• Journal of Microbiology and Biotechnology
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• v.27 no.11
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• pp.1961-1970
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• 2017

Lespedeza cuneata G. Don is a traditional herb that has been associated with multiple biological activities. In this study, we investigated the antioxidative/antiaging activities and performed an active component analysis of the non-fermented and fermented (using Lactobacillus pentosus) extracts of Lespedeza cuneata G. Don. The antioxidative activities of the fermented extract were higher than those of non-fermented extracts. The elastase inhibitory activity, inhibitory effects on UV-induced MMP-1 expression, and ability to promote type I procollagen synthesis were investigated in Hs68 human fibroblasts cells. These tests also revealed that the fermented extract had increased antiaging activities compared with the non-fermented extract. A component analysis of the ethyl acetate fractions of non-fermented and fermented extracts was performed using TLC, HPLC, and LC/ESI-MS/MS to observe changes in the components before and after fermentation. Six components that were different before and after fermentation were investigated. It was thought that kaempferol and quercetin were converted from kaempferol glucosides and quercetin glucosides, respectively, via bioconversion with the fermentation strain. These results indicate that the fermented extract of L. cuneata G. Don has potential for use as a natural cosmetic material with antioxidative and antiaging effects.

• Korean Journal of Pharmacognosy
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• v.48 no.2
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• pp.125-133
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• 2017

In this study, we investigated the total phenolic and flavonoid contents, component analysis, antioxidative activity and cellular protective effects against oxidative stress on human skin cells in 50% ethanol extract, ethyl acetate fraction and aglycone fraction obtained from Gynostemma pentaphyllum (G. pentaphyllum) Makino. The DPPH (1,1-diphenyl-2-picrylhydrazyl) scavenging activites ($FSC_{50}$) of the 50% ethanol extracts, ethyl acetate fraction and aglycone fraction were 246.8, 147.2, $128.9{\mu}g/mL$, respectively. Reactive oxygen species (ROS) scavenging activities ($OSC_{50}$) of the 50% ethanol extract, ethyl acetate fraction and aglycone fraction on ROS generated in $Fe^{3+}-EDTA/H_2O_2$ system using the luminol-dependent chemiluminescence assay were 37.15, 10.74, $7.19{\mu}g/mL$, respectively. We investigated the cellular protective activity and the results showed that treatment of aglycone fraction ($0.05-0.39{\mu}g/mL$) protect human skin cells in a concentration-dependent manner when the skin cell damages were induced by treating them with $H_2O_2$. These results suggest that extract/fractions of G. pentaphyllum Makino may be applicable as natural antioxidants in cosmetics.

• Journal of the Korean Data and Information Science Society
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• v.18 no.1
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• pp.149-159
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• 2007

The main purpose of this paper is to develop a questionnaire creation system by expert co-operation on the web. The most difficult problem in a survey is to make questionnaires. To solve this problem, we suggest the questionnaire creation system which is to create questionnaire for survey by expert collaboration. We can create the best questionnaire because it can gather and exchange to questionnaire information from experts.

• Journal of the Korean Society for Library and Information Science
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• v.42 no.4
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• pp.181-199
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• 2008

This study presents an empirical study of classification system design focused upon an image design team within an organizational setting. It aims to understand collaboration during design practice. Data was collected through on-site interviews, observations, and document and email reviews. This study uses social process model as a conceptual framework. The study revealed type of collaboration, factors influencing collaboration, influences of collaboration on design practice.

• World Technopolis Review
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• v.7 no.1
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• pp.59-70
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• 2018

Taiwan's economy has been characterized by the strong existence and continuous creation of small and medium-sized enterprises. This phenomenon is commonly regarded to be the result of a culturally embedded strong entrepreneurial spirit. In the process of developing a high-technology industry in southern Taiwan, linking a newly established science park with existing local industries was one of the major challenges. This article reviewed the development history of Tainan Technopolis. Following a concise review of Southern Taiwan Science Park's struggle against becoming an assembly of spillover establishments from Hsinchu Science Park, the authors focused on the efforts of incubating startups. Although only an initial study, the authors demonstrated the roles of National Cheng Kung University and Southern Taiwan Science Park Administration in introducing a two-track incubation system based on collaboration between the two institutions and startups.

