• 대한후두음성언어의학회지
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• 제33권2호
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• pp.103-109
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• 2022

Background and Objectives The Voice Perceived Present Control scale (VPPC) has been developed to provide better insight into patients' perceived control over their thoughts or behaviors related to voice disorders. The objective of the present study was to validate the Korean VPPC (K-VPPC) by evaluating its internal consistency and reliability. Materials and Method All items of the English VPPC were translated into Korean. Content validity was analyzed through three Delphi survey rounds by an expert panel (n=44) with active clinical and research experience in treating dysphonic patients. Twenty-three patients with a heterogeneous diagnosis of dysphonia and twenty-three gender-matched vocally normal controls (total n=46) were asked to complete the K-VPPC and the Korean Voice Handicap Index-10 (KVHI-10). Psychometric properties including internal consistency and reliability were evaluated to examine the appropriateness of cross-cultural use of K-VPPC. Results Cronbach's alpha coefficient of K-VPPC was 0.89 for dysphonic patients, indicating good internal consistency in clinical samples. Furthermore, patients with dysphonia scored significantly lower on the total score of K-VPPC and higher on voice handicap than the vocally normal controls. Spearman's correlation coefficients indicated an inverse and moderate association between the K-VPPC and all domains of KVHI-10 (Spearman's r=-0.44- -0.68). Conclusion The findings of the current study indicated that the K-VPPC is a valid and reliable tool for the assessment of perceived control in Korean patients with dysphonia. Therefore, the K-VPPC could be a useful and complementary tool for the comprehensive evaluation of dysphonia, thereby improving care in Korean patients with voice disorders.

• Annals of Clinical Neurophysiology
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• 제23권2호
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• pp.99-107
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• 2021

Background: Pain and autonomic dysfunction are prominent symptoms in some patients with carpal tunnel syndrome (CTS). Infrared thermography (IRT) has been used to evaluate CTS by measuring the cutaneous temperature and sympathetic vasomotor function. Methods: This study enrolled the 66 hands of 33 subjects, some of which had clinical CTS and the others were healthy. The enrolled patients completed the Boston Carpal Tunnel Questionnaire (BCTQ) and Historical-Objective scale, and underwent nerve conduction studies (NCSs) and IRT. Skin temperature was measured at the fingertips and the thenar and hypothenar regions in each hand. We analyzed (1) the correlations between self-reported severity, physician-assessed severity, and test results, and (2) the sensitivity and specificity of IRT in diagnosing CTS. Results: No significant correlation was observed between the results of the BCTQ, NCS, and IRT. IRT had a low sensitivity and high specificity in diagnosing CTS. Conclusions: IRT cannot replace NCS in diagnosing CTS, nor did it provide an advantage in combination with NCS. However, lower temperatures at the median nerve in some hands with moderate-to-severe CTS suggested the involvement of sympathetic nerve fiber function. Follow-up studies with a larger-scale and complementary design are required to elucidate the relationships.

• 스트레스연구
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• 제25권2호
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• pp.145-154
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• 2017

임부들의 심리적 안정과 태아와의 건강한 관계는 주산기 적응에 중요한 것으로 알려져 있다. 본 연구에서는 정신건강과 대인관계 개선에 효과적인 것으로 알려져 있는 자비명상을 임부용으로 개발하기 위하여 탐색적 예비연구를 진행하였다. 효과성과 개선점을 파악하기 위해 4주 자비명상 프로그램 참가자(n=8)들의 스트레스, 우울, 태아애착, 마음챙김 및 자기자비를 기저선과 사후에 측정하였으며, 포커스 그룹 인터뷰를 바탕으로 현상학적 분석을 실시하였다. 결과는 자비명상이 임부의 심리적 안정과 태아와의 관계에 긍정적인 영향을 줄 가능성이 나타났으며, 회기구성 및 가정수련 보강방안 등의 보완점들을 발견할 수 있었다. 본 연구가 임부용 자비명상 개발을 위한 이해의 폭을 넓히고, 추후 연구들을 촉진할 것이라 기대한다.

