• BMB Reports
• /
• 제43권4호
• /
• pp.257-262
• /
• 2010

The aim of work was to investigate changes of 7-ketocholesterol synthesis in alveolar macrophages in the dynamic of lung mechanical ventilation with injurious parameters. The goal of in vitro part of work was to observe influence of 7-ketocholesterol on iNOS and MIP1 $\beta$ production in bronchoalveolar lavage fluid (BALF) cells. We used 17 healthy domestic pigs randomly assigned into two treatment groups: group I with mechanical ventilation with physiological parameters; group II underwent injurious ventilation with high volume tidal (VT) and low positive end expiratory pressure (PEEP). Cells were analyzed for CYP27A1 protein and gene expression levels, 7-ketocholesterol production. In alveolar macrophages of group II, we obtained increase of production of CYP27A1 protein and 7-ketocholesterol, as well as the expression of the CYP27A1 gene at the 2nd hour of ventilation. In the in vitro experiments we show dose-dependent increase of MIP1 $\beta$ and decrease of CYP27A1, iNOS protein production after 7-ketocholesterol treatment.

• 설비공학논문집
• /
• 제18권2호
• /
• pp.112-121
• /
• 2006

To evaluate the performance of ventilation system properly, the correlations among the ventilation rate, indoor air-quality and cooling/heating load should be analysed. In this study, simulation tool to analyze the performance of ventilation system was developed. The simulation tool is based on the TRNSYS and some modules to calculate concentration of pollutants with the operation of ventilation system and to decide the signal of ventilation system were newly developed in this study. And these modules coupled with building load and heating/cooling simulation modules. To verify the validity of developed simulation tool, comparison study between simulation and field study were accomplished. As results, the simulation tool developed in this study can be used to predict the performance of ventilation system with accuracy.

• 설비공학논문집
• /
• 제19권2호
• /
• pp.142-148
• /
• 2007

The purpose of this study is to suggest the effective ventilation strategies and control methods that can minimize energy cost maintaining acceptable IAQ level in apartment house. The effects of the air-cleaning and heat-recovery ventilation system on IAQ under various operating conditions are investigated based on the experimental and CFD analyzed results. The results can be summarized as follows. (1) When a ventilator is not operated, the concentration of several pollutants may highly show in the house even though environment-friendly building materials are applied. Therefore, a mechanical ventilation system is required to obtain proper ventilation. (2) The pollutant concentration is noticeably deceased under air-cleaning/ventilation mode of air-clinic system, however, pollutant of kitchen is stagnant, because fresh air is not carried into the kitchen. (3) When air-clinic system is only equipped at master bedroom and living room, the system does not effectively deliver fresh air throughout the whole house, and then high pollutant concentration is obtained in each room. In contrast the average pollutant concentration meets the guideline when air-clinic system is installed at each room. (4) The air-cleaning/ventilation mode significantly affects on room ventilation in comparison with ventilation mode only.

• 한국산업보건학회지
• /
• 제29권3호
• /
• pp.343-350
• /
• 2019

Objectives: This study aims to identify whether ventilation conditions and their effectiveness can be significantly improved in an experimental chamber by increasing the mixing factor (K-Factor). Methods: In a chamber with a volume of $1m^3$, air velocity was measured at six different points with four roof fans in the upper part of the chamber being operated in order. The impact of the ventilation conditions was analyzed when the flow rates were increasing and the first inlet of the chamber was either open or closed. Smoke patterns were also observed at four corner points where ventilation was limited. Kruskal Wallis and Mann-Whitney tests were performed to compare air velocities measured in the chamber. Results: The air velocities measured at only the third point increased significantly from $0.03{\pm}0.03m/s$ (door open) and $0.05{\pm}0.06m/s$ (door closed) with two fans, $0.08{\pm}0.08m/s$ with three fans, and $0.09{\pm}0.09m/s$ with four fans operating (p<0.05). However, air velocities at the four corner points did not significantly increase. Smoke patters also showed that the open inlet of the chamber had no effect on improvement of ventilation conditions and effectiveness. Conclusions: In this study, the air velocities at six points in the chamber did not significantly increase despite the increase in the mixing factor and flow rates of ventilation in the controlled environment. Therefore, the inflow of outdoor air throughout an open inlet and installation of a forced ventilation system can potentially increase the indoor air velocity and improve ventilation condition without an increase in the mixing factor.

• 대한설비공학회:학술대회논문집
• /
• 대한설비공학회 2007년도 동계학술발표대회 논문집
• /
• pp.119-123
• /
• 2007

Ventilation performance in the storage hall of Janggyeongpan Jeon has maintained for more than 600 years. Janggyeongpan Jeon in Haein temple has window structure of bi-level ventilating opening which consists of upper and lower window. Also, different size and shape of windows are adopted for various locations of the hall. In the present study, to analyze effect of shape of windows on ventilation performance in the storage hall, various design alternatives were considered. Numerical analysis of ventilation in the storage hall was investigated under the same simulation condition except for the shape of windows. Through the comparison of numerical results for various window designs, it was evaluated that the current windows shape gives best ventilation performance.

