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Effectiveness of Oral Glycopyrrolate Use in Compensatory Hyperhidrosis Patients

  • Gong, Tai Kyung;Kim, Do Wan
    • The Korean Journal of Pain
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    • 제26권1호
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    • pp.89-93
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    • 2013
  • Compensatory hyperhidrosis or reflex hyperhidrosis is the increase in sweating in the postoperative stage of thoracic sympathectomy or lumbar sympathectomy. It shares several features with anxiety disorders and has a negative impact on a patient's quality of life. Oralglycopyrrolate is one of the treatment options available. This study reviewed case notes in a series of 19 patients with compensatory hyperhidrosis. We made a comparison between the Milanez de Campos score of a pre-glycopyrrolate medication group and the Milanez de Campos score of a post-glycopyrrolate medication group. The Beck Depression Inventory (BDI) score, Beck Anxiety Inventory (BAI) score, and autonomic nervous system (ANS) scale score were also compared between the pre-medication and post-medication groups. In the post-glycopyrrolate medication group, there was decrease in the Milanez de Campos score, BAI score, and BDI score (P < 0.05). But no meaningful change was seen in the ANS score in the post-glycopyrrolate medication group (P > 0.05). Glycopyrrolate is an effective medication in the treatment of compensatory hyperhidrosis that, can alleviate anxiety and improve patients' quality of life.

뇌졸중환자의 어혈병태모형과 CAVI, 심혈관질환 위험도간의 상호관계에 관한 임상적 연구 (The Relationship among Blood-stasis, CAVI and Cardiovascular Risk in Stroke Patients)

  • 김석민;선종주;최창민;정재한;황재웅;민인규;김창현;정우성;문상관;조기호;배형석;김영석
    • 대한한방내과학회지
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    • 제28권3호
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    • pp.421-433
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    • 2007
  • Objectives : This study was performed to evaluate the relationships among blood-stasis. cardio-ankle vascular index(CAVI) and cardiovascular risk. Methods : We obtained general characteristics. blood-stasis score and CAVI from 150 stroke patients. Blood-stasis score was evaluated by blood-stasis criteria. Cardiovascular risk (the following. Stuart's risk score) was evaluated by Stuart's risk scoring scale. We divided subjects into a blood-stasis group and a non blood-stasis group by blood-stasis scores. high CAVI and normal CAVI groupsby CAVI. We compared the general characteristics. CAVI (excluded from comparison between high CAVI group and normal CAVI group), Stuart's risk score and blood-stasis score (excluded from comparison between blood-stasis group and non blood-stasis group) between each pair of groups. Pearson correlation analysis was applied to examine the relationship between blood stasis score and CAVI, blood stasis score and Stuart's risk score. CAVI and Stuart's risk score. Results : The blood-stasis group had significantly higher CAVI and Stuart's risk scores than the non blood stasis group. The high CAVI group had significantly higher blood-stasis score and Stuart's risk score than the normalCAVI group. In correlation analysis. there were significant positive relationship between blood stasis score and Stuart's risk score, CAVI and Stuart's risk score. and blood stasis score and CAVI. Conclusions : This study suggeststhat there is a significant relationship among blood stasis,CAVI and cardiovascular risk.

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단백질 서열정렬 정확도 예측을 위한 새로운 방법 (A new method to predict the protein sequence alignment quality)

  • 이민호;정찬석;김동섭
    • Bioinformatics and Biosystems
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    • 제1권1호
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    • pp.82-87
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    • 2006
  • 현재 가장 많이 사용되는 단백질 구조 예측 방법은 비교 모델링 (comparative modeling) 방법이다. 비교 모델링 방법에서의 정확도를 높이기 위해서는 alignment의 정확도 역시 매우 필수적으로 필요하다. 비교 모델링 과정 중의 fold-recognition 단계에서 alignment의 정확도에 의해 template을 고르는 방법은 단지 가장 비슷한 template을 선택하는 방법에 비해 주목을 받지 못하고 있다. 최근에는 두 가지의 alignment에 사이의 shift 정보를 바탕으로 한 shift score라는 수치가 alignment의 성능을 표현하기 위해서 개발되었다. 우리는 더 정확한 구조 예측의 첫걸음이 될 수 있는 shift score를 예측하는 방법을 개발하였다. Shift score를 예측하기 위해 support vector regression (SVR)이 사용되었다. 사전에 구축된 라이브러리 안의 길이가 n 인 template과 구조를 알고 싶은 query 단백질 사이의 alignment는 n+2 차원의 input 벡터로 변환된다. Structural alignment가 가장 좋은 alignment로 가정되었고 SVR은 query 단백질과 template 단백질의 structural alignment과 profile-profile alignment 사이의 shift score를 예측하도록 training 되었다. 예측 정확도는 Pearson 상관계수로 측정되었다. Training 된 SVR은 실제의 shift score와 예측된 shift score 사이에 0.80의 Pearson 상관계수를 갖는 정도로 예측하였다.

