• Journal of Food Hygiene and Safety
• /
• v.36 no.5
• /
• pp.363-375
• /
• 2021

Trends in the developing era to discover and design peptide-based treatments throughout an epidemic infection scenario such as COVID-19 could progress into a more efficient and low-cost therapeutic environment. However, the weakening of proteolysis is one downside of natural peptide drugs. But, peptidomimetics may help resolve this issue. In this review, peptide and peptide-based drug discovery were summarized to target one key entry mechanism of severe coronavirus pulmonary emboli syndrome (SARS-CoV-2), which encompasses the association of the host angiotensin-converting enzyme-2 (ACE2) receptor and viral spike (S) protein. Furthermore, the benefits of proteins, peptides and other possible actions that have been studied for COVID-19 through new peptide-based treatments are discussed in the review. Lastly, an overview of the peptide-based drug therapy environment is comprised of an evolutionary viewpoint, structural properties, operational thresholds, and an explanation of the therapeutic area.

• Journal of Distribution Science
• /
• v.12 no.2
• /
• pp.95-103
• /
• 2014

Purpose - Korea has a better geographical location than other nations in the Northeast Asian region. This means that Korea has an opportunity to become the center of international physical distribution in Northeast Asia. Korea should take advantage of this opportunity by exploring appropriate strategies to achieve this goal, assuming government willingness, with a view to capitalizing on the geographical advantage of the Korean peninsula and constructing a comprehensive physical distribution network system. If we prepare for this scenario, Korea could become the center of international physical distribution in Northeast Asia. Research design, data, and methodology - This study has the purpose of determining how shipping companies form partnerships with third-party logistics providers, and the relevant implications. The survey methods used were personal interview and a questionnaire distributed through e-mail, fax, mail, and telephone. A total of 600 questionnaires were distributed, out of which 285 were returned. Of the collected questionnaires, 10 were excluded because of insufficient content, leaving 275 to be used in the study as available valid samples. The data that was collected from these samples was analyzed using the data coating process and by employing a statistical package program. Results - Flexible policies, administration, and systems will be needed to create better business practices. In this dissertation, first and foremost, the results reveal that in order to become the center of Northeast Asian logistics, Korea must transition into a new paradigm based on the current economic and social systems that have stemmed from bureaucracy, inflexibility, chauvinism, and egalitarianism. Flexible policies, administration, and systems will be required to create better business practices. Domestic logistics corporations need to occupy a strategic logistics hub, create a logistics network, and activate value-added logistics business strategies by ensuring significant manpower and by building a logistics information system to strengthen their competitive edge, creating an improved system. Conclusions - In this dissertation, first and foremost, we point out that in order to become a center of North East Logistics, Korea should change to a new paradigm from the old one based on current economic and social systems that have stemmed from bureaucracy, inflexibility, chauvinism, and egalitarianism. More reasonable business laws, systems, and policies based on market-driven flexibility and transparency should be created. Moreover, social norms and rules should be reasonably established, to accomplish political and social security. Korea has to cultivate a culture of tolerance for foreign companies. This involves a change of paradigm for the development of the capital city and satellite cities. It will take a powerful task force or organization to plan and execute the vision that aims to meet these needs, accomplish the necessary goals, use the appropriate system effectively, and make Korea a key country in the field of Northeast Asian logistics.

• Clean Technology
• /
• v.26 no.2
• /
• pp.96-101
• /
• 2020

In this paper, the commercial feasibility of trigeneration, producing heat, power, and hydrogen (CHHP) and using biogas derived from macroalgae (i.e., seaweed biomass feedstock), are investigated. For this purpose, a commercial scale trigeneration process, consisting of three MW solid oxide fuel cells (SOFCs), gas turbine, and organic Rankine cycle, is designed conceptually and simulated using Aspen plus, a commercial process simulator. To produce hydrogen, a solid oxide fuel cell system is re-designed by the removal of after-burner and the addition of a water-gas shift reactor. The cost of each unit operation equipment in the process is estimated through the calculated heat and mass balances from simulation, with the techno-economic analysis following through. The designed CHHP process produces 2.3 MW of net power and 50 kg hr^-1 of hydrogen with an efficiency of 37% using 2 ton hr^-1 of biogas from 3.47 ton hr^-1 (dry basis) of brown algae as feedstock. Based on these results, a realistic scenario is evaluated economically and the breakeven electricity selling price (BESP) is calculated. The calculated BESP is ¢10.45 kWh^-1, which is comparable to or better than the conventional power generation. This means that the CHHP process based on SOFC can be a viable alternative when the technical targets on SOFC are reached.

