• Microbiology and Biotechnology Letters
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• v.48 no.3
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• pp.344-357
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• 2020

Strain improvement and bioprocess development were undertaken to enhance hyaluronic acid(HA) production by Streptococcus zooepidemicus cells. Using a high-yielding mutant strain, statistical medium optimization was carried out in shake flask cultures, resulting in 52% increase in HA production (5.38 g/l) at the optimal medium composition relative to the parallel control cultures. For sufficient supply of dissolved oxygen (DO), which turned out to be crucial for enhanced production of HA, agitation system and speed were intensively investigated in 5 L bioreactor cultures. Increase in oxygen mass transfer coefficient (k_La) through increment of agitation speed (rpm) and 35% expansion of diameter of the newly-designed impellers showed significantly positive effects on HA production. By installing an expanded Rushton-turbine impeller for efficient break-down of sparged air, and an extended marine impeller above the Rushton-turbine impeller for efficient mixing of the air-born viscous fermentation broth, maximum amount of HA (9.79 g/l) was obtained at 450 rpm, 1.8 times higher level than that of the corresponding flask culture. Subsequently, the possibility of bioprocess scale-up to a 50 L bioreactor was investigated. Despite almost identical maximum HA production (9.11 vs 9.25 g/l), the average HA volumetric productivity (r_p) of the 50 L culture turned out only 74% compared to the corresponding 5 L culture during the exponential phase, possibly caused by shear damages imposed on the producing cells at the high stirring in the 50 L culture. The scale-up process could be successfully achieved if a scale-up criterion of constant oxygen mass transfer coefficient (k_La) is applied to the 50 L pilot-scale bioreactor system.

• Journal of Pharmacopuncture
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• v.13 no.1
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• pp.121-128
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• 2010

Objectives : This study was to investigate the effects of Oriental medical treatment on ALS. Methods : We investigated 12 ALS patients which were admitted to Gwang-Ju O.M.hospital for 3 months and follow-up at 8 months after discharge. All patients were treated by SAAM-acupuncture, herb medication, Bee venom Pharmacopuncture therapy, Needle-embedding therapy, etc and after discharge self-therapy at home. We evaluated patients using the Amyotrophic lateral sclerosis Functional Rating Scale-Revised(ALSFRS-R), Medical Research Council (MRC) Scale. Results : After 1 month, mean ALSFRS-R score of patients was $29.08{\pm}7.99$, 2 months $28.70{\pm}7.17$, 3 months $28.16{\pm}8.23$, 1 year $21.33{\pm}9.93$ and mean MRC Scale of patients was $25.34{\pm}8.45$, 2 months $25.34{\pm}8.45$, 3months $21.56{\pm}9.20$. But in both cases, the variation was not statistically significant. Conclusions : We think that the results of this case be a pilot study that proves the effect of Oriental Medical treatment on ALS.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2009.11a
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• pp.32-32
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• 2009

Silicon carbide (SiC) is a wide-bandgap semiconductor that has materials properties necessary for the high-power, high-frequency, high-temperature, and radiation-hard condition applications, where silicon devices cannot perform. SiC is also the only compound semiconductor material. on which a silicon oxide layer can be thermally grown, and therefore may fabrication processes used in Si-based technology can be adapted to SiC. So far, atomic force microscopy (AFM) has been extensively used to study the surface charges, dielectric constants and electrical potential distribution as well as topography in silicon-based device structures, whereas it has rarely been applied to SiC-based structures. In this work, we investigated that the local oxide growth on SiC under various conditions and demonstrated that an increased (up to ~100 nN) tip loading force (LF) on highly-doped SiC can lead a direct oxide growth (up to few tens of nm) on 4H-SiC. In addition, the surface potential and topography distributions of nano-scale patterned structures on SiC were measured at a nanometer-scale resolution using a scanning kelvin probe force microscopy (SKPM) with a non-contact mode AFM. The measured results were calibrated using a Pt-coated tip. It is assumed that the atomically resolved surface potential difference does not originate from the intrinsic work function of the materials but reflects the local electron density on the surface. It was found that the work function of the nano-scale patterned on SiC was higher than that of original SiC surface. The results confirm the concept of the work function and the barrier heights of oxide structures/SiC structures.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2004.08a
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• pp.277-284
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• 2004

