• 동의생리병리학회지
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• 제23권5호
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• pp.950-957
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• 2009

The purpose of this study was to develop generalized validity evaluation indexes for the Sasang type diagnostic test. As a generalized evaluation index for Sasang type diagnostic test, Generalized Squared Correlation (GC2), Mutual Information (I) and Mutual Information Coefficient (IC) as overall validity index, and Correlation Coefficient (C) and Mutual Information Contribution (ID) as type-specific validity index were suggested and the practicability of these indexes was assessed along with Percentage Correctly Predicted (PCP), adjusted PCP, type-specific sensitivity and type-specific specificity which was proposed previously. The usefulness of the nine validity indexes was examined using previously reported data and three mock Sasang type diagnosis results. We demonstrated here that the PCP is not adequate for the analysis of validity. We also showed that our validity index is recommendable for the comparison and improvement of Sasang type diagnosis. The generalized validity analysis of Sasang type diagnosis can provide a guideline for the development of new Sasang type diagnosis or pattern identification. The working sheet for calculating validity indexes can be acquired at http://www.sasangtypology.org/validity.

• 대한약리학회지
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• 제32권2호
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• pp.177-188
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• 1996

The effects of cytokines on the growth and differentiation of glial cells in culture were evaluated to confirm that cytokines could modify the number and function of glial cells. Proliferation of glial cells was determined by the $^3H-thymidine$ uptake and the double immunostain with anti-cell specific marker and anti-bromodeoxyuridine(BrdU) antibody. To check the effect on the differentiation of glial cells, the amount of glial fibrillar acidic protein(GFAP) and the activity of glutamine synthetase(GS) were measured in astrocytes. And also the amounts of myelin basic protein(MBP) and the activity of 2',3'-cyclic nucleotide phosphohydrolase(CNPase) were measured in oligodendrocytes. Among the cytokines used, only interleukin-$1{\beta}(IL-1{\beta})$ stimulated the growth of type 1 and type 2 astrocyte as well as 0-2A precursor cell. When the functional changes in these glial cells by cytokines were tested, $IL-1{\beta}$ did not increase GFAP content in type 1 and type 2 astrocyte, but $IL-1{\beta}$ increased GS activity in type 1 astrocyte, and slightly decreased this enzyme activity in type 2 astrocyte. Also interleukin-2(IL-2) and $interferon-{\gamma}$ $(IFN-{\gamma})$ inhibited the activity of GS in type 1 and type 2 astrocyte. On the other hand, all cytokines used did not modify the growth and differentiation in oligodendrocytes. From these results we could suggest that $IL-1{\beta}$ increases the growth of type 1 and type 2 astrocyte and also promotes the development for 0-2A precursor cell to type 2 astrocyte.

• 대한치과교정학회지
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• 제47권3호
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• pp.195-206
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• 2017

Facial asymmetry can be classified into the rolling-dominant type (R-type), translation-dominant type (T-type), yawing-dominant type (Y-type), and atypical type (A-type) based on the distorted skeletal components that cause canting, translation, and yawing of the maxilla and/or mandible. Each facial asymmetry type represents dentoalveolar compensations in three dimensions that correspond to the main skeletal discrepancies. To obtain sufficient surgical correction, it is necessary to analyze the main skeletal discrepancies contributing to the facial asymmetry and then the skeletal-dental relationships in the maxilla and mandible separately. Particularly in cases of facial asymmetry accompanied by mandibular yawing, it is not simple to establish pre-surgical goals of tooth movement since chin deviation and posterior gonial prominence can be either aggravated or compromised according to the direction of mandibular yawing. Thus, strategic dentoalveolar decompensations targeting the real basal skeletal discrepancies should be performed during presurgical orthodontic treatment to allow for sufficient skeletal correction with stability. In this report, we document targeted decompensation of two asymmetry patients focusing on more complicated yaw-dependent types than others: Y-type and A-type. This may suggest a clinical guideline on the targeted decompensation in patient with different types of facial asymmetries.

• Biomolecules & Therapeutics
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• 제26권5호
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• pp.439-445
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• 2018

