• Bulletin of the Korean Chemical Society
• /
• 제23권8호
• /
• pp.1116-1119
• /
• 2002

Monoclonal antibodies have been generated against a generic hapten, ο,ο-diethyl ο-(5-carboxy-2-fluorophenyl) phosphorothioate, for the determination of organophosphorus (OP) pesticides in a class-specific manner. In an indirect competitive enzyme-linked immunosorbent assay (ELISA) format, employing a heterologous coating antigen, these monoclonal antibodies showed desirable properties for use in the class-specific determination, i.e., broad specificity and high sensitivity. The IC50 values of four commonly used ο,ο-diethyl OP pesticides were fairly uniform ranging from 0.1 to 0.3 ㎛/mL. The IC50 values of three ο,ο-dimethyl derivatives were between 0.3 and 1.4 ㎛/mL. These values, together with the limits of detection (LOD), were better, in terms of the specificity and sensitivity, compared with the values obtained previously with polyclonal antibodies.

• Proceedings of the Computational Structural Engineering Institute Conference
• /
• 한국전산구조공학회 2008년도 정기 학술대회
• /
• pp.216-221
• /
• 2008

Shape design optimization for linear elasticity problem is performed using isogeometric analysis method. In many design optimization problems for real engineering models, initial raw data usually comes from CAD modeler. Then designer should convert this CAD data into finite element mesh data because conventional design optimization tools are generally based on finite element analysis. During this conversion there is some numerical error due to a geometry approximation, which causes accuracy problems in not only response analysis but also design sensitivity analysis. As a remedy of this phenomenon, the isogeometric analysis method is one of the promising approaches of shape design optimization. The main idea of isogeometric analysis is that the basis functions used in analysis is exactly same as ones which represent the geometry, and this geometrically exact model can be used shape sensitivity analysis and design optimization as well. In shape design sensitivity point of view, precise shape sensitivity is very essential for gradient-based optimization. In conventional finite element based optimization, higher order information such as normal vector and curvature term is inaccurate or even missing due to the use of linear interpolation functions. On the other hands, B-spline basis functions have sufficient continuity and their derivatives are smooth enough. Therefore normal vector and curvature terms can be exactly evaluated, which eventually yields precise optimal shapes. In this article, isogeometric analysis method is utilized for the shape design optimization. By virtue of B-spline basis function, an exact geometry can be handled without finite element meshes. Moreover, initial CAD data are used throughout the optimization process, including response analysis, shape sensitivity analysis, design parameterization and shape optimization, without subsequent communication with CAD description.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 한국소음진동공학회 2002년도 춘계학술대회논문집
• /
• pp.353-358
• /
• 2002

Human's vision is mostly confined to the area in the front and we, humans heavily depend on the sense of hearing to gather information in areas out of our sight. Thus, the virtual reality system consisting of the 3D sound effect gives the user a much better sense of reality than the system without the sound effect. Virtual 3D sound technology has mainly been researched with binaural system. The conventional binaural sound systems reproduce the desired sound at two arbitrary points using two channels in 3-D space. Head movement of listener might be change the nominal acoustic transfer function and deteriorate the performance of 3D sound system based on loudspeakers that needs a crosstalk canceller. In this paper, low kinds of sensitivity functions of sphere HRTF are derived to investigate the effect of head movement on HRTF in 3D sound system. Changes of HRTF caused by rotational and translational motion of head are obtained as we calculate the derivatives of HRTF with respect to angle and distance.

• Journal of the Society of Naval Architects of Korea
• /
• 제51권2호
• /
• pp.154-161
• /
• 2014

Naval ships have hull appendages which are more exposed to the outside because of its small block coefficient compared with commercial ships. These exposed hull appendages like skeg, strut and shaft line affect the maneuverability of a ship. The effect of hull appendages has considered at initial design stage to estimate more accurate maneuverability. In this paper, sensitivity analysis is used to analyze the effect on maneuverability by hull appendages. 3 DOF maneuvering equations based on Mathematical Modelling Group (MMG) model are used and propeller & rudder model are modified to reflect the characteristics of twin propeller & twin rudder. Numerical maneuvering simulations (Turning test, Zig-zag test) for benchmark naval vessel, David Taylor Model Basin (DTMB) 5415 are performed. In every simulation, it is calculated that stability indices and maneuverability characteristics (Tactical Dia., Advance, 1st Overshoot, Time of complete cycle) with respect to the parameters (area times lift coefficient slope, attachment location) of hull appendages. As a result, two regression formulas are established. One is the relation of maneuverability characteristics and stability indices and the other is the relation of stability indices and hull appendages.

• Structural Engineering and Mechanics
• /
• 제53권2호
• /
• pp.261-276
• /
• 2015

Structural damage and moving load identification are the two aspects of structural system identification. However, they universally coexist in the damaged structures subject to unknown moving load. This paper proposed a dynamic response sensitivity-based model updating method to simultaneously identify the structural damage and moving force. The moving force which is equivalent as the nodal force of the structure can be expressed as a series of orthogonal polynomial. Based on the system Markov parameters by the state space method, the dynamic response and the dynamic response derivatives with respect to the force parameters and elemental variations are analytically derived. Afterwards, the damage and force parameters are obtained by minimizing the difference between measured and analytical response in the sensitivity-based updating procedure. A numerical example for a simply supported beam under the moving load is employed to verify the accuracy of the proposed method.