Low carbon steels containing Si of up to $1.2\;wt\%$ were oxidized in air at 1373 K and 1523 K, i.e. below and above the eutectic temperature of FeO and $Fe_2SiO_4$. The influence of a impurity element, S on behavior of scale formation during oxidation was investigated by using $M\"{o}chssbauer$ spectroscopy and EDS. This allowed establishment of an interface oxidation model of Si-added steel depending on temperature and an impurity element. A compound of FeO and FeS was formed in the scale/matrix interface of low carbon steels containing S of up to $0.03\;wt\%$ oxidized above 1213 K of the eutectic temperature. This was flat formed between $Fe_2SiO_4$ nodules along the scale/matrix interface without selective oxidation. It is due to low viscosity and high wettability of the compound of FeO and FeS in liquid. Conventional metallographic examinations revealed that roughness of the scale/matrix interface in Si-added steels became flat as the content of S increased. It was independent of oxidizing temperature and Si content. Effects of oxidizing temperature and an impurity element content on descaling characteristics in Si-added steels were evaluated by using a hydraulic descaling simulator. Good descaling characteristics was attributable to this flatness of the scale/matrix interface.

• Journal of Electrical Engineering and Technology
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• v.8 no.6
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• pp.1596-1604
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• 2013

Coordinating operation between large-scale wind power and thermal units in multiple time scale is an important problem to keep power balance, especially for the power grids mainly made up of large coal-fired units. The paper proposes a novel operation mode of multi-scale unit commitment (abbr. UC) that includes mid-term UC and day-ahead UC, which can take full advantage of insufficient flexibility and improve wind power accommodation. First, we introduce the concepts of multi-scale UC and then illustrate the benefits of introducing mid-term UC to the wind-coal intensive grid. The paper then formulates the mid-term UC model, proposes operation performance indices and validates the optimal operation mode by simulation cases. Compared with day-ahead UC only, the multi-scale UC mode could reduce the total generation cost and improve the wind power net benefit by decreasing the coal-fired units' on/off operation. The simulation results also show that the maximum total generation benefit should be pursued rather than the wind power utilization rate in wind-coal intensive system.

• Korean Journal of Child Studies
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• v.35 no.5
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• pp.113-134
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• 2014

This study sought to develop a 'Meaning of Parenting Scale for Mothers(MPS-M)' in order to measure how Korean mothers perceive the meaning of parenting. To this end, in Study I, a preliminary scale was designed, based firstly on socio-cultural and evolutionary psychological perspectives and secondly on the responses from 118 mothers concerning meaning of parenting. This was followed up by the collection of 887 mothers' responses to the preliminary scale, which then underwent exploratory factor analysis for scale revision. In Study 2, confirmatory factor analysis was conducted on a collection of responses from 548 mothers using the revised scale. Concurrent validity was tested using a parenting stress scale, and reliability was then checked by conducting calculations for internal consistency. As a result, the MPS-M was finally developed, consisting of 25 items under six factors: 'Internal Maturity', 'Restoration of Naturality', 'Familial Union', 'Physical Burden', 'Affective Disorientation', and 'Comprehensive Loss'. Accordingly, the meaning of parenting was statistically confirmed as a hierarchical two-sided concept possessing six factors under positive and negative meaning categories.

