were then assessed using the Population, Intervention, Outcomes, and Comparison method, the International Classification of Functioning, Disability and Health (ICF) method, and the modified Evidence Alert Traffic Light Grading System. Results : Development delay was the most commonly applied diagnosis for children's sensory integration therapy and individual sensory integration therapy was the most frequently used intervention method. The intervention effect was 91 percent in the body structure and function of ICF. The areas concentrated on were sensory modulation, sensory processing, fine and gross motor, body scheme, body-self concept, balance, basic movement, postural control and hand function, attention, and self-esteem. Conclusion : This simple overview of the efficacy of children's sensory integration therapy provides a basis for easy understanding and use by therapists, researchers and families with children.

• The Journal of Korean Academy of Sensory Integration
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• v.20 no.3
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• pp.48-59
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• 2022

Objective : This study was intended to systematically consider the sensory integration intervention methods offered in Korea for children with autism spectrum disorder and to provide an evidence base for the application of sensory integration interventions. Methods : The subjects of this study were published studies in a national journal for the last 10 years from January 2011 to December 2020. The databases used for the search were RISS and DBpia. The search terms were 'autism', 'autism spectrum', 'sensory integration', and 'intervention'. A total of 10 studies were used in the analysis, which were analyzed at the qualitative and methodological quality of the research evidence and the results were presented according to the PICO (Patient, Intervention, Comparison, Outcome). Results : In the research analysis, the quality level of the evidence was highest at level IV, followed by level II. The methodological quality of the evidence was the most common for 'Good' research, followed 'Fair'. The study subjects were children with autism spectrum disorder and their parents, and the experimental design had the highest frequency of single-subject studies. Interventions have the highest number of studies confirming adaptive behavior and sensory modulation, and the evaluation tools used to measure interventions have the highest frequency of sensory profiles and Canadian occupational performance measures (COPM). All 10 studies used in the analysis showed positive improvements and statistically significant effects on various outcome values from sensory integration interventions. Conclusion : In the recent clinical environment, sensory integration interventions have been continuously conducted in children with autism spectrum disorder. In future research, it is necessary to conduct research on various sensory integration intervention methods and the high quality of the evidence for the application of sensory integration interventions.