• Journal of Environmental Health Sciences
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• v.37 no.3
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• pp.226-233
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• 2011

Exactly 25 years after the Chernobyl nuclear disaster, 11th of March 2011 the Fukushima nuclear accident occurred in Japan and was ranked at level 7 same to the Chernobyl. A Korean and Japanese joint civil survey was conducted around Fukushima on April 13-17. The radiation survey data clearly shows a large hotspot area between 20 km and 50 km radius north and west direction from the accident reactors, with the highest radiation recorded being 55.64 ${\mu}Sv/hr$ in the air, 99.89 ${\mu}Sv/hr$ in the surface air, and 36.16 ${\mu}Sv/hr$ in a car, respectively. 3.65 ${\mu}Sv/hr$ in the air and 6.89 ${\mu}Sv/hr$ in the surface air were detected at the playground of an elementary school in Fukushima City. Spring came with full cherry blossoms in Fukushima, but it was silent spring of radiation contamination. Interviews with Fukushima nuclear refugees reveal serious problems about Japanese nuclear safety systems, such as there was no practical evacuation drill within 1-10 km and no plan at all for 10-30 km areas. Several reforms items for Korean nuclear safety system can be suggested: minimization of accident damage, clear separation of regulatory and safety bureaus with a new and independent administrating agency, community participation and agreement regarding the safety system and levels, which is the major concern of 80% Korean. To tackle threats of nuclear disaster in neighboring nations like China, a new position entitled 'Ambassador for nuclear safety diplomacy' is highly necessary. The nuclear safety of Korea should no longer be the monopoly of those nuclear engineers and limited technocrats criticized as a 'nuclear mafia'.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.23 no.2
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• pp.108-113
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• 2013

Objectives: Although several cases of lung diseases caused by indium have been reported in Japan, the United States and China, South Korea, which is estimated to have been the world's largest consumer of indium, has not yet established a criteria for the diagnosis of lung diseases caused by indium exposure. In this study, we tried to determine the applicability of the Krebs von den lungen-6, which has been widely recognized for its use with interstitial lung disease in Japan, as a biological exposure index for indium. Methods: Methods: The analysis of indium in serum was conducted by inductively coupled plasma mass spectrometry and the analysis of KL-6 in serum was carried out using enzyme-linked immunosorbent assay kit. Results: The indium levels in serum were distributed from below the detection limit to a peak of $125.78{\mu}g/L$, and the values of the KL-6 were distributed from 104.5 U/mL to 2162.2 U/mL. The serum indium and KL-6 showed good correlation ($R^2$=0.389,pfortrend=0.000) and smoking did not affect the KL-6. Conclusions: The usefulness of KL-6 as a specific biomarker for interstitial lung disease has been recognized. In addition, it is expected that effective prevention of health problems can be achieved by determining the lung-damage progress at an early stage according to individual susceptibility.

• Journal of the Korean Society of Safety
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• v.37 no.6
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• pp.32-39
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• 2022

This study analyzed the relationship between occupational accidents in the construction industry and business cycle factors. Multiple regression analyses were conducted to achieve the research purpose; additionally, time-varying parameter estimations were performed to interpret the results. The results obtained for the construction industry revealed a statistically significant relationship between occupational accidents and wage increase rate, unemployment, construction starts, and other factors. The wage increase rate plays a role in reducing occupational accidents because efforts are made to prevent accidents owing to the increase in income loss due to accidents and the demand for increased safety levels. The number of construction starts affects occupational accidents with a time lag of 1 to 2 or 4 months; therefore, it is likely to be used as a leading indicator for estimating fatal accidents in the construction industry. This study highlighted the importance of monitoring socioeconomic changes that could affect the working conditions of workers and workplaces, and production activities in the workplace for the effective prevention of occupational accidents. This study also reveals the necessity of developing a method to operate prevention projects flexibly and the seasonality of industrial characteristics, particularly those of the construction industry where the highest number of fatal occupational injuries occur.