• Journal of Microbiology and Biotechnology
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• v.29 no.1
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• pp.21-29
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• 2019

The effects of Lavandula angustifolia extract fermented with Pediococcus pentosaceus DK1 on UVB-mediated MMP-1 expression and collagen decrease in human skin fibroblasts were determined, and the conversion of its components was also analyzed. Fermentation was performed at varying L. angustifolia extract and MRS medium concentrations, and optimal fermentation conditions were selected. L. angustifolia extracts showed decreased cytotoxicity after fermentation in the fibroblasts. UVB-irradiated fibroblasts treated with fermented L. angustifolia extract showed MMP-1 expression 8.2-14.0% lower than that in UVB-irradiated fibroblasts treated with non-fermented extract. This was observed even at fermented extract concentrations lower than those of non-fermented extracts. Fibroblasts treated with fermented L. angustifolia extract showed 20% less reduction in collagen production upon UVB irradiation than those treated with non-fermented extracts. UVB-irradiated fibroblasts treated with fermented L. angustifolia extracts showed 50% higher inhibition of ROS generation than those treated with non-fermented extract. Luteolin and apigenin glycosides of L. angustifolia were converted during fermentation, and identified using RP-HPLC and LC/ESI-MS. Therefore, the effects of L. angustifolia extract on MMP-1 expression and collagen decrease in UVB-irradiated human skin fibroblasts were increased through fermentation by P. pentosaceus.

• Journal of Distribution Science
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• v.20 no.12
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• pp.99-108
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• 2022

Purpose: This study attempted to identify determinants affecting research collaboration and R&D distribution activities, especially regarding facility and equipment leasing of small and medium enterprises (SMEs) in South Korea. The objective of this study was to find the most significant firm characteristics that affect firms participating in an R&D collaboration and distribution program and investing in R&D in terms of leasing payment for equipment. Research design, data, and methodology: This study analyzes which SMEs' characteristics influence external research cooperation activities by examining the SMEs that received government support for equipment leasing using multiple regression analysis and residual plots. The survey combined two databases: 1) a fact-finding survey of participating firms by the Ministry of SMEs and Startups, and 2) leasing information by the Korea Association of University, Research Institute and Industry. Results: The study found that firm size positively impacts R&D investment, R&D collaboration and distribution. Conclusions: The study provided evidence to policymakers and government officials that firms with more employees will more likely participate in government support programs. The study results also prove that government officials believe firm location does not impact R&D investment, R&D collaboration and distribution.

• Journal of Korean Library and Information Science Society
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• v.48 no.1
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• pp.191-206
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• 2017

The purpose of this study is to compare the characteristics of research collaborations in the field of LIS. While there are several studies under the unit of analysis of country, there are only a few studies under the unit of analysis of institution in LIS field. For this analysis, we selected eight journals in the KCI (Korea Citation Index) web site, which correspond to the field of LIS through subject classification. The collaborative indices, Collaborative Coefficient, Co-Authorship Index, Local Collaborative Index (LCI), Domestic Collaborative Index (DCI) allowed us to comparatively analyze institutional collaboration patterns in LIS field. In the case of Chung-Ang University, Yonsei University, and Ewha Womans University, collaborative research among professors, graduate students, and professors reflected the fact that collaborations among universities are often performed with professors. In the case of KISTI, which showed a very high index value, the characteristics of project-based research are reflected in the research collaboration pattern.

• Journal of the Economic Geographical Society of Korea
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• v.25 no.3
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• pp.339-356
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• 2022

This study focuses on Hokkaido University Research & Business Park in Japan as an example of establishing a regional innovation ecosystem on campus based on the outstanding research and university-industry collaboration capabilities of local universities in non-metropolitan areas with weak foundations for start-ups and corporate growth. Hokkaido University Research & Business Park established a mid-to long-term plan using the idle sites on campus, and was developed through a gradual development process since 2003. The promotion of university-industry collaboration was pursued through an industrial-based approach of establishing a bio-industry cluster considering the characterization of local universities and the foundation of local industries. It also provides various corporate support services through cooperative governance between local industry, universities, research institutes and the government. This strategy for creating Hokkaido University Research & Business Park provides important policy implications for various policies and projects that promote regional development by utilizing university campuses like the campus innovation park project.

• World Technopolis Review
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• v.4 no.1
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• pp.2-10
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• 2015

This paper examines begins by examining the priorities of the different stakeholders in universities. It then lists some unique technology transfer models practiced by both universities and companies. This is followed by a discussion on the current models of universities and businesses, and science parks and universities. The paper then recommends a new model for science park university engagement that includes six initiatives to make science parks more relevant to universities.