• Journal of Mycology and Infection
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• 제24권1호
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• pp.1-8
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• 2019

Background: Scalp seborrheic dermatitis is a common disease characterized by flaking and itching of the scalp. Conventional treatment options, such as the use of topical corticosteroids and antifungal agents, may cause adverse effects and reduce user satisfaction rates; thus, it is important to explore other treatment options for scalp seborrheic dermatitis. Objective: We aimed to evaluate the efficacy and safety of a new-formula shampoo containing natural ingredients, including the extract of Rosa centifolia petals, epigallocatechin gallate, zinc pyrithione, and climbazole. Methods: A total of 50 patients with scalp seborrheic dermatitis were enrolled and divided into two groups: the new-formula shampoo-treated group and the 1.5% ciclopirox olamine shampoo-treated group. Clinical severity scores, sebum secretion, and inflammatory cytokines were assessed. In addition, patient satisfaction and adverse events were assessed using a questionnaire. Results: The new-formula shampoo was comparable with ciclopirox in reducing the clinical severity scores and sebum secretion. Patients' improvement scores and user satisfaction rates were higher in the new-formula shampoo group than in the 1.5% ciclopirox olamine shampoo-treated group. The inflammatory cytokine levels considerably changed in both groups during the course of the study. Conclusion: Thus, the new-formula shampoo can be considered a treatment option for patients with scalp seborrheic dermatitis.

• 대한본초학회지
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• 제32권3호
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• pp.89-95
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• 2017

Objectives : Seborrheic dermatitis is common abnormal skin condition characterized by flaking and itch. In seborrheic dermatitis, the flakes are greasy and yellowish. Inflammation is also observed. Through this paper we can understand the process of seborrheic dermatitis of the scalp and confirm the scalp changes in the treatment process. The purpose of this study was to report the clinical effects of herbal medicine on Seborrheic dermatitis Methods : We employed oriental medical treatments; herbal-medication (Hyeongbangpaedoksangamibang), infant acupuncture, moxibustion and blood therapy. We treated her three times a week. She took medicine three times a day after a meal. During taking medicine, we let her avoid fatty food, flour based food. Her father took a picture the patient's head parts and we compared the symptom with previous symptom. With the picture, we evaluated the patient's scalp condition. Results : After taking treatment, the scalp condition of the patient was much improved. At first, yellowish to reddish scaly pimples appear along the hairline and itching was severe. There were thick and black crusts on the scalp, red, greasy skin covered with flaky white or yellow scales. After that the crusts were fell off and the itching was disappeared during the treatment period. And then the hair loss was occurred. After a year of treatment, scalp condition and hair were back to normal. Conclusion : Herbal medicine (Hyeongbangpaedoksangamibang) with oriental medical treatments was effective in the treatment of seborrheic dermatitis of the scalp and it helped to improve regenerating the scalp condition.

• 한국산학기술학회논문지
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• 제17권7호
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• pp.311-318
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• 2016

본 연구는 루이보스 추출물이 지루성 두피가 있는 중년 남성의 두피 유, 수분량, 가려움증, 붉음증, 청백색 두피톤 등에 미치는 효과를 규정하고자 시도하였다. 루이보스 추출물을 함유하지 않은 샴푸를 사용한 Control군과 루이보스 추출물을 함유한 샴푸를 사용한 RS군, 루이보스 추출믈을 함유한 샴푸와 두피 개선제를 사용한 RS+S군으로 구분하여 실험을 진행하였다. 본 연구결과 두피의 유분량, 수분량, 각질제거에 의한 두피 표면에 변화, 두피 가려움증, 두피 붉음증, 두피 청백색 두피톤에 대하여 Control군에서는 유의한 두피 변화가 나타나지 않았으나, 루이보스를 함유한 샴푸와 두피개선제를 모두 사용한 RS+S군에서 루이보스가 첨가된 샴푸만 사용한 RS군보다 지루성 두피 개선에 큰 개선율을 보이는 것으로 확인되었다. 이와같은 결과는 루이보스 추출물을 함유한 샴푸 및 두피 개선제가 지루성 두피의 유, 수분 밸런스를 개선해주고, 두피의 가려움증이나 붉음증, 두피톤을 효과적으로 개선시켜 줌에 따라 추후 항산화 활성 성분을 가진 지루성 두피 개선에 효과적인 두피용 화장품 소재로써의 가능성이 있음이 사료된다.

