• Biomolecules & Therapeutics
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• v.24 no.2
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• pp.115-122
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• 2016

Sleep, which is an essential part of human life, is modulated by neurotransmitter systems, including gamma-aminobutyric acid (GABA) and dopamine signaling. However, the mechanisms that initiate and maintain sleep remain obscure. In this study, we investigated the relationship between melatonin (MT) and dopamine D2-like receptor signaling in pentobarbital-induced sleep and the intracellular mechanisms of sleep maintenance in the cerebral cortex. In mice, pentobarbital-induced sleep was augmented by intraperitoneal administration of 30 mg/kg MT. To investigate the relationship between MT and D2-like receptors, we administered quinpirole, a D2-like receptor agonist, to MT- and pentobarbital-treated mice. Quinpirole (1 mg/kg, i.p.) increased the duration of MT-augmented sleep in mice. In addition, locomotor activity analysis showed that neither MT nor quinpirole produced sedative effects when administered alone. In order to understand the mechanisms underlying quinpirole-augmented sleep, we measured protein levels of mitogen-activated protein kinases (MAPKs) and cortical protein kinases related to MT signaling. Treatment with quinpirole or MT activated extracellular-signal-regulated kinase 1 and 2 (ERK1/2), p38 MAPK, and protein kinase C (PKC) in the cerebral cortex, while protein kinase A (PKA) activation was not altered significantly. Taken together, our results show that quinpirole increases the duration of MT-augmented sleep through ERK1/2, p38 MAPK, and PKC signaling. These findings suggest that modulation of D2-like receptors might enhance the effect of MT on sleep.

• Journal of Internet Computing and Services
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• v.12 no.5
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• pp.73-85
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• 2011

Lots of valuable textual information is used to extract relations between named entities from literature. Composite kernel approach is proposed in this paper. The composite kernel approach calculates similarities based on the following information:(1) Phrase structure in convolution parse tree kernel that has shown encouraging results. (2) Predicate-argument structure patterns. In other words, the approach deals with syntactic structure as well as semantic structure using a reciprocal method. The proposed approach was evaluated using various types of test collections and it showed the better performance compared with those of previous approach using only information from syntactic structures. In addition, it showed the better performance than those of the state of the art approach.

• Fashion & Textile Research Journal
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• v.5 no.4
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• pp.331-336
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• 2003

This study is to research the influence of Caesalpinia sappan which was imported through the exchanges between the Chosun dynasty and Japanese envoys during the early Chosun dynasty. Korea interchanged politically and culturally with Japan since ancient times. Particularly, the good-neighbor foreign policy toward Japan grew into trade relations. The diplomatic mission, under the name of Tongshinsa, was dispatched 12 times in total. Plenty of goods were exchanged through the visiting of Japanese envoys as well as through the activities of Korean envoys. In other words, the Korean-Japanese relations were at first focused on the political and diplomatic etiquette and gradually evolved into economic exchanges. Trading goods were various, including food, clothing, etc. Caesalpinia sappan, a red dye, was the most imported goods from Japan, but it was sold at a very high price, which caused luxurious trends in clothing. However, these sumptuous moods of the upper classes were decreased in the 16th century. Some of the reasons are : the difficulties of Japan's trade with the Caesalpinia sappan producing countries in South-east Asia, the transition of the high classes' preference from red clothing into Chinese BaecSa and SaraNeungDan, and the comparative decrease in the demand of Caesalpinia sappan by the changed understanding of Honghwa. Therefore, the early Chosun dynasty's clothing trends were due to the relationships between the Chosun dynasty and Japan.

• The Transactions of the Korean Institute of Electrical Engineers C
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• v.49 no.2
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• pp.107-112
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• 2000

$(Sr_{0.85}Ca_{0.15})TiO_3$(SCT) thin films were deposited on Pt-coated $TiO_2/SiO_2/Si$ wafer by the rf sputtering method. Experiments were conducted to investigate the electrical properties of SCT thin films with various top electrodes. Various top electrodes as Pt, Al, Ag, Cu were deposited on SCT thin films by sputter and thermal evaporator. The characteristics of C-F and C-V of SCT thin films were not obviously varied with various top electrodes, SCT thin films annealed at $600^{\circ}C$ represents as favorable capacitance characteristics than SCT thin films not annealed, and Pt top electrode have the most high capacitance. The characteristic of I-V of SCT thin films showed that Pt top electrode revealed more less leakage current density than other electrodes, had a leakage current density below 10-8$[A/cm^2]$ until 25[V] applied voltage.

