• Title/Summary/Keyword: Saturable

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Solubilization of an Angiotensin II Binding Site from Rat Liver

  • Chung, Sung-Hyun;Ravi Iyengar
    • Archives of Pharmacal Research
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    • v.14 no.3
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    • pp.231-236
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    • 1991
  • The high affinity binding sites for angiotensin II were solubilized from rat liver membranes by treatment with CHAPS. The binding protein was also partially purified by angiotensin III inhibitor-coupled Affi-gel affinity chromatography. Binding to the intact membrances as well as to the solubilized preparation was specific and saturable. According to the Scatchard plot, the membrane preparations exhibited a single class of high affinity binding sites with a Kd OF 0.71 nM. The solubilized preparation also showed the presence of a single class of bindings sites with less affinity (Kd of 14 nM). Meanwhile the competition studies using angiotensin II analogues represented two separate binding sites for angiotensin II and single binding site for antagonist. These latter findings were correlated to the results provided by Garrison's research group. More works are needed to clarify this discrepancy.

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Zero Voltage Switched Converter with Reduced Conduction Loss of Auxiliary Switch (보조 스위치의 전도손실을 줄인 영전압 스위칭 방식의 컨버터)

  • Joung, Gyu-Bum
    • Journal of the Korean Institute of Telematics and Electronics S
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    • v.36S no.2
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    • pp.131-137
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    • 1999
  • New zero voltage switched(ZVS) converter in which main switch is switched at zero voltage is proposed. A resonant inductor of conventional ZVS PW converter is replaced to two small saturable inductors in order to reduce conduction loss of auxiliary switch. Therefore, the switching loss of main switch is very low, and conduction losses of the main and auxiliary switch are lowered. The ZVS and above characteristics are verified by experimental results for a 200 kHz operation.

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IN VIVO INVESTIGATION ON THE INTESTINAL ABSORPTION OF VITAMIN A-ALCOHOL (RETINOL) IN RATS

  • Whang, Eun-Mi;Burger, Hans-Jurgen
    • Proceedings of the Korean Nutrition Society Conference
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    • 1995.05c
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    • pp.21-21
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    • 1995
  • Absorption of fat-soluble vi tamin, retinol occurs mainly in the proximal part of small intestine. But its intestinal transport mechanism isn't yet clear. The aim of the present study was to investigate on the mechanism of absorption of retinol by determining a concentration-dependent kinetic of retinol absorption in rats. The study was carried out by applying in vivo technique in which vitamin solution was infused to intestinal lumen and at the same time thoracic duct and choledochus duct were canulated to collect samples. The investigations showed that retinol is absorbed in the small intestine by a saturable, carrier-mediated transport system, i.e. wi thout signi ficant differences between the proximal and distal halves of the small intestine. The transport of retinol taken up by the enterocytes occured via different mechanisms: while the main vitamin A transport via the thoracic duct was saturated by limiting transport factors such as retinol-CRBP-II-complex formation and retinol esterification with increasing substrate concentrations, the transport of retinol metabolite product via the portal vein was proportional to the substrate concentration.ration.

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A study of SCPT excitation system (SCPT(Saturable Current Potential Transformer) 여자시스템에 관한 연구)

  • Ryu Ho-Seon;Shin Mahn-Su;Lee Joo-Hyun;Lim Ick-Hun;Song Seong-il
    • Proceedings of the KIPE Conference
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    • 2002.07a
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    • pp.466-469
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    • 2002
  • Many power plants in the thermal and hydraulic utilities, the pulp and the paper industry are faced with high maintenance and down time due to the aged excitation system. For the life extension of the aged power plants, the static excitation system with SCPT type had been developed by KEPRI(Korea Electric Power Research Institute) This paper will discuss the design conception and the application results of system which includes the phase controlled rectifiers of the shunt type, SCPT and redundant analog controller.

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Higher-order soilton puliton pulse generation and compression in dispersion decreasing fiber for optical time division multiplexing system source applications (분산감소광섬유에서의 고차 솔리통 펄스 생성 및 압축을 통한 광시간분할다중시스템 광원의 제작에 대한 연구)

  • 이덕기;김나영;박남규
    • Korean Journal of Optics and Photonics
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    • v.11 no.2
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    • pp.102-107
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    • 2000
  • We propose a new scheme for generating a pedestal-free, femtosecond soliton pulse train by utilizing quasI-adiabatic high order soliton pulse evolution in dispersion decreasing fiber in conjunction with the intermediate pedestal suppression stage. Compression factor over 280 was achieved from lOGHz sinusoidal input, to 176 is soliton pulse train. train.

