• Journal of Microbiology and Biotechnology
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• 제32권4호
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• pp.504-513
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• 2022

Chitin deacetylase (CDA) inhibitors were developed as novel antifungal agents because CDA participates in critical fungal physiological and metabolic processes and increases virulence in soil-borne fungal pathogens. However, few CDA inhibitors have been reported. In this study, 150 candidate CDA inhibitors were selected from the commercial Chemdiv compound library through structure-based virtual screening. The top-ranked 25 compounds were further evaluated for biological activity. The compound J075-4187 had an IC50 of 4.24 ± 0.16 µM for AnCDA. Molecular docking calculations predicted that compound J075-4187 binds to the amino acid residues, including active sites (H101, D48). Furthermore, compound J075-4187 inhibited food spoilage fungi and plant pathogenic fungi, with minimum inhibitory concentration (MIC) at 260 ㎍/ml and minimum fungicidal concentration (MFC) at 520 ㎍/ml. Therefore, compound J075-4187 is a good candidate for use in developing antifungal agents for fungi control.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2327-2331
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• 2015

Purpose: To determine the accuracy of visual inspection with acetic acid (VIA) in detecting high-grade cervical intraepithelial neoplasia (CIN) in pre- and post-menopausal women with atypical squamous cells of undetermined significance (ASC-US) and low grade squamous intraepithelial lesion (LSIL) Papanicolaou (Pap) smears. Materials and Methods: Two hundred women (150 pre-menopausal and 50 post-menopausal) with ASC-US and LSIL cytology who attended the colposcopy clinic, Thammasat University Hospital, between March 2013 and August 2014 were included. All women underwent VIA testing and colposcopy by gynecologic oncologists. Diagnostic values of VIA testing including sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for detecting high-grade CIN were determined using the histopathology obtained from colposcopic-directed biopsy as a gold standard. Results: VIA testing was positive in 54/150 (36%) pre-menopausal women and 5/50 (10%) post-menopausal women. Out of 54 pre-menopausal women with positive VIA testing, 15 (27.8%) had high-grade CIN and 39 (72.2%) had either CIN 1 or insignificant pathology. Ten (10.4%), 43 (44.8%) and 43 (44.8%) out of the remaining 96 pre-menopausal women with negative VIA testing had high-grade CIN, CIN 1 and insignificant pathology, respectively. Out of 5 post-menopausal women with positive VIA testing, there were 4 (80%) women with high-grade CIN, and 1 (20%) women with insignificant pathology. Out of 45 VIA-negative post-menopausal women, 42 (93.3%) women had CIN 1 and insignificant pathology, and 3 (6.7%) had high-grade CIN. Sensitivity, specificity, PPV and NPV of the VIA testing were 59.4%, 76.2%, 32.2% and 90.8%, respectively (60%, 68.8%, 27.8% and 89.6% in pre-menopausal women and 57.1%, 97.7%, 80% and 93.3% in post-menopausal women). Conclusions: VIA testing may be used as a screening tool for detecting high-grade CIN in women with minor cervical cytological abnormalities in a low-resource setting in order to lower the rate of colposcopy referral.

• 한국가스학회지
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• 제10권1호
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• pp.32-37
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• 2006

원유정제 플랜트 주요 요소는 운전조건, 사용재료, 내부유체 등에 따라 다양한 열화 손상기구에 노출되므로, 그에 따른 적절한 검사기법 및 진단 방법을 적용하여야 한다. 따라서 원유정제 플랜트 요소에 발생하는 다양한 손상기구에 대한 대처 방안을 제시할 수 있는 정보를 제공할 수 있는 표준화된 데이터베이스를 확보하는 것이 필요하다. 이에 본 연구에서는 API기준에서 제시하는 손상 기구를 모두 포함하는 손상정보 시스템을 개발하였으며, 이를 기본으로 하여 향후 정보시스템을 확장할 수 있도록 시스템을 구성하였다. 시스템 내의 손상 정보 범위는 API기준 내의 컨텐츠를 반영할 수 있도록 하였으며, 미국 및 일본에서 사용하는 손상기구 검색표 방식을 도입하여 요소의 가동온도, 내부유체, 응력상태 등의 운전조건과 재질에 따른 손상기구를 파악할 수 있도록 하였다. 이 시스템은 기존의 RBI프로그램과 연동하여 사용할 수 있다.

