• Molecules and Cells
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• v.37 no.3
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• pp.234-240
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• 2014

Cisplatin is one of the most potent chemotherapy agents. However, its use is limited due to its toxicity in normal tissues, including the kidney and ear. In particular, nephrotoxicity induced by cisplatin is closely associated with oxidative stress and inflammation. Heme oxygenase-1(HO-1), the rate-limiting enzyme in the heme metabolism, has been implicated in a various cellular processes, such as inflammatory injury and anti-oxidant/oxidant homeostasis. Capsaicin is reported to have therapeutic potential in cisplatin-induced renal failures. However, the mechanisms underlying its protective effects on cisplatin-induced nephrotoxicity remain largely unknown. Herein, we demonstrated that administration of capsaicin ameliorates cisplatin-induced renal dysfunction by assessing the levels of serum creatinine and blood urea nitrogen (BUN) as well as tissue histology. In addition, capsaicin treatment attenuates the expression of inflammatory mediators and oxidative stress markers for renal damage. We also found that capsaicin induces HO-1 expression in kidney tissues and HK-2 cells. Notably, the protective effects of capsaicin were completely abrogated by treatment with either the HO inhibitor ZnPP IX or HO-1 knockdown in HK-2 cells. These results suggest that capsaicin has protective effects against cisplatin-induced renal dysfunction through induction of HO-1 as well as inhibition oxidative stress and inflammation.

• Journal of Korean Association for Spatial Structures
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• v.12 no.2
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• pp.55-63
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• 2012

This study is about earthquake-proof reinforcement through structural function evaluation of an school building. The purpose of this study is to comparatively analyze structure reinforcement measures in consideration of safety and usability through structural function evaluation of school buididng, to offer rational measures for earthquake-proof function and to provide help in maintaining safe structures against earthquake. For this purpose, was selected for this study as an existing school building, earthquake-proof function evaluation was conducted, and measures to reinforce earthquake-proof function was offered. As for the research method, the first and the second earthquake-proof function evaluations were conducted which is an existing reinforced concrete school building. Through the abovementioned methods, earthquake-proof function evaluation were conducted, the results were analyzed and the measure to reinforce earthquake-proof function were offered(Steel damper, Carbon plate stiffeners). The offered measure to reinforce earthquake-proof function was applied to the subject structure, and comprehensive results were derived from earthquake-proof function evaluation regarding before and after earthquake-proof function reinforcement.

• Child Health Nursing Research
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• v.14 no.1
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• pp.61-70
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• 2008

Purpose: The purpose of this study was to investigate the relationship between high school students' self-differentiation, family function and their level of stress. Method: A questionnaire which consisted of questions on general characteristics of the high school students, and 36 questions on self-differentiation, 17 questions on family function, and 37 questions on level of stress was used to collect the data. Participants were 201 second grade high school students from Bucheon City. Descriptive statistics, T-test, ANOVA, correlation and multiple regression were used with SPSS 10.0 to analyze the data. Results: The mean scores for self-differentiation, family function, and levels of stress were 3.27, 3.39, and 2.61 respectively. The relationship between self-differentiation and level of stress revealed a significant negative correlation. The relationship between self-differentiation and family function showed a significant positive correlation. The relationship between family function and stress level showed a significant negative correlation. Conclusion: The results of the study show that variation in level of stress was related to family regression, recognition/emotional function, family projection, role recognition and emotional support and emotional cutoff which together explained 40.9% of the variance in level of stress.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.12
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• pp.4567-4583
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• 2021

This study proposes an analytical approximation algorithm based on extreme value theory (EVT) for the inverse of the power of the incomplete Gamma function. First, the Gumbel function is used to approximate the power of the incomplete Gamma function, and the corresponding inverse problem is transformed into the inversion of an exponential function. Then, using the tail equivalence theorem, the normalized coefficient of the general Weibull distribution function is employed to replace the normalized coefficient of the random variable following a Gamma distribution, and the approximate closed form solution is obtained. The effects of equation parameters on the algorithm performance are evaluated through simulation analysis under various conditions, and the performance of this algorithm is compared to those of the Newton iterative algorithm and other existing approximate analytical algorithms. The proposed algorithm exhibits good approximation performance under appropriate parameter settings. Finally, the performance of this method is evaluated by calculating the thresholds of space-time block coding and space-frequency block coding pattern recognition in multiple-input and multiple-output orthogonal frequency division multiplexing. The analytical approximation method can be applied to other related situations involving the maximum statistics of independent and identically distributed random variables following Gamma distributions.

