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Temperature-Dependent Release of Drug from Copolymers of N-Isopropylacrylamide Containing Liposome  

박영심 (한국화학연구원 화학소재부)
한희동 (한국화학연구원 화학소재부)
홍성욱 (한밭대학교 화학공학과)
김승수 (한국화학연구원 화학소재부)
신병철 (한국화학연구원 화학소재부)
Publication Information
Polymer(Korea) / v.28, no.1, 2004 , pp. 59-66 More about this Journal
Abstract
Thermosensitive poly(N-isopropylacrylamide) gels containing temperature-sensitive liposomes showing temperature-dependent sol-gel transition were prepared. The surface of temperature-sensitive liposome was modified with copolymers of N-isopropylacrylamide and octadecylacrylate, which exhibited a lower critical solution temperature at around 30 $^{\circ}C$ After mixing the modified temperature-sensitive liposomes with poly(N-isopropylacrylamide) solution, the temperature-sensitive 1iposomes formed physically cross-linked gels through heating the solution above their lower critical solution temperatures. The release of drug from temperature-sensitive liposomes was determined by measuring fluorescence intensity. The drug release from temperature-sensitive liposomes in poly(N-isopropylacrylamide) gel gradually showed sustained-release with increasing temperature.
Keywords
liposome; thermosensitive gel; poly(N-isopropylacrylamide); drug release;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 5  (Related Records In Web of Science)
Times Cited By SCOPUS : 0
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