• Korean Journal of Clinical Laboratory Science
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• v.50 no.2
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• pp.177-182
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• 2018

This study examined the effects of zerumbone on monocyte migration. Monocytes are recognized as important mediators of various inflammatory diseases, and the possibility of controlling inflammatory diseases by regulating the monocyte functions, such as activity and mobility, has been reported. MCP-1, which is a chemokine with levels that increase upon inflammation, causes the migration of the monocyte cell line, THP-1. Migration occurred at a concentration of 10 ng/mL MCP-1, and the highest migration occurred at 100 ng/mL and 200 ng/mL. MCP-1-induced THP-1 migration decreased by more than 40% in the presence of zerumbone. The concentration of cAMP, an important secondary messenger of the CCR2 signaling pathway, the MCP-1 receptor, was increased in the culture medium after a zerumbone treatment. The concentrations of cAMP decreased significantly under the MCP-1 treatment condition only. On the other hand, an increase in cAMP was observed when zerumbone and MCP-1 were treated simultaneously. Erk phosphorylation induced by an MCP-1 treatment was also found to decrease with the zerumbone treatment. This study introduces the possibility of controlling inflammatory diseases through the function of zerumbone, which regulates the migration of monocytes.

• The Journal of the Petrological Society of Korea
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• v.24 no.3
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• pp.153-164
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• 2015

Jurassic granite from Geochang was analysed with respect to the characteristics of the rock cleavage. we have mainly discussed the structual anisotropy formed by microcracks. The phases of distribution of microcracks were well evidenced from the enlarged photomicrographs(${\times}6.7$) of the thin section. The planes of principal set of microcracks are parallel to the rift plane and those of secondary set are parallel to the grain plane. These rift and grain microcracks are mutually near-perpendicular on the hardway planes. From the directional angle(${\theta}$) - total length($L_t$), number(N) and density(${\rho}$) chart, the curve patterns of the above microcrack parameters reflect the phases of distribution of microcracks. Microcrack parameters such as number, length and density show an order of rift > grain > hardway. These results indicate a relative magnitude of the rock cleavage. Meanwhile, brazilian tensile strengths were measured with respect to the six directions. The results revealed a strong correlation between mechanical property with the above microcrack parameters. These general results correspond to those of the previous study for Jurassic granites from Pocheon and Hapcheon. Image processing technique for the enlarged photomicrograph of the thin section was carried out. The grain 1(G1) microcrack arrays developed in quartz and feldspar grains show excellent distribution on the photomicrograph. In particular, the directional angle of each microcrack set can be ascertained easily by brief image processing for the above photomicrograph.

• Water for future
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• v.21 no.4
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• pp.399-406
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• 1988

Presented in this paper is a brief summary of the basic theory and observation from a laboratory investigation aimed at determining flow characteristics and ice jam topography in a sinuous channel, and in a single-bend channel. The sinuous channel comprised thirteen $90^{\circ}$ bends and was of comparatively small s\aspect ratio. The single-bend channel was a $180^{\circ}$ bend, which was an order of magnitude large in width as well as aspect ratios than the sinuous channel. The simulated ices were polyethylene and polypropylene beads and block. The streamwise velocities near the bottom were larger than that of surface in sinuous channel and forming ice jam in sinuous channel, this phenoumena were found strongly. Jams were generally thicker along the inner bank of bends. The path of maximum-streamwise velocity was displaced towards approachs side of the inner bank of bends. Radial variation of jam thickness was to be regular by increasing size of ice fragments. The rate of jam head progression around outer bank of the single bend was faster than that of inner bank and its velocity was roughly steady. With increasing Froude number, jm thickness became less uniformly distributed; being generally thicker along the inner bank and near the jam's toe. Two-layer model might be adaptable for the computing the streamwise velocity in shallow river bends. Two cells of secondary flow cound be expected in ice covered-river bends.

