• BMB Reports
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• v.31 no.3
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• pp.296-302
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• 1998

A potentiometric flow injection biosensor for the analysis of anti-cholinesterases (anti-ChEs), based on inhibition of enzyme activity, was developed. The sensor system consists of a reactor with acetylcholinesterase (AChE) immobilized on controlled pore glass and a detector with an $H^{+}-selective$ PVC-based membrane electrode. The principle of the analysis is based on the fact that the degree of inhibition of AChE by an anti-ChE is dependent on the concentration of the anti-ChE in contact with AChE. The sensor system was optimized by changing systematically the operating parameters of the sensor to evaluate the effect of the changes on sensor response to ACh. The optimized biosensor was applied to the analysis of paraoxon, an organophosphorus pesticide. Treatment of the inhibited enzyme with pyridine-2-aldoxime fully restored the enzyme activity allowing repeated use of the sensor.

• Journal of Sensor Science and Technology
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• v.14 no.1
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• pp.22-27
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• 2005

A thermoelectric flow sensor for small quantity of gas flow rate was fabricated using silicon wafer semiconductor process and bulk micromachining technology. Evanohm R alloy heater and chromel-constantan thermocouples were used as a generation heat unit and sensing parts, respectively. The heater and thermocouples are thermally isolated on the $Si_{3}N_{4}/SiO_{2}/Si_{3}N_{4}$ laminated membrane. The characteristics of this sensor were observed in the flow rate range from 0.2 slm to 1.0 slm and the heater power from 0.72 mW to 5.63 mW. The results showed that the sensitivities $(({\partial}({\Delta}V)/{\partial}(\dot{q}));{\;}{\Delta}V$ : voltage difference, $\dot{q}$ : flow rate) were increased in accordance with heater power rise and decreasing of flow rate.

• Proceedings of the KSME Conference
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• 2007.05b
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• pp.2482-2487
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• 2007

Numerical simulations are conducted for the analysis of a thermal mass air flow sensor with periodic heating pulses on silicon-nitride ($Si_3N_4$) thin membrane structure. This study aims to find the locations of temperature sensors on the thin membrane and the heating pulse conditions, that the higher sensitivity can be achieved, for the development of a MEMS fabricated mass air flow sensor which is driven in periodic heating pulse. The simulations, thus, focus on the membrane temperature profile according to variation of the flow velocity, heating duration time and imposed power. The flow velocity of the simulations is ranging from 3 m/s to 35 m/s, heating duration time from 1 ms to 3 ms and imposed power from 50 mW to 90 mW. The corresponding Reynolds numbers vary from 1000 to 10000.

• Journal of Biomedical Engineering Research
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• v.35 no.1
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• pp.1-7
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• 2014

Among semi-quantitative or fully quantitative lateral flow assay readers, an image sensor-based instrument has been widely used because of its simple setup, cheap sensor price, and compact equipment size. For all previous approaches, monochrome CCD or CMOS cameras were used for lateral flow assay imaging in which the overall intensities of all colors were taken into consideration to estimate the analyte content, although the analyte related color information is only limited to a narrow wavelength range. In the present work, we introduced a color CCD camera as a sensor and a color decomposition method to improve the sensitivity of the quantitative biosensor system which utilizes the lateral flow assay successfully. The proposed setup and image processing method were applied to achieve the quantification of imitatively dispensed particles on the surface of a porous membrane first, and the measurement result was then compared with that using a monochrome CCD. The compensation method was proposed in different illumination conditions. Eventually, the color decomposition method was introduced to the commercially available lateral flow immunochromatographic assay for the diagnosis of myocardial infarction. The measurement sensitivity utilizing the color image sensor is significantly improved since the slopes of the linear curve fit are enhanced from 0.0026 to 0.0040 and from 0.0802 to 0.1141 for myoglobin and creatine kinase (CK)-MB detection, respectively.

• Journal of Drive and Control
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• v.20 no.4
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• pp.123-132
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• 2023

In disaster situations, to facilitate rapid drainage, electric underwater pumps are installed manually. This poses a high risk of electric shock accidents due to a short circuit, and a lot of time is required for hose connection and installation of electrical devices. To solve these problems, a Venturi pump using the venturi effect without external power is used. However, Venturi pumps that operate without external power make it difficult to install flow sensors such as electric devices; consequently, it is difficult to check the real-time flow rate. This paper proposes a flow estimation logic to replace the function of the flow sensor for the venturi pump . To develop the flow estimation logic, the flow characteristics of the venturi pump, according to the operating conditions, were checked. After that, the relationship with the flow rate of the venturi pump was defined using a pressure sensor corresponding to a low-cost sensor. Finally, an analysis of the estimation error was performed using the developed flow estimation logic.

