• 설비공학논문집
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• 제25권5호
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• pp.269-278
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• 2013

In this study, in order to examine the applicability of computational fluid dynamics with the porous model to the analysis of APR+ (Advanced Power Reactor Plus) internal flow, simulation was conducted with the commercial multi-purpose computational fluid dynamics software, ANSYS CFX V.14. In addition, among the various reactor internals, the effect of flow skirt geometry on reactor internal flow was investigated. It was concluded that the porous model for some reactor internal structures could adequately predict the hydraulic characteristics inside the reactor in a qualitative manner. If sufficient computation resource is available, the predicted core inlet flow distribution is expected to be more accurate, by considering the real geometry of the internal structures, especially located in the upstream of the core inlet. Finally, depending on the shape of the flow skirt, the flow distribution was somewhat different locally. The standard deviation of the mass flow rate (${\sigma}$) for the original shape of flow skirt was smaller, than that for the modified shape of flow skirt. This means that the original shape of the flow skirt may give a more uniform distribution of mass flow rate at the core inlet plane, which may be more desirable for the core cooling.

• 한국안전학회지
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• 제14권1호
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• pp.158-166
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• 1999

Due to the work characteristics of shipyard industry, subcontractors are essential and employees of them consist of 25% of the total employee. Problems of their safety management are as follows; - obscurity of safety management responsibility - flimsiness of subcontractor's safety awareness - absence of ability to develop safety techniques and to provide safety equipments - lack of opportunity of safety education The purpose of this study is modelling safety management system of shipyard industry subcontractors to reduce industrial accidents by employees of subcontractors. A phased model contained organization and work responsibility of related departments, safety management planning and evaluation system, safe work supporting system, safety education supporting system.

• 해양환경안전학회지
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• 제19권4호
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• pp.382-390
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• 2013

해상교통안전진단제도가 도입된 이후 제도개선을 위한 노력은 계속되어 왔다. 이 제도가 정착단계를 거쳐 고도화 단계로 나아가기 위해서는 진단활동 전반에 대한 종합적이고 체계적인 검토가 필요하다. 이에 본 연구에서는 해상교통안전진단에 대한 종합적인 분석 모형 설계를 목적으로 진단수행의 질적 향상을 위한 수단으로 파악되는 평가에 대한 평가, 즉 메타평가에 관한 이론을 적용하였다. 구체적으로는 메타평가의 주요 접근방식인 문헌연구와 전문가 검토, 설문조사 등의 방법으로 해상교통안전진단에 적합한 메타평가 기본모형을 도출하고, 이에 대한 타당성과 신뢰성을 검증하여 활용 가능한 'PIP'OU 메타평가 모형'을 제시하였다. 본 모형은 해상교통안전진단제도에 대한 최초의 메타평가 모형으로써 향후 제도의 문제점 도출과 개선방안 마련을 위한 해상교통안전진단제도의 메타평가 분석틀로 활용될 수 있을 것으로 기대한다.

• Journal of Ginseng Research
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• 제44권4호
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• pp.580-592
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• 2020

Background: Radix et Rhizoma Ginseng (thereafter called ginseng) has been used as a medicinal herb for thousands of years to maintain people's physical vitality and is also a non-organ-specific cancer preventive and therapeutic traditional medicine in several epidemiologic and preclinical studies. Owing to few toxic side effects and strong enhancement on body immunity, ginseng has admirable application potential and value in cancer chemoprevention. The study aims at investigating the chemopreventive effects of ginseng on cutaneous carcinoma and the underlying mechanisms. Methods: The mouse skin cancer model was induced by 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate. Ultraperformance liquid chromatography/mass spectrometry was used for identifying various ginsenosides, the main active ingredients of ginseng. Comprehensive approaches (including network pharmacology, bioinformatics, and experimental verification) were used to explore the potential targets of ginseng. Results: Ginseng treatment inhibited cutaneous carcinoma in terms of initiation and promotion. The content of Rb1, Rb2, Rc, and Rd ginsenosides was the highest in both mouse blood and skin tissues. Ginseng and its active components well maintained the redox homeostasis and modulated the immune response in the model. Specifically, ginseng treatment inhibited the initiation of skin cancer by enhancing T-cell-mediated immune response through upregulating HSP27 expression and inhibited the promotion of skin cancer by maintaining cellular redox homeostasis through promoting nuclear translocation of Nrf2. Conclusion: According to the study results, ginseng can be potentially used for cutaneous carcinoma as a chemopreventive agent by enhancing cell-mediated immunity and maintaining redox homeostasis with multiple components, targets, and links.

• 한국방재학회 논문집
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• 제9권5호
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• pp.1-7
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• 2009

피난안전성의 정량적인 평가를 위해 고려되는 정량적요소로는 피난거리와 피난장해를 대표적으로 들 수 있으며, 선행 연구에서 이론적인 증명과 단순모델 및 실재평면모델을 이용하여 일반성과 적용성에 대하여 검토되었다. 그러나 보다 현실적인 평가수법의 개발을 위해서는 피난경로상에 산재해 있는 다양한 피난장해에 대한 종합적인 검토가 가능해야 하며, 이를 위해서는 각 피난장해와 피난자의 피난조건이 피난안전성에 미치는 영향력에 대한 정량화가 필요하다. 따라서 본 연구에서는 피난장해와 피난자의 피난조건에 대한 이론적 검토를 통하여 피난경로상에 예상되는 다양한 피난장해의 정량화 함수를 도출하고, 선행연구에서 제시된 피난안전성 평가수법에 대입하고, 단순모델을 이용하여 피난자의 피난조건과 피난장해를 동시에 고려한 평가법의 적용성과 타당성에 대한 검토를 행하는 것으로, 보다 현실적인 피난안전성에 대한 정량적인 평가수법개발로의 연구적 발전을 도모한다.