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재조합 인간 GM-CSF의 수용체에 관한 연구

  • 이부연;최상운;이정옥;공재양
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1993.04a
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    • pp.148-148
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    • 1993
  • 본 실험에서는 유전자 재조합으로 제조한 [$^{125}$ I]-labeled human GM-CSF을 사용하여 GM-CSF의 HL-60 (promyelocytic leukemic cell)의 표면에 존재하는 GM-CSF의 수용체의 특성을 알고 GM-CSF의 수용체에 어떤 parameter로 결합하는지를 밝히고 나아가 현재 사용되고 있는 유전자 재조합으로 제조된 Prokine(Sargramostim)과 Lucky에서 제조된 GM-CSF (LDB-005)의 수용체에 대한 결합율을 측정, 비교하고자 하였다. 본 실험의 결과를 보면 유전자 재조립으로 제조된 Human[$^{125}$ I] GM-CSF가 HL-60 cell에 대하여 선택적으로 결합하고 표면수용체에 saturable하게 결합함을 알 수 있었으며 scatchard analysis 결과한 종류의 GM-CSF의 K3값은 2.03$\times$$10^{9}$/M로($IC_{50}$/=~493pM) 세포당 결합부위의 수는 75개 정도로 J. DiPersio et al과 Linda S. Park et al.의 보고와 비슷한 결과를 얻었다.

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A analysis result on the PT ferroresonance at 154 kV GIS substation (154 kV GIS의 PT 철공진 소손사례와 원인규명)

  • Woo, J.W.;Shim, E.B.;Kim, S.K.
    • Proceedings of the KIEE Conference
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    • 1999.07e
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    • pp.2076-2079
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    • 1999
  • This paper describes the analysis results on the PT ferroresonance at 154 kV GIS (gas Insulated substation by EMTP (Electro-magnetic Transient Program). We had simulated the PT ferroresonance between a potential transformer(PT) and an open circuit breaker's grading capacitance. The ferroresonance leads to very large power frequency overvoltages on PT bus and subsequent insulation failure. The large power can be supplied to the PT by the high voltage on the opened circuit due to the grading capacitance and equivalent capacitance of the buses during the ferroresonance. The damping circuit connected on the secondary winding were considered in the model. The actual countermeasure include a saturable inductor and a resistor series-mounted, but the 2 ohms of damping resistance was used in the computational model.

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Topologies of hige freguency PWM DC-DC converter using a new active snubber (새로운 액티브 스너버를 이용한 고주파 PWM DC-DC 컨버터의 토플로지)

  • Cho, M.C.;Kim, C.Y.;Suh, K.Y.;Lee, H.W.;Kwon, S.K.
    • Proceedings of the KIEE Conference
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    • 2006.07b
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    • pp.1010-1011
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    • 2006
  • A new soft switched active snubber circuit is proposed to achieve zero voltage and zero current switching for all the switching devices in PWM DC-DC converters. The unique location of the snubber capacitor and inductor ensures low current/voltage stresses and commutation losses. With a saturable reactor, the conduction loss of the auxiliary switch could be further minimized. A boost converter adopting this technique is presented as an example, to illuminate its operation principles and derive the design procedures. Simulation and hardware implementation have been made to validate its performance. Some other basic PWM DC-DC topologies using the proposed snubber have also been given.

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Nonlinear absorption in charge transfer films

  • Cha, M.;Sariciftici, N.S.;Heeger, A.J.;Hummelen, J.C.;WudI, F.
    • Proceedings of the Optical Society of Korea Conference
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    • 1995.06a
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    • pp.161-168
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    • 1995
  • Nonlinear optical absorption in solid films of poly(3-octyl thiophene) (P3OT) sensitized with methanofullerene was inverstigated for wacelengths from 620 to 960nm. The nonlinear absorption is ehnanced over that in either of the component materials by more than two orders orders of magitude at 760nm. The large nonlinearity results from effient photoinduced interm olecular charge transfer from P3OT to methanofullerene, followed by absorption in the charge separated excited state. P3OT/fullerene films are promising as reverse saturable absorbers and the optical limiting performance is demonstrated at 760nm.

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Operation characteristics of fast pulse generator using a 2-stage magnetic switch (2단 자기스위치를 사용한 고속 펄스발생기의 동작 특성)

  • 김복권;권순걸;서기영;이현우
    • Journal of the Korean Institute of Telematics and Electronics B
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    • v.33B no.10
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    • pp.139-147
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    • 1996
  • In this study a two-stage fast pulse generaor using magnetic switches is proposed. The scheme consist of a switch, an inductor and two pairs of capacitor and saturable inductors, a linear transformer. The basic principle and the operation are described using a set of given parameters. The main issue of the magnetic pulse genration scheme is the system efficiency. This study focuses on the system efficiency improvement using magnetic switches. The voltage compression ratio, energy transfer with respect to core area are investigated. The output voltage and transferred energy as a function of input voltage are also included. Also, an analysis and experiments are performed to verify the porposed topology by implementing a 10[J] class experimental circuit. The efficiency of the transferred energy a tload side is 82%.

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