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Anti-nociceptive and Anti-inflammatory Effects of Gami-cheongyulsaseub-tang in Arthritic Model (관절염 모델에서 가미청열사습탕(加味淸熱瀉濕湯)의 진통 및 소염 효과에 관한 연구)

  • Kim, Il-Hyun;Lee, Ha-Il;Lee, Se-Won;Kwon, Young-Mi;Song, Yung-Sun
    • Journal of Korean Medicine Rehabilitation
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    • v.25 no.1
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    • pp.27-44
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    • 2015
  • Objectives This study was carried out to find the effects of Gami-cheongyulsaseub-tang (hereinafter referred to GCST) on the inhibition of zymosan-induced pain in rats and collagen II-induced arthritis (CIA) in DBA/1J mouse. Methods As an acute inflammatory pain model, peripheral inflammation was induced by intraplantar injection of zymosan into the right hind paw in rats and then the hyperalgesia and pain regulating factors in spinal cord were analyzed. As a chronic inflammation model, the mixture of collagen II and complete Freund's adjuvant was treated into mice to establish rheumatoid arthritis and then body weight, thickness of hind paw, pathological change of spleen, immunological rheumatoid factor (IgG1, IgG2a, IgG2b, IgM and anti-collagen II), pro-inflammatory cytokines, and bone injury were analyzed. Results In the acute inflammatory pain model, GCST significantly inhibited the thermal and mechanical hyperalgesia and the pain regulating factors, including Fos, CD11b, PKA and PKC, in the spinal cord with a dose-dependent manner. In the chronic rheumatoid arthritis model, GCST administration decreased arthritic index and paw edema as compared with CIA control group. In particular, GCST reduced significantly the serum levels of total IgG2a, IgG2b, IgM, and specific anti-collagen II, but not total IgG1. GCST also resulted in the attenuation of bone injury and spleen enlargement/adhesion in CIA mice. Moreover, the secretion of pro-inflammatory cytokines TNF-${\alpha}$ and IL-$1{\beta}$ in CIA mice was significantly reduced by GCST in a dose-dependent manner. Conclusions Comparison of the results in this study showed that GCST had anti-nociceptive and immunomodulatory effects. These data imply that GCST can be used as an effective drug for not only rheumatoid arthritic pain but also other auto-immune diseases.

Member Sizing Optimization for Seismic Design of the Inverted V-braced Steel Frames with Suspended Zipper Strut (Zipper를 가진 역V형 가새골조의 다목적 최적내진설계기법)

  • Oh, Byung-Kwan;Park, Hyo-Seon;Choi, Se-Woon
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.29 no.6
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    • pp.555-562
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    • 2016
  • Seismic design of braced frames that simultaneously considers economic issues and structural performance represents a rather complicated engineering problem, and therefore, a systematic and well-established methodology is needed. This study proposes a multi-objective seismic design method for an inverted V-braced frame with suspended zipper struts that uses the non-dominated sorting genetic algorithm-II(NSGA-II). The structural weight and the maximum inter-story drift ratio as the objective functions are simultaneously minimized to optimize the cost and seismic performance of the structure. To investigate which of strength- and performance-based design criteria for braced frames is the critical design condition, the constraint conditions on the two design methods are simultaneously considered (i.e. the constraint conditions based on the strength and plastic deformation of members). The linear static analysis method and the nonlinear static analysis method are adopted to check the strength- and plastic deformation-based design constraints, respectively. The proposed optimal method are applied to three- and six-story steel frame examples, and the solutions improved for the considered objective functions were found.