• 한국산학기술학회논문지
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• 제17권12호
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• pp.701-707
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• 2016

본 연구는 지루성 두피염 발생빈도가 높은 것으로 알려진 30~50대 남성 150명을 대상으로 생활 습관과 샴푸 습관이 지루성 두피에 어떠한 영향을 미치는지 알아보고자 하였다. 그 결과 지루성 두피의 주요 원인과 관련이 있다고 알려진 두피 가려움증과 과다 유분, 두피 뾰루지, 두피 붉은 증상에 대하여 샴푸 시기와 잦은 피로감은 모든 증상에서 통계적으로 유의한 영향을 미치는 것으로 조사되었으며(p<0.01), 샴푸 시기, 잦은 피로감, 규칙적인 출 퇴근, 스트레스 민감, 헤어스타일 제품사용 유 무와 같은 생활과 샴푸 습관은 지루성 두피에 영향을 미치는 것으로 확인되었다. 연구 결과를 통해 사무직 군무 종사자들의 생활과 샴푸 습관이 지루성 두피의 발생원인과 통계적으로 유의한 것으로 확인 되었으며, 특히 샴푸 습관과 샴푸의 불완전한 세정 및 모발 건조에 의한 습진이 지루성 두피 발생의 일차적인 원인이 되고, 불규칙적인 출 퇴근과 잦은 피로감, 만성 스트레스가 지루성 두피의 이차적 악화 원인이 되고 있음을 알 수 있었다.

• Journal of Acupuncture Research
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• 제19권6호
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• pp.24-34
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• 2002

Objective : To report seborrheic dermatitis of the scalp which is treated by Bee-venom Acupuncture therapy. Methods : Under the assumption that Be-venom Therapy may be effective for treatment seborrheic dermatitis, Bee-venom acupuncture was injected subcutaneously into the lesion including Gv24(神庭), Gv23(上星), Gv22, Gv20(白會), B4(曲差), B5(五處), B6(承光), S8(頭維), etc. Results : The symptoms including erythematous plaque, scale, itching were resolved clearly except a little scale by Bee-venom acupuncture Therapy. Conclusions : Bee-venom acupuncture Therapy is effective in the treatment of seborrheic dermatitis. if more clinical trials like this are proved to be effective in seborrheic dermatitis, we can expect that Bee-venom acupuncture Therapy is used to treatment of seborrheic dermatitis as good method.

• 대한본초학회지
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• 제31권2호
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• pp.1-5
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• 2016

Objectives : Seborrheic dermatitis is an inflammatory skin disorder affecting the scalp, face, and torso. Typically, it presents with scaly, flaky, itchy, and red skin. It may be aggravated by illness, psychological stress, fatigue, sleep deprivation, change of season. The purpose of this study was to report the clinical effects of herbal medicine on Seborrheic dermatitisMethods : We employed oriental medical treatments; herbal-medication (Bangpungtongsungsangamibang), acupuncture, moxibustion and cupping therapy. At the same time, the patient sweated out the skin poison. We treated him two times a week with oriental therapy method. He took medicine three times a day after a meal. During taking medicine, we let him avoid fatty food, flour based food, and alcohol. We took a picture the patient's body parts and compared the symptom with previous symptom. With the picture, we evaluated the patient's condition.Results : After taking treatment - 77 times' acupuncture, moxibustion and cupping therapy during 9 months and taking herbal-medicine, the skin condition of the patient was much improved. At first, he was troubled with itching and hot feeling at reddish area, time after time the itching and hot feeling was weakened. The reddish area was changed to scaly and flaky skin and changed to normal state.Conclusions : Herbal medicine (Bangpungtongsungsangamibang) with oriental medical treatments was an effective in the treatment of Seborrheic Dermatitis and it helped to improve regenerating the skin in the body.

