• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제42권4호
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• pp.221-226
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• 2016

Spindle cell carcinoma (SpCC) is referred to as a variant of oral squamous cell carcinoma. It is also known as "sarcomatoid squamous cell carcinoma" because it consists of normal squamous carcinoma cells with spindle-shaped cells that appear similar to a sarcoma. The term, "second primary tumor" (SPT) or "double primary tumor", is proposed for a second tumor that develops independently from the first. SPTs can present as either synchronous or metachronous lesions. Synchronous SPTs are defined as tumors occurring simultaneously or within 6 months after the first tumor. The patient in this case, whose primary tumor was in the tongue, was diagnosed with SpCC with metastases to both neck lymph nodes. This case also exhibited a second primary cancer as a synchronous lesion in the thyroid gland, which is uncommon. All carcinomas, both in the tongue and thyroid gland, were removed surgically, and especially in the tongue, an anterolateral thigh free flap was performed successfully to replace the defect.

• 대한소아치과학회지
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• 제4권1호
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• pp.7-18
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• 1977

The author carried out to determine the normal range of eruptive time, average age and order of eruption of primary teeth in korean infants. The examimation was given to 1757 healty infants(Male 1032, female 725) from afterbirth 4 months to 32 months. The results was as fallows. 1. The eruption of primary teeth was 0.57 months earlier in male than in female. 2. The average month of eruption of primary teeth was as follows; Upper primary central is $9.66{\pm}0.19$ months Upper primary lateral is $11.58{\pm}0.18$ months. Upper primary canine is $18.06{\pm}0.32$ months. Upper first primary molar is $16.45{\pm}0.29$ months. Upper second primary molar is $24.28{\pm}0.51$ months. Lower primary central is $7.50{\pm}0.12$ months. Lower primary lateral is $12.87{\pm}0.16$ months. Lower primary camine is $18.82{\pm}0.34$ months. Lower first primary molar is $17.66{\pm}0.37$ months. Lower second primary molar is $23.89{\pm}0.51$ months. 3. The eruptive order of the korean is different from that of the American and same to that of Japanese. 4. There is no significant right and left arch. 5. Generally, the eruption of primary teeth on the upper is 1.08 months earlier than on the lower; but the upper central is 2.16 months later than the lower and the upper second primary is 0.39 months later than the lower.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6087-6091
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• 2012

Context: Patients diagnosed with a cancer have a life time risk of developing another de novo malignancy depending on various inherited, environmental and iatrogenic risk factors. Of late the detection of new primary has increased mainly due to refinement in both diagnostic and treatment modalities. Cancer victims are surviving longer and thus are more likely to develop a new metachronous malignancy. Aims: To report our observed trend of increase in prevalence of both synchronous and metachronous second malignant neoplasms among cancer victims and to review the relevant literature. Settings and Design: A hospital based retrospective collection of prospective data of patients diagnosed with second denovo malignancy. Materials and Method: The study was conducted over a 5 year period from July 2008 to June 2012. All patients diagnosed with a histologically proven second malignancy as per Warren Gate's criteria were included. Various details regarding sex, age at presentation, synchronous or metachronous, treatment and outcome were recorded. Conclusions: The occurrence of multiple primary malignancies is not rare. Awareness of the possibility alerts the clinician in evaluation of patients with a known malignancy presenting with unusual sites of metastasis. Individualizing the treatment according to the stages of the primaries will result in durable cancer control particularly in synchronous double malignancy.

• Asian Pacific Journal of Cancer Prevention
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• 제13권1호
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• pp.383-386
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• 2012

Background: Cancer survivors are at increased risk of second cancers. Lymphoproliferative disorders (LPD) are common neoplasms that are primary or subsequent cancers in cases of multiple primary cancer. We here analyzed metachronous or synchronous LPD in multiple primary cancers. Methods: Between 2001 and 2010, LPD were assessed retrospectively in 242 multiple primary cancers patients. Results: Forty nine (20.2%) patients with LPD were detected. Six patients had two LPD where one patient had three LPD. The median age of patients was 60.5 years (range: 28-81). LPD were diagnosed in 29 patients as primary cancer, in 23 patients as second cancer, and in three patients as third cancer in multiple primary cancers. Primary tumor median age was 56 (range: 20-79). Diffuse large B cell lymphoma (n=16), breast cancer (n=9), and lung cancer (n=6) were detected as subsequent cancers. Alklylating agents were used in 19 patients (43.2%) and 20 patients (45.5%) had received radiotherapy for primary cancer treatment. The median follow-up was 70 months (range: 7-284). Second malignancies were detected after a median of 51 months (range: 7-278), and third malignancies with a median of 18 months (range: 6-72). Conclusions: In this study, although breast and lung cancer were the most frequent detected solid cancers in LPD survivors, diffuse large B cell lymphoma was the most frequent detected LPD in multiple primary cancers.