T-type calcium channels are low voltage-activated calcium channels that evoke small and transient calcium currents. Recently, T-type calcium channels have been implicated in neurodevelopmental disorders such as autism spectrum disorder and neural tube defects. However, their function during embryonic development is largely unknown. Here, we investigated the function and expression of T-type calcium channels in embryonic neural progenitor cells (NPCs). First, we compared the expression of T-type calcium channel subtypes (CaV3.1, 3.2, and 3.3) in NPCs and differentiated neural cells (neurons and astrocytes). We detected all subtypes in neurons but not in astrocytes. In NPCs, CaV3.1 was the dominant subtype, whereas CaV3.2 was weakly expressed, and CaV3.3 was not detected. Next, we determined CaV3.1 expression levels in the cortex during early brain development. Expression levels of CaV3.1 in the embryonic period were transiently decreased during the perinatal period and increased at postnatal day 11. We then pharmacologically blocked T-type calcium channels to determine the effects in neuronal cells. The blockade of T-type calcium channels reduced cell viability, and induced apoptotic cell death in NPCs but not in differentiated astrocytes. Furthermore, blocking T-type calcium channels rapidly reduced AKT-phosphorylation (Ser473) and $GSK3{\beta}$-phosphorylation (Ser9). Our results suggest that T-type calcium channels play essential roles in maintaining NPC viability, and T-type calcium channel blockers are toxic to embryonic neural cells, and may potentially be responsible for neurodevelopmental disorders.

• 디지털융복합연구
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• 제14권10호
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• pp.455-461
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• 2016

본 연구는 장애학생의 학교생활적응에 미치는 영향 요인을 분석함으로써 장애 아동 및 청소년들이 학교생활에 잘 적응하도록 돕기 위한 방안을 수립하는 데 필요한 기초자료를 제공하는 것을 목적으로 하고 있다. 이를 위해 보건복지부에서 실시한 2014년 장애인실태조사 원자료를 분석자료로 하여, 초등학교, 중학교, 고등학교에 재학 중인 학생 197명을 대상으로 학교급별, 학교유형, 장애유형, 장애정도, 주관적건강상태, 차별경험 등 학교 및 장애 특성요인이 학교생활 적응에 영향을 미치는 지를 검증하고자 집단 간 평균비교 및 다중회귀분석 등을 실시하였다. 분석결과 학교급별, 학교유형, 장애정도 등이 장애학생의 학교생활 적응에 영향을 미치는 것으로 나타났다. 따라서 장애학생의 학교생활 적응을 돕기 위한 또래지원 프로그램 도입, 특수학급 증설, 보조인력, 제도적 보완 등이 필요하다.

• 한국학교보건학회지
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• 제22권2호
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• pp.1-11
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• 2009

Purpose : The purpose of this study was to examine aggression of middle school girls with type of school and gender role identity. Method : The subjects of this study were 526 second-year middle school girls (265 girls in the coeducational middle schools, 261 girls in the girls' middle schools) in Busan. This study was conducted from 14th to 29th of December, 2008 using Korean Sex Role Inventory(KSRI) and Aggression Inventory. Results : 1. There was statistically significant difference in gender role identity types according school types ($x^2$=8.813, p=.032). 2. The whole aggression grade point average was 1.58${\pm}$.40 points(highest score: 4), and reactive-overt aggression was highest in the aggression types(2.06${\pm}$.63). 3. There was not statistically significant difference in aggression of middle school girls according to type of school (t=.188, p=.664). 4. There was statistically significant difference in degrees of aggression according to gender role identity types. The degrees of aggression in masculinity type was highest [grade point average was 1.70${\pm}$.44 points(highest score: 4)]. 5. There was not interactive effect in aggression between type of school and type of gender role identity. Conclusions : The findings of this study contribute to providing basic data for development of education programs or activities for middle school girls to relieve aggression according to gender role identity types.

• 한국의류학회지
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• 제24권3호
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• pp.345-352
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• 2000

The purpose of this study was to classify lower body types of elementary school girls. The subjects for anthropometric study were 368 girls aged from 10 to 11. Factor analysis, cluster analysis, discriminant analysis, and analysis of variance were performed for statistical analysis of the data. Four lower body construction factors were extracted by the factor analysis of antropometric measurements. The factors extracted were lower body fatness factor, lower body height factor, lower body length from the waist to the crotch factor, and lower body configuration factor. On the basis of the cluster analysis, three different lower body types were categorized. Type 1 was short and small sized type and 42.4% of subjects belonged under this type. Type 2 was tall and fat type and 22.3% of subjects belonged under this type. Type 3 was the most similar to the average type having the largest waist-hip drop value and 35.3% of subjects belonged under this type. Discriminant analysis showed 7 discriminant factors that can classify the children's lower body type were Rohrer's index, height, fibulae length, waist girth, ilio cristale girth, trochanter girth, and weight.