• 한방안이비인후피부과학회지
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• 제31권1호
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• pp.81-90
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• 2018

Objectives : This study was performed to investigate the characteristic of Seborrheic Dermatitis(SD) patients who visited Korean medicine clinics. Methods : The study was carried out with 140 SD outpatients who visited fourteen Gowoongyul Korean traditional medical clinics from January to December 2016 and was completed by reviewing patients' survey. Results : 1. Among 140 patients, there were 61 male patients(43.6%), 79 female patients(56.4%). The average age of the patients was $32.6{\pm}10.9years$ old, with many in their 20s and 30s in the distribution. 2. The average duration of disease was $4.2{\pm}4.11years$. 3. 80% of the patients had experience of treatment, 58.6% only took Western medicine, 17.1% had experience of both Western and Korean medicine treatment, and 4.3% received only Korean medicine treatment. 4. Analysis of seasonal effects of SD showed that 48.6% of the respondents reported that skin disease always appeared regardless of the season, with 33.6% in winter, with 29.3% in summer and 25.7% in seasonal change. 5. The rate of family history of seborrheic dermatitis was low(6.4%), and 75.7% of the patients answered that they had no family history of skin disease. 6. The major lesion of SD appeared on face(87.9%) and scalp(36.4%). 7. 70.7% answered they do some kind of self-managements. 70.0% used moisturizers. Bathing therapy was performed in 17.1%, and 55% were taking the health supplement food, and 35.7% restricted the avoidance diet such as instant and fatty foods. Conclusions : This study demonstrated the various clinical characteristics of Korean patients with seborrheic dermatitis.

• 대한화장품학회지
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• 제38권4호
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• pp.311-319
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• 2012

보통 지루성 피부염은 과다 생성된 피지와 함께 피지를 영양분으로 상재하는 M. globosa 이스트에 의해서 얼굴, 몸 및 두피에 자주 발생하는 피부질환이다. 본 연구는 천연정유성분(Natural essential oils)으로부터 지루성 피부염과 관련된 항염증 활성과 M. globosa 이스트에 대한 증식 억제 활성을 평가하고자 하였다. 지루성 피부염 진정 효능을 평가하기 위해서 지루성 피부염 환경을 모사한 공배양 세포 평가 모델을 구축하였다. 본 평가모델을 통해서 육계(Cinnamomum zeylanicum, Cinnamon bark)의 껍질 및 박하(Mentha arvensis, Cornmint)의 잎에서 추출한 천연정유 성분이 다양한 지루성 피부염 자극원에 따른 Interleukin-$1{\alpha}$ (IL-$1{\alpha}$), Interleukin-6 (IL-6), Interleukin-8 (IL-8) 사이토카인의 발현량 증가와 피지생성 증가를 감소시킴을 확인하였다. 또한, 지루성 피부염 유발균으로 알려진 M. globosa 이스트에 대한 증식 저해 평가를 통해 두 정유성분에서 유의한 M. globosa 증식 억제 능(MIC ${\leq}0.0625%$)을 확인하였다. 본 연구 결과로부터 육계껍질 및 박하 잎 정유성분이 지루성 피부염에 따른 염증성 사이토카인의 발현량을 감소시켰다. 특히 육계 껍질 오일은 지루성 피부염 주요 원인인 Malassezia furfur 및 M. globosa 증식을 억제함으로써, 지루성 두피 염증의 예방과 효과적인 관리 제품의 소재로서 활용가치가 높음을 알 수 있다.