• Safety and Health at Work
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• v.5 no.2
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• pp.91-96
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• 2014

Background: Chronic obstructive pulmonary disease (COPD) is an important cause of occupational mortality in miners exposed to coal mine dust. Although the inflammatory mediators involved in COPD have not been defined, many studies have shown that inflammatory mediators such as reactive oxygen and nitrogen species are involved in orchestrating the complex inflammatory process in COPD. Methods: To investigate the relevance of exhaled biomarkers of oxidative and nitrosative stress in participants with COPD, we determined the levels of hydrogen peroxide, malondialdehyde (MDA), and 3-nitrotyrosine (3-NT) in exhaled breath condensate (EBC) in 90 retired elderly coal miners (53 non-COPD and 37 COPD participants). Results: Mean levels of MDA (4.64 nMvs. 6.46 nM, p = 0.005) and 3-NT (3.51 nMvs. 5.50 nM, p = 0.039) in EBC were significantly higher in participants with COPD. The median level of MDA did show statistical difference among the COPD severities (p = 0.017), and the area under the receiver operating characteristic curve forMDA (0.67) for the diagnostic discrimination of COPD indicated the biomarker. The optimal cutoff values were 5.34 nM (64.9% sensitivity and 64.2% specificity) and 5.58 nM (62.2% sensitivity and 62.3% specificity) forMDA and 3-NT, respectively. The results suggest that high levels ofMDA and 3-NT in EBC are associated with COPD in retired elderly miners. Conclusion: These results showed that the elevated levels of EBC MDA and EBC 3-NT in individuals with COPD are biomarkers of oxidative or nitrosative stress.

• Safety and Health at Work
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• v.12 no.1
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• pp.127-132
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• 2021

Background: Herbicides such as glyphosate, paraquat, and 2,4-dichlorophenoxyacetic acid have been reported to cause adverse side effects through production of reactive oxygen species. However, there were no data representing the adverse effects of a mixture herbicide usage in farmers, especially the changes in oxidative marker and antioxidant defense. This study aimed to determine the urinary malondialdehyde (MDA) and glutathione (GSH) level in farmers using mixed herbicides. Methods: Ninety-three farmers were recruited, and two spot urine samples (before and after work) were collected. The urinary MDA level was evaluated by thiobarbituric acid reactive substance assay, and the urinary GSH level was determined using the enzymatic recycling method. Results: Sixty-two percent of the participants were men, and 59% of the participants worked in a farm for 20-40 years. The common combinations of herbicide usage were glyphosate with 2,4-dichlorophenoxyacetic acid (36.5%). There was no significant difference between pre- and post-work urinary MDA and GSH levels among the 3 groups of herbicides. However, the urinary MDA levels in farmers using the combination of glyphosate and paraquat were significantly higher than those found in farmers using glyphosate alone. The associated factors with changes in MDA levels found that the exposure intensity index (B = 0.154), the cumulative exposure intensity index (B = 0.023), and wearing gloves while working (B = -2.347) were found to be significantly associated with MDA level. Conclusion: The results suggest that the combined use of glyphosate and paraquat caused a significant increase in urinary MDA levels. Moreover, intensity of exposure to herbicide and wearing gloves were associated with the level of MDA.

• Safety and Health at Work
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• v.1 no.1
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• pp.69-79
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• 2010

Objectives: Various cytokines induced by inhalation of coal dust may mediate inflammation and lead to tissue damage or fibrosis, such as coal workers' pneumoconiosis (CWP). Methods: To investigate the relevance of serum cytokines in CWP, the levels of serum interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-${\alpha}$) as CWP biomarkers in 110 retired coal miners (22 controls and 88 CWP subjects) were related to cross sectional findings and 1-year progressive changes of the pneumoconiosis. Progressive changes of CWP were evaluated by paired comparison of chest radiographs. Analysis by a receiver operating characteristic curve assessed the biomarker potential of each cytokine. Results: The mean serum IL-8 level was significantly higher in CWP compared to controls and IL-8 levels correlated with the degree of CWP. The median serum TNF-${\alpha}$ level was significantly higher in subjects with progressive CWP compared to subjects without CWP progression. The area under the ROC curve for IL-8 (0.70) and TNF-${\alpha}$ (0.72) for CWP identification and progression, respectively, indicated the biomarker potential of the two cytokines. Serum cutoff values of IL-8 and TNF-${\alpha}$ were 11.63 pg/mL(sensitivity, 69%; specificity, 64%) and 4.52 pg/mL (sensitivity, 67%; specificity, 79%), respectively. Conclusion: The results suggest that high levels of serum IL-8 are associated with the presence of CWP and those of serum TNF-${\alpha}$ are associated with the progression of CWP.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.30 no.2
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• pp.185-195
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• 2020