• Molecules and Cells
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• v.37 no.1
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• pp.74-80
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• 2014

The peroxisome is an intracellular organelle that responds dynamically to environmental changes. Various model organisms have been used to study the roles of peroxisomal proteins in maintaining cellular homeostasis. By taking advantage of the zebrafish model whose early stage of embryogenesis is dependent on yolk components, we examined the developmental roles of the D-bifunctional protein (Dbp), an essential enzyme in the peroxisomal ${\beta}$-oxidation. The knockdown of dbp in zebrafish phenocopied clinical manifestations of its deficiency in human, including defective craniofacial morphogenesis, growth retardation, and abnormal neuronal development. Overexpression of murine Dbp rescued the morphological phenotypes induced by dbp knockdown, indicative of conserved roles of Dbp during zebrafish and mammalian development. Knockdown of dbp impaired normal development of blood, blood vessels, and most strikingly, endoderm-derived organs including the liver and pancreas - a phenotype not reported elsewhere in connection with peroxisome dysfunction. Taken together, our results demonstrate for the first time that zebrafish might be a useful model animal to study the role of peroxisomes during vertebrate development.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2004.04a
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• pp.349-352
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• 2004

In this literature, the selection of data set among the universe set is carried out with the fuzzy entropy function. By the definition of fuzzy entropy, we have proposed the fuzzy entropy function and the proposed fuzzy entropy function is proved through the definition. The proposed fuzzy entropy function calculate the certainty or uncertainty value of data set, hence we can choose the data set that satisfying certain bound or reference. Therefore the reliable data set can be obtained by the proposed fuzzy entropy function. With the simple example we verify that the proposed fuzzy entropy function select reliable data set.

• Journal of the Korean Institute of Intelligent Systems
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• v.14 no.5
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• pp.655-659
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• 2004

In this literature, the selection of data set among the universe set is carried out with the fuzzy entropy function. By the definition of fuzzy entropy, the fuzzy entropy function is proposed and the proposed fuzzy entropy function is proved through the definition. The proposed fuzzy entropy function calculate the certainty or uncertainty value of data set, hence we can choose the data set that satisfying certain bound or reference. Therefore the reliable data set can be obtained by the proposed fuzzy entropy function. With the simple example we verify that the proposed fuzzy entropy function select reliable data set.

• Structural Engineering and Mechanics
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• v.57 no.2
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• pp.281-294
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• 2016

The paper is devoted to study a mesh-free analysis method of structural elements of engineering structures based on B-spline Wavelet Basis Function. First, by employing the moving-least square method and the weighted residual method to solve the structural displacement field, the control equations and the stiffness equations are obtained. And then constructs the displacement field of the structure by using the m-order B-spline wavelet basis function as a weight function. In the end, the paper selects the plane beam structure and the structure with opening hole to carry out numerical analysis of deformation and stress. The Finite Element Method calculation results are compared with the results of the method proposed, and the calculation results of the relative error norm is compared with Gauss weight function as weight function. Therefore, the clarification verified the validity and accuracy of the proposed method.

• Human Ecology Research
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• v.53 no.1
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• pp.29-47
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• 2015

The purpose of this study is to conceptualize the definition of school readiness specific to the context of the Republic of Korea. The school readiness test can be used as basic data to enable early childhood educational institutes to determine the general readiness of preschoolers and provide support to fit individual characteristics. For this purpose, six stages of the school readiness development process were considered, that is, draft development, primary preliminary survey, primary expert verification, secondary expert verification, secondary preliminary survey, and main survey. In the main survey, tests were conducted using the school readiness final draft targeting 344 preschoolers living in Seoul and Gyeonggi-do. The item discrimination power analysis and factor analysis for the examination area and question area were also conducted. Consequently, a test tool was developed on the basic of the results obtained, consisting of 129 items in the five areas of knowledge, function, adaptation, tendency, and attitude. The knowledge area was divided into general, linguistic, and mathematical knowledge, and the function area into fine motor function, basic living ability, expressive function, and gross motor function. The adaptation area was classified into adaptation activity, separation anxiety, maladaptive behavior, and environment adaptation; the tendency area into learning tendency; others understanding, and individual tendency, and the attitude area into rule compliance and life habits.

• Journal of the Korean Institute of Oriental Medical Informatics
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• v.14 no.1
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• pp.1-18
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• 2008

The elementary idea of 'function-words' in Classical Chinese originates from Han dynasty. But because of the pictographic nature the methodology for 'content words' had been applied to the study on 'function words', ane the conditions had not changed until modern times. In grammar functions of the function-word syntactical, morphological in unit sentence were studied in this using the method of quantitative analysis for all the function-words appeared in ${\ll}$Hwang je nae gyung-Somun${\gg}$. In the previous studies about function word, many data were collected and analyzed diachronically. But those studies failed to examine function-words closed in connection with synchronic study. Besides, in the explain about relevant function-words also, the case which was made centering around exegetic explain was most. And in the case to explain the function-words have in unit sentence also, the explain only about some function-words is made, but the analysis about concrete function to have in syntactical system is being handled negligently. This study stands not only on the background df the traditional studies but also on the basis of the western grammar and linguistics, especially the descriptive grammar and linguistics, especially the descriptive grammar. ${\ll}$Hwang je nae gyung-Somun${\gg}$ is collect and recorded the mythology and special contents related to Daoism in the side of contents as what was written on the basis of the historical consciousness of individual in contents regardless of compilation system. The purpose of this study is to clarify how the role and function of fuction-words are being made in the composition of unit sentence which appeard in ${\ll}$Hwang je nae gyung-Somun${\gg}$ through synchronic grammar system.