• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제25권1호
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• pp.1-12
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• 2022

Inflammation plays an important role in the outcome of patients with cystic fibrosis (CF). It may develop due to cystic fibrosis transmembrane conductance regulator protein dysfunction, pancreatic insufficiency, or prolonged pulmonary infection. Fecal calprotectin (FC) has been used as a noninvasive method to detect inflammation. Therefore, the aim of the current meta-analysis was to investigate the relationship between FC and phenotype severity in patients with CF. In this study, searches were conducted in PubMed, Science Direct, Scopus, and Embase databases up to August 2021 using terms such as "cystic fibrosis," "intestine," "calprotectin," and "inflammation." Only articles published in English and human studies were selected. The primary outcome was the level of FC in patients with CF. The secondary outcome was the relationship between FC and clinical severity. Statistical analysis was performed using Comprehensive Meta-Analysis software. Of the initial 303 references, only six articles met the inclusion criteria. The mean (95% confidence interval [CI]) level of FC was 256.5 mg/dL (114.1-398.9). FC levels were significantly associated with pancreatic insufficiency (mean, 243.02; 95% CI, 74.3 to 411.6; p=0.005; I²=0), pulmonary function (r=-0.39; 95% CI, -0.58 to -0.15; p=0.002; I²=60%), body mass index (r=-0.514; 95% CI, 0.26 to 0.69; p<0.001; I²=0%), and Pseudomonas colonization (mean, 174.77; 95% CI, 12.5 to 337.02; p=0.035; I²=71%). While FC is a reliable noninvasive marker for detecting gastrointestinal inflammation, it is also correlated with the severity of the disease in patients with CF.

• 근관절건강학회지
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• 제29권1호
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• pp.1-10
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• 2022

Purpose: Metabolic syndrome is known as a factor that increases the incidence of chronic diseases, such as diabetes and cardiovascular disease. In particular, the metabolic syndrome among a middle-aged population is rapidly increasing from 15.6% to 31.9%. The purpose of this study was to investigate the effect of muscle strength exercise on the metabolic syndrome in middle aged. Methods: This study was a secondary data analysis using National Health and Nutrition Survey 8th, including 2,739 middle aged people (40~64 years old). We used multivariate logistic regression to identify risk factors associated with metabolic syndrome. Statistical analysis was performed using the SPSS 23.0 program. Results: There were 772 patients in the group with metabolic syndrome and 1,967 patients in the non-metabolic syndrome group. The risk of metabolic syndrome was 1.29 times higher in those who did not do muscle strength exercise than those who did exercise (OR=1.29, 95% CI=1.01~1.66). Conclusion: We have found that muscle strength exercise was effective in lowering the risk of developing metabolic syndrome in middle aged. Thus, it is necessary to develop practical muscle strength exercise and education programs.

• 대한치과의료관리학회지
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• 제9권1호
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• pp.38-43
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• 2021

Based on data from the Korean Academy for Dental Administration, which has been conducting the Dental Quality Improvement (QI) Contest since 2010, we aimed to provide basic data for the development of dental quality improvement indicators by analyzing the trends of dental quality improvement activities. A total of 54 articles in the dental QI contest from 2015 to 2021 were used to search for frequently used words and to classify the quality of dental care. The criteria for the quality dimension of dental care were first classified into structure, process, and outcome, and secondary classification was performed into patient safety, timeliness, patient-centeredness, equity, efficiency, effectiveness, and accessibility. The frequently used key terms were satisfaction (five times), efficiency (four times), system (three times), and implant (three times). The activities for process evaluation were high at 62.26%, structural evaluation activities at 35.85%, and outcome evaluation activities at 1.89%. According to the components of dental care quality improvement, the activity performed under efficiency was the highest (33.96%), followed by patient-centeredness (18.87%), effectiveness (16.98%), patient safety (15.09%), accessibility (5.66%), timeliness (1.89%), and the equity (1.89%). QI activities in dental hospitals were mainly activities on improvement in structure and process, as well as activities on efficiency, patient-centeredness, effectiveness, and patient safety.

• 여성건강간호학회지
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• 제28권3호
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• pp.222-234
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• 2022