• 설비공학논문집
• /
• 제17권10호
• /
• pp.914-921
• /
• 2005

In this study, the 1/20 reduced-scale experiment using Froude scaling were conducted to investigate the effect of longitudinal ventilation velocity on the burning rate in tunnel fires. The methanol pool fires with heat release rate ranging from 2.02 kW to 6.15 kW and the n-heptane pool fires with heat release rate ranging from 2.23 kW to 15.6 kW were used. The burning rate of fuel was obtained by measuring the fuel mass at the load cell. The temperature distributions were observed by K-type thermocouples in order to investigate smoke movement. The ventilation velocity in the tested tunnel was controlled by inverter of the wind tunnel. In methanol pool fire, the increase in ventilation velocity reduces the burning rate. On the contrary in n-heptane pool fire, the increase in ventilation velocity induces large burning rate. The reason for above conflicting phenomena lies on the difference of burning rate. In methanol pool fire, the cooling effect outweighs the supply effect of oxygen to fire plume, and in n-heptane pool vice versa.

• 설비공학논문집
• /
• 제19권11호
• /
• pp.770-775
• /
• 2007

Although these days application of heat recovery ventilation and improved kitchen ventilation system came into wide use in mixed-use residential buildings and exclusive residences, there are not enough ventilation systems except the local ventilation of kitchens and rest rooms. It is very important part to regulate and distribute correct air flow rate for controlling air change rate. The purpose of this study is to investigate the application of distributor at house ventilation system by comparing a duct system with out distributor and with distributor. The results of this study are as follows. (1) When using distributor though the size of duct diameter is reduced rapidly, the pressure loss doesn't rise largely. The pressure loss without distributor is 4.08 mmAq, the pressure loss with distributor 4.10 mmAq. (2) To use distributor can reduce materials of duct and secure enough ceiling space by reducing duct diameter. (3) Diameters and air flow paths of distributor on the design stage are important part for accurate air flow rate.

• 한국주거학회논문집
• /
• 제24권2호
• /
• pp.61-68
• /
• 2013

This study has the purpose to adapt IT technology on Window Type Ventilation System for the energy saving and providing of user-centered comfortable environment. This is Derived a look at the case of the window type ventilation system and researched its IT technology for reducing energy applied to the Green Home. This indicates a solution for the established Window Type Ventilation System which can not be satisfied with user's requirement by proposing Window Type Ventilation System applied to IT technology that makes it control the intelligent, combined indoor environment system and providing information. Also, it shows energy saving efficiency of Window Type Ventilation System applied to IT technology based on the model study, analysing the performance of air-conditioning and ventilation energy saving through the experiment to compare with the established Window Type Ventilation System. The result of this study has the significance that it suggests an alternative for energy saving of housing space.

• 국제초고층학회논문집
• /
• 제11권4호
• /
• pp.315-320
• /
• 2022

With the rapid development of urbanization the problems of pedestrian-level wind comfort and natural ventilation of tall buildings are becoming increasingly prominent. The velocity at the pedestrian level ($\overline{MVR}$) and variation of wind pressure coefficients $\overline{{\Delta}C_p}$ between windward and leeward surfaces of tall buildings were investigated systematically through numerical simulations. The examined parameters included building density ρ, height ratio of building α_H, width ratio of building α_B, and wind direction θ. The linear and quadratic regression analyses of $\overline{MVR}$ and $\overline{{\Delta}C_p}$ were conducted. The quadratic regression had better performance in predicting $\overline{MVR}$ and $\overline{{\Delta}C_p}$ than the linear regression. $\overline{MVR}$ and $\overline{{\Delta}C_p}$ were optimized by the NSGA-II algorithm. The LINMAP and TOPSIS decision-making methods demonstrated better capability than the Shannon's entropy approach. The final optimal design parameters of buildings were ρ = 20%, α_H = 4.5, and α_B = 1, and the wind direction was θ = 10°. The proposed method could be used for the optimization of pedestrian-level wind comfort and natural ventilation in a residential area.

• Architectural research
• /
• 제9권2호
• /
• pp.37-45
• /
• 2007

The proliferation of the House Dust Mite(HDM) is affected by temperature, humidity, ventilation, etc. Measuring temperature and humidity was performed at the very location where dust samplings take place and where they live in reality together with temperature and humidity of the ambient of the room. There has been discussion over the key environment factor of HDM survival; absolute humidity or relative humidity. It seems that relative humidity is the more important determinant for the mite's survival through the analysis of previous studies. Temperature, humidity, ventilation rate and Der P1 were measured in 4 flats in London. Mite allergen was detected in every house. Levels of Der P1 varied between <100ng/g and 22,778ng/g. Flats with high relative humidity(>50%) and poor ventilation(<0.5ach) showed higher levels of mite allergen than flats with lower humidity and adequate air change rate. Questionnaire survey was conducted and the result helped to confirm the findings from monitoring of environmental factors and the dust sampling.