Journal of the Korean Association of Oral and Maxillofacial Surgeons

The Korean Association of Oral and Maxillofacial Surgeons (대한구강악안면외과학회)
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Spindle cell carcinoma of the tongue combined with double primary cancer of the thyroid gland: a case report

  • Kim, Tae-Hwan (Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University) ;
  • Kim, Chul-Hwan (Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University)
  • Received : 2016.02.11
  • Accepted : 2016.04.05
  • Published : 2016.08.31
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Abstract

Spindle cell carcinoma (SpCC) is referred to as a variant of oral squamous cell carcinoma. It is also known as "sarcomatoid squamous cell carcinoma" because it consists of normal squamous carcinoma cells with spindle-shaped cells that appear similar to a sarcoma. The term, "second primary tumor" (SPT) or "double primary tumor", is proposed for a second tumor that develops independently from the first. SPTs can present as either synchronous or metachronous lesions. Synchronous SPTs are defined as tumors occurring simultaneously or within 6 months after the first tumor. The patient in this case, whose primary tumor was in the tongue, was diagnosed with SpCC with metastases to both neck lymph nodes. This case also exhibited a second primary cancer as a synchronous lesion in the thyroid gland, which is uncommon. All carcinomas, both in the tongue and thyroid gland, were removed surgically, and especially in the tongue, an anterolateral thigh free flap was performed successfully to replace the defect.

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References

  1. Su HH, Chu ST, Hou YY, Chang KP, Chen CJ. Spindle cell carcinoma of the oral cavity and oropharynx: factors affecting outcome. J Chin Med Assoc 2006;69:478-83. https://doi.org/10.1016/S1726-4901(09)70312-0
  2. Reyes M, Pennacchiotti G, Valdes F, Montes R, Veloso M, Matamala MA, et al. Sarcomatoid (spindle cell) carcinoma of tongue: a report of two cases. Case Rep Dent 2015;2015:780856.
  3. Lewis JE, Olsen KD, Sebo TJ. Spindle cell carcinoma of the larynx: review of 26 cases including DNA content and immunohistochemistry. Hum Pathol 1997;28:664-73. https://doi.org/10.1016/S0046-8177(97)90175-1
  4. Wenig BM. Squamous cell carcinoma of the upper aerodigestive tract: precursors and problematic variants. Mod Pathol 2002;15:229-54. https://doi.org/10.1038/modpathol.3880520
  5. Yabuki K, Kubota A, Horiuchi C, Taguchi T, Nishimura G, Inamori M. Limitations of PET and PET/CT in detecting upper gastrointestinal synchronous cancer in patients with head and neck carcinoma. Eur Arch Otorhinolaryngol 2013;270:727-33. https://doi.org/10.1007/s00405-012-2081-9
  6. Warren S, Gates O. Multiple primary malignant tumors: a survey of the literature and statistical study. Am J Cancer 1932;16:1358-414.
  7. Cooper JS, Pajak TF, Rubin P, Tupchong L, Brady LW, Leibel SA, et al. Second malignancies in patients who have head and neck cancer: incidence, effect on survival and implications based on the RTOG experience. Int J Radiat Oncol Biol Phys 1989;17:449-56. https://doi.org/10.1016/0360-3016(89)90094-1
  8. Haerle SK, Strobel K, Hany TF, Sidler D, Stoeckli SJ. (18)F-FDG-PET/CT versus panendoscopy for the detection of synchronous second primary tumors in patients with head and neck squamous cell carcinoma. Head Neck 2010;32:319-25.
  9. Greene FL, Page DL, Fleming ID, Fritz AG, Balch CM, Haller DG, et al. American Joint Committee on Cancer (AJCC) cancer staging manual. 6th ed. New York: Springer Science and Business Media; 2003.
  10. Viswanathan S, Rahman K, Pallavi S, Sachin J, Patil A, Chaturvedi P, et al. Sarcomatoid (spindle cell) carcinoma of the head and neck mucosal region: a clinicopathologic review of 103 cases from a tertiary referral cancer centre. Head Neck Pathol 2010;4:265-75. https://doi.org/10.1007/s12105-010-0204-4
  11. Thompson LD, Wieneke JA, Miettinen M, Heffner DK. Spindle cell (sarcomatoid) carcinomas of the larynx: a clinicopathologic study of 187 cases. Am J Surg Pathol 2002;26:153-70. https://doi.org/10.1097/00000478-200202000-00002
  12. Ellis GL, Langloss JM, Heffner DK, Hyams VJ. Spindle-cell carcinoma of the aerodigestive tract. An immunohistochemical analysis of 21 cases. Am J Surg Pathol 1987;11:335-42. https://doi.org/10.1097/00000478-198705000-00001
  13. Shah JP, Gil Z. Current concepts in management of oral cancer: surgery. Oral Oncol 2009;45:394-401. https://doi.org/10.1016/j.oraloncology.2008.05.017
  14. Lambert PR, Ward PH, Berci G. Pseudosarcoma of the larynx: a comprehensive analysis. Arch Otolaryngol 1980;106:700-8. https://doi.org/10.1001/archotol.1980.00790350042012
  15. Ellis GL, Corio RL. Spindle cell carcinoma of the oral cavity. A clinicopathologic assessment of fifty-nine cases. Oral Surg Oral Med Oral Pathol 1980;50:523-33. https://doi.org/10.1016/0030-4220(80)90436-3
  16. Leventon GS, Evans HL. Sarcomatoid squamous cell carcinoma of the mucous membranes of the head and neck: a clinicopathologic study of 20 cases. Cancer 1981;48:994-1003. https://doi.org/10.1002/1097-0142(19810815)48:4<994::AID-CNCR2820480424>3.0.CO;2-M
  17. Dequanter D, Shahla M, Lardinois I, Gilbert O, Hanquet O, Tragas G, et al. Second primary lung malignancy in head and neck cancer patients. Eur Ann Otorhinolaryngol Head Neck Dis 2011;128:11-3. https://doi.org/10.1016/j.anorl.2010.06.004
  18. Rennemo E, Zatterstrom U, Boysen M. Impact of second primary tumors on survival in head and neck cancer: an analysis of 2,063 cases. Laryngoscope 2008;118:1350-6. https://doi.org/10.1097/MLG.0b013e318172ef9a
  19. Liao CT, Kang CJ, Chang JT, Wang HM, Ng SH, Hsueh C, et al. Survival of second and multiple primary tumors in patients with oral cavity squamous cell carcinoma in the betel quid chewing area. Oral Oncol 2007;43:811-9. https://doi.org/10.1016/j.oraloncology.2006.10.003
  20. Shiga K, Tateda M, Katagiri K, Nakanome A, Ogawa T, Asada Y, et al. Distinct features of second primary malignancies in head and neck cancer patients in Japan. Tohoku J Exp Med 2011;225:5-12. https://doi.org/10.1620/tjem.225.5