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성격검사 및 전산화신경심리검사를 활용한 사상체질별 성격, 인지 특성 연구 (A Study on the Personality Traits and Cognitive Characteristics of the Sasang Constitution by the Personality Test and Computerized Neuropsychological Test)

  • 김미선;안윤영;김락형
    • 동의신경정신과학회지
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    • 제28권4호
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    • pp.381-390
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    • 2017
  • Objectives: The purpose of this study is to study the personality traits and cognitive characteristics of the Sasang constitution by comparing the Personality Test and Neuropsychological Test. Methods: A total of 121 subjects were analyzed with the results of a Two Step Questionnaire for the Sasang Constitution Diagnosis (TS-QSCD). Among them, the Personality Tests (SPQ, EPQ, TCI) and the Neuropsychological Tests (A-VLT, CPM, Stroop-CWIT, WCST) were processed and analyzed for Soyangin, Taeeumin, Soeumin. Results: 1. In the results of the SPQ, the Soyangin showed a significantly higher score than did the Taeeumin and Soeumin in Behavior, Emotionality, Cognition, as well as the Total Score. The SPQ-C score and SPQ-T were significantly higher for Soyangin, Soeumin and Taeeumin, in that order. 2. In the results of the EPQ, the Soyangin showed a significantly higher score than did the Taeeumin and Soeumin in Extraversion - introversion. Soeumin showed a significantly higher score than did the Soyangin and Taeeumin in Neuroticism. Soyangin also showed a significantly higher score than Taeeumin in Venturesomeness. 3. For the results of the TCI, the Soyangin showed a significantly lower score than did Taeeumin and Soeumin in Harm-Avoidance, but a significantly higher score in Persistence and Self-Directedness. Soyangin and Taeeumin showed a significantly higher score than did Soeumin for the total score of Self-Directedness+Cooperativeness. 4. The results of the Computerized Neuropsychological Tests (A-VLT, CPM, Stroop-CWIT, WCST) showed no significant differences between the Sasang constitution. Conclusions: The EPQ, TCI score showed significant differences between the Sasang constitution. But the Computerized Neuropsychological Tests developed to evaluate cognitive abilities did not show differences between the constitutional individuals and showed limitations as a research tool. Further studies are needed to devise a research method for ascertaining the cognitive behavioral characteristics of the Sasang constitution.

질적간호 제공을 위한 간호업무 중요도에 관한 조사연구 (A Study on Degree of Importance in Nursing Activities for the Quality of Nursing)

  • 홍춘실;김종임
    • 대한간호학회지
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    • 제14권2호
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    • pp.19-27
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    • 1984
  • This study was carried out for the purpose of investigating the degree of importance in nursing activities for the quality of nursing, and was conducted with 72 nurses and 69 patients in Chungnam National University Hospital from January to April, 1984. The results are as follows; 1. The mean importants score in physical care activities of the patients (2.58) is higher than that of the nurses (2.48). There is not significant difference for the mean important score in physical care activities between the patients and nurses (t=0.637, df=139, p>0.05). 2. The mean important score in psychological aspects of activities of the patients (2.94) is higher than that of the nurses (2.44). There is a significant difference for the mean important score in psychological aspects of activities between the patients and nurses (t=2.338, df= 139, p<0.05). 3. The mean important score in observation, recording and implementing medical care activities of the nurses (2.98) is higher than that of the patients (2.79) There is not significant difference for the mean important score in observation, recording and Implementing medical care activities between the patients and nurses (t=1.329, df=139, p> 0.05) 4. The mean important score in nursing management activities of the nurses (2.63) is higher than that of the patients (2.57). There is not significant difference for the mean important score in nursing management activities between the patients and nurses (t=1.329, df=139, p>0.05). 5. A number of items in nursing activities considered most important by nurses (Mean important score of 3.0 or above) were 12 items. The most importants item was“shift and exchange of information concerning patient”. 6. A number of items in nursing activities considered most important by patients (mean important score of 3.0 or above) were 14 items. The most important item was“Explain about diagnostic test ahead of time”. 7. A number of items in nursing activities considered least important by nurses and patients(Mean important score less than 1.9) were 5 items and 2 items, respectively. The least important item by nurses was“plan some diversion or recreation for patient”, and the least important item by patients was“Give a bed shampoo”.