• Korean Journal of Environmental Agriculture
• /
• 제14권1호
• /
• pp.45-54
• /
• 1995

esters of the acid analytes were synthesized using $H_2SO_4$ as the catalyst. Efficiency of derivatization and instrumental molecular-response were compared with herbicides methylated with $BF_3-methanol$(14% W/V), $H_2SO_4-methanol$(33% V/V), and diazomethane. The molecular integrity of TFE-2,4-D, TFE-dicamba, and TFE-mecoprop, in the mixture, was confirmed by the GC/MSD method. The TFE-Esterification efficiency was maximized by adjusting the volume of $H_2SO_4$ the reaction time, and temperature. Optimal efficiency for the herbicide mixture was obtained by adding 1 ml of $H_2SO_4$ and 1 ml of TFE to the dried sample and allowing the reaction to proceed at $22^{\circ}C$ for 8 hr or using 0.5 ml $H_2SO_4$ and 1 ml of TFE at $60^{\circ}C$. For 120 min increasing the temperature and decreasing the reaction time were required for maximum esterification efficiency. The sensitivity of the GC/ECD to the TFE esters was about $2{\sim}20$ times greater than that to the methyl ester derivatives. The herbicides were extracted and esterified to TFE derivatives simultaneously from soil leachates previously spiked with the analytes. Herbicide recovery, peak resolution, and detector sensitivity were excellent without using column cleanup procedures.

• The Korean Journal of Physiology and Pharmacology
• /
• 제12권1호
• /
• pp.7-12
• /
• 2008

OLETF (Otsuka Long-Evans Tokushima Fatty) rats are characterized by obesity-related insulin resistance, which is a phenotype of type 2 diabetes. Sulfonylurea drugs or benzoic acid derivatives as inhibitors of the ATP-sensitive potassium $(K_{ATP})$ channel are commercially available to treat diabetes. The present study compared sulfonylurea drugs (glimepiride and gliclazide) with one of benzoic acid derivatives (repaglinide) in regard to their long-term effect on ameliorating insulin sensitivity in OLETF rats. Each drug was dissolved and fed with drinking water from 29 weeks of age. On high glucose loading at 45 weeks of age, response of blood glucose recovery was the greatest in the group treated with glimepiride. On immunohistochemistry analysis for the Kir6.2 subunit of $K_{ATP}$ channels, insulin receptor ${\beta}$-subunits, and glucose transporters (GLUT) type 2 and 4 in liver, fat and skeletal muscle tissues, the sulfonylurea drugs (glimepiride and gliclazide) were more effective than repaglinide in recovery from their decreased expressions in OLETF rats. From these results, it seems to be plausible that $K_{ATP}$-channel inhibitors containing sulfonylurea moiety may be much more effective in reducing insulin resistance than those with benzoic acid moiety. In contrast to gliclazide, non-tissue selectivity of glimepiride on $K_{ATP}$ channel inhibition may further strengthen an amelioration of insulin sensitivity unless considering other side effects.

• Applied Chemistry for Engineering
• /
• 제1권2호
• /
• pp.116-123
• /
• 1990

Synthesis and characterization of photosensitive orthonaphthoquinonediazide-sulfonyl derivatives were studied. These photoactive compounds underwent a UV induced transformation to the base-soluble photoproduct. The photoresists were prepared using these photoactive compounds with low molecular weight m-cresol novolacs as matrix resin. And photosensitive characteristics of the photoresists were studied. 3, 4, 5-Trihydroxy-benzophenone with bulky resonance structure increased the sensitivity and the solubility rate of the exposed region. The mixture of PAC and matrix resin having 3:8 weight ratio had the moderate rate of dissolution in the developer. The photoresist using these conditions showed the best snsitivity and contrast under the fixed conditions.

• Bulletin of the Korean Chemical Society
• /
• 제25권9호
• /
• pp.1361-1365
• /
• 2004

Solvatokinetic and solvatochromic behavior of bis(indolinobenzospiropyranyl) sulfide derivatives 1a-1c have been studied in various solvents. The marked negative solvatochromism is exhibited for 1a and 1b in the whole region of solvent polarity examined. Whereas, it is found only in the polar solvent region ($E_T$ > 37) for 1c. The sensitivity order to the solvent media (slope values) is 1a > 1b > 1c. The branched linear plot with a zero slope was shown for the most sterically-hindered compound 1c in the less polar-solvent region (($E_T$ < 37). The biphasic plot is indicative of dual mechanistic process, i.e., a transition state with increased zwitter-ionic character in more polar solvents and electrocyclic process with an isopolar transition state in less polar solvents.

• Journal of the Korean Applied Science and Technology
• /
• 제15권1호
• /
• pp.25-33
• /
• 1998

Photoresist is defined as substance that makes chemical changes in its solubility, colouring and hardening by light energy. In this study, photosensitive photoresists of the positive type for a printing plate were studied. PF, o-, m-, p-CF resins as a matrix resin were synthesized at an identical condition. Photoresists were prepared by mixing NDS derivatives with a matrix resin at various mixing ratios. Characteristics of photoresists were studied by yield method of residual using solubility and Optical microscope was also analyzed. Prepared photoresist using NDS derivatives shows excellent photosensitivity and solubility compared with commercial product. The mixing ratio of 1:4(by mass) of NDS derivative[III] and m-CF resin shows the highest dissoultion rate among others. In addition, photoresist was obtained at this condition resulted in the superior sensitivity and contrast.