• 해양환경안전학회지
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• 제21권3호
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• pp.274-282
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• 2015

This research is the result on calculating the logical speed limit through certain process which some elements must be considered on selecting the speed limit of harbour and waterway. The suggested speed limit select model on this research is processed from 1~6 steps by forming a professional group of experts. Each step has its information which 1st step(water division), 2nd step(selecting the model vessel and vessel applied with speed limit.), 3rd step(selecting the maximum and minimum speed range on each section), 4th step(evaluation on the safeness of traffic), 5th step(suggesting the appropriate speed limit), 6th step(execution and evaluation.). The appropriate speed limit was decided on consideration of the safety of maritime traffic on the range of the maximum speed and the minimum speed. This model was used to derive the appropriate speed limit on the harbour water and Busan harbour entrance waterway. As the result, the harbour water was calculated to be 6.9 knots, the appropriate speed limit of Busan entrance harbour was 9.3 knots. The present calculation of the speed limit on the approaching channel area is 10 knots, inner harbour area is 7 knots, which are similar to the result of the speed limit. This research is the first research on selecting the speed limit model and has its limits on finding the perfect speed limit result. More detailed standards on the safeness of traffic evaluation must be found and additional study is necessary on discriminating consideration of the elements. This research has its value which it provides instances of aboard cases on guidelines of selecting the speed limit.

• 한국강구조학회 논문집
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• 제30권2호
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• pp.97-104
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• 2018

PHC 파일을 연결하기 위해 수평 및 수직 볼트를 사용한 연결부의 안전성 평가를 유한요소해석을 통하여 수행하였다. 수치해석 모델은 유한요소해석 프로그램인 ABAQUS를 이용하였으며 모든 연결 장치를 3D Solid 모델로 모델링하였다. 볼트 연결부는 ABAQUS에 제시된 Contact 및 Tie 조건에 고려하여 검토하였다. 유한요소해석을 통해 PHC 파일 연결부의 압축, 인장, 휨 및 전단 해석을 수행하였으며, 각 연결 장치에서 발생하는 Von-Mises 응력을 도출하여 볼트연결부의 안전성을 평가하였다.

• 농약과학회지
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• 제16권3호
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• pp.261-266
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• 2012

농약을 포함한 화학물질의 독성을 평가하기 위하여 많은 실험동물이 사용되고 있다. 최근 동물실험에 대한 규제 강화와 실험동물의 윤리적 보호를 위해 동물실험을 대체하려는 동물대체시험법 연구가 활발히 진행되고 있다. 우리나라에서 화학농약 등록 시 급성경구독성시험, 급성경피독성시험, 피부자극성시험 등 여러 시험에서 실험동물을 이용하여 인축독성평가를 하고 있다. 세계적인 추세에 맞춰 농약의 안전성 평가를 위한 동물대체시험법 연구제시와 규제가 시급한 실정이다. 본 연구는 국제적으로 승인된 대체시험법 중 인공피부모델을 이용한 피부자극성평가 적용 가능성을 검토하기 위하여 실시하였다. 시험물질은 기존의 토끼를 이용한 피부자극성시험에서 피부반응을 평점화하여 산출한 피부 1차 자극지수(P. I. I.) 0-7(구분:없음-강도) 값을 가진 농약제품 16종을 선발, 인공피부(KeraSkin$^{TM}$)를 이용하여 피부자극성평가를 수행하였다. 그 결과, 중도이상의 농약인 경우 세포생존율 50% 이하로 자극성 물질로 나타났으며, 경도 이하의 농약인 경우 세포생존율 50% 이상으로 비자극성 물질로 나타났다. 피부의 자극성이 있는 경도에서 강도의 농약의 경우 현재 농촌진흥청 고시 농약표시 기준에 따라 주의사항을 표시하게 되어 있고(RDA, 2012b), 농약의 피부자극성의 경우 민감도가 사람에 따라 많은 차이를 보이기 때문에 피부자극성 대체시험법 적용여부는 추후 추가적인 검토가 필요할 것으로 판단되며, 앞으로 농약안전성평가를 위한 동물실험을 대체할 수 있는 시험법 검증연구를 통해 농약등록 시험기준과 방법을 개선할 필요성이 있다고 사료된다.

• 한국철도학회지
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• 제6권2호
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• pp.9-18
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• 2003

This paper discuss advanced safety in the railway signaling system. The specified methods and HAZOP about Hazard identification and analysis of railway signalling system were studied, and loss analysis and ALARP model in order to calculate safety as a standard capacity were proposed. It was also resulted from Hazard identification, analysis and evaluation by applying advanced safety to the railway signalling system.

• 산업경영시스템학회지
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• 제22권51호
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• pp.63-72
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• 1999

Many firms have applied flexible manufacturing systems as a means of increasing productivity, profitability, and quality. Therefore, the purpose of this paper is to develop the more efficient justification model through an analytical scoring model with the quantitative factors, flexibility factors, and safety factors under uncertainty. In this paper, the three factors for properly comparing and evaluating of flexible manufacturing systems are presented. Especially, this paper has emphasized the flexibility and safety factor; the one consists of organization assessment, process treatment function, products and products quantity, useful life assesment, and software function, the other presents risk assesment, Y2K problem, safety device analysis, total productive management system, safety management. Finally, a normalized scoring model by the new flexibility and safety factors can be used in real fields for flexible manufacturing systems project selection under uncertainty.