• Biomolecules & Therapeutics
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• v.23 no.4
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• pp.339-344
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• 2015

Naringenin (NAR) as one of the flavonoids observed in grapefruit has been reported to exhibit an anti-cancer activity. However, more detailed mechanism by which NAR exerts anti-cancer properties still remains unanswered. Thus, in this study, we have shown that NAR down-regulates the level of cyclin D1 in human colorectal cancer cell lines, HCT116 and SW480. NAR inhibited the cell proliferation in HCT116 and SW480 cells and decreased the level of cyclin D1 protein. Inhibition of proteasomal degradation by MG132 blocked NAR-mediated cyclin D1 downregulation and the half-life of cyclin D1 was decreased in the cells treated with NAR. In addition, NAR increased the phosphorylation of cyclin D1 at threonine-286 and a point mutation of threonine-286 to alanine blocked cyclin D1 downregulation by NAR. p38 inactivation attenuated cyclin D1 downregulation by NAR. From these results, we suggest that NAR-mediated cyclin D1 downregulation may result from proteasomal degradation through p38 activation. The current study provides new mechanistic link between NAR, cyclin D1 downregulation and cell growth in human colorectal cancer cells.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.21 no.2
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• pp.157-167
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• 2021

Despite the importance of information technology, research on information-oriented performance management and performance management methods are very insufficient. In this paper, the SSU-ITPM model, a company-wide informatization performance evaluation and management model that reflects the characteristics of the shipbuilding and marine industry with high cooperative and process complexity, was presented. This model consisted of informatization planning and project management, informatization field utilization evaluation, informatization utilization quality evaluation, informatization user satisfaction evaluation, and informatization effect achievement evaluation. In addition, through the application of Company D, the feasibility of practical application of the model was confirmed. This study is expected to provide a practical reference model for informatization performance management of ETO plant-based companies such as the shipbuilding and offshore sector.

• The Journal of the Korea Contents Association
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• v.6 no.5
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• pp.104-112
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• 2006

Game industry developed much from fast development of an information communication technology and an internet technology. Game industry is getting attention by high value-added industry in 21th century And genre of various game appeared. On-line game is taking charge of important role of latest IT industry Now, game software market for education is expanded, but a lot of side effects exist because of wrong game software. In this paper, we investigate existent researches about quality evaluation of on-line game's qualitative improvement. Also, we present improving quality evaluation constituent additionally.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.43 no.5
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• pp.34-42
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• 2011

A fiber processing method, which might be an alternative for conventional refining process, was introduced. The method consists of repetitive, gentle, mechanical impacts on fibers, followed by fiber uncurling process. This method was very effective for OCC and BCTMP for increasing WRVs (water retention value) while keeping fiber lengths from shortening. For OCC and BCTMP, gentle mechanical impacts on fibers using Hobart mixer increased breaking lengths and tear strengths simultaneously at fast drainage level, and straightening fibers using kady mill increased those strength properties further. For SwBKP and HwBKP, only mechanical impacts using the Hobart mixer were effective on increasing tensile and tear strength at fast drainage, but there were no further increase by kady mill treatment. The strength increases of BCTMP by this alternative fiber processing method were exceptionally high. An extensive engineering development should be followed to actualize this fiber processing mechanism in an energy-effect way.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.37 no.2 s.110
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• pp.1-10
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• 2005

Removal of fines from fiber furnish by fractionation improves drainage, but decreases fiber bonding in paper. Fines can be again classified by their size such as the fines that passed 150 and 400 mesh screen, respectively. A hypothesis of different properties between these two kinds of fines was tested. Four different furnishes (SwBKP, HwBKP, KOCC, and BCTMP) were refined in two levels, and all their furnish and handsheet properties were compared in respect of their fines. KOCC fines gave the slowest drainage and least contribution to breaking length while BCTMP fines the fastest drainage and the highest contribution to breaking length. Removal of the fines that passed 400 mesh screen gave high improvement in drainage and large decrease in breaking length. Only KOCC fines removal gave more positive results where there were large improvement in drainage but only small decrease in breaking length.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.37 no.4 s.112
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• pp.8-17
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• 2005

WCT (Wet compaction test) is a new fiber evaluation method developed recently by Seo and its test results can be used as a predictor for pulp quality and its paper property Bleached chemical pulps (SwBKP, HwBKP), recycled pulp (OCC), and mechanical pulp (BCTMP) were used for the furnishes to be tested by WCT We compared the WCT results to conventional fiber evaluation tests such as WRV (Water Retention Value), free ness, and fiber length in this study, and found that WCT always gave better regression coefficients in relation to pulp quality (drainage), and paper properties (density, tensile, tear, and burst strength). WCT may be used on-line in papermachine.

• Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
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• 2006.06b
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• pp.423-426
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• 2006

Paper has fibers and fines network structure and it is strongly affected by interface bonding between fibers. Depending on the inter-fiber bonding, paper bulk is determined. Fines play an important roll in Campbell and consolidation effect through wet pressing and drying operations. Refined Sw-BKP, Hw-BKP and BCTMP fines were used to investigate the fines effect. Wet-web strength, breaking length, scattering coefficient, and hydrodynamic specific volume were measured. According to the result of experiments, chemical and morphological compositions of fines do not strongly affect to wet-web forming, but strongly affect to drying operations which form hydrogen bonding among fiber-fines-fiber matrixes. Paper bulk should be controlled by the extent of hydrogen bonding between fibers during drying operations.

• Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
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• 2006.06b
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• pp.433-440
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• 2006

A fiber processing method, which might be an alternative for conventional refining process, was introduced. The method consists of repetitive, gentle, mechanical impacts on fiber, and ensued fiber uncurling process. This method was very effective for OCC and BCTMP for increasing WRVs (water retention value) while keeping fiber lengths from shortening. For OCC and BCTMP, gentle mechanical impacts on fibers using Hobart mixer increased breaking lengths and tear strengths simultaneously at fast drainage level, and straightening fibers using kady mill increased those strength properties further. For SwBKP and HwBKP, only mechanical impacts using the mixer were effective on increasing tensile and tear strength at fast drainage, but not kady mill treatment. The strength increases of BCTMP by this alternative fiber processing method were exceptionally high. An extensive engineering development should be followed to actualize this fiber processing mechanism in an energy-effect way.

• Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
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• 2005.11a
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• pp.157-171
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• 2005

초지와 인쇄시의 지절은 생산성 또는 운전성의 저하를 야기하므로 최소화해야 한다. 지종에 따라 초지조건이 달라지므로 종이에 가해지는 인장력, 함수율, 초지속도 등을 고려해야 한다. 종이에 있어서 결점 부근에서 일어나는 항복(yield)과 파괴현상을 파괴역학적 관점에서 연구한 바 있다. 초지공정은 섬유 매트 또는 습지에서 점차적으로 수분이 제거되는 과정이며, 인쇄공정은 종이에 물이 가해지는 과정이 있으나, 파괴인성 측면에서 동일한 이론을 적용할 수 있다. 박과 이는 초지시 섬유의 특성, 미세분의 종류 및 함량에 따른 인장 특성 및 파괴 특성에 관한 연구에서 Sw-BKP의 경우 섬유의 파괴가 유도되고, Hw-BKP의 경우 결합면의 파괴가 유도되는 것으로 나타났으며, 미세분 특성에 따른 시험 결과 파괴 인성은 섬유간 실제적 결합이 유도되는 경우 파괴 인성의 향상을 가져올 수 있는 것으로 나타났다. 파괴 역학은 결점 부위의 응력집중 현상에 따른 독특한 파괴 거동으로 지합등과 같은 응력 확산 효과를 기대할 수 없기 때문에 섬유간 실제적인 결합에 직접적으로 의존한다고 할 수 있다.

• Proceedings of the Korea Technical Association of the Pulp and Paper Industry Conference
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• 2008.04a
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• pp.129-134
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• 2008

Properties of newly developed paper from Red Algae Pulp (RAP) were examined. The paper samples were prepared by mixing RAP fiber with wood fibers, HwBKP and SwBKP, to form a paper with $60g/m^2$ in weight. It was prepared in three to four different levels of refining degree and pressure so that it can reveal different bulk level in order to clearly compare the opacity at equivalent bulk for each furnish compositions. Printability of RAP fiber revealed superior effect on print through repression and initial ink absorption. Those properties are expected to improve further if printability improvement effect due to smoothness improvement is added.