• Nuclear Engineering and Technology
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• 제55권4호
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• pp.1485-1494
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• 2023

The bow of the nuclear fuel assembly is a well-known phenomenon. One of the vital criteria during the history of nuclear fuel development has been fuel assembly's mechanical stability. Once present, the fuel assembly bow can lead to safety issues like excessive water gap and power redistribution or even incomplete rod insertion (IRI). The extensive bow can result in assembly handling and loading problems. This is why the fuel assembly's bow is one of the most often controlled geometrical factors during periodic fuel inspections for VVER when compared e.g. to on-site fuel rod gap measurements or other instrumental measurements performed on-site. Our proposed screening method uses existing video records for fuel inspection. We establish video frames normalization and aggregation for the purposes of bow measurement. The whole process is done by digital image processing algorithms which analyze rotations of video frames, extract angles whose source is the fuel set torsion, and reconstruct torsion schema. This approach provides results comparable to the commonly utilized method. We tested this new approach in real operation on 19 fuel assemblies with different campaign numbers and designs, where the average deviation from other methods was less than 2 % on average. Due to the fact, that the method has not yet been validated during full scale measurements of the fuel inspection, the preliminary results stand for that we recommend this method as a complementary part of standard bow measurement procedures to increase measurement robustness, lower time consumption and preserve or increase accuracy. After completed validation it is expected that the proposed method allows standalone fuel assembly bow measurements.

• 한국산학기술학회논문지
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• 제22권6호
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• pp.314-320
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• 2021

최근 사회적으로 결혼연령이 높아짐에 따라 고령산모가 증가하면서 생화학적 표지물질을 이용한 다운증후군 선별검사는 산모들에게 필수적인 검사가 되었다. 다운증후군 임신을 진단하는 과정은 선별검사에서 고위험군으로 보고 되면 융모막 융모생검이나 양수검사 같은 침습적 검사를 통해 염색체 분석을 하는 단계로 진행이 되는데 이러한 확진검사는 비용이 많이 들고 태아손실의 위험도가 높다. 따라서 위험도는 낮고 다운증후군 발견율이 높은 선별검사를 선택하여 불필요한 침습적 검사를 줄여 산모와 태아의 위험도를 낮추는 것이 중요하다. 본 연구는 2018년 용인의 임상검사기관에 산전선별검사를 의뢰한 17세부터 46세까지 총 36,436명을 대상으로 triple test(185명), quad test(3,629명), integrated test(18,932명), sequential test(13,690명) 4가지 검사를 direct sandwich, indirect sandwich 기술을 이용한 Time-resolved fluoroimmunoassay 방법과 sandwich 방법을 이용한 면역측정 방법을 사용하여 35세 미만과 35세 이상 산모의 다운증후군 위험도를 분석하여 산모 연령이 증가함에 따른 양성률의 차이를 확인하였다. 검사결과 전체 산모의 다운증후군 고위험군은 triple test 36명, quad test 408명, integrated tset 1,441명, sequential test 924명 이었다. 이중 35세미만 산모의 고위험군은 triple test 7명(3.8%), quad test 141명(3.9%), integrated tset 644명(3.4%), sequential test 430명(3.4%)이었고, 35세이상 산모의 고위험군은 29명(15.7%), 267명(7.4%), 797명(4.2%), 494명(3.6%)으로 나타나 35세이상 산모가 훨씬 높은 고위험군을 나타내었다. 임상에 있어서 35세 미만과 35세 이상 산모의 위험도 분석을 한 연구는 국내외에 거의 희박하므로 본 연구는 향후 국내외의 많은 검사기관들과 예비 산모들에게 다운증후군 위험의 예방과 치료를 위한 매우 유용한 기초 자료가 될 것으로 생각된다.

• 대한의용생체공학회:의공학회지
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• 제12권2호
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• pp.89-98
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• 1991

This study is concerned on the automation for cell diagnosis which has better objectivity and speed of test than human beings. Diagnosis is on the basis of shape change of abnormal Cells. Used parameters are nucleus area, nucleus perimeter, nucleus shape, cytoplasm area, nucleus/cytoplsm ratio, which was obtained using image processing technics. A new mode method is proposed on the automatic threshold selection for superior process time compared with Otsu's. Contour of the cytoplasm of abnormal cell is obtained using me- dian filter and sorel operator. The mask to get only original shape of abnormal cells is formed uslng the contour filling algorithm. In the result the normal cells are separated from the abnormal cells and the abnormal cells can be distinguished through screwing of abnormal cell's image with reference data to judge abnormal cells. Owing to this study the number of inspections which the pathologists should examine will be decreased and the time for inspection will be shortened.

