• Title/Summary/Keyword: Sensitive

Search Result 13,684, Processing Time 0.044 seconds

Temperature-Dependent Release of Drug from Copolymers of N-Isopropylacrylamide Containing Liposome (리포솜이 함유된 N-이소프로필아크릴아마이드의 공중합체로부터 온도에 따른 약물의 방출)

  • 박영심;한희동;홍성욱;김승수;신병철
    • Polymer(Korea)
    • /
    • v.28 no.1
    • /
    • pp.59-66
    • /
    • 2004
  • Thermosensitive poly(N-isopropylacrylamide) gels containing temperature-sensitive liposomes showing temperature-dependent sol-gel transition were prepared. The surface of temperature-sensitive liposome was modified with copolymers of N-isopropylacrylamide and octadecylacrylate, which exhibited a lower critical solution temperature at around 30 $^{\circ}C$ After mixing the modified temperature-sensitive liposomes with poly(N-isopropylacrylamide) solution, the temperature-sensitive 1iposomes formed physically cross-linked gels through heating the solution above their lower critical solution temperatures. The release of drug from temperature-sensitive liposomes was determined by measuring fluorescence intensity. The drug release from temperature-sensitive liposomes in poly(N-isopropylacrylamide) gel gradually showed sustained-release with increasing temperature.

Characterization and Genetic Diversity of Benzimidazole-resistant and -sensitive Monilinia fructicola Isolates in Korea

  • Lim, Tae-Heon;Johnson, Iruthayasamy;Cha, Byeong-Jin
    • The Plant Pathology Journal
    • /
    • v.22 no.4
    • /
    • pp.369-374
    • /
    • 2006
  • To characterize benzimidazole-resistant and -sensitive Monilinia fructicola populations, the fungal isolates were obtained from peach plants showing brown rot and bloosom blight. Benzimidazole-sensitive isolates did not grow on potato dextrose agar(PDA) amended with $\geq1.0{\mu}g$ active ingredient(a.i.)/ml of the fungicides. However, benzimidazole-resistant isolates grew on PDA regardless of the tested concentrations of fungicides. Benzimidazole-resistant isolates did not grow on diethofencarb-PDA, but sensitive isolates grew on the same PDA. In the nucleotide sequences of $\beta$-tubulin gene, only codon 198(GAG: glutamic acid), a target site for benzimidazole, was replaced with GCG(alanine) in all of the resistant isolates, and this substitution seems to play an important role in the development of resistance. Other interesting codons such as 165(GCT), 200(TTC), and 241(GCT) were not changed among the isolates. Benzimidazole-resistant and -sensitive isolates were clustered clearly in random amplified polymerphic DNA analyses and the results revealed that low levels of genetic diversity between benzimidazole-sensitive and -resistant isolates of M. fructicola in the investigated regions.

A New Filtering System against the Disclosure of Sensitive Internal Information (내부 중요정보 유출 방지를 위한 차단 시스템 개발)

  • Ju, Tae-kyung;Shin, Weon
    • Journal of the Korea Institute of Information and Communication Engineering
    • /
    • v.19 no.5
    • /
    • pp.1137-1143
    • /
    • 2015
  • Sensitive internal information has been transmitted in a variety of services of Internet environment, but almost users do not know what internal information is sent. In this paper, we intend to develop a new filtering system that continuously monitors the sensitive information in outbound network packets and notifies the internal user whether or not to expose. So we design a filtering system for sensitive information and analyze the implementation results. Thus users visually can check whether disclosure of the important information and drop the corresponding packets by the proposed system. The results of this study can help decrease cyber threats various targeting internal information of company by contributing to prevent exposure of sensitive internal information.

Development of Microbial Bioassay for Detection of Pesticide Residues (미생물을 이용한 농약잔류 분석법 개발)

  • 백수봉;양창술;오연선
    • Korean Journal Plant Pathology
    • /
    • v.10 no.4
    • /
    • pp.297-304
    • /
    • 1994
  • This study was carried out to develop bioassay for detection of pesticide residues in agricultural products by using the soil microbial isolates sensitive to pesticides. One hundred bacterial isolates and eighty five fungal isolates were obtained from soil and their sensitivity to 10 ppm of several pesticides was examined in vitro. Five bacterial isolates and three fungal isolates were found sensitive to organochloride fungicide and two fungal isolates sensitive to organocopper fungicide. Among these isolates, B46, B93 and F67 were tested to find out the difference in sensitivity according to the methods of fungicide treatment. All of the isolates were found sensitive to 10 ppm of organochloride fungicides mixed directly in PDA. But they were found insensitive to the fungicide mixed in PDA after filtering through membrane filter. In case of organocopper fungicide, the isolates were found sensitive only when it was treated in PDA. And their sensitivity showed difference among various kinds of organochloride fungicides. B46 and B93 were employed to check the possibility as the agent for detection of the pesticidal residues in twenty eight agricultural products including rice. It was found that all samples had not residues because the samples did not inhibit the growth of isolates. When organochloride fungicides were applied to the above products, it was possible to detect the residues in fruits and vegetables at the concentration of 10 ppm, but not in starch-rich grains. B46 and B93 were identified as Bacillus sp. according to their bacterial characteristics in culture.