• Journal of Korean Society for Geospatial Information Science
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• v.23 no.3
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• pp.49-55
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• 2015

Current medical delivery system in Korea has been distinguished into three types; primary medical facilities, secondary facilities, and tertiary facilities since 1989. This system prevents the waste of medical resources along with the maintenance of balance according to the medical treatment subjects. However, it is inevitable that the imbalance of the medical services among regions has been generated due to the concentration of the medical facilities on large cities. In this regard, this study attempted to evaluate the quality of the primary medical services, emphasizing accessibility and convenience targeting Jinju city, a small and medium-sized city, based on the distribution characteristics of the space. The study results show that cohesion index about the spatial distribution of the primary care facilities was 0~0.25. It conducted a correlation analysis between the location of the hospitals and users, based on the study results. Finally, it is demonstrated the correlation between the location of the hospitals and users tended to be low, while, the cohesion of the Oriental medicine clinics was high in other treatment subjects, and the accessibility to the Oriental medicine clinics was the highest because most Oriental medicine clinics were distributed to the places where users were many. However, on account that the locations of the medical facilities and users were varied in other treatment subjects except for the Oriental medicine clinics, problems were generated in terms of the accessibility. Therefore, it is judged that the preparation of the measures to improve the selection of lots in consideration of users, who use the primary medical services, is required.

• Korean Journal of Environment and Ecology
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• v.32 no.1
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• pp.77-96
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• 2018

We investigated and analyzed three Korean island sites (Bijin-do, Ae-do, and Bogil-do) and one Japanese site (Tachibanayama) of sword-leaf litsea (Actinodaphne lancifolia) forests, known as the climax forest, to discuss the vegetation succession sere of warm-temperature evergreen broad-leaved forests. We then reviewed the literature in Korea, Japan, China, and Taiwan to consider the distribution characteristics of evergreen broad-leaved forests, vegetation succession sere, and climax tree species. Although Mt. Tachibana and Ae-do showed the most advanced vegetation structure, the soil and ordination (CCA) analysis indicated that it was not enough to consider that the sword-leaf litsea forest was at the climax stage in the warm-temperature region. The Actinodaphne lancifolia forest is sparsely distributed in Korea and Japan while the common types of vegetation in the warm temperate zone region in East Asia are Machilus spp., Castanopsis spp., and Cyclobalanopsis spp. The vegetation succession sere of the Korean warm-temperature region is thought to have a secondary succession such as Pinus thunbergii, P. densiflora, Q. serrata (early stage) through Machilus thunbergii, innamomum yabunikkei, Neolitsea sericea, Actinodaphne lancifolia (middle stage) to Castanopsis sieboldii, Q. acuta, Q. salicina (climax stage). However, Machilus thunbergii will be the climax species as an edaphic climax in places where there is a strong influence of the sea wind, or it is difficult to supply the seeds of Castanopsis spp. and Cyclobalanopsis spp.

• Journal of Convergence for Information Technology
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• v.10 no.8
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• pp.194-202
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• 2020

This study was conducted to identify and compare the needs of the integrated by local government, and to provide basic data for the provision of integrated care services. This is a secondary data analysis study using data from 10,299 elderly people living in 17 local governments who participated in the '2017 National Survey on the Aged People in Korea'. The difference in medical needs, daily living support needs, and social activity support needs were 2.4, 6.0, and 2.0 times higher in the highest regions than in the lowest regions. In addition, the size of the medical needs group, welfare needs group, and integrated care needs group varied by region. Through this study, it was confirmed that the level of integrated care needs varied by region. Therefore, in order to efficiently provide the services at the national level, it is necessary to accurately assess the needs of the aged in each local government, and accordingly, prioritize and identify available resources within the care service and appropriate allocation.

• The Journal of the Petrological Society of Korea
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• v.26 no.4
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• pp.311-325
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• 2017

Peridotite xenoliths in middle Miocene alkaline basalt from the Mt. Baekdu area are mainly anhydrous spinel lherzolites, displaying coarse-grained protogranular texture. These xenoliths have late-stage secondary orthopyroxene replacing olivine as the metasomatic mineral and glass formed along the grain boundaries. The studied xenoliths are characterized by the high $Mg{\sharp}[=100{\times}Mg/(Mg+Fe_{total})$ atomic ratio] of olivine, orthopyroxene and clinopyroxene (89~92) and the $Cr{\sharp}[=100{\times}Cr/(Cr+Al)$ atomic ratio] of spinel (10~29). Based on major-element data, the studied xenoliths are similar to those from the abyssal peridotites. Clinopyroxenes of the xenoliths are mostly enriched in incompatible trace elements, exhibiting two types of REE patterns: (1) LREE-depleted with $(La/Yb)_N$ of 0.1~0.2 and $(La/Ce)_N$ of 0.4~0.8. (2) LREE enriched with $(La/Yb)_N$ of 2.2~3.8 and $(La/Ce)_N$ of 1.2~1.6. The calculated equilibrium temperatures and oxygen fugacities resulted in $920{\sim}1050^{\circ}C$ and ${\Delta}fO_2(QFM)=-0.8{\sim}0.2$, respectively. It is suggested that the Mt. Baekdu peridotite xenoliths represent residues left after variable degrees of melt extraction(less than 15 vol%), which was subsequently subjected to different degrees of modal/cryptic metasomatism by silica- and LREE-enriched fluids (or melts).

