• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.111-116
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• 2013

Background: Cigarette smoking is the major risk factor for development of lung cancer. Identification of effects of tobacco on airway gene expression may provide insight into the causes. This research aimed to compare gene expression of large airway epithelium cells in normal smokers (n=13) and non-smokers (n=9) in order to find genes which discriminate the two groups and assess cigarette smoking effects on large airway epithelium cells.Materials and Methods: Genes discriminating smokers from non-smokers were identified by applying a neural network clustering method, growing self-organizing maps (GSOM), to microarray data according to class discrimination scores. An index was computed based on differentiation between each mean of gene expression in the two groups. This clustering approach provided the possibility of comparing thousands of genes simultaneously. Results: The applied approach compared the mean of 7,129 genes in smokers and non-smokers simultaneously and classified the genes of large airway epithelium cells which had differently expressed in smokers comparing with non-smokers. Seven genes were identified which had the highest different expression in smokers compared with the non-smokers group: NQO1, H19, ALDH3A1, AKR1C1, ABHD2, GPX2 and ADH7. Most (NQO1, ALDH3A1, AKR1C1, H19 and GPX2) are known to be clinically notable in lung cancer studies. Furthermore, statistical discriminate analysis showed that these genes could classify samples in smokers and non-smokers correctly with 100% accuracy. With the performed GSOM map, other nodes with high average discriminate scores included genes with alterations strongly related to the lung cancer such as AKR1C3, CYP1B1, UCHL1 and AKR1B10. Conclusions: This clustering by comparing expression of thousands of genes at the same time revealed alteration in normal smokers. Most of the identified genes were strongly relevant to lung cancer in the existing literature. The genes may be utilized to identify smokers with increased risk for lung cancer. A large sample study is now recommended to determine relations between the genes ABHD2 and ADH7 and smoking.

• 대한간호학회지
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• 제35권2호
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• pp.239-251
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• 2005

Purpose: This study was designed to construct a structural model for explaining mental health status in middle - aged women. Methods: The data was collected by self - reported questionnaires from 206 middle - aged women in Seoul. Data analysis was done with the SAS pc program for descriptive statistics and a PC - LISREL Program for finding the best fit model which assumes causal relationships among variables. Results: The overall fit of the hypothetical model to the data was good, but paths and variables of the model were modified by considering theoretical implications and statistical significances of parameter estimates. Thus it was modified by excluding 3 paths, The modified model showed was good fit to the data($x^2=177.55$, p=.00), GFI=0.908, AGFI=0.860, RMR=0.013, NFI=0.972, NNFI=0.982). Perceived stress, anger expression method, and self -esteem were found to have direct effects on mental health status in middle - aged women. These predictive variables of mental health status explained $66.6\%$ of the model. Conclusion: Programs to enhance mental health status in middle - aged women should include stress management skill, anger expression skill, and self -esteem enhancement skills to be effective.

• 아동학회지
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• 제27권3호
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• pp.53-66
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• 2006

An experimental group consisting of 15 boys and 13 girls, and a control group of 12 boys and 18 girls comprised the 58 five-year-old kindergarten sample of this study. Teachers measured children's emotional intelligence with the Emotional Intelligence Rating Scale(Kim, 1998); educational activities for the emotions focusing on self-awareness, self-management, self-motivation, empathy, and social skills were carried out with the experimental group. ANCOVA confirmed effectiveness of the educational activities; the experimental group had higher scores than the control group on self-awareness and expression of emotion, emotional regulation, and awareness of others' emotion. Children of the experimental group also showed higher interpersonal abilities in teacher and in peer relationships than the control group.

