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Sequential magnetic resonance spectroscopic changes in a patient with nonketotic hyperglycinemia

  • Shin, Ji-Hun;Ahn, So-Yoon;Shin, Jeong-Hee;Sung, Se-In;Jung, Ji-Mi;Kim, Jin-Kyu;Kim, Eun-Sun;Park, Hyung-Doo;Kim, Ji-Hye;Chang, Yun-Sil;Park, Won-Soon
    • Clinical and Experimental Pediatrics
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    • v.55 no.8
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    • pp.301-305
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    • 2012
  • Nonketotic hyperglycinemia (NKH) is a rare inborn error of amino acid metabolism. A defect in the glycine cleavage enzyme system results in highly elevated concentrations of glycine in the plasma, urine, cerebrospinal fluid, and brain, resulting in glycine-induced encephalopathy and neuropathy. The prevalence of NKH in Korea is very low, and no reports of surviving patients are available, given the scarcity and poor prognosis of this disease. In the current study, we present a patient with NKH diagnosed on the basis of clinical features, biochemical profiles, and genetic analysis. Magnetic resonance spectroscopy (MRS) allowed the measurement of absolute glycine concentrations in different parts of the brain that showed a significantly increased glycine peak, consolidating the diagnosis of NKH. In additional, serial MRS follow-up showed changes in the glycine/creatinine ratios in different parts of the brain. In conclusion, MRS is an effective, noninvasive diagnostic tool for NKH that can be used to distinguish this disease from other glycine metabolism disorders. It may also be useful for monitoring NKH treatment.

Source Independent Subtree Ray Tracing Method for Wave Propagation Simulation in Urban Environment (도심 환경에서 전파 특성 모의 해석을 위한 신호 독립 부트리 방법에 대한 연구)

  • Kwon, Se-Woong;Moon, Hyun-Wook;Oh, Jae-Rim;Yoon, Young-Joong
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.21 no.3
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    • pp.301-306
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    • 2010
  • In this paper, a SIT(Source Independent Tree) method for ray tracing is proposed to enhance the efficiency of tree construction with reuse of sub tree in urban environment, As the SIT method is applied, the decrease of the number of nodes for picocell and microcell simulations is 100 times. And 88~98 % of the total nodes are reused with change of location of signal source from an analysis of node reuse efficiency. Therefore the proposed SIT method is useful in performance enhancement of ray tracing, especially, for multiple antenna simulation like as MIMO system and cell planning.

A New Global-Local Analysis Using MLS(Moving Least Square Variable-Node Finite Elements (이동최소제곱 다절점 유한요소를 이용한 새로운 전역-국부해석)

  • Lim, Jae-Hyuk;Im, Se-Young
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.20 no.3
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    • pp.293-301
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    • 2007
  • We present a new global-local analysis with the aid of MLS(Moving Least Square) variable-node finite elements which can possess an arbitrary number of nodes on element master domain. It enables us to connect one finite element with a few finite elements without complex remeshing. Compared to other type global-local analysis, it does not require any superimposed mesh or need not solve the equilibrium equation twice. To demonstrate the performance of the proposed scheme, we will show several examples in relation to capturing highly local stress field using global-local analysis.

The Utilization of Medical Care Benefits of School Personnel on Duty (교직원의 공무상 요양급여제도 이용 현황)

  • Lee, Hee-Woo;Shin, Sun-Mi;Kim, Joo-Ja;Kang, Se-Won
    • Journal of the Korean Society of School Health
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    • v.21 no.2
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    • pp.107-117
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    • 2008
  • Purpose: To investigate the utilization of medical care benefits of school personnel on duty in Seoul. Method: The subjects were 551 workers under Seoul Metropolitan Office of Education(male 301, female 250) who got medical care benefits from March 2000 to February 2005. To analyze the data, frequency, chi-square test, and t-test by SAS package 9.12 were used. Result: The results show that elementary school personnel got the highest ranking, 314(57.0%). Among subjects, 57.2% personnel got accident when they were working on their own duty, 21% during school events and 13.5% were during commutes. They got medical care from orthopedics 75.9%, neurosurgery 7.6%, dental 4%, and 8 male and 2 female died during these days. The most frequent diseases of males and female were fracture and joints related disease. The reason of most health problem was due to injury(92.3%). Conclusion: The results of this study suggest that the continuous health care services like regular health check for school personnel, or social safety network to prevent injury are needed.

