• Journal of Food Hygiene and Safety
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• v.26 no.2
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• pp.120-124
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• 2011

Predictive mathematical models were developed for predicting the kinetics of growth of Listeria monocytogenes in smoked salmon, which is the popular ready-to-eat foods in the world, as a function of temperature (4, 10, 20 and $30^{\circ}C$). At these storage temperature, the primary growth curve fit well ($r^2$=0.989~0.996) to a Gompertz equation to obtain specific growth rate (SGR) and lag time (LT). The Polynomial model for natural logarithm transformation of the SGR and LT as a function of temperature was obtained by nonlinear regression (Prism, version 4.0, GraphPad Software). Results indicate L. monocytogenes growth was affected by temperature mainly, and SGR model equation is $365.3-31.94^*Temperature+0.6661^*Temperature^{\wedge^2}$ and LT model equation is $0.1162-0.01674^*Temperature+0.0009303^*Temperature{\wedge^2}$. As storage temperature decreased $30^{\circ}C$ to $4^{\circ}C$, SGR decreased and LT increased respectively. Polynomial model was identified as appropriate secondary model for SGR and LT on the basis of most statistical indices such as bias factor (1.01 by SGR, 1.55 by LT) and accuracy factor (1.03 by SGR, 1.58 by LT).

• Journal of Food Hygiene and Safety
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• v.32 no.6
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• pp.455-459
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• 2017

Norovirus (NoV) is the most common cause of acute gastroenteritis in all age groups worldwide. In this study, prevalence of asymptomatic norovirus infection was investigated in food handler being employed at food catering facilities in South Korea. A total of 2,729 fecal specimens from asymptomatic food handlers were analyzed, and 1.06% of food handlers (29/2,729) had asymptomatic NoV infection. Of these, 17.2% (5/29) were positive for NoV GI and 82.7% (24/29) were positive for NoV GII. Especially, sequencing and phylogenetic analysis showed that GII-4 was the most prevalent genotype and a large number of asymptomatic food handlers were infested with norovirus GII-4 strains. The results of this study show that asymptomatic food handlers may be potential transmission sources for NoV infection. These results emphasize the need for training of food catering employees about norovirus prevention. Asymptomatic norovirus infection should receive more attention.

• Journal of Biomedical Engineering Research
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• v.31 no.4
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• pp.280-284
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• 2010

Approvals of medical device increase every year as industry of medical device grows. Therefore KFDA keeps trying to improve approval systems. However, the firms of medical device are in trouble due to regulation amendment, a firm of small size, exchange of the person in charge. The staffs of KFDA increase their work load because applicants of approval of medical device aren't used to writing of document. Therefore the firm of medical device in business have a long term. KFDA develops eight guidance document item by item for one-step evaluation and approval for Medical Devices because applicants of approval of medical device write documents easily. KFDA reviewer can carry on quick reviewing in use of this eight guidances. This guidance are improved on satisfaction of applicants of approval of medical device.

• Journal of the Korean Society of Safety
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• v.30 no.5
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• pp.52-58
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• 2015

Although lots of safety inspection and precision safety diagnosis have been conducted on concrete retaining wall, there is no comprehensive analysis on the basis of the accumulated data associated with the statistic. Especially, the concentrated management is necessary on the evaluation items that cause critical damages for the efficient performance. In this regard, this study conducted a correlation analysis between the 18 condition evaluation items and defect index for the concrete retaining wall as well as how each item affects the final defect index as much as in the manual. As a result, correlation coefficient between sliding and overturning was 0.601, which means that they have a strong correlation, and the most influential item on defect index is the condition of drainage that scored the 0.750 correlation coefficient. In addition, as a result of regression analysis, the condition of drainage with the 0.683 correlation coefficient has a strong correlation with the defect index. If the condition evaluation items are integrated or readjusted based on the results of the statistical analysis in this study, the more efficient and accurate maintenance will be possible.

• Journal of the Korean Society of Safety
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• v.30 no.6
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• pp.56-62
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• 2015

Recently, one of countermeasures against aging SOC infrastructures, performance-focused management including the serviceability, functionality, durability, and economics has been changed from the structural safety-focused evaluation has changed into The current inspection and diagnosis for the major SOC facilities in Korea has been carried out by the specific principle of details, and most of them checked by the visual inspection are focused on the repair and rehabilitation of the damaged structures, thus they are the preventive maintenance. However, the performance-focused management should be replaced for the effective and economic maintenance as wells as for the minimization of the damage. In this regard, this study the appropriacy of the current evaluation items about the concrete retaining wall, one of SOC infrastructures as the previous step forward the performance-focused management. In order to deduct the effective evaluation items in order, the entropy, analytic hierachy process (AHP), and promethee analysis were peformed and the results were compared and discussed.