• 한국주거학회:학술대회논문집
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• 한국주거학회 2009년도 추계학술발표대회 논문집
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• pp.23-26
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• 2009

The trend that an apartment is regarded as not only a substantial property called 'residence' but also 'means of self-expression' to consumers is increasing in the present housing marketing, and thus, the apartment brand image is settling down as an important field of marketing management. Therefore, the present study aimed to verify difference of brand attitude according to consentaneity between an image of a housing brand and self-image of consumers to propose one kind of direction of strategies for formation of a differentiated brand image. As a result of a research, the trend that consumers show more positive attitude on a brand apartment having a brand image closer to an ideal self-image was analyzed to exist even if it is weak, so it was confirmed that the consentaneity between a brand image and a self-image of housing products can become a variable having some influence on brand attitude. The survey method understood a brand image, a self-image and brand attitude by using a Likert's 5-point scale on apartment brands of upper three companies according to a study result of a national brand competitiveness index(NBCI) and understood self-consentaneity by using a distance measurement model of self-consentaneity of Sirgy(1982). The questionnaire for the present research was carried out by surveying students of D university and the PASW program was used for statistical data analysis.

• 한국유통학회:학술대회논문집
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• 한국유통학회 2007년도 하계통합학술대회 발표논문집
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• pp.127-158
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• 2007

This study discusses salespersons' emotional intelligence, one of the key abilities necessary to meet customers' needs effectively, and express positive emotions in frequent interactions with customer. Emotional intelligence refers to self-controllability and social ability emphasizing pro-social aspect and understanding of others. This study investigates how salespersons' emotional intelligence affects adaptive selling and positive emotional expression during the process of interaction with customers, and how such adaptive selling and positive emotional expression affects the quality of service perceived by customers. The results show that greater salespersons' emotional intelligence results in better adaptive selling and positive emotional expression. Such adaptive selling and positive emotional expression had significant effects on the quality of service perceived by customers. These results are important in that they address emotional intelligence as salespersons' emotional ability, which has been overlooked as an antecedent variable for improving adaptive selling and display of positive emotion, consequently provide another factor to help salespersons improve their selling behavior.

• 한국의류산업학회지
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• 제6권3호
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• pp.275-284
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• 2004

Post-structuralism in Fashion tendency since the late 20th century has been developing in complicated and diverse modes. Post-structuralism has revealed the inconsistency of Western philosophy contering on rationalism, and has formed an important thought system of modern time through open thinking and various ways of expression. Among them, decentering which is formed from the concern for outlying 'others' while denying self-centered 'man himself, has supplied a new cognizance paradigm in the expression and interpretation of fashion formation. This paper has analyzed the expression-form of fashion in three ways: de-construction, discontinuance, and esthetic appreciation of the others. Finarly this study has supplyed, though decentering thinking, a new esthetic cognizance principle for fashion which is expressed in free and multiple meaning and form.

• 한국융합학회논문지
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• 제11권4호
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• pp.79-86
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• 2020

본 연구는 치과위생사의 사회적지지와 자아존중감, 직무스트레스가 분노표현유형에 영향을 미치는 융합적 요인을 확인하고자 하였다. 치과의료기관 근무 치과위생사 402명을 대상으로 하였으며, 군집분석으로 분노표현유형을 분류하였고, 분노표현유형 관련 요인을 확인하기 위해 로지스틱회귀분석을 시행하였다. 치과위생사의 분노표현유형은 분노조절군과 분노표출·억제군으로 분류되었으며, 분노조절군이 233명(58.0%)이었다. 자아존중감(OR=5.952)과 동료의 사회적지지(OR=1.172)가 높을수록 분노조절군일 가능성이 유의하게 높았다. 치과위생사의 자아존중감과 동료의 사회적 지지의 수준을 높임으로써 치과위생사의 분노조절능력을 향상시킬 수 있는 것을 확인하였다.

