Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
권호 표지

Applicability of Serum Krebs von den lungen-6 as a Biological Exposure Index for Workers Exposed to Indium

인듐 노출 근로자를 위한 생물학적 노출지표로써 혈청 Krebs von den lungen-6의 활용가능성

  • Won, Yong Lim (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Yi, Gwang Yong (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Lee, Mi-Young (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Kim, Eun-A (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency)
  • 원용림 (한국산업안전보건공단 산업안전보건연구원) ;
  • 이광용 (한국산업안전보건공단 산업안전보건연구원) ;
  • 이미영 (한국산업안전보건공단 산업안전보건연구원) ;
  • 김은아 (한국산업안전보건공단 산업안전보건연구원)
  • Published : 2013.06.30
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Abstract

Objectives: Although several cases of lung diseases caused by indium have been reported in Japan, the United States and China, South Korea, which is estimated to have been the world's largest consumer of indium, has not yet established a criteria for the diagnosis of lung diseases caused by indium exposure. In this study, we tried to determine the applicability of the Krebs von den lungen-6, which has been widely recognized for its use with interstitial lung disease in Japan, as a biological exposure index for indium. Methods: Methods: The analysis of indium in serum was conducted by inductively coupled plasma mass spectrometry and the analysis of KL-6 in serum was carried out using enzyme-linked immunosorbent assay kit. Results: The indium levels in serum were distributed from below the detection limit to a peak of $125.78{\mu}g/L$, and the values of the KL-6 were distributed from 104.5 U/mL to 2162.2 U/mL. The serum indium and KL-6 showed good correlation ($R^2$=0.389,pfortrend=0.000) and smoking did not affect the KL-6. Conclusions: The usefulness of KL-6 as a specific biomarker for interstitial lung disease has been recognized. In addition, it is expected that effective prevention of health problems can be achieved by determining the lung-damage progress at an early stage according to individual susceptibility.

Keywords

References

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