• 폴리머
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• 제28권1호
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• pp.59-66
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• 2004

온도에 의존하여 졸-젤 전이를 나타내는 온도민감성 리포솜을 함유하는 폴리 N-이소프로필아크릴아마이드 젤을 제조하였다. 온도민감성 리포솜의 표면은 3$0^{\circ}C$에서 하한임계용액온도를 나타내는 N-이소프로필아크릴아마이드와 옥타데실아크릴레이트의 공중합체를 이용하여 변형시켰다. 표면이 변형된 온도민감성 리포솜을 폴리 N-이소프로필아크릴아마이드 수용액에 혼합하였다. 혼합용액을 하한임계용액온도 이상으로 가열했을 때 물리적으로 가교결합이 이루어진 젤의 형태가 이루어지며, 이때 온도 민감성 리포솜이 함유된 폴리 N-이소프로필아크릴아마이드 젤이 만들어진다. 온도민감성 리포솜으로부터 약물의 방출은 형광강도를 측정하여 결정하였다. 폴리 N-이소프로필아크릴아마이드 젤 내부의 온도민감성 리포솜으로부터 약물의 방출은 온도가 증가할수록 지속적인 방출을 나타내었다.

• The Plant Pathology Journal
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• 제22권4호
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• pp.369-374
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• 2006

To characterize benzimidazole-resistant and -sensitive Monilinia fructicola populations, the fungal isolates were obtained from peach plants showing brown rot and bloosom blight. Benzimidazole-sensitive isolates did not grow on potato dextrose agar(PDA) amended with $\geq1.0{\mu}g$ active ingredient(a.i.)/ml of the fungicides. However, benzimidazole-resistant isolates grew on PDA regardless of the tested concentrations of fungicides. Benzimidazole-resistant isolates did not grow on diethofencarb-PDA, but sensitive isolates grew on the same PDA. In the nucleotide sequences of $\beta$-tubulin gene, only codon 198(GAG: glutamic acid), a target site for benzimidazole, was replaced with GCG(alanine) in all of the resistant isolates, and this substitution seems to play an important role in the development of resistance. Other interesting codons such as 165(GCT), 200(TTC), and 241(GCT) were not changed among the isolates. Benzimidazole-resistant and -sensitive isolates were clustered clearly in random amplified polymerphic DNA analyses and the results revealed that low levels of genetic diversity between benzimidazole-sensitive and -resistant isolates of M. fructicola in the investigated regions.

• 한국정보통신학회논문지
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• 제19권5호
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• pp.1137-1143
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• 2015

다양한 서비스를 제공하는 인터넷 환경에서 수많은 중요정보가 전송되고 있으나, 대부분의 내부 사용자는 어떠한 중요 정보가 전송되는지 모르고 있다. 본 논문에서는 네트워크 패킷 내에 포함된 중요정보를 지속적으로 모니터링하고, 유출 여부를 사용자에게 알려주는 차단 시스템 개발을 목표로 한다. 이를 위하여 중요정보 필터링 시스템을 설계하고 구현하여 그 결과를 분석한다. 사용자는 제안 시스템을 사용하여 중요정보의 유출 여부를 시각적으로 직접 확인할 수 있으며, 해당 패킷을 폐기할 수도 있다. 본 연구 결과는 중요정보 유출 방지에 기여함으로써 기업 내부정보를 대상으로 하는 다양한 사이버 침해를 줄이는데 기여할 수 있을 것으로 판단한다.

• 한국식물병리학회지
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• 제10권4호
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• pp.297-304
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• 1994