• Spatial Information Research
• /
• v.21 no.4
• /
• pp.15-24
• /
• 2013

Recently, as the spatial information and various multimedia are fused together, the demand for the high value-added spatial information contents and the necessity of technology for spatial information security are increasing. However, since the current security policy is being managed independently by each system, there is a problem with unreliable or costly to modify or revise the security policy. Such problems occur frequently in the process of coordination or integration of the spatial information management systems that are used in public institutions and private companies. Therefore, in this paper, the access control system that could provide an integrated security policy for many spatial platforms and systems with expandable grammar and semantics was designed and implemented based on GeoXACML proposed by OGC. As the GeoXACML-based access control system designed and implemented in this paper follows the international standard specifications, it provides high portability and interoperability. Finally, in this paper, the efficiency of the system was proved by applying it to a virtual scenario on the military area requiring the access control.

• Nuclear Engineering and Technology
• /
• v.53 no.10
• /
• pp.3217-3228
• /
• 2021

Flow blockage of the fuel assembly in the lead-based fast reactor (LFR) may produce critical local spots, which will result in cladding failure and threaten reactor safety. In this study, the flow blockage characteristics were analyzed with the sub-channel analysis method, and the circumferentially-varied method was employed for considering the non-uniform distribution of circumferential temperature. The developed sub-channel analysis code SACOS-PB was validated by a heat transfer experiment in a blocked 19-rod bundle cooled by lead-bismuth eutectic. The deviations between the predicted coolant temperature and experimental values are within ±5%, including small and large flow blockage scenarios. And the temperature distributions of the fuel rod could be better simulated by the circumferentially-varied method for the small blockage scenario. Based on the validated code, the analysis of blockage characteristics was conducted. It could be seen from the temperature and flow distributions that a large blockage accident is more destructive compared with a small one. The sensitivity analysis shows that the closer the blockage location is to the exit, the more dangerous the accident is. Similarly, a larger blockage length will lead to a more serious case. And a higher exit temperature will be generated resulting from a higher peak coolant temperature of the blocked region. This work could provide a reference for the future design and development of the LFR.

• Journal of the Korean Institute of Gas
• /
• v.25 no.2
• /
• pp.13-21
• /
• 2021

Because of the recent expansion of hydrogen vehicle supply, the installation of hydrogen filling station is expected to gradually expand. This study attempts to predict the damage scale and propose a safer design form based on the scenario that assumes the worst case of a hydrogen station. A Flacs solver using computational fluid dynamics (CFD) was used to predict the damage scale, and the accuracy was verified by comparing it with the experimental results of previous researchers. The damage scale prediction was conducted for hydrogen leakage and explosion, and the prediction target was the KR model based on the measured values. And as a comparative review model, a roofless model was selected without a ceiling. As a result of analyzing the two models, it was possible to confirm the accumulation and retention of hydrogen gas up to 60 vol% or more in the KR model, whereas in the case of the Roofless model, the phenomenon of discharge and diffusion to the outside of the charging station by riding the wall after leakage. I was able to check. In conclusion, it was reviewed that the type of hydrogen charging station without ceiling is more advantageous for safety than the hydrogen filling station model.

• Journal of the Korea institute for structural maintenance and inspection
• /
• v.24 no.6
• /
• pp.206-216
• /
• 2020

As the number of aging railway bridges in Korea increases, maintenance costs due to aging are increasing and continuous management is becoming more important. However, while the number of old facilities to be managed increases, there is a shortage of professional personnel capable of inspecting and diagnosing these old facilities. To solve these problems, this study presents an improved model that can detect Local damage to structures using machine learning techniques of AI technology. To construct a damage detection machine learning model, an analysis model of the bridge was set by referring to the design drawing of a non-ballasted plate-girder railroad bridge. Static strain data according to the damage scenario was extracted with the analysis model, and the Local damage index based on the reliability of the bridge was presented using statistical techniques. Damage was performed in a three-step process of identifying the damage existence, the damage location, and the damage severity. In the estimation of the damage severity, a linear regression model was additionally considered to detect random damage. Finally, the random damage location was estimated and verified using a machine learning-based damage detection classification learning model and a regression model.