Multiplex PCR Detection of Waterborne Intestinal Protozoa: Microsporidia, Cyclospora, and Cryptosporidium

  • Lee, Seung-Hyun;Joung, Mi-Gyo;Yoon, Se-Joung;Choi, Kyoung-Jin;Park, Woo-Yoon;Yu, Jae-Ran
    • Parasites, Hosts and Diseases
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    • v.48 no.4
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    • pp.297-301
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    • 2010
  • Recently, emerging waterbome protozoa, such as microsporidia, Cyclospora, and Cryptosporidium, have become a challenge to human health worldwide. Rapid, simple, and economical detection methods for these major waterborne protozoa in environmental and clinical samples are necessary to control infection and improve public health. In the present study, we developed a multiplex PCR test that is able to detect all these 3 major waterborne protozoa at the same time. Detection limits of the multiplex PCR method ranged from $10^1$ to $10^2$ oocysts or spores. The primers for microsporidia or Cryptosporidium used in this study can detect both Enterocytozoon bieneusi and Encephalitozoon intestinalis, or both Cryptosporidium hominis and Cryptosporidium paNum, respectively. Restriction enzyme digestion of PCR products with BsaBI or BsiEI makes it possible to distinguish the 2 species of microsporidia or Cryptosporidium, respectively. This simple, rapid, and cost-effective multiplex PCR method will be useful for detecting outbreaks or sporadic cases of waterborne protozoa infections.

Kinematic Character istics to Skill Degree during Dance Sports Rumba Forward Walk (댄스스포츠 룸바 Forward Walk 시 숙련도에 따른 운동학적 특성)

  • Seo, Se-Mi;Kim, Tae-Sam
    • Korean Journal of Applied Biomechanics
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    • v.20 no.3
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    • pp.293-301
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    • 2010
  • The purpose of this study was to investigate the kinematic difference between skilled and less skilled group for the forward walk at dance sports rumba. Six female players(skilled group: 3, less skilled group: 3) were participated as the subjects. To obtain the three-dimensional location coordinates in the joints and segments, it shot with 100Hz/s using 8 video cameras. Step length, shoulder rotation angle, orientation angle and angular velocity of pelvis were analyzed for each trail. The skilled group showed a bigger movement than the less skilled group at the shoulder rotation angle and ROM. The skilled group showed a bigger movement than the less skilled group at the up/down obliquity and internal/external rotation movement for pelvis. And the skilled group showed a bigger movement than the less skilled group at Maximum angle (down obliquity) of P2 and Maximum angle (up obliquity) of P3 to pelvis ROM. The skilled group showed a faster angular velocity than the less skilled group at P2 (+ direction, posterior) of anterior & posterior tilt, P2 & P3 (- direction, up) of up & down obliquity, and P2 (+ direction, external) of internal & external rotation.

FACTORS AFFECTING THE LACTATION LENGTH AND MILK YIELD IN NILI-RAVI BUFFALOES

  • Chaudhry, M.A.
    • Asian-Australasian Journal of Animal Sciences
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    • v.5 no.2
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    • pp.375-382
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    • 1992
  • The effect of certain factors such as sex of calf, status of buffalo, season of calving, parity and sire on lactation length and total lactation yield was studied in 391 Nili-Ravi buffaloes. The average lactation length was $301.73{\pm}1.87$ (mean $\pm$ SE) days with a range of 181 to 505 days whereas the average lactation yield was $2031.08{\pm}19.16kg$ and ranged from 1023 to 6535 kg for 984 lactations. The differences in the means of lactation length and lactation yield due to the sex of calf were significant (p<0.05). The status of buffaloes had a significant (p<0.05) effect on lactation length but its effect on lactation yield was non-significant. The season of calving had no effect on lactation length but it influenced the lactation yield significantly. The milk yield was highest ($2150.81{\pm}43.52kg$) in buffaloes which calved in spring and lowest ($1959.92{\pm}30.83kg$) in autumn. The effect of parity on both traits under study was significant (p<0.01). The maximum and minimum lactation lengths of $309.82{\pm}3.96$ and $284.16{\pm}7.17$ days were observed in the first and sixth lactations, respectively. The milk yield was maximum ($2150.38{\pm}58.79kg$) in the seventh lactation and minimum (1818.31 60.04 kg) in the sixth lactation. The influence of sire was significant on lactation length (p<0.05) and milk yield (p<0.01).

