• Asian Pacific Journal of Cancer Prevention
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• v.15 no.21
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• pp.9355-9360
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• 2014

Background: Oral squamous cell carcinoma (OSCC) remains as one of the most difficult malignancies to control because of its high propensity for local invasion and cervical lymph node dissemination. In this study, we evaluate the efficacy of our novel pH and temperature sensitive doxorubicin-methotrexate-loaded nanoparticles (DOX-MTX NP) in affecting HER2 expression profile in OSCC model in rat. Results: DOX-MTX- nanoparticle complexes caused significant decrease in mRNA level of HER2 compared to untreated cancers (p<0.05) and this finding was more pronounced with the IV mode (p<0.000). Surprisingly, HER2 mRNA was not affected in DOX treated as compared to the control group (p>0.05). On the other hand, in the DOX-MTX NP treated group, fewer tumors characterized with advanced stage and decreased HER2 paralleled improved clinical outcome (P<0.05). Moreover, the effectiveness of the oral route in the group treated with nanodrug accounted for the enhanced bioavailability of nanoparticulated DOX-MTX compared to free DOX. Furthermore, there was no significant difference in mRNA level of HER2 (p>0.05). Conclusions: Influence of HER2 gene expression is a new feature and mechanism of action observed only in dual action DOX-MTX-NPs treated groups. Down-regulation of HER2 mRNA as a promising marker and prognosticator of OSCC adds to the cytotoxic benefits of DOX in its new formulation. Both oral and IV application of this nanodrug could be used, with no preferences in term of their safety or toxicity. As HER2 is expressed abundantly by a wide spectrum of tumors, i DOX-MTX NPs may be useful for a wide-spectrum of lesions. However, molecular mechanisms underlying HER2 down regulation induced by DOX-MTX NPs remain to be addressed.

• Journal of Korea Technology Innovation Society
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• v.11 no.2
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• pp.219-240
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• 2008

This paper aims to suggest a policy for biological resource based on a comprehensive understanding on biological resources. Biological resources are different from traditionally recognized viable organisms (Biodiversity) in ecosystems. Biological resources are culturable and replicable resources of living organisms such as tissues, cells and genes. Moreover, biological resources include human-derived biological materials. Biological resources is not simply a matter of science and technology. Biological resources should be dealt with as national resources. There are many international issues regarding biological resources, such as intellectual property rights (IPRs), safety on handling and distribution, material transfer agreements (MTAs) for mutual benefits and biological standards. Ethical debates are also being raised because biological resources are related with human-derived biological materials. Every nation has tendency to adopt its government policies to strengthen its sovereignty on biological resources and international cooperation. In addition, international linkages are essential for providing enhanced worldwide accessibility to biological resources. Japan has shown several international initiatives in the field of biological resources. Korea has just begun to design appropriate policies for the use and R&D of biological resources. Therefore, this paper suggests the following needs: 1) policy at the national level beyond the interests of researchers, 2) inter-ministerial coordination across government ministries, 3) expansion of scope and size of each BRC (Biological Resource Centers), and 4) building networks and systems such as national information center, representative centers by field, and each BRC.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.14 no.1
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• pp.57-67
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• 2015

A large amount of work has been done in the areas of routing, MAC, QoS, capacity, location service, cooperative communication, fault tolerance, mobility models and various applications of mesh networks thanks to their merits of cost-effective way of deployment and flexibility in extending wireline services. Although multi-path routing protocols have been proposed to be used to provide QoS and fault-tolerance, there has not been any significant results discussed that support both in the literature to our best knowledge as they are often required in military and public safety applications. In this paper, we present a novel routing protocol for a mesh network based on the OFDM-TDMA collision-free MAC that discovers and maintains multiple paths that allows retransmitting and forwarding packets that have been blocked due to a link failure using an alternative next-hop node such that the delay-capacity tradeoff is reduced and the reliability is enhanced. Simulation results show that the proposed protocol performs well in terms of both the QoS and delivery ratio.