• Journal of Biomedical Engineering Research
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• v.28 no.2
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• pp.310-315
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• 2007

The axial-flow type blood pump(XVAD) which has been developed in our group consists of mechanical parts (an impeller, a diffuser and a flow straightener) and electrical parts (a motor and a magnetic bearing). The magnetic bearing system fully levitates the impeller to remove mechanical coupling with other parts of the pump with constant gap, which needs non-contact type gap sensing. Conventional gap sensors are too large to be adopted to the implantable axial -flow type blood pump. Thus, in this paper, the compact eddy current type gap sensor system proper for the implantable axial-flow type blood pump was developed and its performance was evaluated in vitro. The developed eddy current type gap sensor system is a transformer type and has a differential probe. Sensor coil(probe) has small dimensions(6 mm diameter, 2 mm thickness) and its optimal inductance was determined as 0.068 mH for the measurement range of $0\sim3mm$. It could be manufactured with 130 turns of the 0.04 mm diameter copper coil. The characteristics of the developed eddy current type gap sensor system was evaluated by in vitro experiment. At experiment, it showed satis(actory performance to apply to the magnetic bearing system of the XVAD. It could measure the gap up to 3mm, but the linearity was decreased at the range of $1.8\sim3.0mm$. Moreover, it showed no difference in different media such as the water and the blood at the temperature range of $35\sim40^{\circ}C$.

• Proceedings of the KIEE Conference
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• 2007.04a
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• pp.377-379
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• 2007

To reduce the chattering errors of reed switch sensors used for automatic remote measurement of water supply system, a reed switch sensor was analyzed and improved. The operation of reed switch sensors can be described as a mechanical contact by approximation of permanent magnet piece to generate an electrical pulse. The reed switch sensors are used in measurement application by detecting the rotational or translational displacement. To apply for flow measurement devices, the reed switch sensors should keep high reliability. They are applied for the electronic digital type of water flow meters. The reed switch sensor is just installed simply on the mechanical type flow meter. A small magnet is attached on a pointer of the water meter counter rotor. Inside the reed sensor, two steel leaf springs make mechanical contact and apart as rotation of flow meter counter. The counting electrical contact pulses can be converted as the water flow amount. The MCU sends the digital flow rate data to the server using the wireless communication network. But it occurs data difference or errors by chattering noise. The reed switch sensor contains chattering error by it self at the force equivalent position. The vibrations such as passing car near to the switch sensor installed location. In order to reduce chattering error, most system uses just software methods for example using filter and also statistical calibration methods. The chattering errors were reduced by changing leaf spring structure using mechanical hysteresis characteristics.

• Journal of Sensor Science and Technology
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• v.8 no.5
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• pp.394-399
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• 1999

An automobile hot-film air flow sensor is deposited with platinum by sputtering method, patterned by photoresisted lift-off method, annealed in $1,000^{\circ}C$ and passivated with PI-2723. The TCR of the fabricated hot-film is about $3500\;ppm/^{\circ}C$. In the experiment, the output voltage of the sensor is in proportional to the fourth power root in the air mass flow range of 300 kg/h. The error in the full flow range is about ${\pm}0.7%$. In the range of air temperature of $-20^{\circ}C{\sim}120^{\circ}C$, the error is about ${\pm}1%$ that is ${\pm}2%$ lower than that of the reference sensor. Therefore, the fabricated hot-film air flow sensor satisfies the specification for automobile. Lower temperature error of the sensor provides to control the precise air/fuel ratio of automobile engine and results in improvement of a fuel mileage and the less amount of toxic gases emitted by automobile.

• Journal of Sensor Science and Technology
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• v.32 no.5
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• pp.307-312
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• 2023

To measure the flow velocity and direction in the near field of an unmanned underwater vehicle, an optical measurement unit containing an image sensor and a phosphor-integrated pillar that mimics the neuromasts of a fish was constructed. To analyze pillar movement, which changes with fluid flow, fluorescence image analysis was conducted. To analyze the flow velocity, mean force analysis, which could determine the relationship between the light intensity of a fluorescence image and an external force, and length-force analysis, which could determine the distance between the center points of two fluorescence images, were employed. Additionally, angle analysis that can determine the angles at which pixels of a digital image change was selected to analyze the direction of fluid flow. The flow velocity analysis results showed a high correlation of 0.977 between the external force and the light intensity of the fluorescence image, and in the case of direction analysis, omnidirectional movement could be analyzed. Through this study, we confirmed the effectiveness of optical flow sensors equipped with phosphor-integrated pillars.

• Journal of Mechanical Science and Technology
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• v.18 no.2
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• pp.286-293
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• 2004

The air fuel ratios of current gasoline engines are almost controlled by several air flow meters. When CVVT (Continuous Variable Valve Timing) is applied to a gasoline engine for higher engine performance, the MAP (Manifold Absolute Pressure) sensor is difficult to follow the instantaneous air fuel ratio due to the valve timing effect. Therefore, a HFM (Hot Film Flow Meter) is widely used for measuring intake air flow in this case. However, the HFMs are incapable of indicating to reverse flow, the oscillation of intake air flow has an negative effect on the precision of the HFM. Consequently, the various duct configurations in front of the air flow sensor affect the precision of HFM sensitivity. This paper mainly focused on the analysis of the reverse flow, flow fluctuation in throttle upstream and the geometry of intake system which influence the HFM measurement.