This study was carried out to develop bioassay for detection of pesticide residues in agricultural products by using the soil microbial isolates sensitive to pesticides. One hundred bacterial isolates and eighty five fungal isolates were obtained from soil and their sensitivity to 10 ppm of several pesticides was examined in vitro. Five bacterial isolates and three fungal isolates were found sensitive to organochloride fungicide and two fungal isolates sensitive to organocopper fungicide. Among these isolates, B46, B93 and F67 were tested to find out the difference in sensitivity according to the methods of fungicide treatment. All of the isolates were found sensitive to 10 ppm of organochloride fungicides mixed directly in PDA. But they were found insensitive to the fungicide mixed in PDA after filtering through membrane filter. In case of organocopper fungicide, the isolates were found sensitive only when it was treated in PDA. And their sensitivity showed difference among various kinds of organochloride fungicides. B46 and B93 were employed to check the possibility as the agent for detection of the pesticidal residues in twenty eight agricultural products including rice. It was found that all samples had not residues because the samples did not inhibit the growth of isolates. When organochloride fungicides were applied to the above products, it was possible to detect the residues in fruits and vegetables at the concentration of 10 ppm, but not in starch-rich grains. B46 and B93 were identified as Bacillus sp. according to their bacterial characteristics in culture.

• Geomechanics and Engineering
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• 제10권6호
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• pp.827-836
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• 2016

The rate of softening is an important factor to determine whether the failure occurs along localized shear band or in a more diffused manner. In this paper, strength loss and softening rate effect depending on sensitivity are investigated for weakly cemented clays, for both artificially cemented high plasticity San Francisco Bay Mud and low plasticity Yolo Loam. Destructuration and softening behavior for weakly cemented sensitive clays are demonstrated and discussed through multiple vane shear tests. Artificial sensitive clays are prepared in the laboratory for physical modeling or constitutive modeling using a small amount of cement (2 to 5%) with controlled initial water content and curing period. Through test results, shear band thickness is theoretically computed and the rate of softening is represented as a newly introduced parameter, ${\omega}_{80%}$. Consequently, it is found that the softening rate increases with sensitivity for weakly cemented sensitive clays. Increased softening rate represents faster strength loss to residual state and faster minimizing of shear band thickness. Uncemented clay has very low softening rate to 80% strength drop. Also, it is found that higher brittleness index ($I_b$) relatively shows faster softening rate. The result would be beneficial to study of physical modeling for sensitive clays in that artificially constructed high sensitivity (up to $S_t=23$) clay exhibits faster strain softening, which results in localized shear band failure once it is remolded.

• 약학회지
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• 제37권4호
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• pp.341-349
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• 1993

To determine the reason of individual variation of the effect of caffeine, the absorption and the disposition of caffeine were studied in caffeine sensitive and caffeine nonsensitive volunteers. And also to study the effect of obesity on caffeine pharmacokinetics, the caffeine disposition in the obese rat and in the lean rat were investigated respectively. In result the caffeine sensitive group showed a longer terminal half-life of caffeine(7.35$\pm$0.71 hr : 5.49$\pm$0.73 hr) and a larger AUC (55.42$\pm$9.09 $\mu\textrm{g}$.$ml^{-1}$.hr:44.0$\pm$7.81$\mu\textrm{g}$.$ml^{-1}$.hr) than that of caffeine non-sensitive group without statistical significance. The obese rat showed a longer terminal half-life (3.47 hr : 2.31 hr) and a larger AUC(35.3 $\mu\textrm{g}$.$ml^{-1}$.hr:26.97$\mu\textrm{g}$.$ml^{-1}$.hr) than that of the lean rat. But there was no correlation in the amount of daily caffeine consumption and obesity. In conclusion, we suggest that the individual variation of the effect of caffeine are being caused from the individual differences of caffeine susceptibility or tolerance rather than the differences of the genetic metabolic capacity or metabolic tolerance.

• 정보처리학회논문지:컴퓨터 및 통신 시스템
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• 제5권9호
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• pp.217-222
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• 2016

최근의 통합 시스템 및 P2P에 대한 데이터베이스의 연구는 다양한 공유된 그룹 및 프로세스 데이터를 위한 새로운 방법들이 개발되었다. 본 논문에서는 XML 제약에 의해 유출될 수 있는 민감한 정보에 대한 사용자의 유추를 원칙적으로 차단하고 권한 부여가 되지 않은 사용자로부터 민감한 정보가 유출되지 않도록 암호화 방법을 이용하여 안전한 데이터 출판 프레임워크를 제안한다. 제안된 프레임워크에서는 XML 문서 내의 민감한 데이터의 각각의 노드는 따로 분리하여 암호화하고 암호화된 모든 데이터들은 본래의 문서로부터 분리되어 민감한 데이터의 각각의 노드는 따로 암호화된다. 암호화된 모든 데이터들은 원래의 문서로부터 분리하여 암호화된 구조 인덱스로 묶어 보호된 데이터를 출판한다. 실험 결과로 제안된 프레임워크는 익명의 사용자로부터 데이터 추론을 통한 사용자 정보 누설을 방지함을 보여준다.