• Journal of Haehwa Medicine
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• v.15 no.2
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• pp.247-261
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• 2006

In oriental medicine, Rhei Radix et Rhizoma & Gardeniae Fructus are frequently used materials for anti-inflammatory effect especially urinary tract disease and for neuropsychosis. Bang-Yak-Hap-Pyun(方藥合編) is widely used for clinical herbal prescription book. In Bang-Yak-Hap-Pyun(방약합편), Rhei Radix et Rhizoma is used 0.8g~16g. and Gardeniae Fructus is used 1.2g~6g. The most important fact is that the prescriptions used Rhei Radix et Rhizoma & Gardeniae Fructus at the same time are 4(Yang-Gyuk-San, Pal-Jung-San, Sa-Chung-Hwan, Suk-Gyul-Myung-San. The ratio of Rhei Radix et Rhizoma & Gardeniae Fructus are 2:1, 1:1, 1:1, 1:2 ). The number of prescription Rhei Radix et Rhizoma & Gardeniae Fructus in Bang-Yak-Hap-Pyun is total 45. 1 in sang-tong(上統), 5 in jung-tong(中統), 39 in ha-tong(下統). The group of mostly used disease is about urinary tract. The ratio of Rhei Radix et Rhizoma in Bang-Yak-Hap-Pyun is 3.33%~57.14%. And the ratio of Gardeniae Fructus is 3.47%~98%. The mostly quoted medical literature what prescription included Rhei Radix et Rhizoma & Gardeniae Fructus in Bang-Yak-Hap-Pyun are Dong-Yi-Bo-Gam and Man-byung-hoe-chun.

• Journal of Ginseng Research
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• v.33 no.4
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• pp.249-255
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• 2009

The oxidation of glycolate to glyoxylate, a key step in plant photorespiration, is carried out by the peroxisomal flavoprotein glycolate oxidase (EC 1.1.3.15). To investigate the altered gene expression and the role of GOX in ginseng plant defense system, a cDNA clone containing a GOX gene designated as PgGOX was isolated and sequenced from Panax ginseng. The cDNA was 692 nucleotides long and have an open reading frame of 552 bp with a deduced amino acid sequence of 183 residues. A GenBank BlastX search revealed that the deduced amino acid of PgGOX shares a high degree homology with the Glycine max (95% identity). In the present study we analyzed the expression of PgGOX under various environmental stresses at different times using real time-PCR. The results showed that the expressions of PgGOX increased after various treatments involving salt, light, cold, ABA, SA, and copper treatment.

• Journal of Korean Medical classics
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• v.13 no.1
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• pp.17-43
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• 2000

This study on the conception of Pyo Bon expressed in Hwang Jae Nai Kyung was summarized as follows: 1. The conception of Pyo Bon in the Yi Jung Byun Gi Lon(移精變氣論) and Tang Eak Yo Le Lon(湯液료醴論) of So Moon(素問) is that Pyo means the doctor and Bon means the disease. The Pyo Bon of this chapter has a meaning of time, namely first and last. 2. The conception of Pyo Bon in the Soo Yul Hyul Lon(水熱穴論) of So Moon is that Pyo means the lung and Bon means the kidney. The Pyo Bon of this chapter has a meaning of space, namely the upper and lower sides. 3. The conception of Pyo Bon in the Pyo Bon Byung Jun Lon(標本病傳論) of So Moon is that Pyo means a earlier disease and Bon means a later disease. The Pyo Bon of this chapter has a meaning of time, namely first and last. 4. The conception of Pyo Bon in the Chun Won Gi Dae Lon(天元紀大論), Yug Mi Ji Dae Lon(六微旨大論) and Ji Jin Yo Dae Lon(至眞要大論) of So Moon is that Pyo means a Yug Gi(六氣), namely wind, cold, heat, dampness, dryness, fire and Bon means a Sam Eum Sam Yang(三陰三陽), The Pyo Bon of this chapter includes a meaning of time and space. 5. The conception of Pyo Bon in the Sa Jun(師傳) of Yung Chu(靈樞) is that Pyo means a inside of the body and Bon means a outside of the body. The Pyo Bon of this chapter a meaning of space, namely the inside and outside. 6. The conception of Pyo Bon in the Wi Gi(衛氣) of Yung Chu is that Pyo means the end of limbs and Bon means the part of head, face, chest, abdomen, back. The Pyo Bon of this chapter has a meaning of space, namely center and circumference.