• Journal of the Korean Society of Safety
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• v.24 no.3
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• pp.96-101
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• 2009

In this study, a risk-appearance frequency evaluation model for railway level-crossing accidents is developed with the frequency estimation based on the accident history. It follows the worldwide common safety management approach and reflects the operation conditions and accident properties of the domestic railway system. The risk appearance frequency evaluation process contains a development of accident scenarios by defining the system configurations and functions, and a frequency estimation of hazardous events based on the accident history. The developed model is verified with the accident history during 5 years('03-'07) for 3 hazardous events: 'Being trapped in level crossing(Hl)', 'Crossing during warning signal(H2)' and 'Breaking through/detouring the barrier(H3)'. This risk appearance frequency evaluation model will be combined with a consequence evaluation model so as to offer full risk assessment for the railway accident. The accident risk assessment will contribute to improving the safety management of the railway system.

• Food Science and Biotechnology
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• v.16 no.6
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• pp.868-872
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• 2007

The microbiological and chemical identification of antibiotic residues was attempted for livestock and seafood products including pork (n=34), beef (n=34), chicken (n=32), flatfish (n=37), armorclad rockfish (n=36), and sea bream (n=27). The meat (n=100) and seafood (n=100) samples were collected from 9 markets in 5 major Korean cities. Antibiotic substances were identified from the classes of tetracyclines, macrolides, penicillins, aminoglycosides, polyethers, peptides, sulfonamides, quinolones, chlorampenicols, and novobiocins using a microbiological assay, the Charm II test and high performance liquid chromatography (HPLC) with ultra violet (UV) and fluorescence detectors. The results showed that 2 tetracyclines (oxytetracycline and tetracycline) and 3 quinolones (ciprofloxacin, norfloxacin, and enrofloxacin) were detected in 4 samples of flatfish among all 100 seafood samples tested. No antibiotic residues were detected in the 100 livestock product samples tested. The amounts (min-max, mg/kg) of the residual antibiotics were as follows; tetracycline 0.78-0.85, oxytetracycline 0.49-0.74, ciprofloxacin 0.09-0.83, norfloxacin 0.01-0.21, enrofloxacin 0.12-2.98. These data indicate that the total detection rate of antibiotics in livestock and seafood products was approximately 2%.

• Analytical Science and Technology
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• v.34 no.4
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• pp.160-171
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• 2021

Synthetic azo dyes are used extensively in herbal medicines to render the medicines more visually attractive to consumers. This study developed and validated a rapid high-performance liquid chromatography (HPLC) method to determine whether synthetic colorants such as Tartrazine, Auramine O, Metanil yellow, Sunset yellow, and Orange II are used extensively in Typha orientalis. To increase the recovery of the synthetic dyes, this method employed containing 50 mM ammonium acetate in 70 % methanol at first extraction and 100 mM HCl in 70 % methanol at second extraction. Five synthetic pigments in Typha orientalis were separated by gradient elution with a mobile phase consisting of acetonitrile and 50 mM ammonium acetate in distilled water at ultra-violet (UV) detection 428 nm or 500 nm. Additionally, this study established the liquid chromatography tandem mass spectrometry (LC-MS/MS) method to confirm positive samples suspected by HPLC results. The HPLC-UV method had good linearity, indicating r²> 0.999. The recoveries of the samples spiked with three different concentration ranged from 73.8~91.5 %, and relative standard deviation values indicated 0.2~5.2 %. The established LC-MS/MS could successfully identify the synthetic pigments in herbal medicine samples. The study demonstrates that Typha orientalis adulterated by yellowish synthetic dyes can be successfully distinguished when using the HPLC-UV method.

• Journal of the Korea institute for structural maintenance and inspection
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• v.1 no.1
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• pp.53-64
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• 1997

Recently, safety evaluation of structures has received great concern in this country. One major problem in safety evaluation is that the results are often quite different depending upon evaluation authority. This is mainly due to arbitrary selection of various modification factors when employing allowable stress method for safety evaluation, The purpose of the present study is, therefore, to establish a rational method to determine the modification factors, especially the stress modification factor and the deterioration modification factor based on visual examination. It is thought that the proposed method yields a rational and consistent result for safety evaluation and may efficiently be used for realistic evaluation of load capacity of bridge structures.

• Journal of Biomedical Engineering Research
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• v.32 no.2
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• pp.151-157
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• 2011

Tattooing is a performance for decorative and cosmetic marking by placing permanent ink into the skin. As the cultural meaning of tattoo in Korea is changing, the tattoo machines are widely spread n permanent cosmetic market. Though the use of the tattoo machine was increased, the evaluation standards of tattoo machine were not existed. Korea Food and Drug Association regulated the electrical and mechanical safety standards which were founded on the IEC 601-1 second edition. Also they regulated he biological safety standards which were derived from the ISO 10993 series, however, these general valuations of common medical device were insufficient for evaluating tattoo machine. We developed the standards of tattoo machine for safety and performance evaluation for tattoo machine by preliminary hazard analysis in ISO 14971. The evaluation criteria of tattoo machines are focused on the mechanical invasion. We suggested the additional evaluation items of the needle speed, length, vibration with general valuation criteria of common medical device. We anticipate that this research may be a primary stage to figure a standard regulation and evaluation for tattoo machine.