Purpose: This study investigated the changes in the health-related behaviors of adult women in Korea during the coronavirus disease 2019 (COVID-19) pandemic. Methods: Data from the eighth Korea National Health and Nutrition Examination Survey (2019-2020) were analyzed. The participants were 4,848 women aged 19 to 64 years in 2019 and 2020. Data analysis using the complex sampling design was performed using SPSS 20.1. Results: Positive changes during the pandemic compared to before the pandemic in Korean adult women were found for improved subjective oral health perceptions (odds ratio [OR], 1.77; p<.001), increased moderate-intensity exercise in work and leisure activities (OR, 1.75; p<.001 and OR; 1.29, p=.004), and a decrease in secondhand smoke exposure at the workplace and in public places (OR, 0.64; p=.004 and OR, 0.60; p<.001). However, the following negative health behavior changes were found: decreased frequency of walking 5 days a week (OR, 0.81; p=.011) and an increase in unhealthy daytime sleep durations (OR, 1.40; p=006). Conclusion: Compared to before the COVID-19 pandemic, Korean adult women perceived their subjective dental health more positively during the COVID-19 pandemic, decreased their exposure to secondhand smoke at work and in public places, decreased walking, and increased sleep duration during the week. Since this study only compared data between 1 year before and after the start of the pandemic, it is necessary to investigate a longer period of time in the future. A future study should attempt to identify the factors related to changes in health behaviors caused by the pandemic.

• 여성건강간호학회지
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• 제28권3호
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• pp.187-196
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• 2022

Purpose: The purpose of this study was to investigate factors related to the levels of health-related quality of life (HRQoL) in elderly women based on Wilson and Cleary's HRQoL model. Methods: This study analyzed data from the eighth Korea National Health and Nutrition Examination Survey 2019 on 868 women over the age of 65 years. Based on the HRQoL model, parameters were categorized as personal, environmental, and physiological characteristics; symptom status; functional status; and perception of health status. The data were analyzed by quantile regression. Results: The overall level of HRQoL was 0.87. Factors related to HRQoL in the 10% quantile were higher education level, higher economic status, economic activity, more walking days, fewer diseases, lower stress, less activity limitation, and higher perceived health status. Factors related to the 25% quantile of HRQoL were more walking days, fewer diseases, less activity limitation, and higher perceived health status. Factors related to the 50% quantile were age, economic activity, more walking days, fewer disease, lower stress, less activity limitation, and higher perceived health status. Factors related to the 75% quantile of HRQoL were smoking, more walking days, fewer diseases, lower stress, less activity limitation, and higher perceived health status. Conclusion: While differing parameters were identified according to the level of HRQoL of elderly women in Korea, there were five common factors. Interventions that focus on increasing walking, mitigating diseases, stress, and activity limitations, and improving perceived health status can improve HRQoL.

• 산업융합연구
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• 제20권1호
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• pp.87-96
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• 2022

본 연구는 알레르기 질환을 가진 청소년들의 실태와 정신건강과 관련된 요인을 파악 하고자 한다. 질환 관리를 위한 기초자료를 제공 하고자 함이다. 연구방법은 제16차 청소년 건강행태 조사 빅데이터를 이차분석 하였으며, SPSS 25 프로그램을 이용하여 x²-test를 사용하고 연관 정도를 파악하기 위해 오즈비와 95% 신뢰구간을 구하였으며, 다중 로지스틱 회귀분석을 시행하였다. 연구 결과 알레르기 질환을 가지고 있는 청소년의 37.1%가 스트레스 인지가 있는 것으로 나타났으며, 우울감 경험률이 27.6%, 자살 생각률이 12.5% 처럼 알레르기 질환을 가지고 있는 청소년의 스트레스 인지, 우울감 경험 및 자살생각의 가능성이 알레르기성 질환을 가지고 있지 않은 청소년에 비해 높았다. 본 연구 결과로 청소년의 알레르기 질환 유무에 따라 정신건강에 많은 영향을 미치는 것을 알 수 있었고 정신질환을 초래할 수 있는 질환 및 청소년 정신건강 관련 예방과 연구에 기초 자료로 삼고자 한다.

• Genomics & Informatics
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• 제19권4호
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• pp.39.1-39.8
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• 2021

Tamoxifen (TAM) is an anticancer drug used to treat estrogen receptor (ER)-positive breast cancer. However, its ER-independent cytotoxic and antifungal activities have prompted debates on its mechanism of action. To achieve a better understanding of the ER-independent antifungal action mechanisms of TAM, we systematically identified TAM-sensitive genes through microarray screening of the heterozygous gene deletion library in fission yeast (Schizosaccharomyces pombe). Secondary confirmation was followed by a spotting assay, finally yielding 13 TAM-sensitive genes under the drug-induced haploinsufficient condition. For these 13 TAM-sensitive genes, we conducted a comparative analysis of their Gene Ontology (GO) 'biological process' terms identified from other genome-wide screenings of the budding yeast deletion library and the MCF7 breast cancer cell line. Several TAM-sensitive genes overlapped between the yeast strains and MCF7 in GO terms including 'cell cycle' (cdc2, rik1, pas1, and leo1), 'signaling' (sck2, oga1, and cki3), and 'vesicle-mediated transport' (SPCC126.08c, vps54, sec72, and tvp15), suggesting their roles in the ER-independent cytotoxic effects of TAM. We recently reported that the cki3 gene with the 'signaling' GO term was related to the ER-independent antifungal action mechanisms of TAM in yeast. In this study, we report that haploinsufficiency of the essential vps54 gene, which encodes the GARP complex subunit, significantly aggravated TAM sensitivity and led to an enlarged vesicle structure in comparison with the SP286 control strain. These results strongly suggest that the vesicle-mediated transport process might be another action mechanism of the ER-independent antifungal or cytotoxic effects of TAM.