• 인간식물환경학회지
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• 제22권6호
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• pp.611-619
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• 2019

This study was conducted to investigate changes in the mental functions of the elderly in nursing facilities affected by a horticultural therapy program based on validation therapy. To meet the purpose, we conducted a horticultural therapy program based on validation therapy with 58 elderly participants (average age 79.12±6.84, men and women) once a week, 50 minutes per session, in a total of 10 sessions. Participants were divided into the control and experimental group with convenience sampling. The program was carried out from March 15 to November 22, 2018. Vibraimage 8 pro(ELSYS, 2014) is a recent, psychologically based, emotional-recognition visual imaging technology that measures pixels microvibration in terms of digital frequency and amplitude parameters. To examine the effects of the horticultural therapy program based on validation therapy, Vibraimage was used to assess aggression, stress, tension, suspect, balance, charm, energy, self-regulation, inhibition, neuroticism and positive, negative, physiological domains of mental functions before and after program. As a result, the mean score of the positive domain in the control group significantly decreased from 63.89±5.09 to 60.74±5.48, but it decreased without statistical significance in the experimental group from 63.98±5.45 to 61.39±6.02. The mean score of neuroticism in the experimental group significantly decreased from 31.64±10.94 to 22.87±13.79. Moreover, the mean score of the physiological domain in the experimental group also significantly decreased from 25.08±6.27 to 19.42±8.80. Accordingly, horticultural therapy program based on validation therapy can be utilized as a program to promote mental health, especially maintaining positive mental health function of the eldery, helping those who live in long-term care facilities enjoy a happier life more happier.

• 융합보안논문지
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• 제23권5호
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• pp.151-156
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• 2023

현재 다양한 정보통신기술들이 독거노인 돌봄과 치매노인 실종방지 등에서 폭넓게 활용되고 있으며, 향후 커뮤니티케어 정책을 통해 인공지능과 로봇활용 비대면 돌봄은 향후 더욱 다양한 영역에서 활용될 전망이다. 따라서 본 연구에서는 4차 산업혁명에 관한 정부정책 방향에 기반하여 커뮤니티케어에 활용도가 점차 증가하고 있는 인공지능 기술 기반 돌봄서비스 현황과 활용 및 활성화 전망을 모색해보고자 하였다. 커뮤니티케어에 활용될 수 있는 서비스인 AI 스피커와 돌봄로봇은 노인층이 경험하고 있는 다양한 문제를 해결하는데 도움이 되며, 감성적인 기능을 추가하여 대화 부족이나 외로움을 해소하는데도 활용하고 있다. 향후 AI 기술을 활용한 커뮤니티케어 활성화를 위해서는 첫째, 커뮤니티케어 고령자의 AI기기 친밀화를 위한 지속적인 교육과 고령층을 위한 '사용자 경험(User Experience, UX) 디자인'이 필요하며, 둘째, 기능위주의 기술 활용보다는 상호보완적 관계를 가지고 감성적인 상호관계가 가능한 인간중심의 기술 활용이 필요하며. 셋째, 사용자의 자기결정권 보장, 사생활 보호 등의 윤리적 문제를 해결할 필요가 있다.

• 한국기록관리학회지
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• 제24권1호
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• pp.137-161
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• 2024

전문직의 역량은 전문성을 입증하고 개발하는데 활용할 수 있다. 이와 관련하여 이 연구에서는 역량의 개념과 역량모델의 개발, 활용에 대한 이론을 정리하고, 해외 기록전문직 역량 체계를 사례 분석을 통해 국내 기록전문직의 전문성 강화를 위한 역량 체계 활용 방안을 제안하였다. 해외 사례 분석 대상은 해외 기록전문가협회 등에서 개발한 기록전문직 역량체계 5가지로 선정하였다. 해외 사례 분석 결과 기록전문직의 역량 체계는 크게 2가지로 활용되고 있었다. 첫 번째는 전문정의 입증을 위한 활용으로 기록전문가 협회 차원에서 공인전문가 등록을 위한 검증 기준으로 활용하는 것이다. 두 번째는 전문성 강화를 위한 활용으로 전문직 개인의 자가 평가 및 전문 계속 교육 프로그램 설계와 연계하여 활용하는 것이다. 그리고 이 두 가지 활용 방안은 역량의 입증과 강화라는 역량 체계의 활용 목적과 함께 상호 보완적인 관계로 운영될 수 있다.