  • PDF

Rate of softening and sensitivity for weakly cemented sensitive clays

  • Park, DongSoon
    • Geomechanics and Engineering
    • /
    • v.10 no.6
    • /
    • pp.827-836
    • /
    • 2016
  • The rate of softening is an important factor to determine whether the failure occurs along localized shear band or in a more diffused manner. In this paper, strength loss and softening rate effect depending on sensitivity are investigated for weakly cemented clays, for both artificially cemented high plasticity San Francisco Bay Mud and low plasticity Yolo Loam. Destructuration and softening behavior for weakly cemented sensitive clays are demonstrated and discussed through multiple vane shear tests. Artificial sensitive clays are prepared in the laboratory for physical modeling or constitutive modeling using a small amount of cement (2 to 5%) with controlled initial water content and curing period. Through test results, shear band thickness is theoretically computed and the rate of softening is represented as a newly introduced parameter, ${\omega}_{80%}$. Consequently, it is found that the softening rate increases with sensitivity for weakly cemented sensitive clays. Increased softening rate represents faster strength loss to residual state and faster minimizing of shear band thickness. Uncemented clay has very low softening rate to 80% strength drop. Also, it is found that higher brittleness index ($I_b$) relatively shows faster softening rate. The result would be beneficial to study of physical modeling for sensitive clays in that artificially constructed high sensitivity (up to $S_t=23$) clay exhibits faster strain softening, which results in localized shear band failure once it is remolded.

Pharmacokinetics of Caffeine in Caffeine Sensitive and Non-Sensitive Volunteers, and in the Obses Rat and the Lean Rat (카페인 약리작용에 민감한 지원자와 둔감한 지원자 및 뚱뚱한 쥐와 마른 쥐에 대한 카페인 약물동태 비교)

  • 윤정옥;권광일
    • YAKHAK HOEJI
    • /
    • v.37 no.4
    • /
    • pp.341-349
    • /
    • 1993
  • To determine the reason of individual variation of the effect of caffeine, the absorption and the disposition of caffeine were studied in caffeine sensitive and caffeine nonsensitive volunteers. And also to study the effect of obesity on caffeine pharmacokinetics, the caffeine disposition in the obese rat and in the lean rat were investigated respectively. In result the caffeine sensitive group showed a longer terminal half-life of caffeine(7.35$\pm$0.71 hr : 5.49$\pm$0.73 hr) and a larger AUC (55.42$\pm$9.09 $\mu\textrm{g}$.$ml^{-1}$.hr:44.0$\pm$7.81$\mu\textrm{g}$.$ml^{-1}$.hr) than that of caffeine non-sensitive group without statistical significance. The obese rat showed a longer terminal half-life (3.47 hr : 2.31 hr) and a larger AUC(35.3 $\mu\textrm{g}$.$ml^{-1}$.hr:26.97$\mu\textrm{g}$.$ml^{-1}$.hr) than that of the lean rat. But there was no correlation in the amount of daily caffeine consumption and obesity. In conclusion, we suggest that the individual variation of the effect of caffeine are being caused from the individual differences of caffeine susceptibility or tolerance rather than the differences of the genetic metabolic capacity or metabolic tolerance.

  • PDF

Efficient Data Publishing Method for Protecting Sensitive Information by Data Inference (데이터 추론에 의한 민감한 정보를 보호하기 위한 효율적인 데이터 출판 방법)

  • Ko, Hye-Kyeong
    • KIPS Transactions on Computer and Communication Systems
    • /
    • v.5 no.9
    • /
    • pp.217-222
    • /
    • 2016
  • Recent research on integrated and peer-to-peer databases has produced new methods for handling various types of shared-group and process data. This paper with data publishing, where the publisher needs to specify certain sensitive information that should be protected. The proposed method cannot infer the user's sensitive information is leaked by XML constraints. In addition, the proposed secure framework uses encrypt to prevent the leakage of sensitive information from authorized users. In this framework, each node of sensitive data in an eXtensible Markup Language (XML) document is encrypted separately. All of the encrypted data are moved from their original document, and are bundled with an encrypted structure index. Our experiments show that the proposed framework prevents information being leaked via data inference.