An Systematic Review of Trend Analysis in the Addiction Treatment Using Virtual Reality Technology (가상현실을 이용한 중독치료 동향 분석을 위한 체계적 문헌고찰)

  • Kim, Jinsoo Jason;Kim, Nami;Amista, Narcie Faith;Jang, Se Eun;Park, Kyung Eun;Kim, Bee
    • Proceedings of the Korea Contents Association Conference
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    • 2017.05a
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    • pp.301-302
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    • 2017
  • 본 논문은 가상현실을 이용한 중독치료 동향분석을 위해 관련 연구사례들을 수집하고 중독현상별로 분류하여 치료방법과 치료의 유용성과 한계점, 발전 방안을 분석하였다. 학술연구 데이터베이스인 Science Direct, Medline, Proquest 그리고 Embase에 등재된 논문들 중 1999년부터 2016년까지 중독치료를 위해 가상현실 기술을 실험적으로 적용하고 효과를 검증한 연구 46편을 선정하여 중독의 범주별 치료효과를 분석하였다. 가상현실 치료내용은 단서노출치료를 주로 활용하고 있으며 연구대상은 청소년들보다 성인들이 더 많았다. 니코틴 중독 가상현실치료 연구가 가장 많은 수를 차지했고 그 다음으로는 알코올, 코카인/필로폰, 마리화나 순으로 확인되었다. 가상현실 치료는 다양한 중독 치료에 효과가 있었으며 인지치료와 함께 적용할 때 효과가 더 높았다. 치료의 한계점으로는 비용과 절차상 특수성, 사이버 멀미 등으로 인해 연구대상이 소수이며, 치료회기가 짧고, 장기연구 또는 추후연구를 실시한 경우 많지 않아 추후에 연구완성도를 보완하는 시도가 필요함을 알 수 있었다.

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Dental utilization and expenditures in Korea Health Panel Survey, 2008-2011 (한국의료패널의 치과외래 이용 및 의료비 지출에 대한 4년간(2008-2011)의 변화추이)

  • Jung, Se-Hwan
    • The Journal of the Korean dental association
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    • v.52 no.5
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    • pp.291-301
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    • 2014
  • Korea Health Panel Survey (KHPS) has been conducted to provide nationally representative estimates of health care use and expenditures for non-institutionalized population in Korea since 2008. The aim of this study was to present estimates from KHPS on dental utilization and expenditures from 2008 to 2011. While weighted estimates were presented for each year from 2008 to 2011, the focus of this study was on the 2011 estimates and changes in dental utilization and expenditures between 2008 and 2011. Weighted estimates were obtained using population weights and statistical significances were analysed by independent t-test or ANOVA test using SPSS version 20 for Windows. In 2011, 21.1% of Korean population obtained outpatient dental services from dentists. From 2008 to 2011, the percent of people with a dental visit in each year increased slightly. In 2011, the mean number of dental visits was 4.46. While the mean number of dental visits remained stable by 2010, it increased slightly in 2011. The total annual dental expense in 2011 for people with a visit was about 460,000 Korean Won and 10% higher in 2008. In summary, this study results highlight low rates of dental utilization and high dental expenses in Korean population.

Estimation of geometry-based manufacturing cost of complex offshore structures in early design stage

  • Nam, Jong-Ho;Sohn, Se-Hwan;Singer, David J.
    • International Journal of Naval Architecture and Ocean Engineering
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    • v.4 no.3
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    • pp.291-301
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    • 2012
  • A scalar metric for the assessment of hull surface producibility was known to be useful in estimating the complexity of a hull form of ships or large offshore structures by looking at their shape. However, it could not serve as a comprehensive measuring tool due to its lack of important components of the hull form such as longitudinals, stiffeners, and web frames attached to the hull surface. To have a complete metric for cost estimation, these structural members must be included. In this paper, major inner structural members are considered by measuring the complexity of their geometric shape. The final scalar metric thus consists of the classes containing inner members with various curvature magnitudes as well as the classes containing curved plates with single and double curvature distribution. Those two distinct metrics are merged into a complete scalar metric that accounts for the total cost estimation of complex structural bodies.