• 한국의상디자인학회지
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• 제21권3호
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• pp.13-24
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• 2019

Adolescence is a transitional stage of physical development which occurs during the period from puberty to adulthood. Going through this period, various parts of an adolescent's body grow at different rates, leading to different body shapes and proportions when compared to adults. Therefore, this study aimed to investigate the body sizes and shapes of junior high school boys from ages 13-15 based on body measurement items that are used as the basis for school uniform designs including jackets, shirts, and pants. For this, the study sought the basic data needed to develop body shapes and school uniform patterns for junior high school boys using the data from the 6th Size Korea Survey (2010). Specifically, it provided basic data for the development of school uniform patterns that fit well through the classification of bodies into particular types. After extracting body shape componen a cluster analysis using ANOVA was performed. According to the factor analysis conducted to determine body shape components, 5 factors were obtained as follows: Factor 1: bulk and horizontal size, Factor 2: body height and length, Factor 3: shoulder shape and length, Factor 4: characteristics of horizontal size, Factor 5: shape of the upper body with a variance of 82.62%. To classify junior high school boys' body shape was determined using various characteristics, and a cluster analysis was performed with the variables obtained by the factor analysis. For this, body shapes were classified into 3 different types: Type 1 accounted for 33.4%, with a total of 463 subjects. This type was a tall, long body individual with the smallest bulk and size. Type 2 accounted for 22.7%, with a total of 315 subjects. This type was large in bulk and horizontal size, but the lowest in height and length. Type 3 accounted for 43.9%, with a total of 610 subjects. This type was close to average in terms of horizontal size, length, and height. To develop well-fitting school uniforms for junior high school students, there should be further studies on changes in body shape and their associated causes. The study results will be available as basic data for comparing branded school uniform patterns for junior high school boys and developing school uniform patterns based on body shape, using 3D virtual clothing simulations.

• 한국아동복지학
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• 제59호
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• pp.209-234
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• 2017

본 연구는 학업중단의 원인을 학교로 보고, 고등학생의 학업중단이 학교마다 학교특성과 학업중단의 영향요인이 다를 것으로 보았다. 이에 학교에 초점을 맞춰 전국 고등학교의 학업중단 추세를 확인하고, 고등학교 학업중단의 변화양상에 따른 유형을 종단적으로 탐색하였다. 그리고 도출된 유형별로 학교의 일반적 특성을 예측하고, 학업중단에 영향을 미치는 주요 요인(학교폭력, 학교상담)의 변화 추이를 살펴보면서 학업중단에 대한 학교의 장기간의 노력과 결과를 되짚어 보았다. 이를 위하여 KERIS EDSS의 "중등학교 정보공시데이터"를 활용하였고, 연구에서는 2012년부터 2016년까지 전국 고등학교의 5년 간 자료를 최종 모형에 투입 분석하였다. 연구는 네 가지 목적에 의해 수행되었고, 그에 따른 결과는 다음과 같다. 첫째, 고등학교의 학업중단에 대한 종단적인 변화양상을 탐색하기 위하여 잠재성장모형으로 분석한 결과, 시간이 지날수록 전국 고등학교의 학업중단은 감소하는 추세를 보였다. 둘째, 고등학교의 학업중단 변화양상에 따른 유형을 성장혼합모형으로 분석한 결과, 학업유지형, 학업중단감소형, 학업중단지속형과 같은 3가지 유형이 도출되었다. 셋째, 도출된 유형별 학교의 일반적 특성을 다항로지스틱 분석으로 예측한 결과에서는 국공립일수록, 전문계고일수록, 국영수 기초학력미달 학생 수가 많을수록 학업중단지속형에 속할 확률이 높았고, 전체학생 수가 많을수록 학업유지형이나 학업중단감소형에 속할 가능성이 높은 것으로 나타났다. 마지막으로 도출된 세 유형별로 학교폭력과 학교상담의 변화추이를 다 집단 성장혼합모형으로 분석한 결과에서 특히 학업중단감소형의 추이가 주목된다. 학업중 단감소형은 초기에 높았던 학교폭력 심의건수와 가해학생 수가 시간이 지날수록 매년 감소하는 양상을 보였고, 이와 함께 학교의 전문상담교사 배치수를 매년 늘리고, 또래상담을 지속적으로 활성화시켰음을 확인하였다. 이러한 점이 초기 학업중단이 가장 높았던 고등학교가 학업중단감소형 학교가 된 이유일 것으로 사료된다.

• Journal of Advanced Marine Engineering and Technology
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• 제33권1호
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• pp.52-61
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• 2009

This experiment was conducted in attempt of improving hydrodynamic efficiency of the propulsion mechanism by installing a spring to the wing so that the opening angle of the wing in one stroke can be changed automatically, compared to the existing method of fixed maximum opening angle in Weis-Fogh type ship propulsion mechanism. Average thrust coefficient was almost fixed with all velocity ratio with the prototype, but with the spring type, thrust coefficient increased sharply as velocity ratio increased. Average propulsive efficiency was larger with bigger opening angle in the prototype, but in the spring type, the one with smaller spring coefficient had larger value. In the range over 1.0 in velocity ratio where big thrust can be generated, spring type had more than twice of propulsive efficiency increase compared to the prototype.