Objectives: The purpose of this study was to analyze noise exposure levels and the rate of exceedance of exposure limits in workplaces from a 2015 measurement of working environments according to area, industry, and scale of workplace and to determine changes compared to the past. Methods: Among the 408,875 measurements of noise in working environments from 27,030 workplaces in 2015, 16,359 workplaces that were linked to special health examination data were selected as the subjects of this study. The eight-hour corrected measurements and geometric mean values of the individual noise measurements of the workplaces were used to calculate noise exposure levels and the exceedance rate of exposure limits. Results: The average noise exposure level of the overall workplaces making up the subjects of this study was 83.6 dBA, and the exceedance rate of exposure limits was 15.1%. At least half of the noise measurements exceeded the exposure limits in 13.7% of the workplaces. Noise exposure levels were higher in the manufacturing industry and in smaller-scale workplaces. The exceedance rate of noise exposure limits was higher in the mining and manufacturing industries and in smaller-scale workplaces. Conclusions: Noise exposure has shown improvements compared to the past, but the exceedance rate of exposure limits was still high, and more than half of the workers were being exposed to noise of 85 dBA or higher. Therefore, it is necessary to make more active improvements in working environments in terms of noise exposure.

• Safety and Health at Work
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• v.9 no.4
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• pp.421-426
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• 2018

Background: The purpose of this study was to investigate the effect of shift work on occupational safety in various industrial sectors. The study analyzes the effects of shift work on the health of workers by considering factors such as the workplace environment and welfare. Methods: Focusing on the $4^{th}$ Korean Working Conditions Survey, this study used an ordinary least-square multiple regression analysis. The dependent variable was the annual frequency of injuries reported by workers. Independent variables were categorized as demographic, shift work, workplace environment, and welfare variables. The analysis was conducted on two levels: 1) Shift work and nonshift work groups were compared, and 2) Shift work was compared with fixed and rotating shifts. Results: For the entire group, age, a low level of education, work hours, and daily and dispatch work negatively impacted the frequency of injuries. Shift work was negatively affected by workplace environment and welfare factors. In the shift group, the frequency of injuries was lower than that of regular workers, and the higher the autonomy in the choice of work hours, the lower the frequency of injuries. Furthermore, shift workers in Korea have more extended work hours (49.25 h/week) than other workers (46.34 h/week). Conclusion: Overall, welfare factors such as workplace satisfaction and worke-life balance reduced the frequency of injuries. The effect of shift work was limited, but it was confirmed that shift worker autonomy could reduce the frequency of injuries.

• Molecular & Cellular Toxicology
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• v.4 no.3
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• pp.211-217
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• 2008

To clarify the DNA damage from reactive oxygen species, we measured the DNA damage through Fpg/Endo III FLARE (Fragment Length Analysis with Repair Enzyme) assay and real time RT-PCR. The 80 SD rats assigned to 4 dose groups exposed to cumene vapor for 90 days. With Fpg/Endo III FLARE assay in hepatocytes, we found the OTM (Olive Tail Moment) and TL (Tail Length) significantly increased in no-enzyme treated and Fpg-treated control and 8 ppm groups with 28 days exposure. In Endo III-treated 8 ppm group, significantly increased the values with 90 days exposure. With lymphocytes, it was founded the values significantly increased in no-enzyme treated 800 ppm group in 28 and 90 days. It was significantly increased in Endo III-treated 80 ppm for 28 days and 800 ppm for 90 days. From the above findings, FLARE assay was suggested as being available as a biological marker for DNA damage induced by cumene exposure in SD rats. And we used real time RT-PCR for the OGG1 mRNA expression, it had dose-dependent biologic effects in 1 day exposure, but decrease the levels of rOGG1 mRNA. Our findings provide evidence that cumene exposure may cause suppression of rOGG1 in the rat hepatocytes or lymphocytes.

• Journal of the Korean Society of Safety
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• v.22 no.3 s.81
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• pp.39-44
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• 2007

Job stresses are realized as harmful factors affected workers' mental health. Job stresses can be defined as the physical and emotional responses that are occurred when the job requirements should be beyond the workers' abilities, followed with health problems and even work-related injuries. Job stresses could be resulted from the work environment and conditions related with workers' personality. This study is conducted to evaluate the job stresses for managers in the construction industry, by the questionaires which collected 302(75.5%) among 400 ones. The evaluation items are the levels of job stresses and stressors as well as the relationship between the variables. The controls should be recommended for physical and mental health.