• 대한소아치과학회지
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• 제40권2호
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• pp.98-105
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• 2013

질 높은 치료를 제공하고 안전한 치료환경을 만들기 위한 러버댐 사용의 중요성은 소아치과에서 더욱 강조된다. 한편 잘못된 클램프의 장착으로 발생하는 통증과 불완전한 방습은 협조도를 떨어뜨리고 진정 치료 중 방해가 되기도 한다. 본 연구에서는 혼합치열기 아동 110명의 경석고 모형을 통해 제2유구치의 치경부 근원심 폭경을 측정하고 이를 #203/204, #10/11, #205 클램프(Dentech, Japan)의 근원심 폭경과 비교하여 다음과 같은 결과를 얻었다. 제2유구치의 치경부 근원심 폭경은 하악이 상악보다 크고, 협측이 설측 보다 컸다. 모든 위치의 계측값이 클램프 폭경과 비교 시 통계적으로 유의한 차이가 있었으나, 그 차이값이 상악 제2유구치에서는 작은 반면 하악 제2유구치에서는 1 mm에 가까운 것으로 나타났다. 상악 제2유구치는 #203/204 및 #10/11 클램프와 비교적 잘 맞는 반면 하악 제2유구치를 위해서는 보다 적절한 크기의 클램프가 필요할 것으로 보인다.

• 대한간호학회지
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• 제44권2호
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• pp.139-148
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• 2014

Purpose: This study was conducted to identify the factors influencing second primary cancer (SPC) screening practice by examining the relationships of physical symptoms, knowledge and attitudes regarding SPC screening, perceived risk, primary cancer type, and demographic factors of cancer survivors. Methods: Participants were 308 survivors of stomach, colon, or breast cancer recruited from 2 university hospitals in Korea. Data were collected using a questionnaire and analyzed using IBM SPSS 21.0 and AMOS 18.0. Results: The proportion of participants taking all cancer screenings according to national guidelines was 40%. They had moderate knowledge and a relatively positive attitude regarding SPC screening and high cancer risk perception. The participants had taken fewer SPC screenings after than before cancer diagnosis. The factors influencing cancer risk perception were age, physical symptoms, knowledge regarding SPC and primary cancer type (stomach). The factors influencing SPC screening practice were age, gender, economic status, knowledge regarding SPC screening, and primary cancer types (colon). Conclusion: It is important for clinical professionals to recognize that survivors of cancer are susceptible to another cancer. Education on SPC screening for these survivors should focus on communicating with and encouraging them to have regular cancer screenings.

• 한국가정과교육학회지
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• 제2권1호
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• pp.15-28
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• 1990

The Sequence of the Curriculum and the Contents of Textbooks on Family Life Field of Home Economics Subject in Primary, Middle and High School. The purpose of this study is to investigate the sequence of curriculum and the contents of textbooks in primary, middle and high school. The problems of this study are as follows. 1. Are the educational contents of Family Life field in primary, middle an high school specified in the contents of textbooks\ulcorner 2. What are the sequence of curriculum and the Contents of textbooks on Family Life Field of Home Economics subject in primary, middle and high school\ulcorner The study results given by the research on the educational contents of Family Life field and the sequence of the contents of textbooks of Home Economics subject in primary, middle and high school can be summarized as follows. 1. Are the educational contents on Family Life field in the primary, middle and high school specified in the contents of the textbooks\ulcorner The results are as follows 1〉Considering the sequence of educational contents on Family Life field in primary school, we can find out that the subject aims have relevance to those of the forth and fifth grade in primary school, and those of the forth grade in primary school are specified in the contents of curriculum of the forth grade and the contents of curriculum of the forth grade are specified in the textbooks for the forth grade in primary school. The subject aims of the fifth grade are specified in the contents of curriculum of the fifth grade and the contents of curriculum of the fifth grade are specified in the textbooks for the fifth grade. 2〉Considering the sequence of educational contents on Family Life field in middle school, we can find out that the subject aims have relevance to those of the first and second grade in middle school, and those of the first grade in middle school are specified in the contents of curriculum of the first grade and the contents of curriculum of the first grade are specified in the textbooks for the first grade in middle school. The subject aims of the second grade are specified in the contents of curriculum of the second grade and the contents of curriculum of the second grade are specified in the textbooks for the second grade.

