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http://dx.doi.org/10.5762/KAIS.2021.22.6.314

Down syndrome in women aged more than 35 Years positive detection rates  

Oh, Taek Min (Department of Biomedical Laboratory Science, Graduate School, Dankook University)
Kim, Ga-Yeon (Department of Dental Hygiene, Dankook University)
Lee, Young ki (Department of Biomedical Laboratory Science, Graduate School, Dankook University)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.22, no.6, 2021 , pp. 314-320 More about this Journal
Abstract
With the increasing age of motherhood in recent years, attributed to late marriages due to social or environmental factors, the Down's syndrome screening test using biochemical markers has become essential for pregnant women. The process of diagnosing Down's syndrome pregnancy in the high-risk group subjects involves chromosomal analysis, which is performed on samples obtained through invasive procedures such as chorionic biopsy or amniotic fluid. Thus, to reduce unnecessary invasive tests and lower the risk to mother and fetus, it is important to identify a screening test with low risk and high Down's syndrome detection rate. Recently, as the average age of mothers has increased, numerous inspection agencies have classified high-risk mothers as women over the age of 35 years. This study evaluated a total of 36,436 pregnant women aged between 17 to 46 years, and who requested prenatal screening at an inspection agency in Yongin in 2018. Test (13,690 people) Four tests were conducted by applying the time-resolved fluoroimmunoassay method using the direct sandwich and indirect sandwich technology, and the immunoassay method using the sandwich method. We aimed to confirm the difference in positivity rate with increasing age of the subjects. We believe that in future, data obtained from this study will be very useful for the prevention and treatment of Down's syndrome risk at varied inspection institutions, and for prospective mothers.
Keywords
Down Syndrome; Prenatal Screening and Diagnosis; Pregnancy of Advanced Maternal Age; Integratred Test; Sequential Test;
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