• Journal of Microbiology and Biotechnology
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• 제27권11호
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• pp.1961-1970
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• 2017

Lespedeza cuneata G. Don is a traditional herb that has been associated with multiple biological activities. In this study, we investigated the antioxidative/antiaging activities and performed an active component analysis of the non-fermented and fermented (using Lactobacillus pentosus) extracts of Lespedeza cuneata G. Don. The antioxidative activities of the fermented extract were higher than those of non-fermented extracts. The elastase inhibitory activity, inhibitory effects on UV-induced MMP-1 expression, and ability to promote type I procollagen synthesis were investigated in Hs68 human fibroblasts cells. These tests also revealed that the fermented extract had increased antiaging activities compared with the non-fermented extract. A component analysis of the ethyl acetate fractions of non-fermented and fermented extracts was performed using TLC, HPLC, and LC/ESI-MS/MS to observe changes in the components before and after fermentation. Six components that were different before and after fermentation were investigated. It was thought that kaempferol and quercetin were converted from kaempferol glucosides and quercetin glucosides, respectively, via bioconversion with the fermentation strain. These results indicate that the fermented extract of L. cuneata G. Don has potential for use as a natural cosmetic material with antioxidative and antiaging effects.

• 생약학회지
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• 제48권2호
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• pp.125-133
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• 2017

In this study, we investigated the total phenolic and flavonoid contents, component analysis, antioxidative activity and cellular protective effects against oxidative stress on human skin cells in 50% ethanol extract, ethyl acetate fraction and aglycone fraction obtained from Gynostemma pentaphyllum (G. pentaphyllum) Makino. The DPPH (1,1-diphenyl-2-picrylhydrazyl) scavenging activites ($FSC_{50}$) of the 50% ethanol extracts, ethyl acetate fraction and aglycone fraction were 246.8, 147.2, $128.9{\mu}g/mL$, respectively. Reactive oxygen species (ROS) scavenging activities ($OSC_{50}$) of the 50% ethanol extract, ethyl acetate fraction and aglycone fraction on ROS generated in $Fe^{3+}-EDTA/H_2O_2$ system using the luminol-dependent chemiluminescence assay were 37.15, 10.74, $7.19{\mu}g/mL$, respectively. We investigated the cellular protective activity and the results showed that treatment of aglycone fraction ($0.05-0.39{\mu}g/mL$) protect human skin cells in a concentration-dependent manner when the skin cell damages were induced by treating them with $H_2O_2$. These results suggest that extract/fractions of G. pentaphyllum Makino may be applicable as natural antioxidants in cosmetics.

• Journal of the Korean Data and Information Science Society
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• 제18권1호
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• pp.149-159
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• 2007

The main purpose of this paper is to develop a questionnaire creation system by expert co-operation on the web. The most difficult problem in a survey is to make questionnaires. To solve this problem, we suggest the questionnaire creation system which is to create questionnaire for survey by expert collaboration. We can create the best questionnaire because it can gather and exchange to questionnaire information from experts.

• 한국문헌정보학회지
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• 제42권4호
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• pp.181-199
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• 2008

본 연구는 실제 분류 시스템 개발자들의 행태를 이해하는 데 그 목적이 있다. 이를 위하여, 협력행태를 중심으로 협력의 유형, 협력에 영향을 미치는 요인, 협력이 분류 시스템 개발에 미치는 영향 등을 조사하였다. 또한 협력에 대한 이해가 분류 교육자, 연구자, 개발자에게 제공하는 의의를 논의하였다. 자료는 문헌조사, 현장인터뷰, 관찰법, 이메일의 방법을 통하여 수집되었다. 본 연구는 이미지 분류 시스템 개발팀을 대상으로 조사하였으며 사회과정모델을 연구의 프레임워크로 채택하였다.

• World Technopolis Review
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• 제7권1호
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• pp.59-70
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• 2018

Taiwan's economy has been characterized by the strong existence and continuous creation of small and medium-sized enterprises. This phenomenon is commonly regarded to be the result of a culturally embedded strong entrepreneurial spirit. In the process of developing a high-technology industry in southern Taiwan, linking a newly established science park with existing local industries was one of the major challenges. This article reviewed the development history of Tainan Technopolis. Following a concise review of Southern Taiwan Science Park's struggle against becoming an assembly of spillover establishments from Hsinchu Science Park, the authors focused on the efforts of incubating startups. Although only an initial study, the authors demonstrated the roles of National Cheng Kung University and Southern Taiwan Science Park Administration in introducing a two-track incubation system based on collaboration between the two institutions and startups.

