• Tuberculosis and Respiratory Diseases
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• v.62 no.5
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• pp.406-416
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• 2007

Background: Single nucleotide polymorphisms (SNPs), which consist of a substitution of a single nucleotide pair, are the most abundant form of genetic variations occurring with a frequency of approximately 1 per 1000 base pairs. SNPs by themselves do not cause disease but can predispose humans to disease, modify the extent or severity of the disease or influence the drug response and treatment efficacy. Single nucleotide polymorphisms (SNPs), particularly those within the regulatory regions of the genes often influence the expression levels and can modify the disease. Studies examining the associations between SNP and the disease outcome have provided valuable insight into the disease etiology and potential therapeutic intervention. Traditionally, the genotyping of SNPs has been carried out using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP), which is a low throughput technique not amenable for use in large-scale SNP studies. Recently, TaqMan real-time PCR chemistry was adapted for use in allelic discrimination assays. This study validated the accuracy and utility of real-time PCR technology for SNPs genotyping Methods: The SNPs in promoter sequence (-37 and -524) of lung cancer suppressor gene, RRM1 (ribonucleotide reductase M1 subunit) with the genomic DNA samples of 89 subjects were genotyped using both real-time PCR and PCR-RFLP. Results: The discordance rates were 2.2% (2 mismatches) in -37 and 16.3% (15 mismatches) in -524. Auto-direct sequencing of all the mismatched samples(17 cases) were in accord with the genotypes read by real-time PCR. In addition, 138 genomic DNAs were genotyped using real-time PCR in a duplicate manner (two separated assays). Ninety-eight percent of the samples showed concordance between the two assays. Conclusion: Real-time PCR allelic discrimination assays are amenable to high-throughput genotyping and overcome many of the problematic features associated with PCR-RFLP.

• The Journal of Korean Academy of Sensory Integration
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• v.18 no.1
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• pp.44-55
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• 2020

Objective : This study used the data of the National Statistical Office to analyze the time use of disabled youth and their self-satisfaction with it by their type of occupation. Methods : Using raw data extracted from Statistics Korea, 84 disabled youth from 10 to 24 years old were re-classified into six occupational areas based on Occupational Therapy Practice Framework (OTPF)-3. The occupational types were classified according to the time use by individuals based on data from Statistics Korea. Finally, according to the type of occupation, self-satisfaction with the use of time was identified. Results : The total amount of time spent by disabled youths was the largest in the rest and sleep categories, followed by daily living, education, leisure, social participation, and play. The analysis of occupational types showed that the groups were turned around (10.71% of participants), high activity group (50.00%), low activity (28.57%), and balanced (10.71%). There were significant differences between types in the first five of the aforementioned categories. There was no significant difference in the lack of time use, but there was a significant difference among their satisfaction with their use of time. The balanced type (21.53%) reported the most satisfaction. inadequacy Conclusion : The purpose of the project was to provide the raw data of intervention activities that can improve the quality of life and health of disabled youth. By analyzing their time use and occupations, deficiencies in time management and their satisfaction with their use of time can be noted.

• The Journal of Korean Academy of Sensory Integration
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• v.9 no.2
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• pp.15-28
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• 2011

Objective : The purpose of the study was to investigate effects of sensory integration therapy on self-regulation capacities of children with cerebral palsy. Methods : Subjects of this study were four years old girl and six years old boy, living in P city. Both were diagnosed as diplegia. Research design used in this study is ABA' design for a single-subject research. The experimental period was 12 weeks with 22 sessions of treatment. It was divided into three phase: 6 sessions for baseline phase (A), 14 sessions for treatment phase (B), 2 sessions for baseline phase (A'). There was no treatment on the baseline phases, and sensory integration therapy focused vestibular and proprioceptive stimuli was conducted on the treatment phase. At each session, subjects' behaviors has been recorded with a Digital Camera for 10 minutes and then the occurrence frequency of problematic behavior was identified based on the operational definition of it. Results : In comparison with the baseline phase (A), the occurrence frequency was reduced during the treatment phase for three types of problematic behavior associated with the self-regulatory capacities. The tendency of reducement was maintained during baseline phase (A'). Conclusion : Based on the result, it was implied that sensory integration therapy has a positive effect on the self-regulation capacities in children with cerebral palsy.