• Journal of the Society of Disaster Information
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• v.10 no.4
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• pp.536-547
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• 2014

With the changing safety services and social order systems accompanied by the economic development and changing public security environment since the Chinese economic reform, the security service industry in China is growing daily and related problems are increasing. For the Chinese security service market to be activated, the monopoly of security services by the public security agencies must be removed. In addition, the research and development, expansion, and applications of safety and crime prevention technologies regarding the safety and protection of exhibition, sales, culture, sports, commerce activities, combinations of safety technologies and crime prevention processes, the provision of relevant technical operations, and the expansion of security service areas are required. Furthermore, the administration rights, property rights, and business management rights of security companies must be separated, the security headquarters must be integrated and coordinated for optimization of various resources solely by market needs, and their rights and affiliation relations must be clear. Besides, the competitiveness of security companies in the security service market must be enhanced by unifying the business management, and optimizing and sharing their resources. The security service ordinances of China that have been implemented now must be applied realistically, methods to activate the true market economy for security services must be researched, and various ordinances related to security services must be realigned in line with the characteristics of security services. Finally, for the mutual cooperation system between public and private security services, the public security agencies must acknowledge the importance of private security services and the status of security service providers in crime prevention and social order maintenance. They must establish partnership relations with each other beyond the unilateral direction and management system for security services and drive with positive attitudes the security service industry which is still in its infancy.

• Journal of the Korean Society of Radiology
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• v.4 no.1
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• pp.11-17
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• 2010

A urolithiasis, also called calculus, is one of the brutal illnesses, which has constantly harassed humanbeings from time immemorial. However, there is no appropriate method of prevention so far. So, Urological therapy must be followed upon those patients. The biggest problem of urolithiasis is usually causing harsh pain, fever, and throw up. The pain would be more intensified when something came through the ureter or the moment of convulsion caused beyond transmission of urinary calculus. Even strong painkillers, such as fentanyl and Pethidine, can not handle those harshly pain easily. Therefore, a prompt action of medical check up and its therapy must be required to those patients. This thesis paper has put the accent on the specific therapy, known as ESWL (Extracorpereal Shock Wave Lithotripsy), which have generated quite optimum resolution to patients, who received harsh pain from Proximal ureteral stone and Mid ureteral stone and because of its low provability of pulverization. The results of the experiment confirmed that the stone, located between Proximal and Mid ureter, has lower provability of pulverization than distal ureter, because its accuracy rate on shock wave, in respect of breathing, are low. However, decrease in discharge interval have enhanced provability of pulverization. it can also intensify probability of pulverization and its safety by discharging high power with appropriate intervals, and that is more efficient than discharging low power with frequent time.

• Fire Science and Engineering
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• v.15 no.1
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• pp.100-107
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• 2001

A Interior material, a main cause of fire-growth and generating toxic gas when it burns, should be dealt with great care in life safety design. Nonetheless, it has been used recklessly with undue attention to its contribution to fire in particular in entertainment occupancy and causes many victims in fire. Therefore, this study attempts to examine the current use of interior material in Korea and find out what to be improved and enhanced in terms of related regulations. Based on the comparison and analysis of the Korea regulation with those of advanced nations, suggestions are made for an effective and efficient improvement and complement to the current system. What can be suggested from this study are as follows. The use of interior material should be controlled under the unified regulation of fire-safety codes. Code should be set up so that the current construction enforcement should be applied in retroactive to those entertainment buildings that obtained a license prior to the implementation of the system certifying that the building is fire-resistant and fire-protective. The legislation should be made to control the fire-protection facilities of small-sized, underground entertainments. It should be obliged to present the blueprint displaying the use of interior material at the time of changing occupancy. Or, it should be compelled to report changes that go way without permit to the administrative office. A compulsory provision should be set up to have a fire-resistant performance to movable furniture. The classification index designating the fire hazard of interior material by flame spread rate and smoke toxicity and its test method should be established.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.11 no.3
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• pp.112-123
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• 2012