• Journal of the Korean Association of Geographic Information Studies
• /
• v.19 no.1
• /
• pp.106-119
• /
• 2016

Flood risk map, flood damage map, disaster information map, inundation trace map are involved with the cartographic analysis of flood inundation based on prevention, preparation, restoration, response from natural disasters such as flood, flooding, etc. In this study, the analysis for channel and basin characteristics Chungju dam to Paldang dam of South han river after four river project. Flood scenario is selected to take advantage of design flood level of schematic design for river. Flood inundation of one dimensional non-uniform flow by using HEC-RAS with basin characteristics is accomplished and two dimensional unsteady flow was interpreted by using FLUMEN. Frequency analysis is carried out about each abundance of South han river for 100 year period, 200 year period and 500 year period. Flooding disaster area of 100 year period on 0.5m damage functions is 2378.8ha, 200 year period on 0.5m damage functions is 3155.2ha, 500 year period on 0.5m damage functions is 3995.3ha respectively. It will be significant data for decision making to establish inundation trace map for providing basic plan for river maintenance, land use plan, flood protection plan, application plan and getting information of flood expectation area.

• Proceedings of the Korean Geotechical Society Conference
• /
• 2010.09c
• /
• pp.72-77
• /
• 2010

The Incheon Bridge, which was opened to the traffic in October 2009, is an 18.4 km long sea-crossing bridge connecting the Incheon International Airport with the expressway networks around the Seoul metropolitan area by way of Songdo District of Incheon City. This bridge is an integration of several special featured bridges and the major part of the bridge consists of cable-stayed spans. This marine cable-stayed bridge has a main span of 800 m wide to cross the vessel navigation channel in and out of the Incheon Port. In waterways where ship collision is anticipated, bridges shall be designed to resist ship impact forces, and/or, adequately protected by ship impact protection (SIP) systems. For the Incheon Bridge, large diameter circular dolphins as SIP were made at 44 locations of the both side of the main span around the piers of the cable-stayed bridge span. This world's largest dolphin-type SIP system protects the bridge against the collision with 100,000 DWT tanker navigating the channel with speed of 10 knots. Diameter of the dolphin is up to 25 m. Vessel collision risk was assessed by probability based analysis with AASHTO Method-II. The annual frequency of bridge collapse through the risk analysis for 71,370 cases of the impact scenario was less than $0.5{\times}10^{-4}$ and satisfies design requirements. The dolphin is the circular sheet pile structure filled with crushed rock and closed at the top with a robust concrete cap. The structural design was performed with numerical analyses of which constitutional model was verified by the physical model experiment using the geo-centrifugal testing equipment. 3D non-linear finite element models were used to analyze the structural response and energy-dissipating capability of dolphins which were deeply embedded in the seabed. The dolphin structure secures external stability and internal stability for ordinary loads such as wave and current pressure. Considering failure mechanism, stability assessment was performed for the strength limit state and service limit state of the dolphins. The friction angle of the crushed stone as a filling material was reduced to $38^{\circ}$ considering the possibility of contracting behavior as the impact.

• Journal of the Korean Society of Marine Environment & Safety
• /
• v.28 no.2
• /
• pp.314-323
• /
• 2022

Vessel Traffic Services (VTS) operators perform traffic management tasks using VTS systems and sensor equipment designated as VTS facilities to promote the safety and efficiency of vessel traffic. The necessary VTS information for effective operations could be obtained through the additional access of various information channels other than the designated VTS facility. To unify these various information access windows, the development of the VTS cloud system is in progress. In this study, the operational information analysis for VTS was performed through VTS tasks-facility linkage analysis to identify the user required information according to the introduction of the VTS cloud system. The VTS task analysis was performed through research of the international and domestic literature, and expert interviews. The necessary information were identified and linked according to the VTS facilities. As a result of the analysis, 37 categories of necessary information were identified for internal and external information windows, and 8 information windows were selected other than the present VTS equipment. The identified user requirements would be applied to the structure design of the VTS cloud system. In the future, it is necessary to update user requirements through scenario-based user operation analysis and to conduct additional research on the system interface design.