• 대한소아치과학회지
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• 제32권1호
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• pp.89-100
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• 2005

형태학적으로 아주 유사한 상, 하악 제2유구치와 제1대구치의 교합면 형태를 분석하고자 정상교합의 유치열기 아동(Hellman dental age II A) 100명(남자 50명, 여자 50명)과 영구치열기의 성인(Hellman dental age IV A) 86명 (남자 43명, 여자 43명)을 대상으로 하였다. 상, 하악 제2유구치와 제 1대구치의 상, 하악 석고모형의 3차원 형상 data로부터 각 교두정간 거리, 교두정을 최소한의 오차로 지나는 평면과 교합면사이의 체적, 평면에서 교두정간 까지의 방향별 Section curve를 구하여 다음과 같은 결론을 얻었다. 1. 형성된 표준평면과 각 교두정과의 거리에 관한 오차는 하악 제2유구치에서 남자 0.05-0.09mm, 여자 0.04-0.09mm로서 제일 작았다. 2. 각 교두정간의 거리는 하악 제2유구치와 제 1대구치 에서 남자가 크게 나타났다. 특히 제2 유구치에서는 유의성이 존재하였다(p<0.05). 3. 남녀 모두에서 사주 교두거리를 제외하고, 상악 제2유구치는 원심 협측교두와 설측교두 사이가, 하악 제2유구치는 원심교두와 원심 설측교두 사이가, 상악 제1대구치는 근심 설측교두와 협측교두 사이가, 하악 제1대구치는 원심 설측교두와 근심 설측교두 사이의 거리가 가장 크게 측정되었다. 4. 제2유구치와 제1대구치에서 교합면 체적은 하악에서 크게 나타났고, 영구치가 1.40-1.75배 값을 보였으며(p<0.05), 남녀간에는 남자가 큰 값을 보이긴 하였지만 통계적인 유의성이 없었다. 5. 대부분의 경우 유치열에서 보다 영구치열에서 section curve가 넓고 깊었으며 교두사이의 사선거리를 제외하고 상악의 경우 근심 협측과 설측교두 사이에서 유치열과 영구치열 모두에서 가장 깊은 section curve를 이루었으며 하악에서는 영구치열은 원심 협측과 원심교두사이 유치열은 원심 설측과 원심교두 사이에서 가장 깊은 section curve를 이루었다.

• Journal of Chest Surgery
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• 제24권1호
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• pp.98-105
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• 1991

There have been reports concerning the association of laryngeal carcinoma and lung cancer. Second primary respiratory tract malignancies occur frequently in patients who have undergone the treatment of laryngeal cancer probably because they are exposed to the same carcinogen. Recently, we have experienced two patients who developed second primary lung cancer 30 and 41 months after the first diagnosis of laryngeal cancer at the Department of Thoracic & Cardiovascular Surgery, Yonsei University College of Medicine. Relative long interval between the two carcinomas indicated metastasis unlikely. From a therapeutic standpoint, it is of great importance that they should be regarded as separate primaries and not as metastasis. Longevity will depends on a presumption that the lesions are separate primaries and the status of stage at the time of detection of second primary lesion. The follow-up of patients who are seen with carcinomas of the head and neck should be done at regular interval and include a chest roentgenogram and cytologic examination of sputum to detect early changes before the tumors becomes incurable. The first 76 year old patient with left upper lobectomy due to the T2N0M0 lung cancer has been in good condition to present. But the second 55 year old patient with right pneumonectomy due to the T2N0M0 lung cancer died of respiratory failure and septic pneumonia 3 months after operation and chemotherapy.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제44권5호
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• pp.220-224
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• 2018

Objectives: The aim of this study was to determine the incidence and characteristics of second primary malignancy (SPM) in patients with head and neck squamous cell carcinoma treated at a tertiary care hospital. Materials and Methods: We retrospectively reviewed the medical records of 221 patients who underwent surgery with or without adjuvant treatment for head and neck cancer from 2000 to 2002. Data of age, sex, risk factors, sites of primary and SPM, TNM stage of primary tumor, incidence of SPM, and survival were collected from medical charts. Results: Eighteen patients developed SPM during a median follow-up of 67 months, with an overall incidence of 8.14%. In addition, 77.7% of SPMs occurred in the oral cavity, followed by 11% in the lungs. The 5-year overall survival after the diagnosis of SPM in the head or neck was 70%, compared to 30% for SPM in other body regions. Conclusion: Considering a high incidence of SPM, i.e., 8.14%, in a mean follow-up period of 67 months suggests the need for long-term follow-up. Since treatment of SPM has shown an acceptable survival rate, early detection and curative therapy should be emphasized.