Different from general roads, intersections are the points where roads having different geometric structure and traffic operation system are met, and thereby they have complicated road structure and environmental factors. Various changes in driving patterns such as collision between vehicles approaching from roads adjacent to intersections, sudden stop of vehicles upon stop sign, quick start upon green lights kept increasing traffic accidents. It is known that traffic accidents are mainly derived from human factors. This study, in order to find out factors affecting drivers' behaviors within intersections, measured physiological responses such as brain wave, sight, driving speed, and so on by using state-of-the-art measuring device. As to concentration brain wave at individual intersections, it was found out that brain wave of testes was higher at main Arterial and accident-prone intersections compared with that of subsidiary Arterial. In addition, it was detected that drivers' visual activity was widely distributed at accident-prone intersections, meaning that it enhanced cautious driving from nearby vehicles. As to major factors causing drivers' workloads, factors from nearby vehicles such as deceleration, acceleration, lane change of nearby vehicles appeared as direct factors causing drivers' workloads, clarifying that these factors were closely related to causes of traffic accidents at intersections. Results of this study are expected to be used as basic data for evaluation of safety at intersections in consideration of physiological response of drivers.

• Journal of the Korean Society of Marine Environment & Safety
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• v.25 no.5
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• pp.609-616
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• 2019

When the fouling of a vessel occurs, its resistance at sea increases and there is a corresponding increase in fuel consumption. The maintenance cost of the vessel also increases because it is time-consuming to remove the fouling. To solve this problem and minimize environmental contamination of sea-water, there have been recent developments in anti-fouling paints as self-polishing copolymers that not include toxic elements such as tin. When these conventional techniques are applied to vessels, polishing is promoted during the operation whereby friction or vibration with seawater occurs. This leads to enhanced anti-fouling performance. However, when fouling is intensified such as during an anchorage, there is no flow of seawater and polishing is suppressed. This leads to a deterioration of the performance of anti-fouling. To solve these problems, we developed a system that induces vibration in a vessel during anchorage. As such, the deterioration of polishing due to insuf icient flow of seawater is inhibited. The reliability of the ultrasonic antifouling system was evaluated by calculating its repeatability. The removal efficiency of fouling of the proposed system was qualitatively evaluated using test specimens. The test revealed that the value of the coefficient of variation for the reproducibility of the frequency and amplitude was 0.2 % and 4.0 % on average. The degree of fouling of the specimens was the highest at 73.3 g in the No.5 sepcimen. Moreover, efficiency of fouling removal was 93.2 % on average compared to the specimens without the proposed system.

• Korean Journal of Food Science and Technology
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• v.37 no.1
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• pp.11-14
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• 2005

White radish was minimally processed, packed with air, $CO_{2}$ (100%), and $CO_{2}/N_{2}$ (25/75%), and irradiated at 0, 1, and 2 kGy, and its microbiological quality and pH were investigated during storage for 2 weeks at $4^{\circ}C$. Irradiation significantly reduced total aerobic, coli-form, and lactic acid bacteria counts. Modified atmosphere packaging (MAP) enhanced microorganism control during storage. Acidity decreased by MAP but was restored during storage, Irradiation did not affect sample pH. Results show irradiation at 2 kGy combined with MAP can enhance microbiological safety and quality of minimally processed radish.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.5
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• pp.151-159
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• 2017

The aspect of modern warfare is gradually changing to a network of warfare, and its central information electronic warfare is evolving every day. Recently, domestic equipment of electronic warfare, which have succeeded in domestic localization, are strongly influenced by the nature of the environment. Therefore, the structural reliability of the antenna switching module that connects the mast and antenna of the ES equipment is the most important. This study proposed a structure that has an improved structure of antenna switching module by currently analyzing the structure of the antenna switching module and the environmental influence. By modifying the structure of the antenna switching module welding method and part of the reinforcement block, the structure was improved and the validity of the improved antenna switching module was simulated using a load test. The simulation showed that the safety factors of antenna switching module welding point and reinforced block part was enhanced 5.3 and 1.5 times compared to the existing values. These values were verified by load (181kg) test results, which was each 3.7Mpa and 64.4Mpa. The load test results were similar to the simulation results and load supporting capacity of the proposed antenna switching module was enhanced.