• IMMUNE NETWORK
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• 제24권1호
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• pp.10.1-10.17
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• 2024

In this review, we will explore the intricate roles of cytokines and vascular endothelial growth factors in autoimmune diseases (ADs), with a particular focus on rheumatoid arthritis (RA) and multiple sclerosis (MS). AD is characterized by self-destructive immune responses due to auto-reactive T lymphocytes and Abs. Among various types of ADs, RA and MS possess inflammation as a central role but in different sites of the patients. Other common aspects among these two ADs are their chronicity and relapsing-remitting symptoms requiring continuous management. First factor inducing these ADs are cytokines, such as IL-6, TNF-α, and IL-17, which play significant roles in the pathogenesis by contributing to inflammation, immune cell activation, and tissue damage. Secondly, vascular endothelial growth factors, including VEGF and angiopoietins, are crucial in promoting angiogenesis and inflammation in these two ADs. Finally, placental growth factor (PlGF), an emerging factor with bi-directional roles in angiogenesis and T cell differentiation, as we introduce as an "angio-lymphokine" is another key factor in ADs. Thus, while angiogenesis recruits more inflammatory cells into the peripheral sites, cytokines secreted by effector cells play critical roles in the pathogenesis of ADs. Various therapeutic interventions targeting these soluble molecules have shown promise in managing autoimmune pathogenic conditions. However, delicate interplay between cytokines, angiogenic factors, and PlGF has more to be studied when considering their complementary role in actual pathogenic conditions. Understanding the complex interactions among these factors provides valuable insights for the development of innovative therapies for RA and MS, offering hope for improved patient outcomes.

• 농촌의학ㆍ지역보건
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• 제27권2호
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• pp.17-26
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• 2002

아로마요법의 스트레스 및 수면장애 감소 효과를 평가하기 위하여 경주시보건소 보완대체의학센타에서 1999년 7월부터 2000년 2월까지 매주 2회씩 1회 2시간씩 총 1개월 동안 아로마요법을 받은 48명을 대상으로 요법 실시 전후 통일한 양식의 설문지를 이용하여 자기기입식 설문조사를 실시하였다. 아로마요법 시행 전후의 스트레스 점수와 수면장애 점수를 비교한 결과, 스트레스 점수는 시행 전 $92.5{\pm}17.5$점에서 시행 후 $87.4{\pm}14.2$점으로 유의하게 감소하였으며(p<0.01), 수면장애 점수는 시행 전 $2.5{\pm}1.2$점에서 시행 후 $1.0{\pm}1.1$점으로 유의하게 감소하였다(p<0.01). 스트레스 점수는 연령별로는 40대 이상이 39세 이하보다, 종교가 있는 사람이 없는 사람보다, 직업이 없는 사람이 있는 사람보다, 주관적 경제상태는 '중'인 경우가 '상'과 '하'인 경우보다, 주관적 성격은 중간형 성격 소유자가 내성적 성격 소유자와 외향적 성격 소유자보다 시행 후 유의하게 감소하였다. 수면장애 점수는 연령, 교육 수준, 종교 유무, 직업유무, 주관적 경제상태, 주관적 성격, 만성질환 유무에 관계없이 시행 전보다 시행 후 모두 유의하게 감소하였다. 스트레스와 수면장애 정도가 심한 사람에게서 아로마요법으로 인한 스트레스와 수면장애 감소효과가 더욱 크게 나타났다. 따라서 적절한 방법이 아로마요법을 사용하면 스트레스와 수면장애를 효과적으로 해소시킬 수 있을 것으로 본다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5349-5357
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• 2015