• Korean Journal of Remote Sensing
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• v.34 no.1
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• pp.89-99
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• 2018

Spatial downscaling is often applied to coarse scale satellite products with high temporal resolution for environmental monitoring at a finer scale. An area-to-point regression kriging (ATPRK) algorithm is regarded as effective in that it combines regression modeling and residual correction with area-to-point kriging. However, an open source tool or package for ATPRK has not yet been developed. This paper describes the development and code organization of an R-based spatial downscaling tool, named R4ATPRK, for the implementation of ATPRK. R4ATPRK was developed using the R language and several R packages. A look-up table search and batch processing for computation of ATP kriging weights are employed to improve computational efficiency. An experiment on spatial downscaling of coarse scale land surface temperature products demonstrated that this tool could generate downscaling results in which overall variations in input coarse scale data were preserved and local details were also well captured. If computational efficiency can be further improved, and the tool is extended to include certain advanced procedures, R4ATPRK would be an effective tool for spatial downscaling of coarse scale satellite products.

• Journal of Information Processing Systems
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• v.19 no.4
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• pp.427-438
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• 2023

Plenty of works have indicated that single image super-resolution (SISR) models relying on synthetic datasets are difficult to be applied to real scene text image super-resolution (STISR) for its more complex degradation. The up-to-date dataset for realistic STISR is called TextZoom, while the current methods trained on this dataset have not considered the effect of multi-scale features of text images. In this paper, a multi-scale and attention fusion model for realistic STISR is proposed. The multi-scale learning mechanism is introduced to acquire sophisticated feature representations of text images; The spatial and channel attentions are introduced to capture the local information and inter-channel interaction information of text images; At last, this paper designs a multi-scale residual attention module by skillfully fusing multi-scale learning and attention mechanisms. The experiments on TextZoom demonstrate that the model proposed increases scene text recognition's (ASTER) average recognition accuracy by 1.2% compared to text super-resolution network.

• Journal of muscle and joint health
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• v.8 no.1
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• pp.109-121
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• 2001

The purpose of this study was to find out the long-term effects of the self-help program through the follow-up with peer group meetings of arthritis patients. In order to fulfil the purposes, the follow-up program with peer group meetings was developed by researchers with consisting of monthly health contract, group discussion, group counseling, recreation, and exercise. This program was carried out 2-3 hours once in a month for 5 months (1999-2000) and evaluated in a nonequivalent control group pretest-posttest quasi-experimental design. The subjects were 34 patients of experimental group and 24 of control group. The measurement tools of this study are pain rating scale(Lee & Song), KHAQ(Bae), rating scale of fatigue, and goniometer. The results of this study revealed no significant differences on number of pain site, fatigue, physical functioning, flexibility of the shoulder joints, and level of the extension of the knee joints between experimental group and control group. Whileas pain reaction of the control group was significantly high. However, the peers expressed very much their satisfaction and appreciations with the follow-up program with Peer group meetings. Actually, they wanted to have this peer group meeting continuously. This results suggested that the follow-up program with peer group meeting could be recommended as good nursing intervention to help the arthritis patients after having the Self Help Program in the community setting.

• Journal of Korean Society of Water and Wastewater
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• v.29 no.3
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• pp.359-370
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• 2015

This study developed an up-flow wetland providing either an eco-friendly follow-up process of medium-sized public treatment facility for livestock manure or a non-point source pollution controller near livestock farms. The four bench-scale up-flow wetlands were operated with four different bed media sets. The removal efficiencies of the wetland effluent for CODCr, TN, TP, SS were 35.2 %, 29.5 %, 31.2 % and 52.2 % for set 1(Blank, without reed, with bio-ceramic), 40.6 %, 43.4 %, 42.2 % and 55.4 % for set 2(with bio-reed & without bio-ceramic), 45.2 %, 48.7 %, 46.6 % and 66.3 % for set 3(with bio-reed & bio-ceramic), 32.9 %, 27.3 %, 29.3 % and 54.1 % for Set 4(with reed & bio ceramic), respectively. The set 3 condition having a mixture of bio-reed and bio-ceramic showed the highest efficiency in the bench-scale evaluation. This study suggests a mixture of bio-reed and bio-ceramic as suitable bed media in the construction of artificial wetlands near livestock farms. Soils including the bed media were monitored during the evaluation for trace elements. Soil analysis results were satisfied with the Korean Soil Contamination Standard. This study showed that the up-flow constructed wetland was feasible to treat the effluent livestock wastewater treatment facility.