• 한국군사과학기술학회지
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• 제24권3호
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• pp.281-292
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• 2021

With the development of deep learning technology, researchers and technicians keep attempting to apply deep learning in various industrial and academic fields, including the defense. Most of these attempts assume that the data are balanced. In reality, since lots of the data are imbalanced, the classifier is not properly built and the model's performance can be low. Therefore, this study proposes cost-sensitive learning as a solution to the imbalance data problem of image classification in the defense field. In the proposed model, cost-sensitive learning is a method of giving a high weight on the cost function of a minority class. The results of cost-sensitive based model shows the test F1-score is higher when cost-sensitive learning is applied than general learning's through 160 experiments using submarine/non-submarine dataset and warship/non-warship dataset. Furthermore, statistical tests are conducted and the results are shown significantly.

• Nuclear Engineering and Technology
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• 제55권10호
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• pp.3559-3570
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• 2023

In the decommissioning of nuclear facilities, Derived Concentration Guideline Level (DCGL) derivation is necessary for the release of the facility after the site remediation, which also needs to be implemented in the stage of establishing a decommissioning planning. In order to derive DCGL, the dose assessment for the receptors can be conducted from residual radioactivity by using RESRAD code. When performing sensitivity analysis on probabilistic parameters, secondary evaluation is performed by assigning a single value for parameters classified as sensitive. However, several options may arise in the handling of nonsensitive parameters. Therefore, we compared the results of the first execution of RESRAD applying probabilistic parameters for each scenario with the results of the second execution applying a single value to sensitive parameters among the probabilistic parameters. In addition, we analyzed the effect of setting options for non-sensitive parameters. As a result, the effect on DCGL were different depending on the application scenario, the target radionuclides, and the input parameter selections. In terms of the overall evaluation period, the DCGL graph of the default option was generally shown as the most conservative except for some radionuclides. However, it will not necessarily be given priority in the aspect of the need to reflect site characteristics. The reason for selecting a probabilistic parameter is the availability of the parameter and the uncertainty of applying a single value. Therefore, as an alternative, it can be consistently applied to distribution as an option for non-sensitive parameters after sensitivity analysis.

• 환경영향평가
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• 제25권6호
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• pp.402-413
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• 2016

유류의 해상운송은 필수 불가결한 요소이기 때문에 이로 인한 해양 유류유출 사고는 지속적으로 발생하고 있다. 유류유출을 미연에 방지하는 시스템의 구축도 중요하지만, 불가피하게 사고가 발생하였다면 어떻게 대처할 것인가에 대한 체계적인 대안 마련이 필요하다. 지금까지는 유류유출로 인한 환경적 민감자원들에 대한 대응 및 지원 방안 연구가 주를 이루었다면, 이제는 지역 주민의 삶의 터전을 구성하는 사회 경제적 민감자원에 대한 피해 평가까지 확장하여 연구할 필요가 있다. 본 연구는 해양 유류유출로 인한 사회 경제적 민감자원 평가를 위한 일련의 분석 프레임워크를 구축하기 위한 과정으로, 우리나라의 실정에 맞는 사회 경제적 민감자원을 파악하고 지수화하는 방안을 제안한다. 기존의 민감자원 선정 사례를 정리하여 우리나라에 맞는 민감자원 선정 대안을 제시하는 것도 중요하지만 다양한 지표들 가운데 평가를 위해 실제 분석에서 가용한 데이터를 고려하여야 할 필요가 있다. 본 연구에서는 기존의 선정 대안 및 지수화, 사회영향평가 등 다양한 연구들을 기반으로 하여 사회 경제적 민감자원을 수산물 획득, 인구, 토지이용, 관리지역, 문화유산 및 관광지로 구분하였다.