• Physical Therapy Rehabilitation Science
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• 제11권3호
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• pp.311-320
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• 2022

Objective: To investigate the reliability and validity of static balance measurements using an acceleration sensor and a gyroscope sensor in smart phone inertial sensors. Design: Equivalent control group pretest-posttest. Methods: Subjects were forty five healthy adults aged twenty to fifty-years-old who had no disease that could affect the experiment. After pre-test, all participants wore a waist band with smart phone, and conducted six static balance measurements on the force plate twice for 35 seconds each. To investigate the test-retest reliability of both smart phone inertial sensors, we compared the intra-correlation coefficient (ICC 3, 1) between primary and secondary measurements with the calculated root mean scale-total data. To determine the validity of the two sensors, it was measured simultaneously with force plate, and the comparision was done by Pearson's correlation. Results: The test-retest reliability showed excellent correlation for acceleration sensor, and it also showed excellent to good correlation for gyroscope sensor(p<0.05). The concurrent validity of smartphone inertial sensors showed a mostly poor to fair correlation for tandem-stance and one-leg-stance (p<0.05) and unacceptable correlation for the other postures (p>0.05). The gyroscope sensor showed a fair correlation for most of the RMS-Total data, and the other data also showed poor to fair correlation (p<0.05). Conclusions: The result indicates that both acceleration sensor and gyroscope sensor has good reliability, and that compared to force plate, acceleration sensor has unacceptable or poor correlation, and gyroscope sensor has mostly fair correlation.

• Journal of Periodontal and Implant Science
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• 제51권1호
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• pp.3-17
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• 2021

Purpose: The pathology of peri-implantitis is still not fully understood and there have been recent challenges to the consensus on its aetiology and pathology, especially in comparison with periodontitis. The assessment of biomarkers allows a comparison of the pathology of these diseases. The aim of this systematic review was to answer the research question: "Is there a difference in the biomarkers associated with peri-implantitis compared with periodontitis in adult humans?" Methods: Electronic databases were searched and screened, and a manual search was also undertaken. The inclusion criteria were adults with peri-implantitis who had been compared to adults with periodontitis with the outcome of biomarkers assessed via biopsies or crevicular fluid samples in primary or secondary care settings, as recorded in case-control, case series and retrospective, prospective and cross-sectional observational studies. Two reviewers independently screened titles and abstracts and assessed full text articles for eligibility and inclusion. Both reviewers independently extracted data and assessed risk of bias. Differences in biomarker levels were the primary outcome and a narrative review was undertaken due to the heterogeneity of studies. Results: In total, 2,374 articles were identified in the search, of which 111 full-text articles were assessed for eligibility and 13 were included in the qualitative synthesis. Five of the 13 included studies were deemed to be at high risk of bias, with the others having moderate risk. All studies were cross-sectional and performed at university hospitals. Nine of the 13 included studies found significant differences in the levels of biomarkers or their ratios between periimplantitis and periodontitis. Four of the studies found no significant differences. Conclusions: Within the limitations of the included studies, it appears that there may be a difference in biomarker levels and ratios between peri-implantitis and periodontitis, suggesting that these disease processes are somewhat distinct.

• 한국융합학회논문지
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• 제13권5호
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• pp.463-471
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• 2022

COVID-19 사회적 거리두기 실천의도에 영향을 미치는 요인을 확인하였다. 본 연구는 2021년 3월 초 대한민국에 거주하는 19세 이상 성인 379명을 대상으로 COVID-19 감염예방을 위한 손실과 이득 메시지 프레이밍 광고중 1개를 무작위 할당하여 본 후 조사된 자료의 2차 분석연구이다. COVID-19 사회적 거리두기 실천의도에 광고태도(𝛽=.03, p<.001), COVID-19에 대한 관여(𝛽=.14, p=.006) 및 감정적 낙인(𝛽=-0.17, p<.001)이 영향을 미쳤으며 이들 변수의 설명력은 19%였다(Adjusted R²=.19). 따라서 보건의료전문가는 현장에서 대중과 소통하고 정책을 보급할 때 제공된 정보에 대한 관여를 높여 긍정적 광고태도를 유도하며 정확한 정보에 의해 낙인의 감정을 갖지 않도록 효과적인 메시지를 제시함으로써 건강관리 리더로서 역할을 충실히 해야 할 것이다.