The production of monoclonal antibodies against canine distemper virus (Canine Distemper Virus에 대한 단클론성 항체의 생산)

  • Kim, Tae-jong;Kim, Se-young
    • Korean Journal of Veterinary Research
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    • v.37 no.2
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    • pp.375-381
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    • 1997
  • The purpose of the production of monoclonal antibodies aganist the Canine distemper virus(CDV) were perfect diagnosis and a new approach to treat canine distemper because the diagnosis and treatment of canine distemper were difficult. Canine distemper virus(CDV) was purified using saturated ammonium sulfate, and injected into hind footpads of BALB/c mouse. 12-15 days later, popliteal lymph node(PN) cells were harvested and fused with SP2/O myeloma cells. Characteristics of monoclonal antibodies were analysed. 1. 9 hybridomas produce the specific antibody against CDV. 2. 6 monoclonal antibodies are against intranuclear and cytoplasmic component of CDV, and 3 monoclonal antibodies are against cytoplasmic inclusions. 3. All monoclonal antibodies did not react with other 5 different viruses (CAV-I, CAV-II, CCV, CPV and CPIV) and react with another CDV-FXNO strain. 4. 3 monoclonal antibodies have neutralizing activity against CDV. 5. Antigenic difference was observed between CDV by IFA.

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Facile Regiocontrolled Three-Step Synthesis of Poly-Substituted Furans, Pyrroles, and Thiophenes: Consecutive Michael Addition of Methyl Cyanoacetate to α,β-Enone, CuI-Mediated Aerobic Oxidation, and Acid-Catalyzed Paal-Knorr Synthesis

  • Kim, Se-Hee;Lim, Jin-Woo;Lim, Cheol-Hee;Kim, Jae-Nyoung
    • Bulletin of the Korean Chemical Society
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    • v.33 no.2
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    • pp.620-624
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    • 2012
  • An efficient synthesis of poly-substituted furans, pyrroles, and thiophenes was carried out in a regiocontrolled manner via a three-step process; (i) conjugate addition of methyl cyanoacetate derivatives to ${\alpha}$,${\beta}$-enones, (ii) CuI-mediated aerobic oxidation, and (iii) Paal-Knorr type synthesis of five-membered heterocycles.

Determination of Traces of Selenium in Plant Materials by Cathodic Stripping Voltammetry (Cathodic Stripping Voltammetry법에 의한 식물체 중 극미량 셀렌의 분석)

  • 문동철;홍성화;박만기;김중기;이광우
    • YAKHAK HOEJI
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    • v.29 no.3
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    • pp.144-151
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    • 1985
  • Cathodic stripping voltammetric determination of traces of selenium in plant samples was studied. Stripping peak of selenium (IV) from Cu-Se intermettalic deposit in acidic media containing copper (II) ion is specific, highly sensitive and well defined, is successfully used for the quantitative determination of selenuin down to the level of 1ng/ml. Sample is burnt in a calorimeter bomb under the oxygen pressure of 40atm. and the selenium is absorbed in 0.1M NaOH. After the solution is filtrated, concentrated and acidified with HCl, then passed through a column of cation exchange resin in the $H^{+}$ form(Dowex 50X-8). The column eluate is analyzed for selenium by differential pulse cathodic stripping voltammetric method. Analytical results of selenium for NBS SMR is well agreement with the certified values. Results are given for a series of plant materials.

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Pontryagin's Minimum Principle Applied to a Double Capacitive Thermal System (최소원리의 적용에 의한 이중열용량계의 최적계속온도제어방식에 관한 연구)

  • Se Hoon Chang
    • 전기의세계
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    • v.21 no.3
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    • pp.31-40
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    • 1972
  • This study intends to investigate the optimal switching modes of a double-capacitive thermal system under different constraints on the state and the control variable, by the application of the Pontryagin's Minimum Principle. Throughout the development, the control effort is assumed to have two modes of state: M or zero and the terminal times being fixed. In the first part of this study, the Principle is discussed under various conditions for this particular problem, with different criterion functions and in the same time imposing a certain constraints; i) on the terminal states, ii) on functions of the terminal states. Depending upon the upper bound value of the control vector, possible driving modes of the states are studied from which particular optimal driving modes are extracted so as to meet the specified constraints and boundary conditions imposed in the problem. Numerical solutions are evaluated for an over0damped, double-capacitive thermal plant and the optimal solutions: the switching mode, the optimal switching time, and the control effort are compared with the analytical results, in the second part of this work, to confirm the development.