• Journal of Korean Physical Therapy Science
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• v.8 no.2
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• pp.977-987
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• 2001

The purpose of this study was to examine the effects of sensory integration therapy (SIT) on sensory' motor development and adaptive behavior of cerebral palsy children. The design of this study was quasi experiments with a non-equivalent pre- and post-test control design. Subjects of the study were arbitrarily chosen based on predetermined selection criteria among the cerebral palsy children who were treated as out-patients at two rehabilitation hospitals one in Seoul, and the other in Kyunggi-do. The study was conducted between early April and late July in 2000. Fifteen children were in the experimental group and eleven in the control group. The allocation was done based on ease of experimental treatment. A five-step SIT program was devised from a combination of SIT programs suggested by Ayres(1985) and Finks(1989), and an author-designed SIT program for cerebral palsy children. The experimental group was subjected to 20 to 30 minutes of SIT per session. two sessions a week for ten -week period. The effects of SIT were measured with respect to 9 sub-areas that can be administered to cerebral palsy children out of a total of 17 sub-areas in the Southern California Sensory Integration Test (SCSIT) developed by Ayres (1980). In addition. the scale developed by Russell (1993) for Gross Motor Function Measure (GMFM). and Perception Motor Development Test developed by 中司利一 et al.(1987) were also applied. Adaptive behavior was analyzed using guidelines in two unpublished documents - School-Age Checklist for Occupational Therapy by the Wakefield Occupational Therapy Associates, and the OTA-Watertown Clinical Assessment by the Watertown Occupational Therapy Associates-, and an author-developed Adaptive Behavior Checklist. Collected data were statistically analyzed by SPSS PC for chi square test, Mann-Whitney test, Wilcoxon signed rank test, and paired t-test. The results were as follows: 1. In sensory development, the experimental group exhibited a score increase compared to the control group, but the difference was not statistically significant, Although the experimental group showed improvements in all. 9 sub-areas compared to the control group, only right-left discrimination exhibited statistically significant change. 2. In gross motor development, the experimental group showed improvements in score compared to the control group, but it was not statistically significant. In fine motor development, the experimental group exhibited statistically significant improvements compared to the control group. In sub-area analysis, figure synthesis showed positive change. 3. In adaptive behavior development, post-experimental adaptive behavior scores were higher compared to pre-experimental scores with statistical significance. Furthermore, sub-areas emotional behavior, perception behavior, gross-fine motor function, oral-respiration function, motor behavior, motor planning, and adaptive response exhibited higher scores after SIT. In conclusion SIT was found to be partially effective in sensory and fine motor development, effective in all adaptive behavior areas, and not effective in gross motor development. Thus, this study has shown that SIT is an effective intervention for sensory development, fine motor development, and adaptive behavior for cerebral palsy children. But, for the effectiveness of SIT on gross motor development, further studies employing longer-time experiments are recommended.

• Journal of Korean Medicine Rehabilitation
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• v.24 no.2
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• pp.107-114
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• 2014

Objectives The purpose of this study is analyzing internal research trends of oriental obesity pattern identification in korean literature based on obesity pattern identification questionnaires, development and application of Pattern Identification System to help solve problems of future researches. Methods 6 Korean databases were searched for articles of oriental obesity pattern identification, irrespective of publication year and 13 studies were reviewed. An analytical method such as descriptive statistics and an actual number and percentage was used. Results We collected 13 studies. 4 studies were published in 2012 and 2008, the highest number of studies. 7 Clinical studies were the major research method. The Studies were classified according to the characteristics and design. 5 studies were about research of analysis and improvement of oriental obesity pattern identification questionnaire, the most number of studies. 4 studies were about research of observational studies in clinical on obesity pattern identification. 3 studies were about research of intervention studies in clinical on obesity pattern identification and 1 study was about clinical practice recommendation. Conclusions Establishment of obesity pattern identification system and its clinical application could lead to standardizing obesity pattern identification and clinical practice guideline. Applied on other diseases, obesity pattern identification system could also lead to improving treatment rate, contributing to the development of clinical practice guidelines and academic field of research.

• The Journal of Korean society of community based occupational therapy
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• v.1 no.1
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• pp.29-39
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• 2011

Object : The relationships between the TSQ(Time structure questionnaire) and Well-being were examined. Methods : TSQ and questionnaire about Well-being were executed for 223 university students from April 26th to May 7th, 2010. The questionnaire adapted the item of the TSQ and Korean WHOQOL-BREF, SWLS(Satisfaction with Life Scale), LSES(Life Satisfaction Expectancy Scale), SHS(Subjective Happiness Scale). The questionnaires were distributed directly to the participants. Relativity between the TSQ and questionnaire about Well-being were analyzed using Pearson's correlation analysis. Results : As a result of the relationship between the TSQ and questionnaire about Well-being, overall there was a positive correlation. TSQ(sense of purpose, structured routine, persistence, past orientation) and questionnaire about Well-being showed a statistically significant correlation(p<.05). Conclusion : A structured time use and well-being by investigating the relationship, we were able to see the importance of time management. Currently, clinical occupational therapy focused on performance components, in future, intervention of personal time management to help make ones live well-being.