• The Journal of Society for e-Business Studies
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• v.19 no.4
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• pp.135-150
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• 2014

As the collection and use of personal information increases, the accidents that abuse and leak personal information are continuously increasing. The nation has established new laws and strengthened related laws for the prevention of the mass leakage of personal information and the secondary damage due to the leaked personal information. The nation also established the guidelines that need to be implemented by the institutions handling personal information for the safety of the personal information. For the efficient implementation of guidelines under the limited time and resources, it is necessary to establish the priorities between guidelines. This paper compares the relative importance of the guidelines by AHP (Analytic Hierarchy Process) technique. We performed the analysis on two expert groups, the group of consultants working in information security consulting company and the group of information security staffs handling personal information directly in the company. We compared the differences between groups and recommended the relative importances of the guidelines.

• Water for future
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• v.14 no.4
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• pp.73-81
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• 1981

More than 650 numbers of water well ranging in depth from 100M to 200M were installed in South Korean Penninsula during the last decade for the purpose of industrial use and municipal water supply. Those data were compiled and synthesized by writer to determine their hydrogeologic occurences in accordance with their geologic and areal characteristics. Rocks yielding the deep seated ground water beared in the geologic primary and secondary porosities are classified into 6 groups according to their geologic, hydrogeologic, and topographic characteristics, that are: volcanic, sedimentary, meta-sediment and/or schist, andesitic, gneissic, and granitic rocks. The order of ground water productivity of the groups is as written above. Even granitic rocks including porphyries, granite, and intermediate and basic plutonic rocks is considered to be the most poorest ground water yielding group among 6, it's average yield form a single well with average drilling depth of 116M is about 225 cubic meters per day if it's drilling site is properly located. Generally speaking, seizable geologic structures such as fractured, sheared, and faulted zone at the flat surface and valley center yield almost 310% more of deep seated bet rock ground water in comparision with minor structures of joints, bedding planes, and so on that are occured at high land. 50 numbers of water well drilled at crystalline rocks were specially checked and measured it's ground water yie 1ds at each drilled depth to determine each interval's productivity while hammer drilling was going on. The results indicate that the specific capacity and yield of each water well at a depth below 70M to 80M was almost neglegible. It means that optimum well depth of crystalline rocks, except the area having seizable geologic structures, shall be not deeper than 80M.

• Food Science and Preservation
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• v.23 no.7
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• pp.1004-1011
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• 2016

Flavonoids, non-nutrient secondary metabolites of plants, are widely distributed in commonly consumed agro-food resources. Flavonoids include aglycones, and their glycosides are reported to have potential health-promoting compounds. The aim of this study was to investigate flavonoid glycosides in the fruit and leaves of Zizyphus jujuba var. inermis (Bunge) Rehder (jujube). A total of six flavonoids (five flavonols and one chalcone) were identified in jujube fruit and leaves by using ultra-performance liquid chromatography-diode array detector-quadrupole time of flight mass spectrometry along with chemical library and an internal standard. In positive ion mode, six flavonoids were linked to the C- and O-glycosides which were conjugated with sugar moieties based on kaempferol, quercetin, and phloretin aglycones. Total flavonoid contents of leaves (8,356.5 mg/100 g dry weight (DW)) was approximately 900-fold higher than that of fruit (fresh fruit, 13.6 mg/100 g dry DW; sun-dried fruits, 9.2 mg/100 g dry DW). Quercetin 3-O-rutinoside (rutin) and quercetin 3-O-robinobioside were the predominant flavonols in fruit and leaves of jujube. In particular, rutin had the highest content (6,735.2 mg/100 g DW) in leaves, and rutin is a widely reported bioactive compound. Phloretin 3',5'-di-C-glucoside (chalcone type) was detected only in leaves. The leaves of jujube contain a high content of flavonoids and the results of this study indicate that jujube leaves may be a source of bioactive flavonoids.