• 한방재활의학과학회지
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• 제15권2호
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• pp.141-154
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• 2005

Objectives : This study was planned to evaluate clinical status of the alopecia patients who had visited oriental medicine clinic. Methods : 80 patients with alopecia, who had visited oriental medicine clinic from January 2004 to August 2004, were examined. Results & Conclusions : 1. The kinds and incidences of Alopecia : androgenetic alopecia 57.5%(46/80), alopecia areatea 20.0%(16/80), telogen effluvium 16.3%(13/80), seborrheic alopecia 6.3%(5/80). 2. In distribution of sex, the rate of male to female was 1:1 and most patients belonged to 20-30 year old group. 3. The most common onset of age was adolescence(63.8%) and the most common duration of hair loss was 1 to 3 years. 4. Among the 30 male androgenetic alopecia patients, Hamilton's type 4 was most common and among the 16 female androgenetic alopecia patients, Ludwig's type II and III were most common. 5. Family history of baldness in Androgenetic alopecia and alopecia areata were 56.5% and 25.0%, respectively. 6. Self-conscious causes of hair loss : stress(48.8%), irregular eating habits(21.3%), and lack of sleep(20.0%). 7. Associated diseases with alopecia patients : chronic neck pain(58.8%), temporomandibular disorders(55.0%) and seborrheic dermatitis(20.0%). 8. Associated symptoms with alopecia Patients : stress(78.8%), sleep disorders(68.8%), irregular eating habits(55.0%), Hot flush(43.8%), Stool disorders(43.8%), cold hands and feet(37.5%) and menstruation disorders(31.3%). 9. The most common scalp type was oily scalp(70.0%) and the symptoms of scalp were iching, dandruff, pain, inflammation. 10. $Bi{\grave{a}}n$ $zh{\grave{e}}ng$(辨證) of alopecia patients : $xu{\grave{e}}-r{\grave{e}}-f{\bar{e}}ng-z{\grave{a}}u$(血熱風燥) (25.0%), $g{\bar{a}}n-sh{\grave{e}}n-b{\grave{u}}-z{\acute{u}}$(肝腎不足) (23.8%), $shi-r{\grave{e}}-sh{\grave{a}}ng-zh{\bar{e}}ng$(濕熱上蒸) (16.3%), $xu{\grave{e}}-r{\grave{e}}-sh{\bar{e}}ng-f{\bar{e}}ng$(血熱生風) (13.8%), $xu{\grave{e}}-x{\bar{u}}-f{\bar{e}}ng-z{\grave{a}}u$(血熱風燥) (13.8%), $y{\bar{u}}-xu{\grave{e}}-z{\check{u}}-lu{\grave{o}}$(瘀血阻絡) (7.5%).

• Toxicological Research
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• 제26권1호
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• pp.47-52
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• 2010

The Malassezia fungi are responsible for various human skin disorders including dandruff and seborrheic dermatitis. Of the Malassezia fungi, Malassezia globosa (M. globosa) is one of the most common in human scalp. The completed genome sequence of M. globosa contains four putative cytochrome P450 genes. To determine the roles of Malassezia P450 enzymes in the biosynthesis of ergosterol, we isolated MGL3996 gene from M. globosa chromosomal DNA by PCR. The MGL3996 gene encodes an enzyme of 616 amino acids, which shows strong similarity with known CYP52s of other species. MGL3996 gene was cloned and expressed in Pichia pastoris (P. pastoris) heterologous yeast expression system. Using the yeast microsomes expressing MGL3996 protein, a typical P450 CO-difference spectrum was shown with absorption maximum at 448 nm. SDS-PAGE analysis revealed a protein band of apparent molecular weight 69 kDa and Western blot with anti-histidine tag antibody showed that MGL3996 was successfully expressed in P. pastoris. Cloning and expression of a new P450 gene is an important step to study the P450 monooxygenase system of M. globosa and to understand the role of P450 enzymes in pathophysiology of dandruff.