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초등학교 아동의 자아개념과 성별 및 학년에 따른 의복행동에 관한 연구 (A Study on the Relationship Between Self-Concept and Clothing Behavior of Elementary School Children)

  • 하선정;정미경
    • 한국가정과교육학회지
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    • 제13권3호
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    • pp.69-84
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    • 2001
  • The purpose of the present study is to investigate the relationship between self-concept and clothing behavior of elementary school children. For this purpose. 301 third and sixth graders two schools in Daegu-city were sampled. The \`Test of Self-Concept\` and \`Questionnaire on the Clothing Behavior\` were administered purpose of this study. The collected data were analyzed by the SPSS/PC Windows programs according to the research issues. Means and standard deviations were calculated and a three-way analysis of variance was applied to analyze the effects of grades, sex(gender) and self-concept on the clothing behavior. The major results of this study were as follows: 1. It was found that the mean score of the clothing behavior was significantly different depending the level of self-concept (group). The mean scores of manageability. psychological dependency interest and conformity of the high self-concept. group were significantly higher than those of the low self-concept group. But. there was no significant difference between the high and low self-concept groups in the mean score of comformity. 2. There were statistically significant differences between the sex of children in the mean score of the clothing behavior. It was found that the mean score of manageability, psychological dependency and interest of the female students were significantly higher than those of the male students. However the mean score of the comfortability of male students was significantly higher than that of the female students. In the meantime there was no significant difference between the sex of students in the mean score of comformity. 3. There were statistically significant differences in the mean score of the clothing behavior according to the graders of children . It was found that the mean scores of manageability, psychological dependency, interest and comfortability of the third graders were significantly higher those that of the sixth graders. But, there was no significant difference depending the grades of students in the mean score of conformity. 4. There were statistically significant interaction effects between the sex and the grade of children on the mean score of interest and comfortability. It was found that the mean score of interest of male third graders was higher than that of male sixth graders. The mean score of comfortability of the female third graders higher than that of sixth graders.

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Midazolam 진정요법 시 Bispectral index (BIS) Monitoring 효과의 평가를 위한 혈장농도, 진정지수(Sedation Score) 사이의 상관 관계 분석 (RELATIONSHIP BETWEEN BISPECTRAL INDEX (BIS), SEDATION SCORE AND PLASMA CONCENTRATION FOR EVALUATION OF MONITORING EFFECT OF BISPECTRAL INDEX IN MIDAZOLAM SEDATION)

  • 박은진;염광원;김은석;김현정
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • 제29권3호
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    • pp.169-172
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    • 2003
  • Purpose : We examined the relationship between BIS, sedation score and plasma midazolam concentration to verify the usefulness of BIS to assess the patient's consciousness during sedation. Patients and Methods : Twenty-five young, healthy adult volunteers participated in this clinical study. Midazolam was administered intravenously up to 0.08 mg/kg to induce unconsciousness and we monitored the patient's physiological and conscious status until complete recovery from sedation. BIS and sedation score were measured before sedation, 10, 20, 30 minutes after midazolam administration. Plasma midazolam concentration was measured 10 minutes after midazolam administration. BIS was measured using A-2000 BISTM monitor (Aspect Medical Systems, USA) and the degree of sedation was evaluated with the sedation score. Results : The BIS score correlated with the sedation score (r = 0.676; P < 0.05). With the decreased plasma midazolam concentration, the correlation was better with sedation score (r = -0.656). Although BIS values did not correlate with calculated plasma concentration of midazolam (r = 0.467) at 10 minutes after midazolam administration, values after sedation were well distinguished from those before sedation. Conclusions : BIS is known for an effective predictor of patient's hypnotic state, and it is correlated with the sedation score. But, it doesn't always coincide with the clinical parameters of depth of sedation. So more attention is needed using BIS only during sedation, and it is advisable that the patient's consciousness is monitored with variable sedation score systems every several minutes.