• Biomolecules & Therapeutics
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• 제20권3호
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• pp.280-285
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• 2012

The developing embryo naturally experiences relatively low oxygen conditions in vivo. Under in vitro hypoxia, mouse embryonic stem cells (mESCs) lose their self-renewal activity and display an early differentiated morphology mediated by the hypoxia-inducible factor-$1{\alpha}$ (HIF-$1{\alpha}$). Previously, we demonstrated that histone deacetylase (HDAC) is activated by hypoxia and increases the protein stability and transcriptional activity of HIF-$1{\alpha}$ in many human cancer cells. Furthermore HDAC1 and 3 mediate the differentiation of mECSs and hematopoietic stem cells. However, the role of HDACs and their inhibitors in hypoxia-induced early differentiation of mESCs remains largely unknown. Here, we examined the effects of several histone deacetylase inhibitors (HDACIs) on the self-renewal properties of mESCs under hypoxia. Inhibition of HDAC under hypoxia effectively decreased the HIF-$1{\alpha}$ protein levels and substantially improved the expression of the LIF-specific receptor (LIFR) and phosphorylated-STAT3 in mESCs. In particular, valproic acid (VPA), a pan HDACI, showed dramatic changes in HIF-$1{\alpha}$ protein levels and LIFR protein expression levels compared to other HDACIs, including sodium butyrate (SB), trichostatin A (TSA), and apicidin (AP). Importantly, our RT-PCR data and alkaline phosphatase assays indicate that VPA helps to maintain the self-renewal activity of mESCs under hypoxia. Taken together, these results suggest that VPA may block the early differentiation of mESCs under hypoxia via the destabilization of HIF-$1{\alpha}$.

• Ocean and Polar Research
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• 제39권2호
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• pp.149-158
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• 2017

The opsin family of light sensitive proteins family makes up are the universal photoreceptor molecules of all visual systems in the vertebrates including teleosts. They can change their conformation from a resting state to a signaling state upon light absorption, which activates the G-protein coupled receptor, thereby resulting in a signaling cascade that produces physiological responses. However, this species is poorly characterized at molecular level due to little sequence information available in public databases. We have investigated the opsin family of nocturnal cutlass fish using the whole transcriptome sequencing method. The opsin genes were cloned and its expression in the tissues and organs were examined by qPCR. We cloned 6 opsin genes (RRH, Opn4, Rh1, Rh2, VA-opsin, and Opn3) in retina and brain tissue. It contained the seven presumed transmembrane domains that are characteristic of the G-protein-coupled receptor family. However, short wavelength sensitive pigment (SWS) and long wavelength sensitive pigment (LWS) were not detected in this study. The mRNA expression of the 6 photoreceptor genes were detected in retina and peripheral tissue. Our studies will lead to further investigation of the photic entrainment mechanism at molecular and cellular levels in cutlass fish and can be used in comparative studies of other fishes.

• 디지털융복합연구
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• 제15권1호
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• pp.97-108
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• 2017

Web 2.0 환경의 도래 이후 SNS 등을 기반으로 한 온라인 커뮤니티에 이용자들이 자발적이고 적극적으로 정보를 공헌하고 있다. 이에 본 연구는 온라인 커뮤니티에서 정보공헌에 영향을 주는 주요 요인을 규명하여 검증하고자 한다. 동기 이론, 정보리터러시 및 자기표현이론에 기초해서 온라인 커뮤니티에서 정보공헌에 영향을 주는 요인을 도출하여 연구모형을 제시하였다. 온라인 커뮤니티에 정보 또는 지식을 업로드한 경험이 있는 사용자들을 대상으로 설문조사를 실시하여 설문데이터를 수집하였다. 총 262개의 설문데이터를 기반으로 구조방정식모형을 이용하여 연구가설을 검증하였다. 연구결과, 온라인 커뮤니티에서 자기표현동기는 정보공헌과 정보표현능력에 긍정적인 영향을 주었다. 정보리터러시는 정보표현능력의 결정요인으로 검증되었고, 정보표현능력은 정보공헌에 기여하는 것으로 나타났다. 또한 인정 동기는 정보표현능력과 정보공헌에 긍정적인 영향을 미치는 것으로 검증되었다. 본 연구결과는 온라인 커뮤니티에서 정보공헌을 설명할 수 있는 학문적 시사점과 실무적 시사점을 제공한다.