• The Journal of Korean society of community based occupational therapy
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• v.5 no.2
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• pp.31-42
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• 2015

Objective : The aim of this study is to prove the effects of mental practice in balance ability of elderly population, and to investigate the possibility of application as an effective intervention method for fall prevention. Methods : This study provided mental practice to 3 subjects over 65 years old who have experienced fall, but do not have cognitive dysfunctions and independent in gait without any use of assistive devices from July to October, 2013. Within the individual case study, 4 sessions of initial baseline process (A), 5 sessions of mental practice (B), 4 sessions of re-initial baseline process (A') were proceeded using ABA design. Independent variable used mental practice for enhancing balance ability and fall efficacy in elderly population, and dependent variable were Berg Balance Scale (BBS) to find out the change in overall balance ability, Fall Efficacy Scale (FES) to see the change in fall efficacy, One-Leg Standing test(OLS), and Timed Up and Go Test (TUG) to determine the changes in both static and dynamic balance. Analysis of the results were provided via mean value and graph. Results : After the application of mental practice method, all of the subjects have shown increase in fall efficacy baseline values, and in addition, overall balance ability and both static and dynamic balances either increased or maintained. Conclusion : This study demonstrated that mental practice has positive effects on fall efficacy improvement and maintenance in elderly, thereby suggesting mental practice for fall prevention in elderly populations.

• Journal of the Korean Dietetic Association
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• v.23 no.1
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• pp.1-13
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• 2017

It is well known that malnutrition is a predictor of mortality in hemodialysis patients. The number of diabetic nephropathy patients is increasing rapidly. This study aimed to investigate nutritional status and nutrient intake according to the presence of diabetes among hemodialysis patients. The nutritional intake and general characteristics of outpatients at Ajou University Hospital (24 with diabetes and 30 without diabetes) were investigated between July and September 2015. Patients' general data were collected, and nutritional status by Patient-Generated Subjective Global Assessment (PG-SGA) was evaluated. Nutrient intakes were assessed according to 3-day food records. There was no significant difference regarding body weight between the two groups. However, the non-diabetic group showed a better nutritional status by Patient-Generated Subjective Global Assessment (PG-SGA) ($5.2{\pm}4.4$ vs. $8.0{\pm}4.3$ score, non-diabetics vs. diabetics, P<0.05). There was no difference in daily calorie intake ($1,473.9{\pm}370.5$ vs. $1,503.8{\pm}397.5kcal$) and protein intake ($60.3{\pm}19.7$ vs. $65.6{\pm}20.5g$) in those with diabetes. Intakes of vegetables protein, sodium, potassium, vitamin C, folic acid and fiber were significantly higher in the diabetic group compared to those of the non-diabetic group. There was no difference in daily nutrient intake between the hemodialysis weekday and weekend groups. The non-diabetic group had higher calorie and sodium intakes per meal in the hemodialysis weekday group, but the difference was not significant. Based on these results, intervention should be performed to improve nutritional status in consideration of diabetes and dietary patterns.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.5
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• pp.3333-3343
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• 2015

The purpose of this study is to investigate factors related to substance use focusing on the sexual experiences and risky sexual behaviors among Korean adolescents. This study conducted with a secondary data analysis using the Seventh Korea Youth Risk Behavior Web-based Survey 2011 in South Korea. The study participants selected 75,643 Korean adolescents who were recruited anonymously through national web-based survey. Data were analyzed using descriptive statistics, rao-Scott ${\chi}^2$, and logistic regressions considering complex samples. Results indicated that substance use was significantly associated with sexual experiences such as sexual intercourse with the opposite sex (adjusted OR=5.691; 95% CI=4.223-7.670), sexual intercourse with the same sex (adjusted OR=21.180; 95% CI=14.704-30.507) and risky sexual behaviors such as sexual assaults (adjusted OR=9.936; 95% CI=7.217-13.680), date rape (adjusted OR=16.979; 95% CI=11.648-24.751), sexual intercourse after drinking (adjusted OR=6.564; 95% CI=3.986-10.810), unexpected pregnancies (adjusted OR=18.628; 95% CI=8.476-40.936), and sexually transmitted diseases (adjusted OR=21.872; 95% CI=13.920-34.367) in Korean adolescents. Findings of this study show that adolescents who use substances are more likely to engage in risky sexual behaviors. Therefore, intervention program should be designed to consider both substance use and sexual problems and to include the effective approaches at the family and school level.

• Journal of Hospice and Palliative Care
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• v.18 no.3
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• pp.196-207
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• 2015

Purpose: We comprehensively analyzed domestic studies on the effects of death preparation education in order to present objective data. Methods: Meta-analysis was conducted with a total of 22 master's and doctoral theses published between 2004 and 2014. Results: According to our analysis, the death preparation education had a mid-size effect. The effect size of a moderator variable was the greatest in infants and children, and the effect size was bigger in younger ages. The effect size was the greatest when education was given through a total of 10~15 sessions, twice a week, and less than 60 minutes per session. The effect variable and death-related variable showed a significant effect size, and sub-variables were equivalent to the death-related variable with a biggest effect size. Non-death related variables had a mid-level effect size and sub-variables were found to have the highest ego integrity. Conclusion: The significance of this study lies its systematic integration of advanced research on the effects of death preparation education through meta-analysis. By suggesting guidelines for the design of a death preparation education program, evidence-based basic data were proposed which will more likely strengthen intervention effects. Based on these results, more studies are needed to develop and extensively carry out a death preparation program which can meet needs of specific age groups from children to seniors.