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Production of GMO markers by genetic recombination and their characterization toward immuno-analytical reagents

  • Hwang, Ok-Hwa;Paek, Se-Hwan;Park, Won-Mok
    • 한국생물공학회:학술대회논문집
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    • 2003.10a
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    • pp.220-222
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    • 2003
  • Legislation enacted worldwide to regulate the content of genetically modified organisms (GMOs) in crops, foods, and ingredients, reliable and sensitive methods for GMO detection have been developed. Proteins produced in GMO plants can be determined by qualitative and quantitative analyses and thus GMO designation has performed exactly. Target proteins selected in this study were neomycin phosphotransferase II (NPTII), 5-enolpyruvylshikimate-3-phosphate synthase (CP4 EPSPS), cucumber mosaic virus(CMV), and phosphinothricin acetyltransferase (PAT). Analytical method employing western blotting was used for final characterization.

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어류양식용 사료의 위생화. II. 어류양식용 사료의 조성분과 지방산화에 대환 방사선 조사 및 butylated hydroxyanisole의 효과

  • Kim, Se-Ra;Oh, Heon;Lee, Hae-Jun;Lee, Jong-Hwan;Cho, Sung-Ki;Byun, Myung-Woo;Kim, Sung-Ho
    • Proceedings of the Korean Society of Veterinary Pathology Conference
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    • 2001.09a
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    • pp.24-24
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    • 2001
  • 양어용 사료로 사용되는 생어사료(고등어, 전어, 새우) 및 배합사료에 대한 방사선 조사(5 kGy) 후 조성분의 변화와, 사료의 방사선 조사에 의한 산패정도 및 BHA (200 ppm)의 효과를 저장온도 (2$0^{\circ}C$, 4$^{\circ}C$, -2$0^{\circ}C$) 및 저장기간 (0, 3, 7, 14일)에 따라 측정하였다. TBA가 및 과산화물가를 산패도 측정에 적용하였다. 5 kGy의 방사선 조사에서 사료의 조성분은 변화되지 않았다. 방사선 조사에 의한 초기 산패는 증가되었으며, BHA첨가에 따라 양어용 생어사료의 자연산패 및 방사선에 의한 초기산패는 억제되었으며 (p<0.05) 농림부에서 고시된 사료의 공정규격의 미량첨가 사료의 사용제한 범위 (300 ppm)내 에서도 충분한 산패억제 효과를 나타냈다.

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FPGA Design of High-Performance Memory Controller for Video Processing (비디오 처리를 위한 고성능 메모리 제어기의 FPGA 설계)

  • Noh, Hyuk-Rae;Seo, Young-Ho;Choi, Hyun-Jun;Kim, Dong-Wook
    • Proceedings of the Korean Society of Broadcast Engineers Conference
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    • 2010.07a
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    • pp.411-414
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    • 2010
  • 본 논문은 비디오 처리를 위한 고성능의 메모리 제어기를 설계하였다. 메모리 제어기는 arbiter에 의해 제어되며 이것은 메모리 억세스를 요구하는 모듈들의 요구 신호를 받아 데이터를 전송하는 역할을 해주게 된다. 구현된 메모리 제어기는 버스를 사용하기 위한 승인을 받기 위해서 마스터와 신호를 주고 받는 MAU블록, grant 신호를 디코딩하고 컨트롤 신호의 상태를 정의한 arbiter 블록, SDRAM의 ac parameter를 저장하고 bank의 준비 여부, read/write 가능 여부, precharge와 refresh의 가능 여부를 확인하여 system과 read/write가 준비되었다는 신호를 출력, SDRAM의 실질적인 입력신호를 생성하는 memory accelerator 블록, 생성된 입력신호를 저장하고 마스터에서 직접 write data를 입력 받는 memory I/F 블록으로 구성된다. 이 메모리 제어기는 174.28MHz의 주파수로 동작하였다. 본 설계는 VHDL을 이용하여 설계되었고, ALTERA의 Quartus II를 이용하여 합성하였다. 또한 ModelSim을 이용하여 설계된 회로를 검증하였다. 구현된 하드웨어는 StatixIII EP3SE80F1152C2 칩을 사용하였다.

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