• Journal of the Korean Institute of Intelligent Systems
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• v.24 no.6
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• pp.622-627
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• 2014

This paper proposes a new method which improves recognition rate on the gait recognition system using wavelet transform, linear discriminant analysis and genetic algorithm. We use wavelet transform to obtain the four sub-bands from the gait energy image. In order to extract feature data from sub-bands, we use linear discriminant analysis. Distance values between training data and four sub-band data are calculated and four weights which are calculated by genetic algorithm is assigned at each sub-band distance. Based on a new fusion distance value, we conducted recognition experiments using k-nearest neighbors algorithm. Experimental results show that the proposed weight fusion method has higher recognition rate than conventional method.

• The KIPS Transactions:PartD
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• v.18D no.5
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• pp.329-338
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• 2011

Terminology recognition system which is a preceding research for text mining, information extraction, information retrieval, semantic web, and question-answering has been intensively studied in limited range of domains, especially in bio-medical domain. We propose a domain independent terminology recognition system based on machine learning method using dictionary, syntactic features, and Web search results, since the previous works revealed limitation on applying their approaches to general domain because their resources were domain specific. We achieved F-score 80.8 and 6.5% improvement after comparing the proposed approach with the related approach, C-value, which has been widely used and is based on local domain frequencies. In the second experiment with various combinations of unithood features, the method combined with NGD(Normalized Google Distance) showed the best performance of 81.8 on F-score. We applied three machine learning methods such as Logistic regression, C4.5, and SVMs, and got the best score from the decision tree method, C4.5.

• Journal of Haehwa Medicine
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• v.9 no.2
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• pp.293-313
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• 2001

The oriental-western Literatural study of Amnesia, the results were as follows. 1. esia is caused by qi-depression resulted from excessive thought and deficiency of the kidney resulted from congenital deficiency and deficiency of the heart, the disharmony between the heart and the kidney, phlegm, stagnant blood, loss of the blood etc. resulted from deficiency of the heart blood. 2. The treatment method of Amnesia is as follows, the highest frequence was growing blood-tranquilization-regulating spleen, in descending order removing phlegm-stagnant blood-relaxing the mind and invigorate the heart-spleen-kidney and much tonification qi-blood and growing nutrient qi-manifesting source qi and regulating the harmony between the heart and the kidney and maintaining patency for the flow of gi were the most treatment method. 3. The treatment medicine of Amnesia is as follows, the highest frequence was Kuei Bi Tang(歸脾湯) in decending order Jeng Ji Whan(定志丸), Su Seng Whan(壽星丸), Chun Whang Boo Sim Dan(天王補心丹), Ju Jak Whan(朱雀丸), Doo Dam Tang(導痰湯), Yin Sin Kuei Sa Dan(引神歸舍丹), Ga Gam Go Bon Dan(加減固本丸), Ryung Ji Go(寧志膏), Jang Won Dan(壯元丹), Tong Ol Tang(通鬱湯). 4. In oriental medicine functional physiology and pathology was significant in differential diagnosis and treatment and in western medicine it was explained organically and psychologically. 5. In western medicine As one of memory disorder Amnesia is divided into psychogenic amnesia and organic amnesia, and organic amnesia is divided into anterograde amnesia and retrograde amnesia and psychogenic amnesia is divided into localized amnesia, generalized amnesia selective amnesia.