Background: Breast cancer is the most common cancer and the leading cause of cancer mortality among women of all ethnic and age groups in Malaysia. Delay in seeking help for breast cancer symptoms is preventable and by identifying possible factors for delayed diagnosis, patient prognosis and survival rates could be improved. Objectives: This narrative review aimed to understand and evaluate the level of in-depth breast cancer knowledge in terms of clinical breast examination and breast self-examination, and other important aspects such as side-effects and risk factors in Malaysian females. Since Malaysia is multicultural, this review assessed social perceptions, cultural beliefs and help-seeking behaviour in respect to breast cancer among different ethnic groups, since these may impinge on efforts to 'avoid' the disease. Materials and Methods: A comprehensive literature search of seven databases was performed from December 2015 to January 2015. Screening of relevant published journals was also undertaken to identify available information related to the knowledge, perception and help-seeking behaviour of Malaysian women in relation to breast cancer. Results: A total of 42 articles were appraised and included in this review. Generally, women in Malaysia had good awareness of breast cancer and its screening tools, particularly breast self-examination, but only superficial in-depth knowledge about the disease. Women in rural areas had lower levels of knowledge than those in urban areas. It was also shown that books, magazines, brochures and television were among the most common sources of breast cancer information. Delay in presentation was attributed mainly to a negative social perception of the disease, poverty, cultural and religion practices, and a strong influence of complementary and alternative medicine, rather than a lack of knowledge. Conclusions: This review highlighted the need for an intensive and in-depth breast cancer education campaigns using media and community health programmes, even with the existing good awareness of breast cancer. This is essential in order to avoid misconceptions and to frame the correct mind-set about breast cancer among women in Malaysia. Socio-cultural differences and religious practices should be taken into account by health care professionals when advising on breast cancer. Women need to be aware of the risk factors and symptoms of breast cancer so that early diagnosis can take place and the chances of survival improved.

• Preventive Nutrition and Food Science
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• 제9권1호
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• pp.21-28
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• 2004

We purified and characterized a crude polysaccharide from Spirodela polyrhiza with anti-complement activities. The crude polysaccharide fraction (SP-0) which had potential anti-complement activity was extracted in hot water for 4 hrs at 10$0^{\circ}C$. The ethanol-precipitate, the crude polysaccharide traction (SP-1), showed a potent anti-complement activity. Further purification of the crude polysaccharide (SP-1) was carried out by cetavlon, ion exchange chromatography and gel column chromatography. Among cetavlon fractions, SP-4 showed the most potent anti-complement activity. When 100 $\mu\textrm{g}$/mL of SP-4 was incubated with an equal volume of normal human serum (NHS), the TCH$_{50}$ was reduced by about 78%. When the SP-4 fraction was further purified by DEAE-Sepharose (Cl$^{[-10]}$ ), the SP-4IIa, SP-4IIb and SP-4IIc, absorbed fractions, were almost the same as the anti-complement activities of SP-4. SP-4IIc, having the greatest potential activation and the highest yield by ion exchange chromatography, was further purified by gel column chromatography on a Sepharose CL-6B column. Four polysaccharide fractions of SP-4IIc-1, SP-4IIc-2, SP-4IIc-3 and SP-4IIc-4 were obtained, consisting mainly of arabinose, rhamnose, galactose and glucose, with approximate molecular weights of about 305,000, 132,000, 64,000 and 12,000, respectively. Among these subfractions, SP-4IIc-1 had the most potent anti-complement activity. When the SP-4IIc-1 aggregate was applied to a gel column chromatography in 10 mM and 50 mM NaCl solution, the position of the peak fractions shifted to a low molecular weight region, and the molecular weight of SP-4IIc-1 decreased with increased NaCl concentration in the gel column chromatography. It was found that the self-aggregation formed spontaneously in void volume by gel column chromatography using Sepharose CL-6B in water and the self-aggregation significantly affected the anti-complement function.