Associations of post-warming embryo or blastocyst development with clinical pregnancy in vitrified embryo or blastocyst transfer cycles

  • Hong, Yeon Hee;Lee, Jang Mi;Kim, Seul Ki;Youm, Hye Won;Jee, Byung Chul
    • Clinical and Experimental Reproductive Medicine
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    • 제47권2호
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    • pp.140-146
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    • 2020
  • Objective: To investigate whether the degree of post-warming embryo or blastocyst development is associated with clinical pregnancy in vitrified embryo or blastocyst transfer cycles. Methods: Ninety-six vitrified cleavage-stage embryos and 58 vitrified blastocyst transfer cycles were selected. All transfer cycles were performed from February 2011 to March 2019, and all vitrified embryos or blastocysts were warmed from 4 PM to 6 PM and then transferred the next morning from 9 AM to 10 AM. The scores of the cleavage-stage embryos and blastocysts were assessed at warming and at transfer using the modified Steer method and the Gardner method, respectively. The mean embryo or blastocyst score, score of the single top-quality embryo or blastocyst, and the difference in the score between warming and transfer were compared between nonpregnant and pregnant women. Results: In the cleavage-stage embryo transfer cycles, both the top-quality embryo score at transfer and the difference in the score between warming and transfer were significantly associated with clinical pregnancy. A top-quality embryo score at transfer of ≥ 60.0 (area under the curve [AUC], 0.673; 95% confidence interval [CI], 0.531-0.815) and a difference in the score between warming and transfer of ≥ 23.0 (AUC, 0.675; 95% CI, 0.514-0.835) were significant predictors of clinical pregnancy. In blastocyst transfer cycles, the top-quality blastocyst score at transfer was the only significant factor associated with clinical pregnancy. A top-quality blastocyst score at transfer of ≥ 38.3 was a significant predictor of clinical pregnancy (AUC, 0.666; 95% CI, 0.525-0.807). Conclusion: The top-quality embryo score at transfer and the degree of post-warming embryo development were associated with clinical pregnancy in vitrified cleavage-stage embryo transfer cycles. In vitrified blastocyst transfer cycles, the top-quality blastocyst score at transfer was the only significant factor affecting clinical pregnancy.

중환자실 욕창예방 프로그램 효과의 비교순위: 네트워크 메타분석 (Comparative Effects and Ranks of Pressure Ulcer Preventive Programs in Intensive Care Units: A Network Meta-analysis)

  • 고지운
    • 한국융합학회논문지
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    • 제12권12호
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    • pp.563-572
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    • 2021
  • 본 연구의 목적은 네트워크 메타분석 방법을 활용하여 중환자실 환자들의 욕창예방 중재의 비교효과와 순위를 평가하기 위하여 수행하였다. 네트워크 메타 분석은 R software의 "netmeta": 패키지를 이용한 빈도주의 방법을 이용하였다. 최종적으로 10편의 논문이 선정되었으며. 네트워크 메타 분석에 결과에 따른 욕창예방의 프로그램의 중재 간 비교우위는 욕창 표준중재와 비교하여 순위는 피부보호 용품 사용이(P-Score 85.3.%: OR=0.12, 95% CI: 0.03, 0.49) 가장 효과적일 확률이 높았으며 두 번째는 실리콘 폼 드레싱(P-Score 84.5%: OR=0.14, 95% CI: 0.05, 0.38)으로 나타났다. 그 다음으로는 통합중재 (P-Score 60.0%: OR=0.29, 95% CI: 0.07, 1.25), 체위변경 (P-Score 32.3%: OR=0.66, 95% CI: 0.21, 2.09) 그리고 마찰을 감소시킬 수 있는 직물의 사용(P-Score 23.8%: OR=0.85, 95% CI: 0.20, 3.65) 순이었다. 본 연구의 결과는 중환자실 욕창예방 프로그램의 효과적인 적용을 위한 정보를 제공 할 수 있을 것으로 생각된다.

사상체질에 따른 의사결정 및 학습 유형 (Decision Making Style and Learning Style according to Sasang Constitution)

  • 신은주
    • 동의신경정신과학회지
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    • 제20권4호
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    • pp.115-126
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    • 2009
  • Objectives : This study was performed to investigate the relationship between decision making style and learning style according to Sasang constitution. Methods : The subjects were 213 nursing students of K college in Jeonbuk, and the period of data gathering was limited from 1 Sep. 2009 to 7 Sep. 2009. The instrument tools included QSCC II, decision making style, and learning style. The collected data were analyzed by SPSS-PC programme. Results : 1. Decision making style: Soeumin group had significantly high score in rational score compared with Soyangin(F=7.174 p=.001), and in dependent score compared with Taeumin and Soyangin (F=3.414, p=.035). 2. Learning style: Soyangin group had significantly high score in cooperation score compared with Taeumin(F=5.688 p=.004), and Taeumin group had significantly high score in emulous score compared with Soeumin and Soyangin (F=.148, p=.002). Conclusions : In conclusion, it was found that decision making style and learning style are significantly different according to Sasang constitution. Therefore, these results suggest that nursing educational program needs to be developed considering Sasang constitution.

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