• Journal of Microbiology and Biotechnology
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• 제29권1호
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• pp.21-29
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• 2019

The effects of Lavandula angustifolia extract fermented with Pediococcus pentosaceus DK1 on UVB-mediated MMP-1 expression and collagen decrease in human skin fibroblasts were determined, and the conversion of its components was also analyzed. Fermentation was performed at varying L. angustifolia extract and MRS medium concentrations, and optimal fermentation conditions were selected. L. angustifolia extracts showed decreased cytotoxicity after fermentation in the fibroblasts. UVB-irradiated fibroblasts treated with fermented L. angustifolia extract showed MMP-1 expression 8.2-14.0% lower than that in UVB-irradiated fibroblasts treated with non-fermented extract. This was observed even at fermented extract concentrations lower than those of non-fermented extracts. Fibroblasts treated with fermented L. angustifolia extract showed 20% less reduction in collagen production upon UVB irradiation than those treated with non-fermented extracts. UVB-irradiated fibroblasts treated with fermented L. angustifolia extracts showed 50% higher inhibition of ROS generation than those treated with non-fermented extract. Luteolin and apigenin glycosides of L. angustifolia were converted during fermentation, and identified using RP-HPLC and LC/ESI-MS. Therefore, the effects of L. angustifolia extract on MMP-1 expression and collagen decrease in UVB-irradiated human skin fibroblasts were increased through fermentation by P. pentosaceus.

• 유통과학연구
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• 제20권12호
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• pp.99-108
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• 2022

Purpose: This study attempted to identify determinants affecting research collaboration and R&D distribution activities, especially regarding facility and equipment leasing of small and medium enterprises (SMEs) in South Korea. The objective of this study was to find the most significant firm characteristics that affect firms participating in an R&D collaboration and distribution program and investing in R&D in terms of leasing payment for equipment. Research design, data, and methodology: This study analyzes which SMEs' characteristics influence external research cooperation activities by examining the SMEs that received government support for equipment leasing using multiple regression analysis and residual plots. The survey combined two databases: 1) a fact-finding survey of participating firms by the Ministry of SMEs and Startups, and 2) leasing information by the Korea Association of University, Research Institute and Industry. Results: The study found that firm size positively impacts R&D investment, R&D collaboration and distribution. Conclusions: The study provided evidence to policymakers and government officials that firms with more employees will more likely participate in government support programs. The study results also prove that government officials believe firm location does not impact R&D investment, R&D collaboration and distribution.

• 한국도서관정보학회지
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• 제48권1호
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• pp.191-206
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• 2017

본 연구는 국내 문헌정보학 분야의 연구협업의 특성을 기관 단위로 협업지수들을 활용하여 비교 분석 하였다. 학문 분야로서 문헌정보학 분야에서의 협업에 대한 연구는 국가 단위로 비교하는 연구는 몇몇 이루어졌으나, 단위 국가 내에서 일어나는 기관 단위 협업에 대한 연구는 많지 않다. 본 분석을 위해 KCI(Korea Citation Index) 웹사이트에서 주제별 분류를 통해 문헌정보학 분야에 해당하고 KCI에 등재된 8개의 저널들을 데이터로 선택하였다. CC(Collaborative Coefficient), CAI(Co-Authorship Index), Local Collaborative Index(LCI), Domestic Collaborative Index(DCI)의 협업지수를 통하여 문헌정보학 분야 기관 간 협업 패턴에 대해서 비교 분석하였다. 중앙대학교, 연세대학교, 이화여자대학교의 경우 대학교라는 기관 특성 상 공동 연구가 주로 교수와 대학원생 간의 협업, 교수들 간의 협업 형태로 많이 이루어지는 점이 반영되었다. 멀티, 메가 단위의 공동 저자 유형에서 매우 높은 지수를 나타낸 KISTI의 경우 연구소라는 기관의 특성이 반영된 것으로, 팀 단위로 프로젝트 성격의 공동 연구가 이루어지는 것이 보편적인 연구소의 특성이 영향요인으로 작용한 것으로 볼 수 있다.

• 한국경제지리학회지
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• 제25권3호
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• pp.339-356
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• 2022

본 연구는 창업과 기업 성장 기반이 취약한 비수도권 지역에서 지역대학의 우수한 연구·산학협력 역량을 기반으로 캠퍼스에 지역혁신생태계를 구축한 사례로서 일본의 홋카이도대학 리서치&비즈니스파크에 주목한다. 홋카이도대학 리서치&비즈니스파크는 캠퍼스 유휴부지를 활용하여 지역 주도로 중장기계획을 수립하고, 그에 따라 2003년부터 지금까지 점진적인 개발과정을 거쳐서 조성되고 있으며, 지역대학 특성화와 지역산업 기반을 고려한 바이오산업클러스터 구축이라는 산업적 접근 방식을 통해 산학협력 활성화를 추구하였다. 또한 지역 산학연관 협력적 거버넌스에 의해 다양한 기업지원 서비스를 제공한다. 이러한 홋카이도대학 리서치&비즈니스파크 조성전략은 최근 캠퍼스 혁신파크 등 대학 캠퍼스를 활용하여 지역의 발전을 도모하는 각종 정책 및 사업에 중요한 정책적 시사점을 제공한다.

• World Technopolis Review
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• 제4권1호
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• pp.2-10
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• 2015

This paper examines begins by examining the priorities of the different stakeholders in universities. It then lists some unique technology transfer models practiced by both universities and companies. This is followed by a discussion on the current models of universities and businesses, and science parks and universities. The paper then recommends a new model for science park university engagement that includes six initiatives to make science parks more relevant to universities.