A Study on the Improvement of Image Classification Performance in the Defense Field through Cost-Sensitive Learning of Imbalanced Data (불균형데이터의 비용민감학습을 통한 국방분야 이미지 분류 성능 향상에 관한 연구)

  • Jeong, Miae;Ma, Jungmok
    • Journal of the Korea Institute of Military Science and Technology
    • /
    • v.24 no.3
    • /
    • pp.281-292
    • /
    • 2021
  • With the development of deep learning technology, researchers and technicians keep attempting to apply deep learning in various industrial and academic fields, including the defense. Most of these attempts assume that the data are balanced. In reality, since lots of the data are imbalanced, the classifier is not properly built and the model's performance can be low. Therefore, this study proposes cost-sensitive learning as a solution to the imbalance data problem of image classification in the defense field. In the proposed model, cost-sensitive learning is a method of giving a high weight on the cost function of a minority class. The results of cost-sensitive based model shows the test F1-score is higher when cost-sensitive learning is applied than general learning's through 160 experiments using submarine/non-submarine dataset and warship/non-warship dataset. Furthermore, statistical tests are conducted and the results are shown significantly.

The effect of sensitive and non-sensitive parameters on DCGL in probability analysis for decommissioning of nuclear facilities

  • Hyung-Woo Seo;Hyein Kim
    • Nuclear Engineering and Technology
    • /
    • v.55 no.10
    • /
    • pp.3559-3570
    • /
    • 2023
  • In the decommissioning of nuclear facilities, Derived Concentration Guideline Level (DCGL) derivation is necessary for the release of the facility after the site remediation, which also needs to be implemented in the stage of establishing a decommissioning planning. In order to derive DCGL, the dose assessment for the receptors can be conducted from residual radioactivity by using RESRAD code. When performing sensitivity analysis on probabilistic parameters, secondary evaluation is performed by assigning a single value for parameters classified as sensitive. However, several options may arise in the handling of nonsensitive parameters. Therefore, we compared the results of the first execution of RESRAD applying probabilistic parameters for each scenario with the results of the second execution applying a single value to sensitive parameters among the probabilistic parameters. In addition, we analyzed the effect of setting options for non-sensitive parameters. As a result, the effect on DCGL were different depending on the application scenario, the target radionuclides, and the input parameter selections. In terms of the overall evaluation period, the DCGL graph of the default option was generally shown as the most conservative except for some radionuclides. However, it will not necessarily be given priority in the aspect of the need to reflect site characteristics. The reason for selecting a probabilistic parameter is the availability of the parameter and the uncertainty of applying a single value. Therefore, as an alternative, it can be consistently applied to distribution as an option for non-sensitive parameters after sensitivity analysis.

Methodology for Selection and Sensitivity Index of Socio-economic Resources for Marine Oil Spill Incidents (해양 유류유출 오염으로 인한 사회·경제적 민감자원 선정 및 지수화 방안)

  • Roh, Young-Hee;Kim, Choong-Ki
    • Journal of Environmental Impact Assessment
    • /
    • v.25 no.6
    • /
    • pp.402-413
    • /
    • 2016
  • Marine oil spill accidents are occurring continuously due to the marine transportation of the oil. While building a preventive system for oil spill is uttermost necessary, we also need to have a systematic response system to handle the oil spills that inevitably occur. So far, studies have focused on the environmentally sensitive resources affected by oil spills. However, there is a need to conduct research to evaluate the damage to the socially and economically sensitive resources that make up the life of local residents. This study represents the process of building an analytical framework for the assessment of socioeconomic resources affected by marine oil spills. While it is important to provide a scheme for identification and indexation of socially and economically sensitive resources that is compatible with Korea's situations, using existing data for identifying socio-economically sensitive resources might also be meaningful. However, to allow accurate analysis for better evaluation, we need to select more applicable data among the various indicators. In this research, we have reviewed many existing case studies of sensitive resources, studies of the variables that have been used for indexing sensitive resources, and various factors considered in SIA (Social Impact Assessment). Based on the findings, we classify socio-economically sensitive resources into marine products acquisition, population, land usage, administrative area, and cultural heritage and tourist region.