• 한국지반공학회논문집
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• 제20권7호
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• pp.15-24
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• 2004

본 논문은 1994 Northridge 지진에 의해 발생된 주거건물손상에 관하여 건물 교체시의 가격에 대한 상대적 수리비용의 개념으로 GIS기반의 손상평가에 관하여 기술하였다. 빌딩손상은 164개의 서로 다른 지역에서 얻어진 지진기록으로부터 유도된 지진매개변수와 빌딩위치 및 안전조사보고서를 바탕으로 평가하였다. 본 논문은 가장 심한 건물피해를 받은 위치를 규명하는 인식 알고리즘이 GIS를 통하여 개발되었다. 이러한 알고리즘은 지진 후 신속한 응급조치와 위성으로부터 얻어진 데이터를 짧은 시간에 분석할 수 있는 프레임을 제공한다.

• Earthquakes and Structures
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• 제11권5호
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• pp.873-885
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• 2016

Determination of earthquake-safety of existing buildings requires a rather long and challenging process both in terms of time and expertise. In order to prevent such a tedious process, rather rapid methods for evaluating buildings were developed. The purpose of these rapid methods is to determine the buildings that have priority in terms of risk and accordingly to minimize the number of buildings to be inspected. In these rapid evaluation methods detailed information and inspection are not required. Among these methods the Canadian Seismic scanning method and the first stage evaluation method included in the principles concerning the determination of risk-bearing buildings promulgated by the Ministry of Environment and Urbanization in Turkey are used in the present study. Within the scope of this study, six reinforced concrete buildings damaged in Van earthquakes in Turkey are selected. The performance scores of these buildings are calculated separately with the mentioned two methods, and then compared. The purpose of the study is to provide information on these two methods and to set forth the relation they have between them in order to manifest the international validity.

• 품질경영학회지
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• 제27권1호
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• pp.35-45
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• 1999

A process monitoring procedure using a correlated variable is presented when a lower specification limit is given on the performance variable. Every item is inspected with a variable correlated with the performance variable. When an item is rejected in the screening inspection, the process is checked for change using the mean and variance of measurements of the correlated variable for n preceding items including the rejected one. The performance variable is assumed to be normally distributed. A linear relationship between the performance and surrogate variables is assumed with normally distributed error term. The monitoring procedure is designed so that the prespecified outgoing quality can be attained.

• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.1907-1912
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• 2015

Purpose: The study was designed to: (1) investigate the prevalence of high-risk human papillomavirus (HR-HPV) infection and cervical neoplasia; and (2) evaluate clinical performance of visual inspection with acetic acid/ Lugol's iodine (VIA /VILI), Pap smear, high-risk human papillomavirus (HR-HPV) DNA test for detecting cervical intraepithelial neoplasia grade 2 or worse (CIN2+) and (3) explore appropriate screening approach in rural areas of Shandong Province. Materials and Methods: A total of 3,763 eligible women from Yiyuan County in Yimeng mountainous areas of rural Shandong, China, were enrolled and underwent Pap smear, HR-HPV DNA testing by Hybrid Capture 2 (HC2), and VIA /VILI tests. Women positive in any test were referred to colposcopy and biopsy as indicated. Results: The prevalence of HR-HPV infection among all enrolled women was 11.1% and that in healthy women was 9.9%. In total 33 cases of CIN1, 16 cases of CIN2, 6 cases of CIN3 but none of cervical cancer were detected and the crude prevalence of CIN2+ was 0.58%. For detecting CIN2+, the sensitivity of HR-HPV DNA testing, VIA/VILI, Pap smear was 90.9%, 77.3%, 81.8%, respectively. Pap smear had the best specificity of 98.2%, followed by HR-HPV DNA testing with specificity of 89.4%, VIA/VILI had the lowest specificity of 81.2%. Colposcopy referral rate of HR-HPV DNA testing, VIA/VILI, Pap smear was 11.1%, 18.5%, 2.3%, respectively. Conclusions: Our results suggest that HR-HPV DNA testing alone might be appropriate for primary cervical cancer screening in rural low-resource areas of Shandong Province, China.